DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pnr and Gata1

DIOPT Version :9

Sequence 1:	NP_476685.1	Gene:	pnr / 44849	FlyBaseID:	FBgn0003117	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_032115.1	Gene:	Gata1 / 14460	MGIID:	95661	Length:	413	Species:	Mus musculus

Alignment Length:	335	Identity:	133/335 - (39%)
Similarity:	161/335 - (48%)	Gaps:	72/335 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ILLSDGDSTSDQQSTRDYPHFSGDYQNVTLSAASASTSASASATHVAAVKMY-------HSSAVA 60
            ::.|..|||.         .||...:.  |.|||:|||.:|:....:|:..|       ||....
Mouse    23 LVSSPSDSTG---------FFSSGPEG--LDAASSSTSPNAATAAASALAYYREAEAYRHSPVFQ 76

  Fly    61 AYTDL----AAAGSAASAGVGVGVSGYHQQAVNAPVYVPSNRQYNHVAAHFGSAAAQNAW----- 116
            .|..|    ...|.:..|....|.:..:.    |....||:......|.......:.|.:
Mouse    77 VYPLLNSMEGIPGGSPYASWAYGKTALYP----ASTVCPSHEDAPSQALEDQEGKSNNTFLDTLK 137

  Fly   117 ---------------------TTEGFGSAH--AQFYSPNAAVMMGSWRSAYDPSGFQRSSPYESA 158
                                 |...:|.|.  :.|:||..:.:..   :||....|..|.|....
Mouse   138 TERLSPDLLTLGTALPASLPVTGSAYGGADFPSPFFSPTGSPLSS---AAYSSPKFHGSLPLAPC 199

  Fly   159 MDFQFGEGRECVNCGAISTPLWRRDGTGHYLCNACGLYHKMNGMNRPLIKPSKRLVSATATRRMG 223
                  |.||||||||.:|||||||.|||||||||||||||||.|||||:|.||::   .::|.|
Mouse   200 ------EARECVNCGATATPLWRRDRTGHYLCNACGLYHKMNGQNRPLIRPKKRMI---VSKRAG 255

  Fly   224 LCCTNCGTRTTTLWRRNNDGEPVCNACGLYYKLHGVNRPLAMRKDGIQTRKRK-----PKKTGSG 283
            ..||||.|.||||||||..|:|||||||||:|||.|||||.|||||||||.||     .||.||.
Mouse   256 TQCTNCQTTTTTLWRRNASGDPVCNACGLYFKLHQVNRPLTMRKDGIQTRNRKASGKGKKKRGSN 320

  Fly   284 SAVGAGTGSG 293
            .| |||...|
Mouse   321 LA-GAGAAEG 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pnr	NP_476685.1	ZnF_GATA	164..212	CDD:214648	39/47 (83%)
		ZnF_GATA	168..212	CDD:238123	37/43 (86%)
		ZnF_GATA	223..270	CDD:214648	36/46 (78%)
		ZnF_GATA	226..276	CDD:238123	40/49 (82%)
Gata1	NP_032115.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..49		10/30 (33%)
		Interaction with MED1 and CCAR1. /evidence=ECO:0000269\|PubMed:24245781	200..330		94/134 (70%)
		ZnF_GATA	203..249	CDD:238123	39/45 (87%)
		Required for interaction with ZFPM1. /evidence=ECO:0000250	203..222		15/18 (83%)
		Interaction with CALCOCO1. /evidence=ECO:0000269\|PubMed:24245781	249..315		44/68 (65%)
		ZnF_GATA	<268..308	CDD:238123	32/39 (82%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..325		17/28 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..413
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1745
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840