DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pnr and GATA5

DIOPT Version :9

Sequence 1:	NP_476685.1	Gene:	pnr / 44849	FlyBaseID:	FBgn0003117	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_536721.1	Gene:	GATA5 / 140628	HGNCID:	15802	Length:	397	Species:	Homo sapiens

Alignment Length:	373	Identity:	143/373 - (38%)
Similarity:	188/373 - (50%)	Gaps:	81/373 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 YQNVTLSAA--SASTSASASATH--------------VAAVKMYHSSA--------VAAYTDLAA 67
            ||::.|:|:  .|:.:.|.|..|              |.::..|.|..        :||....|.
Human     2 YQSLALAASPRQAAYADSGSFLHAPGAGSPMFVPPARVPSMLSYLSGCEPSPQPPELAARPGWAQ 66

  Fly    68 AGSAASAGVGVGVSGYHQQAVNAP-------VYVPSNRQYNHVAAHFGSAAAQNAWTTEGFGSAH 125
            ..:|.|:..|.|  ..|..|.:.|       .:.||.      ....|||..::....:|.....
Human    67 TATADSSAFGPG--SPHPPAAHPPGATAFPFAHSPSG------PGSGGSAGGRDGSAYQGALLPR 123

  Fly   126 AQFYSPNAAVMMGSWRSAY------DPSGFQRSSPYESAM-------------DF--QF-GEGRE 168
            .||.:|....:..|:.:.|      |.:....:.|::.::             ||  :| |||||
Human   124 EQFAAPLGRPVGTSYSATYPAYVSPDVAQSWTAGPFDGSVLHGLPGRRPTFVSDFLEEFPGEGRE 188

  Fly   169 CVNCGAISTPLWRRDGTGHYLCNACGLYHKMNGMNRPLIKPSKRLVSATATRRMGLCCTNCGTRT 233
            ||||||:||||||||||||||||||||||||||:||||::|.|||   :::||.|||||||.|..
Human   189 CVNCGALSTPLWRRDGTGHYLCNACGLYHKMNGVNRPLVRPQKRL---SSSRRAGLCCTNCHTTN 250

  Fly   234 TTLWRRNNDGEPVCNACGLYYKLHGVNRPLAMRKDGIQTRKRKPKKTGS--GSAVGAGTGSGTGS 296
            |||||||::|||||||||||.|||||.|||||:|:.|||||||||....  ||:......|.:.|
Human   251 TTLWRRNSEGEPVCNACGLYMKLHGVPRPLAMKKESIQTRKRKPKTIAKARGSSGSTRNASASPS 315

  Fly   297 TLEAIKECKEEHDLKPSLS---------------LERHSLSKLHTDMK 329
            .:.:..........||||:               .|..||:..|.:.|
Human   316 AVASTDSSAATSKAKPSLASPVCPGPSMAPQASGQEDDSLAPGHLEFK 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pnr	NP_476685.1	ZnF_GATA	164..212	CDD:214648	42/47 (89%)
		ZnF_GATA	168..212	CDD:238123	38/43 (88%)
		ZnF_GATA	223..270	CDD:214648	37/46 (80%)
		ZnF_GATA	226..276	CDD:238123	39/49 (80%)
GATA5	NP_536721.1	GATA-N	1..170	CDD:283099	34/175 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..116		15/75 (20%)
		ZnF_GATA	184..229	CDD:214648	41/44 (93%)
		ZnF_GATA	188..232	CDD:238123	38/43 (88%)
		ZnF_GATA	<253..293	CDD:238123	32/39 (82%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..356		22/74 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142153
Domainoid	1	1.000	81	1.000	Domainoid score	I8514
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	223	1.000	Inparanoid score	I3525
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	1	1.000	-	-		otm40560
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10071
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1745
SonicParanoid	1	1.000	-	-		X1091
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.880