Protein Alignment mud and Numa1

DIOPT Version :10

• Sequence 1: NP_727769.3
• Gene: mud / 44839
• FlyBaseID: FBgn0002873
• Length: 2567
• Species: Drosophila melanogaster
• Sequence 2: XP_038969271.1
• Gene: Numa1 / 308870
• RGDID: 1308777
• Length: 2114
• Species: Rattus norvegicus
• Alignment Length: 2572
• Identity: 535/2572 - (20%)
• Similarity: 995/2572 - (38%)
• Gaps: 689/2572 - (26%)

  Fly     3 TRSWRKVLLQWIGECHFIESNYITLEQSDLDSFFSVFIQKIQETENVKGKNELQDQPTEQSPLVQ 67
            ||:  ..||.|:...|..:.....|:..|...|..: |..|.:|:  :|:..||....|:...|.
  Rat     6 TRA--STLLSWVNSLHVADPVETVLQLQDCSIFIKI-INSIHDTK--EGQQILQQPLPERLDFVC 65

  Fly    68 EFLAHNYPEFIAQQDDKEVDLPLDCLYVYTLLLHYSCVKKPSLFFHNICNKLPELTQTCIASFFR 132
            .||          |.:::......||.....::..|.:               ||.:..:...:.
  Rat    66 SFL----------QKNRKHPSSTQCLVSVQKVMEGSEM---------------ELAKMVMLFLYH 105

  Fly   133 ETVDRLLTR-----EYLSQAIANVAVVYRQGVSTSVSPCLPSSSLSPDPRSDDAPCPST-PSSSS 191
            .|:.....|     ||..|  |.:||:.:..:....||     :|:.|..:.....||| ||:.|
  Rat   106 STMSSRNPRDWEQFEYGVQ--AELAVILKFMLDHEDSP-----NLTEDLENFLEKVPSTYPSTLS 163

  Fly   192 SQPSSSTPQLRNHREQLRL---------NGCEMPPPSTPKTELLEQRTKELRGIRTQLEVVRYEK 247
            .:.|..:.|.:.....|.:         |......||:|..::|:....::|.::.||...|..:
  Rat   164 EELSPPSHQAKRKIRFLEIQRIASSSSENNFLSGSPSSPVGDILQTPQFQMRRLKKQLADERNNR 228

  Fly   248 ALLEEQQMEKDELIKVLNKEKMMAKMELEKLRNVKLTEEHHDNESHHIMPYEFEHMKGCLLKEIG 312
               :|.::|..|.:|:|.::.....|..:::.::.|.     ||.....|.|
  Rat   229 ---DELELELSESLKLLTEKDAQIAMMQQRIDHLALL-----NEKQAASPQE------------- 272

  Fly   313 LKESLIAEITDKLHDLRVENSELSEKLNLAGKRLLEYTDRIRFLESRVDDLTRIVSSRDVMISSL 377
                     ..:|.:||.:|..|:.:|:...|:                            ..:|
  Rat   273 ---------PSELEELRGKNESLTVRLHETLKQ----------------------------CQNL 300

  Fly   378 ESDKQELDKCLKEARDDLHNRIEVLNASSDLLDCSLSPNTTPENLASSVIDKQLREKEHENAELK 442
            :::|.::|:.:                                        .||.|   ||.:|.
  Rat   301 KTEKNQMDRKI----------------------------------------SQLSE---ENGDLS 322

  Fly   443 EKLLNLNNSQRELCQALSSFLQKHNIDHEFPVEWTSSSLLSTISAIESKFVNTLEKSTQMKKECD 507
            .|:....|..::|..|.:..:::|:   :...||....     :.:||:....|:....::::.:
  Rat   323 FKVREFANHLQQLQGAFNDLIEEHS---KASQEWAEKQ-----AHLESELSTALQDKKCLEEKSE 379

  Fly   508 VQSVCVEKLLEKCKLLSVSLGCQPKELDGFEATIPEAMESGFESSRECETILSCCHMKVVDIASK 572
            :....:.:|.::...|..|...:..|:.|      :|::            |.....:...:|:.
  Rat   380 ILQEKISQLEDRAAQLQGSPAPEKGEVLG------DALQ------------LDTLKQEAAKLATD 426

  Fly   573 NNDLELDNERLNDKCAELKSIIDRGDQHLADINLQLI-------EKEKQIKDVGAEIQELRKRNI 630
            |.:|:...|.|  :|       :||.|     ..||:       |:::|:..:.|::|.
  Rat   427 NTELQARVETL--EC-------ERGKQ-----EAQLLAERGHFEEEKRQLASLVADLQS------ 471

  Fly   631 NLENMLSQIADKEASAASHAQHLKQCGELLRAKYEVCRNELIAKNAAQDELVRMMMVPDGETLNG 695
            ::.| ||| |.:|...||.||..:...:|.         .|.|.||               ||..
  Rat   472 SVSN-LSQ-AKEELQQASQAQGAQLTAQLA---------SLTALNA---------------TLQQ 510

  Fly   696 RVRQLIDLEMMHDEHNKMYAQMLKQLNE-------LSAKHDNMTHSHLDFVKRTEIEL-ETKNAQ 752
            :.::|..|:   ::..|..||||:.|.|       |..:.:.::.|    :|..|.:| |....|
  Rat   511 QDQELTSLK---EQAKKEQAQMLQTLQEQEQAAQGLRQQVEQLSSS----LKLKEQQLEEAAKEQ 568

  Fly   753 IMAFDEHNNHFDRFLTRIFTLLRSRNCPKSTTMGSATNFLESMHIEK--RFENIEMLIEGQLLSA 815
            ..|..:|.......:......:|.|:        :|...||::..||  :.|:::..::....:.
  Rat   569 EAARQDHAQQLATIVEAREASVRERD--------AARQQLETLEKEKDAKLESLQQQLQASNEAR 625

  Fly   816 DDLKRELDDLRSKNEELAKQNINGIIKRNKFITSLEVNTEKVKQYITDLEEEAFKRKQKVVQLEN 880
            |..:..:...:.:..||:::    |.:.:..|.:......:.:.::|:||.:....:||..:.|.
  Rat   626 DTAQTSVTQAQREKAELSQK----IGELHACIEAAHQEQRQAQAHVTELEAQLKAEQQKATEREK 686

  Fly   881 TLSKEQSNAKEMAQRLDIAQQEIKDYHVEAIRFINTIRDRLQQDFNGVNTPQQLGTCMTEFLKMY 945
            .: :|:...:|..|.|:           |.::.   :|..|:::      ..:....:.|..:..
  Rat   687 VV-QEKVQLQEQLQALE-----------ETLKI---VRGSLEEE------KCRAADALKEQQRHA 730

  Fly   946 DQMEVRYEESSSLVEKLTESQAKLEMQVAELQVELENKDTNQHSGALIKQLNDTIQ-NLEKVNAK 1009
            .:||.   |:..|:|:..:.|.:||.:.|| :..||         |.::||.:..| ..|.:..:
  Rat   731 TEMEA---ETRHLMEQREQEQKELEQEKAE-RKGLE---------ARLQQLEEAHQAETEALRHE 782

  Fly  1010 LSEDNTVSHTVHSKLNESLLKAQKELDLRAKIIENLEASERNLSMKLCELKDLKNKLKSSDEKIA 1074
            |:......|...|: .|.||:                           |::..:.::::..::.|
  Rat   783 LAGATAAQHGAESE-REQLLR---------------------------EVESWQKRVEARQQEEA 819

  Fly  1075 QIKETYEEQIKALQ---AKCDMEAKKNE---HLERNQNQSLTQLKEDALENCVLMSTKLEELQAK 1133
            :....::||:.||:   .|...|.:|..   |.|....|..:||.:  |..|  ::..|:::|.|
  Rat   820 RYGAMFQEQLMALKGEHGKIGQEEQKEAGEIHGEGQTGQQQSQLAQ--LHAC--LAKALQQVQEK 880

  Fly  1134 LQEGQQLVD---SQKLELDMNRKEL----ALVKSAYEAQTKLSDDLQRQKESGQQLVDNLKVELE 1191
            ....|:|:|   :.:.::....||:    |||..|.|.|...|.:|:....:|.|..|    ..|
  Rat   881 EARAQKLLDDLSALREKMAATNKEVACLKALVLKAGEQQAAASHELKEPPRAGNQESD----WEE 941

  Fly  1192 KERKELAHVNSAIGA----QTKLSDDLE-----CQKESGQQLVDNLKVELEKERKELAQVKSVIE 1247
            ::.:.|....:|:.|    ..::..:||     ..:..|||  ..::.:.|:|...|.|.:...:
  Rat   942 EQARPLGSTQAALKAVQREAEQMGGELERLRAALMQSQGQQ--QEVRGQQEREVARLTQERGQAQ 1004

  Fly  1248 AQTKLSDDLQREKESAQQLVDNLKVELDKERKELAQVNSAF-EAQTKLSDDLQ-----RQKESAQ 1306
            |      ||.:||.:..:|...|:..|:::|.|.|.:..|. .|.|:.....|     |::|:||
  Rat  1005 A------DLAQEKAAKAELEMRLQNTLNEQRVEFAALQEALTHAMTEKEGKDQELAKLREQEAAQ 1063

  Fly  1307 QLVDNLKV------ELDKERKEL----------------AQVNS---------AFEAQTKLSDDL 1340
              :..||.      ||.|:.||.                :|:::         ..||.......|
  Rat  1064 --ISELKALQQTLEELKKKEKEHPTGGARGEDASGDGPGSQLHTPGKTEAPGPEVEALRAEISKL 1126

  Fly  1341 QREKESAQQLVDNLKVELDKERKELAQVKSVIEAQTKLSDDLQRQ-KESAQQLVDNLKVELDKER 1404
            :|:.:..||.|:.|...|:.||...|:       |.|..:.||.| :|.|::|..|.......:|
  Rat  1127 ERQWQQQQQQVEGLTHSLESERACRAE-------QDKALETLQGQLEEKARELGHNQAASASAQR 1184

  Fly  1405 KELAKVKSVIEAQTKLSDDLQRQKESAQQLEAQTKLSDDLQRQKESAQQLVDNLKVELDKERKEL 1469
             ||..:::..:..:|..::.:.|....|| ||:.|.|  |....|....:::...:|.:.|.|||
  Rat  1185 -ELQALRAKAQDHSKAEEEWKAQVARGQQ-EAERKSS--LISSLEEEVSILNRQVLEKEGESKEL 1245

  Fly  1470 AQVKSVIEAQTKLSDDLQRQKESAQQLVDNLKMELDKERKELAQVKSAIGAQTKLSDDLECQKES 1534
               |.::.|:::.|..|:                   ||..|.||::| .:..:.::.....:|.
  Rat  1246 ---KRLVVAESEKSQKLE-------------------ERLRLLQVETA-SSSARAAERSSALREE 1287

  Fly  1535 VQQL---VDNLKVELEKERKELAKVNSAFEAQTKLSDDLKLQKEDAQREVFLVKERLVKE-KREF 1595
            ||.|   |:..:|..|..|:|||   |..|...:...:||     |.:|.|..||:.:.. :.|.
  Rat  1288 VQSLREEVEKQRVVSENLRQELA---SQAERAEESGQELK-----AWQEKFFQKEQALSALQLEH 1344

  Fly  1596 EVKLATLEDIIETLEMRCTQMEEERATAYEQINKLENRCQEKDNVKSSQ-----LQVETFKV--- 1652
            ....|.:.:::....: |.|::.|:|.|       |.|.:|:  ::.|:     ||.|..:.
  Rat  1345 TSTQALVSELLPAKHL-CQQLQAEQAAA-------EKRFREE--IEQSKQAAGGLQAELMRAQRE 1399

  Fly  1653 --------------ECLHHQLKSEMAT-----------HNSLVEDLNRKLAEKVSKLDFVQSRLM 1692
                          |....||::|.|:           |..|.|: ||.|.|:.:     ..|..
  Rat  1400 LGELGSLRQKIVEQERAAQQLRAEKASYAEQLSMLKKAHGLLAEE-NRGLGERAN-----LGRQF 1458

  Fly  1693 TEIAEHNQVKDQLAQITDIPKVVELQHRLEAET--AE-REEAQNKLAVVTGR-LDEITRELDNAR 1753
            .|: |.:|.:::..|  ::..|     |.:|||  || |:|||:     |.| |:.:|.:.::|:
  Rat  1459 LEV-ELDQAREKYVQ--ELAAV-----RTDAETHLAEMRQEAQS-----TSRELEVMTAKYESAK 1510

  Fly  1754 LEHGAQILRMEETAREVGNKNAELCELIEFYR---NRVEALERLLLASNQ----ELEELNSIQSN 1811
            ::...:..|.:|..:::   .|::.:|..|:|   .:||.|.:.|..|.|    :.::|.:.|:.
  Rat  1511 VKVLEERQRFQEERQKL---TAQVEQLEVFHREQTKQVEELNKKLTESEQASRVQQQKLKAFQAQ 1572

  Fly  1812 QAEG---VRDLGDTYSAAEGRQTESDQDKERYQKLALDCKILQAK-YRDAKDEIKRCEKKIKDQR 1872
            ..|.   |:.|....|..:.:.::.:|..|.| ||.::    :|| :.|||   |:..:::::|.
  Rat  1573 GGESQQEVQCLQTQLSELQAQLSQKEQAAEHY-KLQME----KAKTHYDAK---KQQNQELREQL 1629

  Fly  1873 LEMEGKLEKMKNKMRSLYTAEVTR------MKEKQERDAAKS-ASELEALTAQNAKYEEHTRKLS 1930
            .::| :|:|...::|| .|..:.|      :|.|:...|.:. .:::.:|.||.:.|      .:
  Rat  1630 QDLE-QLQKDNKELRS-ETERLGRELQQAGLKTKEAEQACRHLTAQVRSLEAQASFY------FT 1686

  Fly  1931 NQIVRLNEKILEQQK-QHAIISTNLRHLQMQPISETKPSSTTLTV------SSSSSAPNDDWQPF 1988
            :::...::::.:..| |.|..:...|..|::|..:....|..|::      |.:|..|.......
  Rat  1687 SKVAHADQQLRDLGKFQVATDALKSREPQVKPQLDLSIDSLDLSLEEGTPCSVASKLPRTQPDGT 1751

  Fly  1989 KRPNVPSSNLAME-DEEGEVFNNTYLTDLKL-GRVPADMTAEELIYRNSLQPPHLKSTYAAQYDL 2051
            ..|..|:|.::.. ..:.|...:.|.|.:.. |:.|.:.:.:.|   ....|...:.|.:|:...
  Rat  1752 SVPGEPASPISQRLPPKVESLESLYFTPIPARGQAPLETSLDSL---GDAFPDSGRKTRSARRRT 1813

  Fly  2052 G-------SQDEDLKDGPHSLDDSMSALLS--SSSTGTRKKSMGTHYKRPGPPTPSKNGGRLSFG 2107
            .       ::..:|:: |.|.:.|..:..|  :|....|..|......|.|.|..| |...||..
  Rat  1814 TQIINITMTKKLELEE-PDSANSSFYSTQSAPASQANLRATSSTQSLARLGSPDDS-NSALLSLP 1876

  Fly  2108 SSEPPREILREFGDHNNTSKTPARFKFLTQRFSVGSSGLP-----------RDEP--------IP 2153
            ...|             |:::.|| :..|:.    |||.|           :|||        |.
  Rat  1877 GYRP-------------TTRSSAR-RSQTRT----SSGAPHGRNSFYMGTCQDEPEQVDDWNRIA 1923

  Fly  2154 QLPRRKR---PNLLTGIHRRRLRHAVDIFCTSTPRKSRSYYDQQRMIGASDADKSEAVETEDEVI 2215
            :|.:|.|   |:|.|              |  .|.:||...             |.|..|::|:.
  Rat  1924 ELQQRNRVCPPHLKT--------------C--YPLESRPAL-------------SLATITDEEMK 1959

  Fly  2216 EVEPDAVPELEPLEDADQQGTPHLSTAALLALTKGNTRRLTGTTKSKKGRVSLSLH---GNIFAK 2277
            ..:|     .|.|..|..|.......|.:             ||:.::.|||...|   |...:|
  Rat  1960 TGDP-----RETLRRASMQPAQIAEGAGI-------------TTRQQRKRVSSETHQGPGTPESK 2006

  Fly  2278 SRPASFVAGKRVQLRRKLRRDRIMGRFDEA------------RHLDQMRLSHSAQAAKSPENNNY 2330
            ...:.|.       |....|||..||...:            :..|: |.|.:.....:|:....
  Rat  2007 KATSCFP-------RPMTPRDRHEGRKQNSTADAQKKAAPVLKQSDR-RQSMAFSILNTPKKLGN 2063

  Fly  2331 SLHNRNEEEHLPSENNVMGKTVVLVGKRRLSPVVSTT 2367
            ||..|...:..|::.:...::    |.|| ||.::||
  Rat  2064 SLLRRGTSKKTPAKVSPNPRS----GTRR-SPRIATT 2095

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mud	NP_727769.3	SMC_prok_B	<224..>467	CDD:274008	36/242 (15%)
		SMC_prok_B	<576..1365	CDD:274008	184/865 (21%)
		SMC_prok_B	994..1863	CDD:274008	229/981 (23%)
Numa1	XP_038969271.1	HkD_NuMA	6..151	CDD:411795	37/181 (20%)
		PRK02224	<243..738	CDD:179385	119/707 (17%)
		SMC_prok_B	530..1321	CDD:274008	199/923 (22%)
		Smc	<1115..>1633	CDD:440809	146/599 (24%)
		MreC	<1613..>1674	CDD:480808	15/65 (23%)
		PHA03307	1735..>2018	CDD:223039	73/359 (20%)
		NuMA_LGNBD	1872..1930	CDD:412093	17/75 (23%)