Protein Alignment mud and golg-4

DIOPT Version :9

• Sequence 1: NP_727769.3
• Gene: mud / 44839
• FlyBaseID: FBgn0002873
• Length: 2567
• Species: Drosophila melanogaster
• Sequence 2: NP_001355507.1
• Gene: golg-4 / 175445
• WormBaseID: WBGene00010306
• Length: 1642
• Species: Caenorhabditis elegans
• Alignment Length: 1996
• Identity: 427/1996 - (21%)
• Similarity: 791/1996 - (39%)
• Gaps: 549/1996 - (27%)

  Fly   300 FEHMKGCLLKEIG-LKES-------LIAEITDKLHDLRVE--NSELSEKLNLAGKRLLEYTDRIR 354
            |:::|..|..|.| ||:|       |.|::......:..:  .|:.|..::   ||   :|....
 Worm     2 FKNLKNRLDNEAGKLKQSAQQYGEQLAAQVGQYRQAMNEQPAGSDASASIS---KR---FTGESG 60

  Fly   355 FLESRVDDLTRIVSSRDVM------------ISSLESDKQELDKCLKEARDDLHNRIEVL----- 402
            ..::.....|.|.||..:|            :||.||......:...|  |.:|:....|
 Worm    61 ETKAENPANTSIESSSAIMSEIPEADLLGLGLSSTESPSNRRRRSPSE--DSIHSNESTLAALLQ 123

  Fly   403 ---NASSDLLDCSLSPNTTP---ENLASSVIDKQLREKEHENAELKEKLLNLNNSQRELCQALSS 461
               ||.|..|:      |.|   |::||.....:.......|:.||::|.......|:.
 Worm   124 SIPNAISSALE------TIPSDSESVASDAFSVRSTNDPAYNSRLKQRLATYKAKYRDA------ 176

  Fly   462 FLQKHN--IDHEFPVEWTSSSLLSTISAIESKFVNTLEKSTQMKKECDVQSVCVEKL-LEKCKLL 523
             :.:||  :|.                      |||..|..:..::..:|.  |||| ||| ::|
 Worm   177 -VHRHNKLVDD----------------------VNTTRKLLETTQDECLQK--VEKLRLEK-RIL 215

  Fly   524 SVSLGCQPKELDGFEATIPEAMESGFESSRECE---TILSCCHMKV----------VDIASKNND 575
            :..|.......||.|           |..::||   .:|..|.:|:          ..:.:.:||
 Worm   216 AEKLSNSAGNGDGKE-----------ELEKKCEDYKRMLEQCKIKIKSLQQDKKEQQQLITVDND 269

  Fly   576 LELD------NERLNDKCAELKSIIDRGDQHLADINLQLIEKEKQ--IKDVGAEIQELRKRNINL 632
            ..:|      .:|:.....|..:.|:..||..| |||...:.|..  :::..:||::.|::...|
 Worm   270 DSVDPRIREMEQRIQKTEEEWTNRINESDQQHA-INLATTKAEMHAALENKDSEIEQWRRKCATL 333

  Fly   633 ENMLSQIADKEASAASHAQHLKQCGELLRAKYEVCRNELIAKNA-----------AQDELVRMMM 686
            |   .|.||.....:...:.::...:.|.::    :||:|.|.:           .::|..|..|
 Worm   334 E---QQDADANQRWSDKVEKVQAMNKALESE----KNEMIEKLSEAKAQGVKAVLEEEERKRTEM 391

  Fly   687 VPDGETLNGRVRQLIDLEMMHDEHNKMYAQMLKQLNELSAKHDNMTHSHLDFVKRTEIELETKNA 751
            ..|   ||.      ::|.:.:|..||..:|                      ...:::||.|.:
 Worm   392 ETD---LND------EIERLKEETEKMRLEM----------------------STYKVQLEAKES 425

  Fly   752 QIMAFDEHNNHFDRFLTRIFTLLRSRNCPKSTTMGSATNFLESMHIE--KRFENIEMLIEGQLLS 814
            :  .|||.....:       .|....|..|||     .:.|||...|  ..|||.....|..|.:
 Worm   426 R--EFDEEREDVE-------ALKLELNAVKST-----RDDLESRITENSSSFENYRSEAEKTLAA 476

  Fly   815 A----DDLKRELDDLRSKNEELAKQNINGIIKRNKFITSLEVNTEKVKQY-ITDLEEEAFKRKQK 874
            |    :.:..|.|..|.|.||.|        ..::.|.::|..|::...: |.:.|.|.....:|
 Worm   477 AKAQFEKMVSECDKWREKYEERA--------AASEHIATVEFETQETDAHRILEFEAEKKALAEK 533

  Fly   875 VVQLENTLSKEQSNAK--EMAQRLDIAQQEIKDYHVEAIRFINTIRDRLQQDFNGVNTPQQLGTC 937
            ..:|  ||..||::.:  ||.|:|...|||:.:.           .|.||.:.|
 Worm   534 CEEL--TLKFEQADKEKNEMVQQLSRLQQEMLEK-----------CDALQAEVN----------- 574

  Fly   938 MTEFLKMYDQMEVRYEESSSLVEK----LTESQAKLEMQVAELQVELENKDTNQHSGALIKQLND 998
              |...:.::::.:|::.:...|:    |.||:..||.:....:.|.|.:...|.:.|: ::||.
 Worm   575 --EAKALREEIQAKYDDVTQKAERIQGELEESKKVLESEKQAFENEKEQEREEQLAKAM-EKLNS 636

  Fly   999 TIQNLEKVNAKLSEDNTVSHTVHSKLNESLLKAQKELDLRAKIIENLEASERNLSMKLCELKDLK 1063
            ....|::|..||.:.           .|.:|.|:..:.   ::.|.||.||:..|....||:.:.
 Worm   637 EQNILDEVTKKLEQS-----------EEEVLAARGAIQ---ELTEKLEESEKETSTAKTELEAVS 687

  Fly  1064 NKLKSSDEKIAQIKETYEEQIKALQAK---CDMEAKKNEHLERNQNQSLTQLKEDALENCVLMST 1125
            .||.||:   ..:|| :.:.|:|::.:   |:.:                  |::|:|   |:..
 Worm   688 KKLDSSE---TSLKE-FSDMIEAMKIQLINCEKQ------------------KDEAVE---LLKQ 727

  Fly  1126 KLEELQAKLQ----EGQQLVDSQKLELDMNRKELALVKSAYEAQTKLSDDLQRQKESGQQLVDNL 1186
            ||||::..:.    :.|.|::|...|:..:.:...:||              :|.|..|..::||
 Worm   728 KLEEVEKNMSDVEVQKQLLLESTTSEMKQHAEAAEIVK--------------KQLEEAQSSIENL 778

  Fly  1187 KVELEKERKELAHVNSAIGAQTKLSDDLECQKESGQQLVDNLKVELEKERKELAQVKSVIEAQTK 1251
            |.:.|.||              .|...||..:.|.   :..:..::|..:|||       ||..|
 Worm   779 KKDAENER--------------NLKTALESDESSA---ISEITKQMEAAKKEL-------EASEK 819

  Fly  1252 LSDDLQREKESAQQLVDNLKVELDKERK----ELAQVNSAFE----AQTKLSDDLQRQKESAQQL 1308
            ...:|:.:.:..|::.:..:.::.|.:|    |:|::..:.|    |:.:|:.:|:..||
 Worm   820 EKSELREQMDRLQKVHNAGQEDIQKLQKTWELEMAKIAKSTEDEKLAREQLAGELENAKE----- 879

  Fly  1309 VDNLKVELDKERKELAQVNSAFEAQTK----LSDDLQREK---ESAQQLVDNLKV----ELDKER 1362
              :|||..:::...:.:...|.:...|    |.:.|:|.:   ||:|:|..:.|.    ||:||.
 Worm   880 --DLKVVEEEKHTGIQRAQGALDDAEKEVKVLKEQLERAQSALESSQELASSQKADKIQELEKEL 942

  Fly  1363 KELAQVKSVIEAQTKLSDDLQRQKESAQQLVDNLKVELDKERKELAKVKSVIEAQTKLSDDLQRQ 1427
            :         .||.:.|::|    |:|.::|.:|...|:....|...:|..:|.   |..:||.:
 Worm   943 Q---------NAQKRSSEEL----ETANEMVRSLTATLENSNSETEILKQKLET---LDKELQAR 991

  Fly  1428 KESAQQLEAQTKLSDDLQRQKESAQQLVDNL-----KVELDKERK-ELAQVKSVIEAQTKLSDDL 1486
            :::.:.|..:..:......:||.....:.||     ::|::||.| ||.:|:            |
 Worm   992 QQTEKALTEEINVLTTSLAEKEQQTAQIQNLQTQIYQMEVEKEEKVELVKVQ------------L 1044

  Fly  1487 QRQKESAQQLVDNLKMELDKERKELAQVKSAIGAQTKLSDDLECQKESVQQLVDNLKVELEKERK 1551
            |:..:|:....:.|:.|:::..   |::|:...|:.:..:.|..:||.:|..:..|.||.| |:.
 Worm  1045 QQAAQSSSSAEEALRAEIEQLE---AKLKAVEQAKAEALNSLLAEKEHLQAQLHQLGVEKE-EKL 1105

  Fly  1552 ELAKVNSAFEAQTKLS----------------DDLKLQKEDAQREVFLVKERLVKEKREFEVKLA 1600
            |:.||.....||:..|                .:::.:|::|.......||:...:.:|.:.:|.
 Worm  1106 EMVKVQLQQAAQSSSSVEQALRAEIEKLEAKLQEIEEEKKNALNASLAEKEQQTAQIQELQAQLH 1170

  Fly  1601 TLE-DIIETLEMRCTQMEE--ERATAYEQ-----INKLENRCQEKDNVK---SSQLQVETFKVEC 1654
            .|| :..|.|||...|:::  :.:::.||     |.|||.:.||.:..|   ||:.:.:..::..
 Worm  1171 QLEVEKEEKLEMVKVQLQQAAQSSSSVEQALRAEIEKLEAKLQEIEKAKMQNSSKREQKVRELSN 1235

  Fly  1655 LHHQLKSEMATHNSLVEDLNRKLAEKVSKLDFVQSRLMTEIAEHNQVKDQLAQITDIPKVVELQH 1719
            |:.:::.|......::.||.       |:|..:.:.|:.:.|...:.|....         ||:.
 Worm  1236 LNEKMRVEFIAKEKIISDLR-------SELSTISTELVVQKATVEKTKMDFG---------ELET 1284

  Fly  1720 RLEAETAEREEAQNKLAVVTGRLDEI-TRELDNARLEHGAQILRMEETAREVGNKNAELCELIEF 1783
            |.:..||:||..         :::|| .||.....||.....|.::|||               :
 Worm  1285 REKRATADRENE---------KMEEIRLRETFAKELETMGSALEVKETA---------------Y 1325

  Fly  1784 YRNRVEALERLLLASNQELEELNSIQSNQAEGVRDLGDTYSA-AEGRQTESDQDKERYQKL--AL 1845
            ...:..|.:::...::|..|:|...|::|.|.......|..| ||..:.||:|.....::|  :.
 Worm  1326 NELKASAEKKIAKLTSQFEEKLKKAQNSQDEASESRFKTLEASAEQAKLESEQKLRALEELLKSS 1390

  Fly  1846 DCKILQAKYRDAKDEIKRCEKKIKDQRLEMEGKLEKMKNKMRSLYTAEVTRMKEKQERDAAKSAS 1910
            :.:|.:.|.::...|..|...:::.:.|  ||:.:::.:::..| .|||.::....|..|.|:.:
 Worm  1391 ESEIEELKIKEISAEKDRSHWEVEKEML--EGEAKELTDRIEGL-EAEVKKLTAANETKAVKADT 1452

  Fly  1911 ELEALTAQNAKYEEHTRKLSNQIVRLNEKILEQQKQHAIISTNLRHLQMQPISETKPSSTTLTVS 1975
            :...:          .|:|..::.:|..::.::.:|..::...|..|:                :
 Worm  1453 DARKV----------VRELQKEVKQLYNELNDKNQQFDMVQEELTRLK----------------T 1491

  Fly  1976 SSSSAPNDDWQPFKRPNVPSSNLAMEDEEGEVFNNTYLTDLKLGRVPADMT-AEEL---IYRNSL 2036
            |..:|.|...|..|:       :..||...|......:..|| .::.|.:| |::|   :.||..
 Worm  1492 SKETAENGQLQVQKQ-------MDEEDRRSEFSFKEEIASLK-QKLDASLTEADDLRMQVSRNEK 1548

  Fly  2037 QPPHLKSTYAAQYDLGSQDEDLKDGPHSLDDSMSALLSSSSTGTRKKSMGTHYKRPGPPTPSKNG 2101
            .|   :|.                             .::||| |.|||..|
 Worm  1549 TP---RSN-----------------------------GNASTG-RTKSMELH------------- 1567

  Fly  2102 GRLSFGSSEPPR-EILREFGDHNNTSKTPARFKFLTQRFSVGSSGL 2146
                 |.::|.. |.||.           ..::::|.|.|:|...:
 Worm  1568 -----GIADPAEAEYLRN-----------VLYRYMTNRESLGKESV 1597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mud	NP_727769.3	SMC_prok_B	319..1178	CDD:274008	200/938 (21%)
		SCP-1	853..1571	CDD:114219	172/772 (22%)
		Smc	1234..>1944	CDD:224117	167/765 (22%)
		DUF948	1392..1517	CDD:295114	28/130 (22%)
golg-4	NP_001355507.1	DUF3584	207..>884	CDD:378817	190/860 (22%)
		SMC_prok_B	577..1442	CDD:274008	226/1024 (22%)
		SH3_and_anchor	<1444..1549	CDD:275056	25/138 (18%)
		Grip	1572..1620	CDD:197860	8/37 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000