Protein Alignment mud and si:dkey-230p4.1

DIOPT Version :9

• Sequence 1: NP_727769.3
• Gene: mud / 44839
• FlyBaseID: FBgn0002873
• Length: 2567
• Species: Drosophila melanogaster
• Sequence 2: XP_692550.3
• Gene: si:dkey-230p4.1 / 564101
• ZFINID: ZDB-GENE-081104-380
• Length: 2775
• Species: Danio rerio
• Alignment Length: 2844
• Identity: 614/2844 - (21%)
• Similarity: 1112/2844 - (39%)
• Gaps: 729/2844 - (25%)

  Fly     1 MDTRSWRKVLLQWIG------------------ECHFIESNYITLEQSDL-----------DSFF 36
            :|.:..::||..:||                  :||.::    |....||           .|..
Zfish   191 IDWQKEKEVLTGYIGKEHSRLMTLWGRVVTLRRQCHSLK----TATDKDLWELKADFSRLSSSLL 251

  Fly    37 SVFIQ-----KIQETENVKGKNELQDQPTEQSPLVQEFLAHNYPEFIAQQDD-KEVDLPLDCLYV 95
            ||:..     |:....::......|...|.|.||..:.|.|.      |.|: |..:|..|
Zfish   252 SVWASPLSAPKLTHNSSLSQSTSAQPLSTTQGPLSLDDLNHE------QTDERKSSELKAD---- 306

  Fly    96 YTLLLHYSCVKKPSLFFHNICNKLPELTQTCIA-SFFRETVDRLLTR------------------ 141
                     ::..:|   .:.|::.||..|..| ...||..:..:.|
Zfish   307 ---------IESETL---ELRNRITELNMTVKALESEREKQEEEMERRHRHEMEREQEQERKWER 359

  Fly   142 --------EYLSQAIANVAVVYRQGVSTSVSPCLPSSSLSPDPRSDDAPCP--STPSSSSSQPSS 196
                    |.:.||:..::   |..:|..:|.  .|||||.|..|.|..|.  |..:.:.:....
Zfish   360 QMELERNFESVCQAVKTLS---RALLSQKMSG--ESSSLSADDASSDGLCSVLSVIAQAETALQW 419

  Fly   197 STPQLRNHREQLRLNGCEMPPPSTPKTELLEQRTKELRG---------------IRTQLEVVRYE 246
            ...:::..:..||..|.|        .|.||||..:|..               |:...|::..|
Zfish   420 REQEVQEAQMSLRRLGTE--------KESLEQRITQLESEWVELQEQTNQGALQIKHTQELLNSE 476

  Fly   247 KAL---LEEQQMEKDELIKVLNKEKMMAKMELEKLRNVKLTEEHHDNESHHIMPYEFEHMKGCLL 308
            |.:   |..|..|.::|.:.|.||....:.:.||....::.:   |.|.|..|
Zfish   477 KEIVSSLRGQVEEAEKLTEELRKENEHMRRQREKQEEDRIQQ---DRERHKRM------------ 526

  Fly   309 KEIGLKESLIAEITDKLHDLRVENSELSEKLNLAGKRLLEYTDRIRFLESRVDDLTRIVSSRDVM 373
             |..:.||  |::.::....|:|    ..:|.:|.:|  |..||.|..:........::.:|:.:
Zfish   527 -EAEMLES--AQLCERESRTRLE----LHRLQVALER--ETLDRARAEQEAEQAKDALIKARESL 582

  Fly   374 ISSLESDKQELDKCLKEARDDLHNRIEVLNASSDLLDCSLSPNTTPENLASSVIDKQLREKE--- 435
            ::. .|.:.:|.:.|..|.|.| .::..||.       :|:.:.....:.|..::.::.|.:
Zfish   583 LAQ-SSGQNQLKRELAGAGDAL-EKMAALNE-------ALAKDKRELGVRSLQLETEVAEAQAQI 638

  Fly   436 ----HENAELKEKLLNLNNSQRELCQALSSFL--------QKHNIDHEFPVEWTSSSLLSTI--- 485
                .|.|.|..:|..::....||.|...|.|        ::..:::|..:|........|.
Zfish   639 QAFGTETAGLHRELKAMSLEVHELRQRRESDLKALQQLRERERELENELELEREDRQREQTARTE 703

  Fly   486 --SAIESKFVNTLEKSTQMKKECDVQSVCVEKLLEKCKLLSVS------LGCQPKELDGFEATIP 542
              |..|.|.....|:.:.:.||  :|||.|| ||:..:|...:      |..:.:.|:....|:.
Zfish   704 DKSTDEQKISELTEQCSTVMKE--LQSVKVE-LLKAAELQRRAERERDDLMRESQRLEDTVCTLE 765

  Fly   543 EAMESGFESSRECETILSCCHMKVVDIASKNNDLELDNERLNDKCAELKSIID---------RGD 598
            ...|...:...|...::.|...::.....:.:.|||       ||.:|:..:|         :|:
Zfish   766 REKEELAQVKEELRGVVVCLQKQMAQAQEQTSGLEL-------KCIQLQMQVDTLTQTKDVLQGE 823

  Fly   599 -QHL-ADINLQLIEKEKQIKDVGAEIQELRKRNINLENMLSQIADKEASAASHAQHLK-QCGELL 660
             |.| .|:..:..:||:::::   .|:|.||....:||..|:....:......:::.| |..|..
Zfish   824 IQCLQTDLERETAQKERELQE---SIEERRKFEREIENWKSECKKFQRDVEQESENSKIQAEESK 885

  Fly   661 --RAKYEVCRNELIAKNAAQDELVRMMMVPDGETLNGRVRQLIDLEMMHDEHNKMYAQMLKQLNE 723
              |.:::..|..|.|:...:|..|.::            |..||             .:||:..|
Zfish   886 TDRERWQKERESLSAELGQKDGEVEIL------------RNRID-------------GLLKEKEE 925

  Fly   724 LSAKHDNMTHSHLDFVKRTEIE-LETKNA---------------QIMAFDEHNNHFDRFLTRIFT 772
            |.        .||: .:.||:| |:||:|               ::..:.|..|...|....:
Zfish   926 LL--------DHLE-KRNTELEKLQTKSAAEQKAAELRLRGACDEVERWKERENKVQREKEEL-- 979

  Fly   773 LLRSRNCPKSTTMGSATNFLESMHIEKRFENIEMLIEGQLLSADDLKRELDDLRSKNEELAKQNI 837
                           ...|||  .:|:..:|:|:....:...:|.:|::.|::|.:.|::.:..:
Zfish   980 ---------------NQKFLE--RVERESQNLEITQREKAKMSDLMKKKEDEIRRRGEDIEELKL 1027

  Fly   838 NGIIKRNKFITSLEV----------NTEKVKQYITDLEEEAFKRKQKVVQLENTLSK--EQSNAK 890
            . :....|.|.|||:          ..|.:::..|.|:|   |:..|:.:.|:...|  ||...|
Zfish  1028 K-LQSNEKTIESLEIELQQKETLESRVETLEKLNTQLKE---KKLDKIRENESRQKKRDEQEREK 1088

  Fly   891 EMAQRLDIAQQ-----EIKDYHVEAI---RFINTIRDRLQQDFNGVNTPQQLGTCMTEFLKMYDQ 947
            |:..|..:.|:     |:|....|.|   ..|:.:.:..::|..     |...|..||    ...
Zfish  1089 EVRWRRQLEQKDEGLIELKSRIDELIGEKEHISLLVEEREKDIE-----QLQSTLSTE----KRA 1144

  Fly   948 MEVRYEES----------SSLVEKLTESQAKL-EMQVAELQVEL-ENKDTNQHSGALIKQLNDTI 1000
            :|:|.:|:          :..:||:.||..:: |.:..||...| |.::..|....:|..|.:.|
Zfish  1145 LELRLKEARDNAEWWKRRAGNMEKVKESVNRVAEREKTELSELLREREEEVQKREEVISDLKNRI 1209

  Fly  1001 QNLEKVNAKLSEDNTVSHTVHSKLNESL-------LKAQKELDLRAKIIENLEASERNLSMKLCE 1058
            |:||.:..||..|....:.....|||.:       ::.|||||   ::.|||:..|:.|..:|..
Zfish  1210 QSLEVIIEKLETDIEQKNEQLELLNEQISQIKEREIENQKELD---RMQENLKEQEKQLKRELDH 1271

  Fly  1059 L-----------KDLKNKLKSSDEKIA--QIKET-----YEEQIKALQA---KC-----DMEAKK 1097
            |           ::|..:::..|.::.  |:|.|     :|:::||..|   :|     :||..:
Zfish  1272 LNIKMAGVIQEKEELLERIEERDGELTELQVKFTQEQRMFEQKLKAEHAEVNRCKAKIAEMEQDQ 1336

  Fly  1098 NEHLERNQNQSLTQLKED------ALENCVLMSTKLEELQAKLQE-GQQLVDSQKLELDMN---R 1152
            ....||::.|...|..|:      ..|..|....::.:|:.|::| .|::...:::.::..   .
Zfish  1337 VNLKERDEEQRKRQKMEERYREQKQTEELVQKDVEVRQLKLKIEELNQEIEQDRRIRMEQQEDLE 1401

  Fly  1153 KELALVKSAYEAQTKLSDDLQRQKESGQQLVDNLKVELEKER---KELAHVNSAIGAQTKLSDDL 1214
            ::.||::.|.|....|...|| ||:..::  |.|..| |||:   ||..|
Zfish  1402 QQTALLRDAEEEARTLKKTLQ-QKDKEER--DRLHHE-EKEKTLLKEKLH--------------- 1447

  Fly  1215 ECQKESGQQL--VDNLKVELEKERKEL-AQVKSVIEAQTKL---SDDLQREKESAQQLVDNLKVE 1273
            |.::.:.:.|  :..::..|||||.:| .:.:.::|...:|   ..:..:||||.::| :.|..|
Zfish  1448 EAEQRNIKVLSSLQEIETTLEKERYQLRGKEERLMECNEELFLIKRERDQEKESIEEL-NKLIGE 1511

  Fly  1274 LDKERKEL-AQVNSAFEAQTKLSDDLQRQKESAQQL---VDNLKVELDKERKELAQVNSAFEAQT 1334
            ..||.|.| .:::...|.:.:||..||.|:...|.|   .:|::.|..:.::.|:|:.   |.:.
Zfish  1512 QGKEVKTLRGKLDERLEEEGRLSKLLQNQRVEVQVLESRAENIEEEKQQLKRSLSQIE---EEKR 1573

  Fly  1335 KLSDDLQREKESAQQLVDNLKVELDKERKELAQVKSVIEAQTKLSDDLQRQKESAQ--------- 1390
            .|...|..||...::    |:|.|:.:..|:.::..::|.:.|||..||..:..||
Zfish  1574 HLETQLTDEKVDKER----LRVRLEDQATEVTKLNKILEEERKLSQLLQNSRVEAQMFESRAQNT 1634

  Fly  1391 ----QLV-----------DNLKVELDKERKELAKVKSVIEAQTKLSDDLQRQKESAQQ-LEAQTK 1439
                ||:           ..|:.:|..|:.:..|:|:.:|.|.|   ::.:.||...: ||.:.|
Zfish  1635 EEEKQLLKRSLSQIEREKSRLETQLTDEKMDKEKLKARLEDQDK---EVTKLKEKMNEILEEERK 1696

  Fly  1440 LSDDLQRQKESAQQL---VDNLKVELDKERKELAQVKSVIEAQTKLSDDLQRQKESAQQLVDNLK 1501
            ||..||..:..||.|   .:|::||..:.::.|.|::             :.::....||.|.
Zfish  1697 LSQLLQNSRVEAQMLESRAENIEVEKQQLKRSLTQIE-------------EEKRHLGTQLTDE-- 1746

  Fly  1502 MELDKER---------KELAQVKSAIGAQTKLSDDLECQKESVQQLVDNLKVE----------LE 1547
             ::||||         .|:.::|.      |||:.:| ::..:.||:.|.:||          :|
Zfish  1747 -KMDKERLRAWVEDQATEVTKLKE------KLSEMIE-EERKLSQLLQNSRVEAHILESRTENIE 1803

  Fly  1548 KERKELAKVNSAFE-----AQTKLSDDLKLQKE-------DAQREVFLVKERL---VKEKREFEV 1597
            :|:::|.:..:..|     .:|:|:|: |:.||       |...||..:||:|   ::|:|:...
Zfish  1804 EEKQQLTRSLTQIEKEKRHLETQLTDE-KMDKERLRARLKDQATEVTKLKEKLNEMIEEERKLSQ 1867

  Fly  1598 KLATLEDIIETLEMRCTQMEEERATAYEQINKLENRCQEKDNVKSSQLQVETFKVECLHHQLKSE 1662
            .|.......:.||.|.....||:    :|:.::.::.:|:..:..:||..|....|.|..:|:.:
Zfish  1868 LLQNSRVEAQMLESRAENTIEEK----QQLKRVLSQVEEEKRLLETQLTDEKIDRERLKARLEDQ 1928

  Fly  1663 MATHNSLVEDLNRKLAE--KVSKL--------DFVQSRLMTEIAEHNQVKDQLAQITDIPKVVEL 1717
            ......|.|.||:.:.:  |:|.|        ..::||......|..|:|..|.||.:..:.:|.
Zfish  1929 ATEVTKLKEKLNKMVEDERKLSHLLQNSQVETQMLESRTENLEEEKQQLKRSLTQIEEEKRCLET 1993

  Fly  1718 QHRLEAETAEREEAQNKL-----------AVVTGRLDEI---TRELDNARLEHGAQILRME---- 1764
            |  |..|..:||..:.:|           ....||.:::   .|||:..|....|::.|.|
Zfish  1994 Q--LTDEKIDRERLRARLEDFQKDQQILFEEKMGRAEKLGSRVRELEEQRDHLSAELRRKEREME 2056

  Fly  1765 ----ETAREVGNKNAELCELIEFYRNRVEAL--------ERLLLASN---------QELEELN-S 1807
                ||.||...|: .:..|:...:.|.|:|        |:|:..|.         ||.:|.| .
Zfish  2057 VLRDETLRERREKD-RISSLLSDAKERKESLSVQVDSLQEQLVSLSRSKEQTKLKIQEQKEQNKE 2120

  Fly  1808 IQSNQAEGVRDLGDTYSAAEGRQTESDQDKERYQKLALDCKILQAKYRDAKDEIKRCEK------ 1866
            ::.....|::::.......|    ||.::.||          |::..::.|||:.|..:
Zfish  2121 MREGLVAGLQEMATLKELLE----ESHREGER----------LRSMMQERKDELVRSREEGIKVA 2171

  Fly  1867 --KIKDQRLEMEGKLEKMKNKMRSLYTAEVTRMKEK-----QERDAAKSASE-LEA-LTAQNAKY 1922
              :.||.:|::: .|||.|.::.:....:|.::|:|     ||::..:...| ||. |.|..:..
Zfish  2172 HIEAKDLQLKVQ-MLEKQKQELETTLQLQVEQLKKKNEEGMQEKEQLQQRQEKLEGELMAMKSVK 2235

  Fly  1923 EEHTRKLSNQIVRLNEKILEQQKQHAIISTNLRHLQMQPISETKPSSTTL--------TVSSSSS 1979
            |....:|:....||:  |||.|:      |.|..|..:...:.:..|...        .:.....
Zfish  2236 EHREAELTRAKARLD--ILEDQR------TELSSLAAERTKDAEELSNRFRDLRLEADRLREDRI 2292

  Fly  1980 APNDDWQPFKRPNVPSSNLAMEDEEGEVFNNTYL---TDLKLGRV-------------------- 2021
            ...::|:..||.|....|..   ||.|:...|.:   .::||.:.
Zfish  2293 REKNNWEELKRENKEKQNAL---EELELLRKTLMEKEKEMKLVKEKYENEKRRSERFQQGDEQNV 2354

  Fly  2022 -PADMTAEELIYRNSLQPPHLKSTY---AAQYDLGSQDEDLKDGPHSLDDSMSALLSSSSTGTRK 2082
             ..::.:|.|..:.:......:..|   :|:..|..|.||.|.....|.:.:..|.........|
Zfish  2355 RQIELVSERLRDKETELESIREKAYKEQSARLRLQDQFEDEKRVTKKLREKLETLEKVKQEMKTK 2419

  Fly  2083 KSMGTHYKRPGPPTPSKNGG---RLSFGSSEPPREILREFGDHNNTSKTPARFKFLTQRFSVGSS 2144
            ......|.|   .:..||.|   ....|:.....||..|:..|....:.....|.||:
Zfish  2420 MENDIRYFR---DSEKKNNGLKMDSGHGTLADSLEINAEYRSHVKLLEADTLRKDLTK------- 2474

  Fly  2145 GLPRDEPIPQLPRRKRPNLLTGIHRRRLRHAV--DIFCTSTPRKSRSYYDQQRMIGASDADKSEA 2207
               :|:.|.:| |.|...|.|.|.|   .|::  :....:.|.::..:..:::.:.....:|.|
Zfish  2475 ---KDQEIRRL-RIKAETLQTEIDR---LHSLLKNGNMKTGPTENEDWDREKQQVSTILLEKEE- 2531

  Fly  2208 VETEDEVI---EVEPDAVPEL--EPLEDADQQGTPHLSTAALLALTK------GNTRRLTG---- 2257
               .|.::   :||..|:.|.  |..:|.|:.......|.|:|...|      .:.|:.||
Zfish  2532 ---RDRLLREKDVEVYALKERAEEMSKDRDRVRIALEKTEAMLIYYKERLGHQEHKRKQTGGDIS 2593

  Fly  2258 ----------TTKSKKGRVS--------LSLHGNIFAKSRPASFVAGK----------------R 2288
                      |..:..||:|        |.:..|:..|..  |.:..|                :
Zfish  2594 LEKVSADELDTESAVHGRLSAMQQAVAQLEVQQNLLEKKN--SHLEKKIERLRTERQHLRETLTQ 2656

  Fly  2289 VQLRR-KLRRDRIM---GRFDEARHLDQMRLSHSAQAAKSPENNNYSL-------HNRNEE---- 2338
            |:|.| ||||...:   |..|::...|...|.|....|...|...:.|       |.:..|
Zfish  2657 VELERGKLRRQLSLSEAGVLDQSVGTDDAELKHLRVRANELEEQVHHLRLMLAVDHRQRAEFIDR 2721

  Fly  2339 -----EHLPSENNVMGKTVVLVGKRRLSPVVSTTFNVEERSETSLLQQQ 2382
                 :.|.|....:.:::..|.:|   ||:|...:..:|.:.|:.:::
Zfish  2722 SLKNSQSLMSLRQDLNESLSAVSQR---PVLSVLESETQRLDRSIREEE 2767

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mud	NP_727769.3	SMC_prok_B	319..1178	CDD:274008	211/989 (21%)
		SCP-1	853..1571	CDD:114219	204/847 (24%)
		Smc	1234..>1944	CDD:224117	205/844 (24%)
		DUF948	1392..1517	CDD:295114	35/148 (24%)
si:dkey-230p4.1	XP_692550.3	SMC_prok_B	<10..673	CDD:274008	112/553 (20%)
		Rootletin	70..243	CDD:291694	10/55 (18%)
		Smc	885..1702	CDD:224117	210/915 (23%)
		Myosin_tail_1	1360..2394	CDD:279860	255/1120 (23%)
		SMC_prok_B	2093..>2771	CDD:274008	146/727 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000