DRSC/TRiP Functional Genomics Resources

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Protein Alignment mud and Dsp

DIOPT Version :10

Sequence 1:NP_727769.3 Gene:mud / 44839 FlyBaseID:FBgn0002873 Length:2567 Species:Drosophila melanogaster
Sequence 2:NP_001406527.1 Gene:Dsp / 306871 RGDID:1305794 Length:2877 Species:Rattus norvegicus


Alignment Length:2823 Identity:572/2823 - (20%)
Similarity:1014/2823 - (35%) Gaps:886/2823 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 LQWIGECHFIESNYITLEQSDLDSFFSVFIQKIQETENVKGKNELQDQPTEQSPLVQE---FLAH 72
            :.||.:|   |...:..:.||.::..:   || ||..::: .::|:.:..|.:.|.||   .:.:
  Rat   290 IMWINDC---EEEELLYDWSDKNTNIA---QK-QEAFSIR-MSQLEVKEKELNKLKQESDQLVLN 346

  Fly    73 NYPEFIAQQDDKEVDLPLDCLYV-YTLLLHYS-CV----KKPSLFFHNICNKLPELTQTCIASFF 131
            .:|     ..|| ::..:|.|.. ::.:|..: |:    |:.:.:|                .||
  Rat   347 QHP-----ASDK-IEAYMDTLQTQWSWILQITKCIDVHLKENAAYF----------------QFF 389

  Fly   132 RET-------------------VDRLLTREYLSQAIANV------AVVYRQGVSTSVSPCLPSSS 171
            .|.                   .|:.:..::|.:.|..:      .:.|::.|...|:.......
  Rat   390 EEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQ 454

  Fly   172 LSPDPRSDDAPCPSTPSSSSSQP-----------------SSSTPQLRNHREQLRL-----NGCE 214
            |.          |..|...|::|                 ......|:::.|:.:.     .|.:
  Rat   455 LK----------PRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVD 509

  Fly   215 M---------PPPSTPKTEL---LEQRTKELRGIRTQL-----EVVRYEKALLEEQQMEKDELIK 262
            |         |||:....:|   :||..:.:..:..||     .:|.:...:::           
  Rat   510 MLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQLYINMKSLVSWHYCMID----------- 563

  Fly   263 VLNKEKMMAKMELEKLRNVKLTEEHHDNESHHIMPYEFEHMKGCLLKEIGLKESLIAEITDKLHD 327
             :.|.:.|...:|:.:|.....:...|.|.|:   .:|                           
  Rat   564 -IEKIRAMTIAKLKTMRQEDYMKTIEDLELHY---QDF--------------------------- 597

  Fly   328 LRVENSELSEKLNLAGKRLL--EYTDRIRFLESRV--------------DDLTRIVSSRD----- 371
              ::||:.||......||.:  ::||..:..::.|              .::|.:.:.:|     
  Rat   598 --IKNSQGSEMFGDDDKRRMQSQFTDAQKHYQTLVIQLPGHPQHQTVTKTEITHVGTCQDVNHNK 660

  Fly   372 VMISSLESDKQE-------------LDKCLKEARDDLHNRIEVLNASSDLLDCSLSPNTTPE-NL 422
            |:.::.|:||||             ::.|  |||..|.|.:        |.|...:.|.|.: |.
  Rat   661 VIETNRENDKQETWLLMELQKIRRQMEHC--EARMTLKNLL--------LTDQGSTHNITVKINE 715

  Fly   423 ASSVIDKQLREKEHENAELKEKLLNLNNSQR--ELCQALSSFLQKHNIDHEFPVEWTSSSLLSTI 485
            ..||.:......|..| :||:.|.|...|::  .|...:....||                |..|
  Rat   716 LKSVQNDSQALAEVLN-QLKDMLANFRGSEKYCYLQNEIFGLFQK----------------LENI 763

  Fly   486 SAIESKFVNTLEKSTQMKKECDVQSVCVEKLLEKCKLLSVSLGCQPKELDGFEATIPEAMESGFE 550
            :.:...::|:|         |.|::: ::.:|:...:|.|           :||.:.|.      
  Rat   764 NGVTDGYLNSL---------CSVRAL-LQAILQTEDMLKV-----------YEARLTEE------ 801

  Fly   551 SSRECETILSCCHMKVVD-----IASKNNDLELDNERLNDKCAELKSIIDRGDQ-H--------L 601
                 ||:  |..:..|:     :....|||.|....|    |.:|:.:.:..| |        |
  Rat   802 -----ETV--CLDLDKVEAYRCGLKKIKNDLNLKKSLL----ATMKTELQKAQQIHSQSSQQYPL 855

  Fly   602 ADINL-QLIEKEKQIKDVGAEI-QELRKRNINLENMLSQIADKEASAASHAQHLKQCGELLRAKY 664
            .|::| :..||..|:.|...:| :::..|..:||..:.|:.:...:..|..:.|          |
  Rat   856 YDLDLGKFTEKVTQLTDRWQKIDKQIDFRLWDLEKQIKQLRNYRDNYQSFCKWL----------Y 910

  Fly   665 EVCRNELIAKNAAQDELVRMMMVPDGETLNGRVRQLIDLEMMHDEHNKMYAQMLKQLNELSAKHD 729
            :..|.        ||.| ..|...|..|:   :|.|.:.:.:|              ||:|.|.|
  Rat   911 DAKRR--------QDSL-ESMKFGDSNTV---MRFLNEQKNLH--------------NEISGKRD 949

  Fly   730 NMTHSH------LDFVKRTEIELETKNAQIMAFDEHNNHFDRFLTRIFTLLRSRNCPKSTTM--- 785
            .....|      .:.:|..|::|.:                 :.:.:.|||   |.|...||   
  Rat   950 KSEEVHKIAELCANSIKDYELQLAS-----------------YTSGLETLL---NIPIKRTMVQS 994

  Fly   786 GSATNFLESMHIEKRFENIEMLIEG----QLLSADDLKRELDDLRSKN-------EELA------ 833
            .|.....|:..|..|:  ||:|...    :.||  ::.:.|:||:.||       |||.      
  Rat   995 PSGVILQEAADIHARY--IELLTRSGDYYRFLS--EMLKSLEDLKLKNTKIEVLEEELRLARDAN 1055

  Fly   834 KQNINGIIKRNKFITSLEVNTEKVKQYITDLEEEAFKRKQKVVQLENTLSKEQSNAKEMAQRLDI 898
            .:|.|    :|||   |:.|.:|       .:.|..:.|.|:|.||....:.:.:.|...|.||.
  Rat  1056 SENCN----KNKF---LDQNLQK-------YQAECSQFKAKLVSLEELKRQAELDGKSAKQNLDK 1106

  Fly   899 AQQEIKDYHVEAIRFI----------NTIRDRLQQDFNGVNTPQQLGTCMTEFLKMYDQME-VRY 952
            ...:||:.:.:..|..          .|:.||..|..|.                 |||:: .|.
  Rat  1107 CYGQIKELNEKITRLTYEIEDEKRRRKTVEDRFDQQKND-----------------YDQLQKARQ 1154

  Fly   953 EESSSLVEKLTESQAKL---EMQVAELQVELENKDT--NQHSGALIK---QLNDTIQNLEKVNAK 1009
            .|..||..:..||:..:   |.::..|:|.|:.:..  .::...|.|   ..|:.:.||.  |..
  Rat  1155 CEKESLGWQKLESEKAIKEKEYEIERLRVLLQEEGARKREYENELAKVRNHYNEEMSNLR--NKY 1217

  Fly  1010 LSEDNTVSHTVHSKLNESLLKAQKELDLRAKIIENLEASERNLSMKLCELKDLKNKLKSSDEKIA 1074
            .:|.|....|:..      :..|||.|.:     ||......||.   |.:|||:::...::.|.
  Rat  1218 ETEINITKTTIKE------ISMQKEDDSK-----NLRNQLDRLSR---ENRDLKDEIVRLNDSIL 1268

  Fly  1075 QIKETYEE-QIKALQAK-CDME-AKKNEHLERNQNQSLTQLKEDALENCVLMSTKLEELQAKLQE 1136
            |..|.... :..|||.| |..| .:|.:|||....|.:.|..||...:    ...|||....:|:
  Rat  1269 QATEQRRRAEENALQQKACGSEIMQKKQHLEVELKQVIQQRSEDNARH----KQSLEEAAKTIQD 1329

  Fly  1137 GQQLVDSQKLELDMNRK-------ELALVKSAYEAQ--------------TKLS-DDLQRQKE-- 1177
            ..:.::..|.|.....|       ||:.|:::|:.:              ||.: ..|..|||  
  Rat  1330 KNKEIERLKAEYQEEAKRRWEYENELSKVRNSYDEEIISLRNKFETEINITKTTIHQLTMQKEED 1394

  Fly  1178 -SGQQL-VDNLKVELEKERKELAHVNSAIGAQT-----KLSDDLECQKESGQQLVDNLKVELEKE 1235
             ||.:. :|||..|.....:|:..:.:.: |||     ::.::::.||.||.:: ...|.:||.|
  Rat  1395 TSGYRAQIDNLTRENRSLSEEVKRLKNTL-AQTTENLRRVEENVQQQKASGSEM-SQRKQQLEIE 1457

  Fly  1236 RKELAQV--------KSVIEAQTKLSDDLQREKESAQQLVD---NLKVELDKERKELAQV----- 1284
            .::::|:        |..::...|...|..:|.|..:||||   |.:..|:.|..:|.:|     
  Rat  1458 LRQVSQMRTEESMRYKQSLDDAAKTIQDKNKEIERLKQLVDKETNERKCLEDENSKLQRVQYDLQ 1522

  Fly  1285 ---NSAFEAQTKLS----------------------------------DDLQRQKESAQQLVDNL 1312
               |||.||.:||.                                  .|||.||:.|::.:..|
  Rat  1523 KANNSATEAMSKLKVQEQELTRLRIDYERVSQERTVKDQDITRIQSSLKDLQLQKQKAEEELSRL 1587

  Fly  1313 K--------------VELDKERKEL-----------AQVNSAFEAQTKLSDDLQ----------R 1342
            |              .||:..|:.|           .|:..|...:.:..|||:          |
  Rat  1588 KRTASDESSKRKMLEEELEAMRRSLKEQAVKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHVR 1652

  Fly  1343 EKESAQQLVDNLKVELDKERKELAQVKSVIEAQTKLSDDLQRQKESAQQLVDNLKVELDKER--- 1404
            ||:..|:.:..|.::::..|::|.|.:..::.....::..|:..|...:.::..|:|:::.:   
  Rat  1653 EKQRTQEELRRLSLDVEALRRQLVQEQENVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLT 1717

  Fly  1405 KELAKVKSVIEAQTK----LSDDLQRQKESA--------QQLEAQTKLS-----------DDLQR 1446
            :.|.|...::|.:.:    ..|||:|.:..|        .:|.:|.::|           :||||
  Rat  1718 ENLTKEHLMLEEELRNLRLEYDDLRRGRSEADNDKNSTISELRSQLQISNNRTLELQGLINDLQR 1782

  Fly  1447 QKESAQQLVDNLKVELDKERKELAQVKSVIEAQTKLSDDLQRQKESAQQLVDNLKMELDKER--- 1508
            ::|       ||:.|::|.:|:..:..:.|:........:.:::||.  ||....:|.||.|   
  Rat  1783 ERE-------NLRQEIEKFQKQALEASNRIQESKSQCTQVVQERESL--LVKIKVLEQDKARLQR 1838

  Fly  1509 --KELAQVKSAIGAQTKLSDDLECQKESVQQLVDNLKVELEKERKELAKVNSAFEAQTKLSDDLK 1571
              .||.:.|:.:.|:|::...|||:|:.:|..::..|.:..::.:.:.|:.|..|...:..:.|:
  Rat  1839 LEDELNRAKATLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEETIRKIESEREKSEREKNSLR 1903

  Fly  1572 LQKEDAQREVFLVKERLVKEKREFEVKLATLEDIIETLEMRCTQMEEERATAYEQINKL------ 1630
            .:.|..|.|:..::||..::          |||  .|.|.: :|:|.||....::|:||      
  Rat  1904 SEIERLQAEIKRIEERCRRK----------LED--STRETQ-SQLETERCRLQKEIDKLRQRPYG 1955

  Fly  1631 ---ENRCQEKDNVKSSQLQVETFK--------VEC-------LHHQLKSEMATHN---------- 1667
               |.:.:.:..|.||:|..:..:        .||       |...||.:.:...          
  Rat  1956 SHRETQTEYEWTVDSSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLR 2020

  Fly  1668 ----------------SLVEDLNRKLAEKVSKLDFVQSRLMTE--IAEHNQVK------------ 1702
                            ||||...:|.....|.:..::::..|.  |..|...|            
  Rat  2021 GAGAIAGASASPKEKYSLVEAKRKKFITPESTVMLLEAQAATGGIIDPHRNEKLTVDNAIARDLI 2085

  Fly  1703 --DQLAQI---------TDIP---KVVELQHRLEAETAERE------EAQ--------------- 1732
              |...||         .|.|   |.|.:...::....:||      |||               
  Rat  2086 DFDDRQQIYTAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQLASGGVVDPVNSVFL 2150

  Fly  1733 -NKLAVVTGRLD-EITRELDNARLEHGAQILRMEETAREVGNKNAELCELIEFYRNRVEALERLL 1795
             ..:|:..|.:| ::.|.|::.|..       .:.....:..|.....:|.|  |.|:|....||
  Rat  2151 PKDVALARGLIDRDLYRSLNDPRDS-------QKNFVDPITKKKVSYMQLRE--RCRIEPHTGLL 2206

  Fly  1796 LASNQELEELNSIQSNQAEGVR---------DLG----DTYSAAEGRQTESDQDKERYQKLALDC 1847
            |.|.|:       :|...:|:|         |.|    .|.:..|..|...|:..||.:......
  Rat  2207 LLSVQK-------RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGS 2264

  Fly  1848 KILQAKYRDAKDEIKRCEKKIKDQRLEMEGKLEKMKNKMRSLYTAE-VTRMK----EKQERDAA- 1906
            ..:...|.:...:.....:.:|...:.....||.::.:..:.:..: |:.::    |..:|... 
  Rat  2265 SCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVG 2329

  Fly  1907 -----KSASELEALTAQNAKYEEHTRKLSNQIVRLNEKILEQQKQHAIISTNLRHLQMQ------ 1960
                 |..|...|:|..|   :..|..:.:....:|::::|  |.|.|     |.|:.|      
  Rat  2330 IEFKEKLLSAERAVTGYN---DPETGNIISLFQAMNKELIE--KGHGI-----RLLEAQIATGGI 2384

  Fly  1961 ---------PISET-KPSSTTLTVSSSSSAPNDDWQPFKRPNVPSSNL--------AMEDEEGEV 2007
                     |:... |.......:|...|.|:||.:.|..||. ..||        .::|||   
  Rat  2385 IDPKESHRLPVDMAYKRGYFNEELSEILSDPSDDTKGFFDPNT-EENLTYLQLKERCIKDEE--- 2445

  Fly  2008 FNNTYLTDLKLGRVPADMTAEELIYRNSLQ-------PPHLKSTYAAQ--YDLGSQD-EDLKDGP 2062
               |.|..|.|......:...:   :|:|:       .|......:.|  |..|..| |..|:..
  Rat  2446 ---TGLCLLPLKEKKKQVQTSQ---KNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELC 2504

  Fly  2063 HSLDDSMSALLSSSSTGTR----KKSMGTHYK------------------RPGPPTPS------- 2098
            ....:.....::.|...||    .:..|:.|.                  |.|..:.:       
  Rat  2505 EQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMIS 2569

  Fly  2099 -KNGGRLSFGSSEPPREILREFGDHNNTSK--TPARFKFLTQRFSVGSSGLPRDEPIPQL---PR 2157
             |||...|.|.|....:.:.....|.:.||  |.:..:.||.|.|..|..|....||..:   ..
  Rat  2570 LKNGVGTSSGLSGSVNDDVFSSSRHESVSKISTISSVRNLTIRSSSLSDPLEESSPIAAIFDTEN 2634

  Fly  2158 RKRPNLLTGIHR--------RRLRHAVDIFCTSTPRKSRSYYDQQRMIGASDADKSEAVETEDEV 2214
            .::.::..||.|        :||..|.  .||.               |.......:.:..:|.|
  Rat  2635 LEKISITEGIERGIVDSITGQRLLEAQ--ACTG---------------GIIHPTTGQKLSLQDAV 2682

  Fly  2215 IE--VEPDAVPELEPLEDA-----DQQGTPHLSTAAL-----LALTKGNT----RRLTGTTKSKK 2263
            .:  ::.|....|:|.:.|     ..:|...:|.|..     |....|..    :.|||      
  Rat  2683 SQGLIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQFLTG------ 2741

  Fly  2264 GRVSLSLHGNIFAKSR-PASFVAGKRVQ 2290
            |.|...:||.|..:.. ...|:.|:..|
  Rat  2742 GLVDPEVHGRISTEEAIRKGFIDGRAAQ 2769

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mudNP_727769.3 SMC_prok_B <224..>467 CDD:274008 54/287 (19%)
SMC_prok_B <576..1365 CDD:274008 222/966 (23%)
SMC_prok_B 994..1863 CDD:274008 246/1138 (22%)
DspNP_001406527.1 Globular 1. /evidence=ECO:0000305 1..1063 184/985 (19%)
Interaction with PKP1, JUP, PKP2. /evidence=ECO:0000250|UniProtKB:P15924 1..591 56/352 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
SPEC 197..373 CDD:413338 21/96 (22%)
SPEC 292..457 CDD:238103 34/204 (17%)
SH3_10 454..520 CDD:407754 9/75 (12%)
Spectrin_like 555..632 CDD:465730 18/120 (15%)
CCDC158 <855..>1317 CDD:464943 135/572 (24%)
Central fibrous rod domain. /evidence=ECO:0000305 1064..1952 221/958 (23%)
SMC_prok_B 1129..1919 CDD:274008 190/837 (23%)
Globular 2. /evidence=ECO:0000305 1953..2877 165/876 (19%)
4.5 X 38 AA tandem repeats (Domain A). /evidence=ECO:0000250|UniProtKB:P15924 1967..2215 48/263 (18%)
Plectin 2055..2093 CDD:459901 5/37 (14%)
PLEC 2091..2128 CDD:197605 8/36 (22%)
Plectin 2131..2169 CDD:459901 7/37 (19%)
4.5 X 38 AA tandem repeats (Domain B). /evidence=ECO:0000250|UniProtKB:P15924 2251..2453 42/218 (19%)
PLEC 2258..2295 CDD:197605 2/36 (6%)
Plectin 2298..2336 CDD:459901 3/37 (8%)
PLEC 2335..2371 CDD:197605 9/40 (23%)
Plectin 2374..2412 CDD:459901 5/37 (14%)
Plectin <2475..2503 CDD:459901 7/27 (26%)
4.5 X 38 AA tandem repeats (Domain C). /evidence=ECO:0000250|UniProtKB:P15924 2616..2828 35/177 (20%)
PLEC 2618..2654 CDD:197605 6/35 (17%)
Plectin 2657..2695 CDD:459901 8/54 (15%)
Plectin 2733..2771 CDD:459901 11/43 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2817..2877
6 X 4 AA tandem repeats of G-S-R-[SR]. /evidence=ECO:0000250|UniProtKB:P15924 2830..2853
Blue background indicates that the domain is not in the aligned region.

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