Protein Alignment mud and DSP

DIOPT Version :10

• Sequence 1: NP_727769.3
• Gene: mud / 44839
• FlyBaseID: FBgn0002873
• Length: 2567
• Species: Drosophila melanogaster
• Sequence 2: NP_004406.2
• Gene: DSP / 1832
• HGNCID: 3052
• Length: 2871
• Species: Homo sapiens
• Alignment Length: 2766
• Identity: 549/2766 - (19%)
• Similarity: 1028/2766 - (37%)
• Gaps: 772/2766 - (27%)

  Fly    11 LQWIGECHFIESNYITLEQSDLDSFFSVFIQKIQETENVKGKNELQDQPTEQSPLVQE---FLAH 72
            :.||.:|   |...:..:.||.::..:   || ||..::: .::|:.:..|.:.|.||   .:.:
Human   283 IMWINDC---EEEELLYDWSDKNTNIA---QK-QEAFSIR-MSQLEVKEKELNKLKQESDQLVLN 339

  Fly    73 NYPEFIAQQDDKEVDLPLDCLYV-YTLLLHYS-CV----KKPSLFFHNICNKLPELTQTCIASFF 131
            .:|     ..|| ::..:|.|.. ::.:|..: |:    |:.:.:|                .||
Human   340 QHP-----ASDK-IEAYMDTLQTQWSWILQITKCIDVHLKENAAYF----------------QFF 382

  Fly   132 RET-------------------VDRLLTREYLSQAIANV------AVVYRQGVSTSVSPCLPSSS 171
            .|.                   .|:.:..::|.:.|..:      .:.|::.|...|:.......
Human   383 EEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQ 447

  Fly   172 LSPDPRSDDAPCPSTPSSSSSQP-----------------SSSTPQLRNHREQLRL-----NGCE 214
            |.          |..|...|::|                 ......|:::.|:.:.     .|.:
Human   448 LK----------PRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVD 502

  Fly   215 M---------PPPSTPKTEL---LEQRTKELRGIRTQL-----EVVRYEKALLEEQQMEKDEL-- 260
            |         |||:....:|   :||..:.:..:..||     .:|.:...:::.:::....:
Human   503 MLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAK 567

  Fly   261 IKVLNKE---KMMAKMEL---EKLRNVKLTEEHHDNESHHIMPYEF----EHMKGCLLKEIGLKE 315
            :|.:.:|   |.:|.:||   |.:||.:.:|...|::...|.. :|    :|.:..:::..|..:
Human   568 LKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQS-QFTDAQKHYQTLVIQLPGYPQ 631

  Fly   316 S---LIAEIT------DKLHDLRVE-NSELSEKLNLAGKRLLEYTDRIRFLESRVD----DLTRI 366
            .   ...|||      |..|:..:| |.|..::.......|.:...:|...|.|:.    .|...
Human   632 HQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQ 696

  Fly   367 VSSRDVMI-----SSLESDKQELDKCLKEARDDLHN-------------------RIEVLNASSD 407
            .||..:.:     .|:::|.|.:.:.|.:.:|.|.|                   ::|.:|..:|
Human   697 GSSHHITVKINELKSVQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTD 761

  Fly   408 -----------LLDCSLSPNTTPENLASSVIDKQLREKEHENAELK---------EKLLNLNNSQ 452
                       ||...|.   |.:.|  .|.:.:|.|:|....:|.         :|:.|..|.:
Human   762 GYLNSLCTVRALLQAILQ---TEDML--KVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLK 821

  Fly   453 RELCQALSSFLQKHNIDH-----EFPVEWTSSSLLSTISAIESKFVNTLEKSTQMKKECDVQSVC 512
            :.|...:.:.|||....|     ::|:....      :.....|.....::..::.|:.|.:...
Human   822 KSLLATMKTELQKAQQIHSQTSQQYPLYDLD------LGKFGEKVTQLTDRWQRIDKQIDFRLWD 880

  Fly   513 VEKLLEKCKLLSVSLGCQPKELDGFEATIPEAMESGFESSRECETILSCCHMKVVDIASKNNDLE 577
            :||              |.|:|..:........:..:::.|..:::.|   ||..|   .|..:.
Human   881 LEK--------------QIKQLRNYRDNYQAFCKWLYDAKRRQDSLES---MKFGD---SNTVMR 925

  Fly   578 LDNERLN---------DKCAELKSIIDRGDQHLADINLQLIE-------------KEKQIK---- 616
            ..||:.|         ||..|::.|.:.....:.|..|||..             |...|:
Human   926 FLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSG 990

  Fly   617 -------DVGAEIQELRKR----------------NINLENMLSQIADKEASAASHA-------- 650
                   ||.|...||..|                ::.|:|...::.::|...|..|
Human   991 VILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKN 1055

  Fly   651 ----QHLKQCGELLRAKYEVCRNELIAKNAAQDELVRMMMVPDGETLNGRVRQLIDLEMMHDEHN 711
                |:|:        ||:...::..||.|:.:||.|...: ||::    .:|.:|
Human  1056 KFLDQNLQ--------KYQAECSQFKAKLASLEELKRQAEL-DGKS----AKQNLD--------- 1098

  Fly   712 KMYAQMLKQLNELSAKHDNMTHSHLDFVKRTEIELETKNAQIM--AFDEHNNHFDRFLTRIFTLL 774
            |.|.| :|:|||   |...:|:         |||.|.:..:.:  .||:..|.:|:       |.
Human  1099 KCYGQ-IKELNE---KITRLTY---------EIEDEKRRRKSVEDRFDQQKNDYDQ-------LQ 1143

  Fly   775 RSRNCPKSTTMGSATNFLESMHIEKRF--ENIEMLIEGQLLSADDLKRELDDLRSK-NEELAKQN 836
            ::|.|.|. .:|......|....||.:  |.:.:|::.:.....:.:.||..:|:. |||::  |
Human  1144 KARQCEKE-NLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMS--N 1205

  Fly   837 INGIIKRNKFITSLEVNTEKVKQYITDLEEEAFKRKQKVVQLENTLSKEQSNAKEMAQRLDIAQQ 901
            :     |||:.|.:.:....:|                    |.::.|| .::|.:..:||...:
Human  1206 L-----RNKYETEINITKTTIK--------------------EISMQKE-DDSKNLRNQLDRLSR 1244

  Fly   902 EIKDYHVEAIRFINTIRDRLQQDFNGVNTPQQLGTCMTEFLKMYDQMEVRYEESSSLVEKLTESQ 966
            |.:|...|.:|..::|....:|.........|...|.:|.::....:|:   |...::::.:|..
Human  1245 ENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEI---ELKQVMQQRSEDN 1306

  Fly   967 AKLEMQVAELQVELENKDTNQHSGALIKQLNDTIQ-----------NLEKVNAKLSED------- 1013
            |:.:..:.|....:::|:..      |::|....|           .|.||.....|:
Human  1307 ARHKQSLEEAAKTIQDKNKE------IERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQ 1365

  Fly  1014 -----NTVSHTVHSKLNESLLKAQKELD---LRAKIIENLEASERNLSMKLCELKDLKNKLKSSD 1070
                 |....|:|.      |..|||.|   .||: |:||....|:||.   |:|.|||.|..:.
Human  1366 FETEINITKTTIHQ------LTMQKEEDTSGYRAQ-IDNLTRENRSLSE---EIKRLKNTLTQTT 1420

  Fly  1071 EKIAQIKETYEEQIKALQAKCDMEAKKNEHLERNQNQSLTQLKEDALENCVLMSTKLEELQAKLQ 1135
            |.:.:::|..::| ||..::.   :::.:.||....| :||::   .|..|.....|::....:|
Human  1421 ENLRRVEEDIQQQ-KATGSEV---SQRKQQLEVELRQ-VTQMR---TEESVRYKQSLDDAAKTIQ 1477

  Fly  1136 EGQQLVDSQKLELDMNRKELALVKSAYEAQTKLSDDLQRQKESGQQLVDNLKV---ELEKERKEL 1197
            :..:.::..|..:|....:...::.......::..|||:...|..:.::.|||   ||.:.|.:.
Human  1478 DKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDY 1542

  Fly  1198 AHVNSAIGAQTKLSDDLECQKESGQQLVDNLKVELEKERKELAQVKSVIEAQTKLSDDLQREK-- 1260
            ..|     :|.:...|.:..:  .|..:..|:::.:|..:||.::|     :|...|..:|:|
Human  1543 ERV-----SQERTVKDQDITR--FQNSLKELQLQKQKVEEELNRLK-----RTASEDSCKRKKLE 1595

  Fly  1261 ESAQQLVDNLKVELDKERKELAQVNSAFEAQTKLSDDLQRQKESAQQLVDNLKVELDKERKELAQ 1325
            |..:.:..:||.:..|......|:..|...:.:..|||::|::    ::|....|..:.::||.:
Human  1596 EELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRD----VLDGHLREKQRTQEELRR 1656

  Fly  1326 VNSAFEAQTKLSDDLQREKESAQQL---VDNLKVELDKERKELAQVKSVIEAQTKLSDDLQRQKE 1387
            ::|..||   |...|.:|:||.:|.   .::.:..::.:.:.|.:.|..||....|:::|.::..
Human  1657 LSSEVEA---LRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHL 1718

  Fly  1388 SAQQLVDNLKVELDKERKELAKVKS-----VIEAQTKLSDDLQRQKESAQQLEAQTKLSDDLQRQ 1447
            ..::.:.||::|.|..|:..::..|     ::|.:::|      |..:.:.||.| .|.:||||:
Human  1719 MLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQL------QISNNRTLELQ-GLINDLQRE 1776

  Fly  1448 KESAQQLVDNLKVELDKERKELAQVKSVIEAQTKLSDDLQRQKESAQQLVDNLKMELDKER---- 1508
            :|       ||:.|::|.:|:..:..:.|:........:.:::||.  ||....:|.||.|
Human  1777 RE-------NLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESL--LVKIKVLEQDKARLQRL 1832

  Fly  1509 -KELAQVKSAIGAQTKLSDDLECQKESVQQLVDNLKVELEKERKELAKVNSAFEAQTKLSDDLKL 1572
             .||.:.||.:.|:|::...|||:|:.:|..::..|.:..::.:.:.|:.|..|...:..:.|:.
Human  1833 EDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRS 1897

  Fly  1573 QKEDAQREVFLVKERLVKEKREFEVKLATLEDIIETLEMRCTQMEEERATAYEQINKLENR--CQ 1635
            :.|..|.|:..::||..::          |||  .|.|.: :|:|.||:....:|:||..|  ..
Human  1898 EIERLQAEIKRIEERCRRK----------LED--STRETQ-SQLETERSRYQREIDKLRQRPYGS 1949

  Fly  1636 EKDNVKSSQLQVETFKV---------------EC-------LHHQLKSEMATHN----------- 1667
            .::.....:..|:|.|:               ||       |...||.:.:...
Human  1950 HRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRG 2014

  Fly  1668 ---------------SLVEDLNRKLAEKVSKLDFVQSRLMTE--IAEHNQVK------------- 1702
                           ||||...:||....|.:..::::..|.  |..|...|
Human  2015 AGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLID 2079

  Fly  1703 -DQLAQI---------TDIP---KVVELQHRLEAETAERE------EAQ---------------- 1732
             |...||         .|.|   |.|.:...::....:||      |||
Human  2080 FDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 2144

  Fly  1733 NKLAVVTGRLD-EITRELDNARLEHGAQILRMEETAREVGNKNAELCELIEFYRNRVEALERLLL 1796
            ..:|:..|.:| ::.|.|::.|..       .:.....|..|.....:|.|  |.|:|....|||
Human  2145 KDVALARGLIDRDLYRSLNDPRDS-------QKNFVDPVTKKKVSYVQLKE--RCRIEPHTGLLL 2200

  Fly  1797 ASNQELEELNSIQSNQAEGVR---------DLG----DTYSAAEGRQTESDQDKERYQKLALDCK 1848
            .|.|:       :|...:|:|         |.|    .|.:..|..|...|:..||.:.......
Human  2201 LSVQK-------RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSS 2258

  Fly  1849 ILQAKYRDAKDEIKRCEKKIKDQRLEMEGKLEKMKNKMRSLYTAE-VTRMK----EKQERDAA-- 1906
            .:...|.:...:.....:.:|...:.....||.::.:..:.:..: |:.::    |..:|...
Human  2259 CIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 2323

  Fly  1907 ----KSASELEALTAQNAKYEEHTRKLSNQIVRLNEKILEQQKQHAIISTNLRHLQMQ----PIS 1963
                |..|...|:|..|   :..|..:.:....:|::::|  |.|.|     |.|:.|    .|.
Human  2324 EFKEKLLSAERAVTGYN---DPETGNIISLFQAMNKELIE--KGHGI-----RLLEAQIATGGII 2378

  Fly  1964 ETKPSST------------TLTVSSSSSAPNDDWQPFKRPNVPSSNL--------AMEDEEGEVF 2008
            :.|.|..            ...:|...|.|:||.:.|..||. ..||        .::|||
Human  2379 DPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNT-EENLTYLQLKERCIKDEE---- 2438

  Fly  2009 NNTYLTDLKLGRVPADMTAEELIYRN-------------SLQPPHLKS--TYAAQYDLGSQDEDL 2058
            ....|..||..:.....:.:..:.:.             |:|..:.|.  .|....:|..|:.:.
Human  2439 TGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 2503

  Fly  2059 KD----GPHSLDDSMSALLSSSSTGTR------------KKSMGTHYK---------------RP 2092
            ::    |.   |.|...:|....||::            .:.....|:               :.
Human  2504 EEITITGS---DGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKN 2565

  Fly  2093 GPPTPSKNGGRLS---FGSSEPPREILREFGDHNNTSK--TPARFKFLTQRFSVGSSGLPRDEPI 2152
            |..|.|..|..:|   |.||.           |.:.||  |.:..:.||.|.|..|..|....||
Human  2566 GVGTSSSMGSGVSDDVFSSSR-----------HESVSKISTISSVRNLTIRSSSFSDTLEESSPI 2619

  Fly  2153 PQL---PRRKRPNLLTGIHR--------RRLRHAVDIFCTSTPRKSRSYYDQQRMIGASDADKSE 2206
            ..:   ...::.::..||.|        :||..|.  .||.               |.......:
Human  2620 AAIFDTENLEKISITEGIERGIVDSITGQRLLEAQ--ACTG---------------GIIHPTTGQ 2667

  Fly  2207 AVETEDEVIE--VEPDAVPELEPLEDA-----DQQGTPHLSTAAL-----LALTKGNT----RRL 2255
            .:..:|.|.:  ::.|....|:|.:.|     ..:|...:|.|..     |....|..    :.|
Human  2668 KLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYL 2732

  Fly  2256 TGTTKSKKGRVSLSLHGNIFAKSR-PASFVAGKRVQ 2290
            ||      |.|...:||.|..:.. ...|:.|:..|
Human  2733 TG------GLVDPEVHGRISTEEAIRKGFIDGRAAQ 2762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mud	NP_727769.3	SMC_prok_B	<224..>467	CDD:274008	63/320 (20%)
		SMC_prok_B	<576..1365	CDD:274008	189/888 (21%)
		SMC_prok_B	994..1863	CDD:274008	223/1026 (22%)
DSP	NP_004406.2	Globular 1	1..1056		148/844 (18%)
		Interaction with PKP1, JUP, PKP2. /evidence=ECO:0000269|PubMed:10852826, ECO:0000269|PubMed:11790773	1..584		55/340 (16%)
		SPEC	190..366	CDD:413338	21/96 (22%)
		SPEC	285..450	CDD:238103	34/204 (17%)
		SH3_10	447..513	CDD:407754	9/75 (12%)
		Spectrin_like	548..625	CDD:465730	15/77 (19%)
		CCDC158	<672..>1310	CDD:464943	146/742 (20%)
		SMC_prok_B	1014..1881	CDD:274008	220/999 (22%)
		Central fibrous rod domain	1057..1945		236/1033 (23%)
		Globular 2	1946..2871		164/885 (19%)
		4.5 X 38 AA tandem repeats (Domain A). /evidence=ECO:0000269|PubMed:12101406	1960..2208		49/263 (19%)
		Plectin	2048..2086	CDD:459901	5/37 (14%)
		PLEC	2084..2121	CDD:197605	8/36 (22%)
		Plectin	2124..2162	CDD:459901	7/37 (19%)
		4.5 X 38 AA tandem repeats (Domain B). /evidence=ECO:0000269|PubMed:12101406	2244..2446		41/216 (19%)
		PLEC	2251..2288	CDD:197605	2/36 (6%)
		Plectin	2291..2329	CDD:459901	3/37 (8%)
		PLEC	2328..2364	CDD:197605	9/40 (23%)
		Plectin	2367..2405	CDD:459901	6/37 (16%)
		Plectin	<2468..2496	CDD:459901	4/27 (15%)
		4.5 X 38 AA tandem repeats (Domain C). /evidence=ECO:0000269|PubMed:12101406	2609..2822		35/177 (20%)
		PLEC	2611..2647	CDD:197605	6/35 (17%)
		Plectin	2650..2688	CDD:459901	8/54 (15%)
		Plectin	2726..2764	CDD:459901	11/43 (26%)
		PLEC	2762..2799	CDD:197605	1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2810..2871
		6 X 4 AA tandem repeats of G-S-R-[SR]	2824..2847