DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mud and Golga3

DIOPT Version :9

Sequence 1:	NP_727769.3	Gene:	mud / 44839	FlyBaseID:	FBgn0002873	Length:	2567	Species:	Drosophila melanogaster
Sequence 2:	XP_006249625.1	Gene:	Golga3 / 312077	RGDID:	1305262	Length:	1487	Species:	Rattus norvegicus

Alignment Length:	1685	Identity:	354/1685 - (21%)
Similarity:	639/1685 - (37%)	Gaps:	449/1685 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 STSVSPC----LPSSSLSPDPRSDDAPCPSTPSSSS-----------SQPSSSTPQLRNHR-EQL 208
            |:.|..|    :|...||.||.:.    |..|.:|:           ||.:|:...:|... :.|
  Rat    64 SSQVPICQNGQIPDLQLSLDPTTS----PVGPDASTGVDGFHDNLRKSQGTSAEGSVRKEALQSL 124

  Fly   209 RLNGCEMPPPSTPKTELLEQRTKELRGIRTQLEVVRYEKALLEEQQME---------------KD 258
            ||        |.|..|.....|.....:..:.:|....:..||||.|:               |.
  Rat   125 RL--------SLPMQETQLCSTASSLPLEKEEQVRLQARKRLEEQLMQYRVKRHRERSSQPATKM 181

  Fly   259 ELIKVLNKEKMMAKMELEKLRNVKLTEEHHDNESHHIMPYEFEHM---KGCLLKEIGLKESLIAE 320
            :|...|:.|.|:....|.:...|.:|:|           |.|...   :|..:..:||
  Rat   182 KLFSTLDPELMLNPENLPRASAVAVTKE-----------YSFLRTSVPRGPKVGSLGL------- 228

  Fly   321 ITDKLHDLRVENSELSEKLNLAGKRLLEYTDRIRFLESRVDDLTRIVSSRDVMISSLESDKQELD 385
               ..|....:||:.|:..:||..|..:.:|.           ..:.|:.|.:.|||:..:....
  Rat   229 ---LAHSKEKKNSKSSKIRSLADYRTEDPSDS-----------GGLGSTADAVGSSLKQSRSSTS 279

  Fly   386 -------KCLKEARDDLHNRIEVLNASSDLLD--------------------CSLSPNT-TPENL 422
                   .|      :..||.|..:.:.|.:.                    |::..|. ||.
  Rat   280 VVSEVSPSC------ETDNRAESASLAGDSVSEADGNESDSSSHSSFSARGACAVLGNVGTPG-- 336

  Fly   423 ASSVIDKQLREKEHENAELKEKLLNLNNSQRELCQALSSFLQKHNIDHEFPVEWTSSSLLSTISA 487
            |:.|:|.|         |:..:.|....|.:::.||.::..|..|.:....|:....|:.|::|
  Rat   337 AAYVVDGQ---------EISAEALGQFPSIKDVLQAAAAQHQDQNQEANGEVQSRRDSICSSVS- 391

  Fly   488 IESKFVNTLEKSTQMKK-----ECDVQSVCVE---KLLEKCKL------LSVSLGCQ-------P 531
            :||.|....|:..|:.|     |..|:::.:|   .|.||.:|      ||..|..|       .
  Rat   392 MESSFAEPQEELLQILKDKRRLEGQVEALSLEASQALQEKAELQAQLAALSTRLQAQVEHSHSSQ 456

  Fly   532 KELDGFEATIPEAMESGFESSRECETILSCCHMKVVDIASKNNDLELDNE---RLNDKCAELKSI 593
            ::.|...:.:....:|.::..|....:.:....|...:||.||||::..|   ||..|...::..
  Rat   457 QKQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEAMQRN 521

  Fly   594 IDRGDQHLADINLQLIEKEKQIKDV--------------GAEIQEL--------------RKRNI 630
            |...|..:.|:..|:...:.|::.|              .|||..|              ::..:
  Rat   522 ILSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLQASQAEITSLQQARQWYQQQLALAQEARV 586

  Fly   631 NLENMLSQIADKEASAASHAQHLK-----QCGELLRAKY-EVCRNELIAKNAAQ------DELVR 683
            .|:..::.|...:.:.|...:|||     ...:|...:: .:...|.||.....      |:...
  Rat   587 RLQGEMAHIQVGQMTQAGLLEHLKLENVSLSHQLTETQHRSIKEKERIAVQLQSIEADMLDQEAA 651

  Fly   684 MMMVPDGETL--NGRVRQLIDLEMMHDEHNKM------YAQMLKQLNELSAKHDN----MTHSHL 736
            .:.:.:.:|:  ....|:|.:.|...::..|:      ..|.|:|:.....:.|.    :...||
  Rat   652 FVQIREAKTMVEEDLQRKLEEFEGEREQLQKVADAAASLEQQLEQVKLTLFQRDQQLAALQQEHL 716

  Fly   737 DFVKRTEIELETKNAQIMAFDEHNNHFDRFLTRIFTLLRSRNCPKSTTMGSATNFLESMHIEKRF 801
            |.:|:.....|...|:..:.|:....:|....|:..|.|     ::.:...|.:||
  Rat   717 DVIKQLTSTQEALQAKGQSLDDLQTRYDELQARLEELQR-----EADSREDAIHFL--------- 767

  Fly   802 ENIEMLIEGQLLSADDLKRELDDLRSKNEELAKQNINGIIKRNKFITSLEVNTEKVKQYITDLEE 866
            :|.::::|..|.||...|.|||                     :....||.:||:....:..|.:
  Rat   768 QNEKIVLEVALHSARSDKEELD---------------------RGARRLEEDTEETSGLLEQLRQ 811

  Fly   867 EAFKRKQKVVQLEN---TLSKEQSNAKEMAQRLDIAQQEIKDYHVEAIRFINTIRDRLQQDFNGV 928
            :...:..:|..|:.   ||.|:....||     ...||::.   |||.|     ||...:|
  Rat   812 DVAVKSNQVEHLQQETATLRKQMQKVKE-----QFLQQKVM---VEAYR-----RDAASKD---- 859

  Fly   929 NTPQQLGTCMTEFLKMYDQMEVRYEESSSLVEKLTESQAKLEMQVAELQVELENKDTNQHSGALI 993
                                        .|:.:|..::.:|:.::.||:.|            ||
  Rat   860 ----------------------------QLINELKATKKRLDSEMKELRQE------------LI 884

  Fly   994 KQLNDTIQNLEKVNAKLSEDNTVSHTVHSKLNESLLKAQKELDLRAKIIENLEASERNLSMKLCE 1058
            | |:...:.:|..:::|.:|.::.|...::|...|...|||.|              .:.:.|..
  Rat   885 K-LHGEKKTVEVEHSRLQKDMSLVHQQMAELEGHLQSVQKERD--------------EMEIHLQS 934

  Fly  1059 LKDLKNKLKSSDEKIAQIKETYEEQIKALQAKCDMEAKK-----NEHLER-----NQNQSLTQLK 1113
            ||..|.::.:    :.:..||.::||:.||    .||||     .:.::|     ...|...:.|
  Rat   935 LKFDKEQMIA----LTEANETLKKQIEELQ----QEAKKAITEQKQKMKRLGSDLTSAQKEMKTK 991

  Fly  1114 EDALENCV-LMSTKLEELQAKLQEGQQLVDSQKLELDMNRKELALVKSAYEAQTKLSDDLQRQKE 1177
            ..|.||.| ::|.:|:|..|..:.....::..:.:......:.||.:..:..:.:|
  Rat   992 HKAYENAVSILSRRLQEALANKEATDAELNQLRAQSTGGSSDPALHEKIHALEVEL--------- 1047

  Fly  1178 SGQQLVDNLKVELEKERKELAHVNSAIGAQTKLSDDLECQKESGQQLVDNLKVELEKERKELAQV 1242
               |.|...|:.||||.:|:.         |..|.:||..:|...:|.|    ||::.|....::
  Rat  1048 ---QNVGQSKILLEKELQEVI---------TMTSQELEESREKVLELED----ELQESRGFRRKI 1096

  Fly  1243 KSVIEAQTKLSDDLQREK-------ESAQQLVDN---LKVELDKERKELAQVNSAFEAQTKLSDD 1297
            |.:.|:..||:.:|:.|:       :|...|.::   |:..|.|...:|.|:|...:|..:..::
  Rat  1097 KRLEESNKKLALELEHERGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEE 1161

  Fly  1298 LQRQKESAQQLVDNLKVELDKERKELAQVNSAFEAQTKLSDDLQREKESAQQLVDNLKVELDKER 1362
            ..||   .:|||..|::.|:||:.|::.:.....|                     .:||....|
  Rat  1162 EDRQ---MKQLVQALQISLEKEKTEVSSLKEQMAA---------------------ARVEAGHNR 1202

  Fly  1363 K-------ELAQVKSVIEAQTKLSDDLQRQKESAQQLVDNLKVELDKERKELAKVKSVIEAQTKL 1420
            :       ||::||..::|:..|...||.:       ||.|:::..|..:|:|      :.||:|
  Rat  1203 RHFKAATLELSEVKKELQAKEHLVQTLQAE-------VDELQIQEGKHSQEIA------QFQTEL 1254

  Fly  1421 SDDLQRQKESAQQLEAQTKLSDDLQRQKESAQQLVDNLKVELDKERKELAQVK---SVIEAQTKL 1482
            :       |:..||:...|..::.:.|:.:..|.:::||.|||::.:|:..:|   .:.|.|.|
  Rat  1255 A-------EARTQLQLLQKKLEEQRSQQPTGSQEMEDLKWELDQKEREIQSLKQQLDLTEHQGK- 1311

  Fly  1483 SDDLQRQKESAQQLVDNLKMELDKERKELAQV-KSAIGAQTKLSDDLECQKESVQQLVDNLKVEL 1546
                 ::.|..||.:..:|.||:..:::|::. |.....|.|:| :|:...:::.|....||::|
  Rat  1312 -----KELEGTQQTLQTIKSELETVQEDLSETQKDKFMLQAKVS-ELKNNMKTLLQQNQQLKLDL 1370

  Fly  1547 EKERKELAKVNSAFEAQTKLSDDLKLQKEDAQREVFLVKERLVKEKREFEVKLATLEDIIETLEM 1611
               |:..||........:..|....::..|......|::|.|.......:..|..|...::.|:.
  Rat  1371 ---RRGAAKKKEPKGESSSSSPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQ 1432

  Fly  1612 RC----TQMEEERATAYEQINKLENRCQEKDNVKSSQLQVETFKVECLHHQLKSEMATHN 1667
            ..    .||||...|.:|.:              ||..|||....|  |...:.:...||
  Rat  1433 EMDSLQRQMEEHTITVHESL--------------SSWAQVEAAPAE--HAHARGDTKVHN 1476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mud	NP_727769.3	SMC_prok_B	319..1178	CDD:274008	190/976 (19%)
		SCP-1	853..1571	CDD:114219	167/752 (22%)
		Smc	1234..>1944	CDD:224117	105/459 (23%)
		DUF948	1392..1517	CDD:295114	33/128 (26%)
Golga3	XP_006249625.1	SMC_prok_B	<338..986	CDD:274008	154/772 (20%)
Golga3	XP_006249625.1	SMC_prok_B	663..1351	CDD:274008	191/878 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR18902
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100