DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ext1 and sotv

DIOPT Version :9

Sequence 1:	NP_001006730.1	Gene:	ext1 / 448393	XenbaseID:	XB-GENE-867525	Length:	738	Species:	Xenopus tropicalis
Sequence 2:	NP_725536.1	Gene:	sotv / 3772101	FlyBaseID:	FBgn0029175	Length:	717	Species:	Drosophila melanogaster

Alignment Length:	711	Identity:	233/711 - (32%)
Similarity:	367/711 - (51%)	Gaps:	90/711 - (12%)

- Green bases have known domain annotations that are detailed below.

Frog    73 SPRQ-----KRDGNSSIY------------------KGKRCRMESCFDLALCRRNGFKVYIYPQQ 114
            |||.     |||.::.|.                  :...|....|.::..|..:..||||||.|
  Fly    52 SPRDGFFHGKRDSHTLILDLEHIQELAVNPEAEQRARNVNCTFWDCLNIYKCEHDRLKVYIYPLQ 116

Frog   115 -----KGDK----LSESYQHILAAIESSRLYTSDPSQACLFVLSLDTLDRDQLSPQYVHNLKSKV 170
                 :.||    ||..|..||.|:..||.|||:|::||||:.|||.|:::....   |...:.:
  Fly   117 EFVDEQSDKTATTLSSEYFQILEAVLKSRYYTSNPNEACLFLPSLDLLNQNVFDK---HLAGAAL 178

Frog   171 QNLHLWNNGRNHLIFNLYSGTWPDYTEDVGFDIGQAMLAKASISTENFRPNFDVSIPLFS----K 231
            .:|..|:.|.||:|||:..|..|.|...:..:...|::......:.::||.|||:||::|    :
  Fly   179 ASLDFWDRGANHIIFNMLPGGAPSYNTVLDVNTDNAIIFGGGFDSWSYRPGFDVAIPVWSPRLVR 243

Frog   232 DHPRTGGEKGFL----RFNNIPPMRKYMLVFKGKRYLTGIGSDTRNALYHVHNGEDVVLLTTCKH 292
            .|.....::.||    :.|.:|            |::.     |...|...|: |.::||..|::
  Fly   244 QHAHATAQRKFLLVVAQLNILP------------RFVR-----TLRELSLAHS-EQLLLLGACEN 290

Frog   293 GKDWQKHKDARCDKDNAEYEKYDYREMLHNATFCLVPRGRRLGSFRFLEALQAACVPVMLSNGWE 357
                 .....||.. :..::..:|..:|....|||:.|..|:|....:|.:...|:||:..:.:.
  Fly   291 -----LDLTMRCPL-SQHHKSLEYPRLLSRGKFCLLGRSLRMGQPDLVEIMSQHCIPVIAVDNYV 349

Frog   358 LPFSEVIDWNQAAVIGDERLLLQIPSTIRSIHQDKILALRQQTQFLWEAYFSSVEKIVLTTLEII 422
            |||.:||||:.|:|...|..|..:...:::|...||:.:::|.|:|:..||..::.:.||.||::
  Fly   350 LPFEDVIDWSLASVRIRENELHSVMQKLKAISSVKIVEMQKQVQWLFSKYFKDLKTVTLTALEVL 414

Frog   423 QDRIFKHISRNSLMWN---KHPGALFVLPQYSAYLGDFPYYYSNLGAKTPSKFTAVIHAVTPLVS 484
            :.|||...:|:|..||   .:..:.|           .|.:..:|..|:.. |||||.....:.|
  Fly   415 ESRIFPLRARSSRQWNTIDTNARSTF-----------NPLFLPSLAPKSQG-FTAVILTYDRVES 467

Frog   485 QSQPILKLLVAVAKSQYCYQIIVLWNCDKPLPAK-HRWPATTVPVIVIEGESKVMSSRFLPYDNI 548
            ....|.||.|..:    ...|:|:||..|..|.. ..:|:.:.|:.:.:.:...:|:||.||..|
  Fly   468 LFLLIQKLAVVPS----LQSILVIWNNQKKSPPHLSTFPSISKPLKIRQTKENKLSNRFYPYPEI 528

Frog   549 VTDAVLSLDEDTVLSTT-EVDFAFTVWQSFPERIVGYPARSHFWDSAKERWGYTSKWTNDYSMVL 612
            .|:|:|::|:|.::.|| |:||.:.||:.||:.|||:|:|.|.|::...||.|.|:|||..||||
  Fly   529 ETEAILTIDDDIIMLTTDELDFGYEVWREFPDHIVGFPSRIHVWENVTMRWHYESEWTNQISMVL 593

Frog   613 TGAATYHKYYHYLYTNYLPASLKNMVDQLANCEDILMNFLVSAVTKLPPIKVTQKKQYKETMMGQ 677
            ||||.:|||:.::||:.:|..:|:.||:..|||||.|||||:.:|..||||||.:|::|......
  Fly   594 TGAAFHHKYWSHMYTHAMPGDIKDWVDEHMNCEDIAMNFLVANITNNPPIKVTPRKKFKCPECTN 658

Frog   678 TSRASRWADPDHFAQRQTCMNTFASWFGYMPLIHSQMRLDPVLFKDQVSILRKKYRDIERL 738
            |...|  ||.:|..:|..|::.|:..:|.|||...:.|.|||||:|......|:|.||..|
  Fly   659 TEMLS--ADLNHMRERSACIDRFSKIYGRMPLRTVEFRADPVLFRDNFPDKLKRYNDIGSL 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ext1	NP_001006730.1	Exostosin	102..388	CDD:308581	88/302 (29%)
ext1	NP_001006730.1	Glyco_transf_64	472..717	CDD:312681	101/246 (41%)
sotv	NP_725536.1	Exostosin	105..380	CDD:281069	88/301 (29%)
sotv	NP_725536.1	Glyco_transf_64	455..689	CDD:286358	99/239 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314330at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X187
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920