DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nkd and NKD1

DIOPT Version :9

Sequence 1:	NP_524788.2	Gene:	nkd / 44843	FlyBaseID:	FBgn0002945	Length:	928	Species:	Drosophila melanogaster
Sequence 2:	NP_149110.1	Gene:	NKD1 / 85407	HGNCID:	17045	Length:	470	Species:	Homo sapiens

Alignment Length:	608	Identity:	117/608 - (19%)
Similarity:	196/608 - (32%)	Gaps:	232/608 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 QDVSSGGSHSKHLRISSTSNGKHGKYSN------MQQQLPQDED---VVDAAATMQQQQHTGHAH 161
            |....|.|..:.||::.|.    |:.:.      ::..|.::|:   .::.|...::....|...
Human    41 QRCPGGVSGPRQLRLAGTI----GRSTRELVGDVLRDTLSEEEEDDFRLEVALPPEKTDGLGSGD 101

  Fly   162 SRHLHHHKE------ERIRLEEFTCDVSVEGGKSSQPLQFSFTFYDLDGHHGKITKDDIVGIVYT 220
            .:.:....|      ::::.||..||||:|   .....:::||.||.| ::||:|::||..:::|
Human   102 EKKMERVSEPCPGSKKQLKFEELQCDVSME---EDSRQEWTFTLYDFD-NNGKVTREDITSLLHT 162

  Fly   221 IYESIGKSVVVPHCGSKTINVRLTVSPEGKSKSQPVVPVPVAAGFSSSHASKLKKLPTGLAAMSK 285
            |||.:..||......||.:.|:|||:|:|....:
Human   163 IYEVVDSSVNHSPTSSKMLRVKLTVAPDGSQSKR------------------------------- 196

  Fly   286 PLAGGGVGSGGASALTTSAGNRRQHRYRPRKLIKSDDEDDDSNSEKEKDAAHAPAADQPSGSGTK 350
                        |.|...|..:..   |||...| ..||..|..:|::    ||...|
Human   197 ------------SVLVNQADLQSA---RPRAETK-PTEDLRSWEKKQR----APLRFQ------- 234

  Fly   351 ATGKSHHHQSQSARYHQKNNSRAEQCCTEQNTPDNGHNTYENMLNLKCC-------KPEVDQ--- 405
              |.|  ...||..||.         |.::|.....|  |.::..::..       .|.|.|
Human   235 --GDS--RLEQSGCYHH---------CVDENIERRNH--YLDLAGIENYTSQFGPGSPSVAQKSE 284

  Fly   406 ----VDCPSHRQHHQSHPNH--QMRQQDI------YMKQATQRVKMLRRARKQKYQD---HCLET 455
                ...|:..:.|:....|  ..:.|.:      ::.....:|..|:: |.:..||   |.:.:
Human   285 LPPRTSNPTRSRSHEPEAIHIPHRKPQGVDPASFHFLDTPIAKVSELQQ-RLRGTQDGSKHFVRS 348

  Fly   456 -RQRSLSVGNDSACPNRHLQLQQPPVGHPQPQSLNHKSASGSPPLGVGGGGDMMLDGVQLRQPRP 519
             :.:..|||                |||..      :.|...||||         ..:....|..
Human   349 PKAQGKSVG----------------VGHVA------RGARNKPPLG---------PAIPAVSPSA 382

  Fly   520 H---------SLTPHQHQQQNQQQQQQQRKSAECWKSALNRNDLISIIRESMEKNRLCFQLNGKP 575
            |         ||.|..|::...:.::.|:.                           |..|.. |
Human   383 HLAASPALLPSLAPLGHKKHKHRAKESQQG---------------------------CRGLQA-P 419

  Fly   576 QANVSPIRQPAAQQQPQQQQRQRCNTGSKIPTLITNHSPVAQQSPLSCSPPTAEPTTPSIPAAPP 640
            .|:..|:       ..::..|:       :|.|:...|...|
Human   420 LASGGPV-------LGREHLRE-------LPALVVYESQAGQ----------------------- 447

  Fly   641 AIEVNGQQHHPTHPTHPSHHNHH 663
              .|...:||..|..|  ||.||
Human   448 --PVQRHEHHHHHEHH--HHYHH 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	Identity
nkd	NP_524788.2	None
NKD1	NP_149110.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..114	2/23 (9%)
		Interaction with DVL1, DVL2 and DVL3. /evidence=ECO:0000250	125..190	27/68 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	192..228	11/82 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	271..314	7/42 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..357	4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..470	10/48 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159554
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CN06
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.918296	Normalized mean entropy	S8263
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003914
OrthoInspector	1	1.000	-	-		otm41278
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22611
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.880