DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mud and GOLGA3

DIOPT Version :9

Sequence 1:NP_727769.3 Gene:mud / 44839 FlyBaseID:FBgn0002873 Length:2567 Species:Drosophila melanogaster
Sequence 2:NP_001376612.1 Gene:GOLGA3 / 2802 HGNCID:4426 Length:1498 Species:Homo sapiens


Alignment Length:1754 Identity:356/1754 - (20%)
Similarity:666/1754 - (37%) Gaps:495/1754 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   412 SLSPNTTPENLASSV----IDKQLREKEHENAE---LKEKL----LNLNNSQRELCQALSSFLQK 465
            ||.|.|:|....:|.    ....||:.:..:||   .||.|    |:|...:.:||         
Human    81 SLDPTTSPVGPDASPGVAGFHDNLRKSQGTSAEGSVRKEALQSLRLSLPMQETQLC--------- 136

  Fly   466 HNIDHEFPVE-----------WTSSSL----------LSTISAIESKFVNTLE------------ 497
             :.|...|:|           |....|          .|:..|.:::..:||:            
Human   137 -STDSPLPLEKEEQVRLQARKWLEEQLKQYRVKRQQERSSQPATKTRLFSTLDPELMLNPENLPR 200

  Fly   498 -KSTQMKKECDVQSVCVEKLLEKCKLLSVSLGCQPKEL-----------------------DGFE 538
             .:..|.||.......|.:   ..|:.|:.|...|:|.                       .|..
Human   201 ASTLAMTKEYSFLRTSVPR---GPKVGSLGLPAHPREKKTSKSSKIRSLADYRTEDSNAGNSGGN 262

  Fly   539 ATIPEAMESGFESSRECETILSCCHMKVVDIA-SKNNDLELDNERL-NDKCAELKSIIDRGDQHL 601
            ...|::.:...:.:|      |.....|.:|: |.:.|..|:|..| .|..:|    :|..|...
Human   263 VPAPDSTKGSLKQNR------SSAASVVSEISLSPDTDDRLENTSLAGDSVSE----VDGNDSDS 317

  Fly   602 ADIN-------LQLIEKEKQIKDV-----GAEIQELRKRNINLENMLSQIAD-KEASAASHAQHL 653
            :..:       ..::.|....:|.     |.||.         .:.|.|... |:...|:.|:|.
Human   318 SSYSSASTRGTYGILSKTVGTQDTPYMVNGQEIP---------ADTLGQFPSIKDVLQAAAAEHQ 373

  Fly   654 KQ----CGELLRAKYEVCRNELIAKNAAQDELVRMMMVPDGETLNGRVRQLIDLEMMHDEHNKMY 714
            .|    .||:...:..:|.:..:..:||:.:...:.::.:...|.|   ||..|.:...:..|..
Human   374 DQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEG---QLEALSLEASQALKEK 435

  Fly   715 AQMLKQLNELSAK-HDNMTHSHLDFVKRTEIELETKNAQIMAFDEHNNHFDRFLTRIFTLLRSRN 778
            |::..||..||.| ...:..||....::..:..|....:...:|     .:|.:|.:..:|.::|
Human   436 AELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWD-----LERAMTDLQNMLEAKN 495

  Fly   779 CPKSTTMGSATNFLESMHIEKRFENIEMLIEGQLLSADDLKRELDDLRSKNEELAKQNINGIIKR 843
                .::.|:.|.|:.  .|::::.:       :...:|::|.:         |:|.|       
Human   496 ----ASLASSNNDLQV--AEEQYQRL-------MAKVEDMQRSM---------LSKDN------- 531

  Fly   844 NKFITSLEVNTEKVKQYITDLEEEAFKRKQKVVQLENT--LSKEQSNAKEMAQRLDIAQQEIKDY 906
                     ....::|.:|.|:.:.     :.||||.|  .||.:::..|::     :.|.::.:
Human   532 ---------TVHDLRQQMTALQSQL-----QQVQLERTTLTSKLKASQAEIS-----SLQSVRQW 577

  Fly   907 HVEAIRFINTIRDRLQQDFNGVNTPQQLGTCMTEFLKMYDQMEVRYEESSSLVEKLTESQAKLEM 971
            :.:.:......|.|||.:...:...|.....:.|.||:         |:.||.::|||:|.:...
Human   578 YQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKL---------ENVSLSQQLTETQHRSMK 633

  Fly   972 QVAELQVELENKDTNQHSGALIKQLNDTIQNLEKVNAKLSEDNTVSHTVHSKLNESLLKAQKELD 1036
            :...:..:|:..:.:.                                               ||
Human   634 EKGRIAAQLQGIEADM-----------------------------------------------LD 651

  Fly  1037 LRAKIIENLEAS---ERNLSMKLCELKDLKNKLKSSDEKIAQIKETYEE-QIKALQAKCDMEAKK 1097
            ..|..::..||.   |.:|..:|.|.:..:.:|:...:..|.:::..|: ::..||....:||.:
Human   652 QEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQ 716

  Fly  1098 NEHLERNQNQSLT----QLKEDALENCVLMSTKLEELQAKLQEGQQLVDSQKLELDMNRKELALV 1158
            .|||:..:..:||    |.:|.:|:   .:.|..:||||:|.|.|....|::..:.:.:.|..::
Human   717 QEHLDLMKQLTLTQEALQSREQSLD---ALQTHYDELQARLGELQGEAASREDTICLLQNEKIIL 778

  Fly  1159 KSAYEAQTKLSDDLQRQKESGQQLVDNLKVELEKERKELAHVNSAIGAQTKLSDDLECQKESGQQ 1223
            ::|.:|.....::|.|.....::..:.....|||.|:||| :.|.             |.|..||
Human   779 EAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELA-IKSG-------------QVEHLQQ 829

  Fly  1224 LVDNLKVELEKERKELAQVKSVIEAQTKLSDDLQREKESAQQLVDNLKV-------ELDKERKEL 1281
            ....||.:::|.:::..|.|.::||       .:|:..|..||:..||.       ||.:.|:||
Human   830 ETAALKKQMQKIKEQFLQQKVMVEA-------YRRDATSKDQLISELKATRKRLDSELKELRQEL 887

  Fly  1282 AQVNSAFEAQTKLSDDLQRQKESAQQLVDNLKVELDKERKELAQVNSAFEAQTKLSDDLQREKES 1346
            .||:.              :|.:|:       .||.:..:|:|||.....       ||:...:|
Human   888 MQVHG--------------EKRTAE-------AELSRLHREVAQVRQHMA-------DLEGHLQS 924

  Fly  1347 AQQLVDNLKVELDK---ERKELAQVKSVIEAQTKLSDDLQRQKESA----QQLVDNLKVELDKER 1404
            ||:..|.::..|..   :::::..|....||..|..::||::...|    :|.:..|..:|...:
Human   925 AQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQ 989

  Fly  1405 KEL-AKVKSVIEAQTKLSDDLQR---QKESAQ----QLEAQTKLSDDLQRQKESAQ------QLV 1455
            ||: .|.|:...|...||..||.   .||:|.    ||.||...||......|..|      |.|
Human   990 KEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAV 1054

  Fly  1456 DNLKVELDKERKELAQVKSVIEAQTKLSDDLQRQKESAQQLVDNLKMELDKERKELAQVKSAIGA 1520
            .:.|..|:||.:|:..:         .|.:|:..:|...:|.|    ||.:.|          |.
Human  1055 SHSKTLLEKELQEVIAL---------TSQELEESREKVLELED----ELQESR----------GF 1096

  Fly  1521 QTKLSDDLECQKESVQQLVDNLKVELEKERKE---LAKVNSAFEAQTKLSDDLKLQKEDAQREVF 1582
            :.|:....|..|:        |.:|||.|:.:   |.:.|:|......:     |:...|:||..
Human  1097 RKKIKRLEESNKK--------LALELEHEKGKLTGLGQSNAALREHNSI-----LETALAKREAD 1148

  Fly  1583 LVKERL----VKEKREFEVKLATLEDIIETLEMRCTQMEEERATAYEQINKLENRCQEKDNVKSS 1643
            ||:..|    |.:::|.|.:  .::.:::.|:   ..:|:|:    |::|.|:.           
Human  1149 LVQLNLQVQAVLQRKEEEDR--QMKHLVQALQ---ASLEKEK----EKVNSLKE----------- 1193

  Fly  1644 QLQVETFKVECLHHQLKSEMATHNSLVEDLNRKLAEK---VSKLDFVQSRLMTEIAEHNQVKDQL 1705
              ||...|||..|::...:.|:..  :.::.::|..|   |.||......|.....:|:|   ::
Human  1194 --QVAAAKVEAGHNRRHFKAASLE--LSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQ---EI 1251

  Fly  1706 AQITDIPKVVELQHRLEAETAEREEAQNKLAVVTGRLDEI-------TRELDNARLEHGAQILRM 1763
            ||.                .||..||:.:|.::..:|||.       .:|::|.:.|       :
Human  1252 AQF----------------QAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWE-------V 1293

  Fly  1764 EETAREVGNKNAELCELIEFYRNRVEALERLLLASNQELEELNSIQSNQAEGVRDLGDTYSAAEG 1828
            ::..||:.:...:|....:..|..:|.|::||.....|||                         
Human  1294 DQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELE------------------------- 1333

  Fly  1829 RQTESDQDKERYQKLALDCKILQAKYRDAKDEIKRCEKKIKDQRLEMEGKLEKMKNKMRSLYTAE 1893
               .:.:|....||   |..:||||..:.|:.:|...::.:..:|::.....|            
Human  1334 ---MAQEDLSMTQK---DKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAK------------ 1380

  Fly  1894 VTRMKEKQERDAAKSASEL-------------EALTAQNAKYEEHTRKLSNQIVRLNEK---ILE 1942
             ||.:.|.|..::..|:.:             |.|....|..:|..:.|::.:.:|.::   :..
Human  1381 -TRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQR 1444

  Fly  1943 QQKQHAIISTNLRHLQMQPISETKPSSTTLTVSSSSSAPNDDWQPFKRPNVPSSNLAMEDEEGE 2006
            |.::||:..    |..:...:..:|::.:.......:.|..|      |...|.:.|.::..||
Human  1445 QMEEHALTV----HESLSSWTPLEPATASPVPPGGHAGPRGD------PQRHSQSRASKEGPGE 1498

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mudNP_727769.3 SMC_prok_B 319..1178 CDD:274008 162/863 (19%)
SCP-1 853..1571 CDD:114219 170/758 (22%)
Smc 1234..>1944 CDD:224117 168/770 (22%)
DUF948 1392..1517 CDD:295114 37/138 (27%)
GOLGA3NP_001376612.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..118 10/36 (28%)
Interaction with GOPC. /evidence=ECO:0000269|PubMed:15951434 121..141 6/29 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 166..195 4/28 (14%)
Golgi-targeting domain 172..257 13/87 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 216..325 21/121 (17%)
SMC_prok_B <393..743 CDD:274008 83/464 (18%)
Smc 630..1358 CDD:224117 206/943 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 789..809 2/19 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 974..993 5/18 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1376..1400 6/36 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1440..1498 10/67 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR18902
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.100

Return to query results.
Submit another query.