Protein Alignment mud and GOLGA3

DIOPT Version :10

• Sequence 1: NP_727769.3
• Gene: mud / 44839
• FlyBaseID: FBgn0002873
• Length: 2567
• Species: Drosophila melanogaster
• Sequence 2: NP_005886.2
• Gene: GOLGA3 / 2802
• HGNCID: 4426
• Length: 1498
• Species: Homo sapiens
• Alignment Length: 1754
• Identity: 356/1754 - (20%)
• Similarity: 666/1754 - (37%)
• Gaps: 495/1754 - (28%)

  Fly   412 SLSPNTTPENLASSV----IDKQLREKEHENAE---LKEKL----LNLNNSQRELCQALSSFLQK 465
            ||.|.|:|....:|.    ....||:.:..:||   .||.|    |:|...:.:||
Human    81 SLDPTTSPVGPDASPGVAGFHDNLRKSQGTSAEGSVRKEALQSLRLSLPMQETQLC--------- 136

  Fly   466 HNIDHEFPVE-----------WTSSSL----------LSTISAIESKFVNTLE------------ 497
             :.|...|:|           |....|          .|:..|.:::..:||:
Human   137 -STDSPLPLEKEEQVRLQARKWLEEQLKQYRVKRQQERSSQPATKTRLFSTLDPELMLNPENLPR 200

  Fly   498 -KSTQMKKECDVQSVCVEKLLEKCKLLSVSLGCQPKEL-----------------------DGFE 538
             .:..|.||.......|.:   ..|:.|:.|...|:|.                       .|..
Human   201 ASTLAMTKEYSFLRTSVPR---GPKVGSLGLPAHPREKKTSKSSKIRSLADYRTEDSNAGNSGGN 262

  Fly   539 ATIPEAMESGFESSRECETILSCCHMKVVDIA-SKNNDLELDNERL-NDKCAELKSIIDRGDQHL 601
            ...|::.:...:.:|      |.....|.:|: |.:.|..|:|..| .|..:|    :|..|...
Human   263 VPAPDSTKGSLKQNR------SSAASVVSEISLSPDTDDRLENTSLAGDSVSE----VDGNDSDS 317

  Fly   602 ADIN-------LQLIEKEKQIKDV-----GAEIQELRKRNINLENMLSQIAD-KEASAASHAQHL 653
            :..:       ..::.|....:|.     |.||.         .:.|.|... |:...|:.|:|.
Human   318 SSYSSASTRGTYGILSKTVGTQDTPYMVNGQEIP---------ADTLGQFPSIKDVLQAAAAEHQ 373

  Fly   654 KQ----CGELLRAKYEVCRNELIAKNAAQDELVRMMMVPDGETLNGRVRQLIDLEMMHDEHNKMY 714
            .|    .||:...:..:|.:..:..:||:.:...:.::.:...|.|   ||..|.:...:..|..
Human   374 DQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEG---QLEALSLEASQALKEK 435

  Fly   715 AQMLKQLNELSAK-HDNMTHSHLDFVKRTEIELETKNAQIMAFDEHNNHFDRFLTRIFTLLRSRN 778
            |::..||..||.| ...:..||....::..:..|....:...:|     .:|.:|.:..:|.::|
Human   436 AELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWD-----LERAMTDLQNMLEAKN 495

  Fly   779 CPKSTTMGSATNFLESMHIEKRFENIEMLIEGQLLSADDLKRELDDLRSKNEELAKQNINGIIKR 843
                .::.|:.|.|:.  .|::::.:       :...:|::|.:         |:|.|
Human   496 ----ASLASSNNDLQV--AEEQYQRL-------MAKVEDMQRSM---------LSKDN------- 531

  Fly   844 NKFITSLEVNTEKVKQYITDLEEEAFKRKQKVVQLENT--LSKEQSNAKEMAQRLDIAQQEIKDY 906
                     ....::|.:|.|:.:.     :.||||.|  .||.:::..|::     :.|.::.:
Human   532 ---------TVHDLRQQMTALQSQL-----QQVQLERTTLTSKLKASQAEIS-----SLQSVRQW 577

  Fly   907 HVEAIRFINTIRDRLQQDFNGVNTPQQLGTCMTEFLKMYDQMEVRYEESSSLVEKLTESQAKLEM 971
            :.:.:......|.|||.:...:...|.....:.|.||:         |:.||.::|||:|.:...
Human   578 YQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKL---------ENVSLSQQLTETQHRSMK 633

  Fly   972 QVAELQVELENKDTNQHSGALIKQLNDTIQNLEKVNAKLSEDNTVSHTVHSKLNESLLKAQKELD 1036
            :...:..:|:..:.:.                                               ||
Human   634 EKGRIAAQLQGIEADM-----------------------------------------------LD 651

  Fly  1037 LRAKIIENLEAS---ERNLSMKLCELKDLKNKLKSSDEKIAQIKETYEE-QIKALQAKCDMEAKK 1097
            ..|..::..||.   |.:|..:|.|.:..:.:|:...:..|.:::..|: ::..||....:||.:
Human   652 QEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQ 716

  Fly  1098 NEHLERNQNQSLT----QLKEDALENCVLMSTKLEELQAKLQEGQQLVDSQKLELDMNRKELALV 1158
            .|||:..:..:||    |.:|.:|:   .:.|..:||||:|.|.|....|::..:.:.:.|..::
Human   717 QEHLDLMKQLTLTQEALQSREQSLD---ALQTHYDELQARLGELQGEAASREDTICLLQNEKIIL 778

  Fly  1159 KSAYEAQTKLSDDLQRQKESGQQLVDNLKVELEKERKELAHVNSAIGAQTKLSDDLECQKESGQQ 1223
            ::|.:|.....::|.|.....::..:.....|||.|:||| :.|.             |.|..||
Human   779 EAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELA-IKSG-------------QVEHLQQ 829

  Fly  1224 LVDNLKVELEKERKELAQVKSVIEAQTKLSDDLQREKESAQQLVDNLKV-------ELDKERKEL 1281
            ....||.:::|.:::..|.|.::||       .:|:..|..||:..||.       ||.:.|:||
Human   830 ETAALKKQMQKIKEQFLQQKVMVEA-------YRRDATSKDQLISELKATRKRLDSELKELRQEL 887

  Fly  1282 AQVNSAFEAQTKLSDDLQRQKESAQQLVDNLKVELDKERKELAQVNSAFEAQTKLSDDLQREKES 1346
            .||:.              :|.:|:       .||.:..:|:|||.....       ||:...:|
Human   888 MQVHG--------------EKRTAE-------AELSRLHREVAQVRQHMA-------DLEGHLQS 924

  Fly  1347 AQQLVDNLKVELDK---ERKELAQVKSVIEAQTKLSDDLQRQKESA----QQLVDNLKVELDKER 1404
            ||:..|.::..|..   :::::..|....||..|..::||::...|    :|.:..|..:|...:
Human   925 AQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQ 989

  Fly  1405 KEL-AKVKSVIEAQTKLSDDLQR---QKESAQ----QLEAQTKLSDDLQRQKESAQ------QLV 1455
            ||: .|.|:...|...||..||.   .||:|.    ||.||...||......|..|      |.|
Human   990 KEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAV 1054

  Fly  1456 DNLKVELDKERKELAQVKSVIEAQTKLSDDLQRQKESAQQLVDNLKMELDKERKELAQVKSAIGA 1520
            .:.|..|:||.:|:..:         .|.:|:..:|...:|.|    ||.:.|          |.
Human  1055 SHSKTLLEKELQEVIAL---------TSQELEESREKVLELED----ELQESR----------GF 1096

  Fly  1521 QTKLSDDLECQKESVQQLVDNLKVELEKERKE---LAKVNSAFEAQTKLSDDLKLQKEDAQREVF 1582
            :.|:....|..|:        |.:|||.|:.:   |.:.|:|......:     |:...|:||..
Human  1097 RKKIKRLEESNKK--------LALELEHEKGKLTGLGQSNAALREHNSI-----LETALAKREAD 1148

  Fly  1583 LVKERL----VKEKREFEVKLATLEDIIETLEMRCTQMEEERATAYEQINKLENRCQEKDNVKSS 1643
            ||:..|    |.:::|.|.:  .::.:::.|:   ..:|:|:    |::|.|:.
Human  1149 LVQLNLQVQAVLQRKEEEDR--QMKHLVQALQ---ASLEKEK----EKVNSLKE----------- 1193

  Fly  1644 QLQVETFKVECLHHQLKSEMATHNSLVEDLNRKLAEK---VSKLDFVQSRLMTEIAEHNQVKDQL 1705
              ||...|||..|::...:.|:..  :.::.::|..|   |.||......|.....:|:|   ::
Human  1194 --QVAAAKVEAGHNRRHFKAASLE--LSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQ---EI 1251

  Fly  1706 AQITDIPKVVELQHRLEAETAEREEAQNKLAVVTGRLDEI-------TRELDNARLEHGAQILRM 1763
            ||.                .||..||:.:|.::..:|||.       .:|::|.:.|       :
Human  1252 AQF----------------QAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWE-------V 1293

  Fly  1764 EETAREVGNKNAELCELIEFYRNRVEALERLLLASNQELEELNSIQSNQAEGVRDLGDTYSAAEG 1828
            ::..||:.:...:|....:..|..:|.|::||.....|||
Human  1294 DQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELE------------------------- 1333

  Fly  1829 RQTESDQDKERYQKLALDCKILQAKYRDAKDEIKRCEKKIKDQRLEMEGKLEKMKNKMRSLYTAE 1893
               .:.:|....||   |..:||||..:.|:.:|...::.:..:|::.....|
Human  1334 ---MAQEDLSMTQK---DKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAK------------ 1380

  Fly  1894 VTRMKEKQERDAAKSASEL-------------EALTAQNAKYEEHTRKLSNQIVRLNEK---ILE 1942
             ||.:.|.|..::..|:.:             |.|....|..:|..:.|::.:.:|.::   :..
Human  1381 -TRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQR 1444

  Fly  1943 QQKQHAIISTNLRHLQMQPISETKPSSTTLTVSSSSSAPNDDWQPFKRPNVPSSNLAMEDEEGE 2006
            |.::||:..    |..:...:..:|::.:.......:.|..|      |...|.:.|.::..||
Human  1445 QMEEHALTV----HESLSSWTPLEPATASPVPPGGHAGPRGD------PQRHSQSRASKEGPGE 1498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mud	NP_727769.3	SMC_prok_B	<224..>467	CDD:274008	17/65 (26%)
		SMC_prok_B	<576..1365	CDD:274008	166/827 (20%)
		SMC_prok_B	994..1863	CDD:274008	206/921 (22%)
GOLGA3	NP_005886.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..118		10/36 (28%)
		Interaction with GOPC. /evidence=ECO:0000269|PubMed:15951434	121..141		6/29 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	166..195		4/28 (14%)
		Golgi-targeting domain	172..257		13/87 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	216..325		21/121 (17%)
		SMC_prok_B	<345..982	CDD:274008	165/809 (20%)
		SMC_prok_B	668..1339	CDD:274008	191/836 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	789..809		2/19 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	974..993		5/18 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1376..1400		6/36 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1440..1498		10/67 (15%)