DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppp2r1b and Pp2A-29B

DIOPT Version :9

Sequence 1:	NP_001006775.1	Gene:	ppp2r1b / 448463	XenbaseID:	XB-GENE-950078	Length:	589	Species:	Xenopus tropicalis
Sequence 2:	NP_001245944.1	Gene:	Pp2A-29B / 2768940	FlyBaseID:	FBgn0260439	Length:	650	Species:	Drosophila melanogaster

Alignment Length:	589	Identity:	435/589 - (73%)
Similarity:	499/589 - (84%)	Gaps:	2/589 - (0%)

- Green bases have known domain annotations that are detailed below.

Frog     1 MAGADG--DDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRTELLPFLTDTIYDED 63
            ||.:|.  ||||||||||||||:||||||||||||||||||||||.||||:||:||||:||||||
  Fly     1 MAASDKSVDDSLYPIAVLIDELKNEDVQLRLNSIKKLSTIALALGEERTRSELIPFLTETIYDED 65

Frog    64 EVLLALAEQLGSFTSLVGGSEFVHCLLPPLESLATVEETVVRDKAVESLRKISNEHSPVDLEAHF 128
            |||||||:|||:|||||||.||...|:|||||||||||||||||||||||.::.|||..|||.|.
  Fly    66 EVLLALADQLGNFTSLVGGPEFAMYLIPPLESLATVEETVVRDKAVESLRTVAAEHSAQDLEIHV 130

Frog   129 VPLVKRLASGDWFTSRTSACGLFSVCYPRVSSTVKAEIRQHFRNLCSDDTPMVRRAAASKLGEFA 193
            ||.::||.||||||||||||||||||||||:..||||:|.:||.||.|:|||||||||:||||||
  Fly   131 VPTLQRLVSGDWFTSRTSACGLFSVCYPRVTQPVKAELRANFRKLCQDETPMVRRAAANKLGEFA 195

Frog   194 KVLELEYVKNDLIPLFTNLASDEQDSVRLLAVEACVSIAQLLPEEDLEALVMPTLRQATEDKSWR 258
            ||:|.||:|:||||.|..||.|:||||||||||||||||||||::|:|.||:|||||...|.|||
  Fly   196 KVVETEYLKSDLIPNFVQLAQDDQDSVRLLAVEACVSIAQLLPQDDVEHLVLPTLRQCASDSSWR 260

Frog   259 VRYMVADKFSELQKAVGPEITKNDLVPAFQNLLKDCEAEVRAAAAHKVKEFCENLPADGRETIIM 323
            ||||||:||.:||||||||||:.|||||||.||||.|||||||.|.|||:||.||....:..||:
  Fly   261 VRYMVAEKFVDLQKAVGPEITRVDLVPAFQYLLKDAEAEVRAAVATKVKDFCANLDKVNQVQIIL 325

Frog   324 NHILPYVKELVSDTNQHVKSALASVIMGLSTILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNL 388
            :.|||||::||||.|.||||||||||||||.:||...|:|.||||||.|||||||||||||||||
  Fly   326 SSILPYVRDLVSDPNPHVKSALASVIMGLSPMLGAYQTVEQLLPLFLIQLKDECPEVRLNIISNL 390

Frog   389 DCVNEVIGIRQLSQSLLPAIVELAEDTKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVD 453
            ||||:||||:||||||||||||||||:|||||||||||||.||||||.||||:||..|||.||.|
  Fly   391 DCVNDVIGIQQLSQSLLPAIVELAEDSKWRVRLAIIEYMPALAGQLGQEFFDQKLRGLCMGWLND 455

Frog   454 HVYAIREAATNNLMKLVEKFGAEWAQNTIVPKVLAMANDPNYLHRMTTLFCVNALSEACGKEITT 518
            ||||||||||.|:.||||:|||.||:..|:|.:|.|:.:.|||||||.|||:|.|:|.||.:|||
  Fly   456 HVYAIREAATLNMKKLVEQFGAPWAEQAIIPMILVMSRNKNYLHRMTCLFCLNVLAEVCGTDITT 520

Frog   519 KLMLPIVLKMAADQVANVRFNVARSLQRIGPVLDGTTLQSDVKPILLKLGQDEDMDVKYFAQEAM 583
            ||:||.||.:|||.|||||||||::||:|.|.|:.:.:.:.|||.|.||..|.|:|||:||.:|:
  Fly   521 KLLLPTVLLLAADPVANVRFNVAKTLQKISPFLEASVIDAQVKPTLDKLNTDTDVDVKHFAAQAI 585

Frog   584 TVLA 587
            ..:|
  Fly   586 AGIA 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppp2r1b	NP_001006775.1	HEAT repeat	13..37	CDD:293787	22/23 (96%)
		HEAT repeat	51..78	CDD:293787	22/26 (85%)
		HEAT repeat	88..118	CDD:293787	24/29 (83%)
		HEAT repeat	131..153	CDD:293787	17/21 (81%)
		HEAT	<165..>303	CDD:224331	105/137 (77%)
		HEAT repeat	166..194	CDD:293787	20/27 (74%)
		HEAT repeat	204..234	CDD:293787	24/29 (83%)
		HEAT repeat	245..269	CDD:293787	17/23 (74%)
		HEAT repeat	283..311	CDD:293787	22/27 (81%)
		HEAT repeat	325..355	CDD:293787	24/29 (83%)
		HEAT repeat	364..390	CDD:293787	23/25 (92%)
		HEAT repeat	401..430	CDD:293787	27/28 (96%)
		HEAT repeat	442..468	CDD:293787	19/25 (76%)
		HEAT repeat	479..508	CDD:293787	15/28 (54%)
		HEAT repeat	518..544	CDD:293787	19/25 (76%)
		HEAT repeat	557..586	CDD:293787	14/28 (50%)
Pp2A-29B	NP_001245944.1	HEAT_2	15..115	CDD:290374	87/99 (88%)
		HEAT repeat	15..39	CDD:293787	22/23 (96%)
		HEAT repeat	53..80	CDD:293787	22/26 (85%)
		HEAT repeat	90..120	CDD:293787	24/29 (83%)
		HEAT repeat	129..154	CDD:293787	19/24 (79%)
		HEAT repeat	165..194	CDD:293787	21/28 (75%)
		HEAT_2	175..267	CDD:290374	70/91 (77%)
		HEAT_EZ	181..230	CDD:290247	38/48 (79%)
		HEAT repeat	206..232	CDD:293787	20/25 (80%)
		HEAT repeat	247..271	CDD:293787	17/23 (74%)
		HEAT repeat	285..313	CDD:293787	22/27 (81%)
		HEAT repeat	327..357	CDD:293787	24/29 (83%)
		HEAT repeat	366..392	CDD:293787	23/25 (92%)
		HEAT repeat	403..432	CDD:293787	27/28 (96%)
		HEAT repeat	444..470	CDD:293787	19/25 (76%)
		HEAT repeat	481..510	CDD:293787	15/28 (54%)
		HEAT repeat	520..546	CDD:293787	19/25 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	263	1.000	Domainoid score	I1900
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	852	1.000	Inparanoid score	I430
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171719at33208
OrthoFinder	1	1.000	-	-		FOG0001701
OrthoInspector	1	1.000	-	-		otm49232
Panther	1	1.100	-	-	LDO	PTHR10648
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1
SonicParanoid	1	1.000	-	-		X1096
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.190