Protein Alignment mud and FILIP1L

DIOPT Version :9

• Sequence 1: NP_727769.3
• Gene: mud / 44839
• FlyBaseID: FBgn0002873
• Length: 2567
• Species: Drosophila melanogaster
• Sequence 2: NP_001374779.1
• Gene: FILIP1L / 11259
• HGNCID: 24589
• Length: 1190
• Species: Homo sapiens
• Alignment Length: 1418
• Identity: 296/1418 - (20%)
• Similarity: 541/1418 - (38%)
• Gaps: 398/1418 - (28%)

  Fly  1080 YEEQIKALQAKCDM-----EAKKNEHLERNQNQSLTQLKEDALENCVLMSTKLEELQAKLQEGQQ 1139
            :.:|.|...::.|:     :|:|......:|.:.|:  ::|.|   .|:|....||||: .|...
Human    33 HRQQDKDSPSESDVILPCPKAEKPHSGNGHQAEDLS--RDDLL---FLLSILEGELQAR-DEVIG 91

  Fly  1140 LVDSQKLELDM---------NRKEL-ALVKSAYEAQT-------------KLSDDLQRQKESGQQ 1181
            ::.::|::|.:         .:|.| ||.:.|::|::             :|...:::.|||.::
Human    92 ILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRR 156

  Fly  1182 LVDNLKVELEKERKELAHVNSAIGAQTKLSDDLECQKESGQQLV---DNLKVELEKERKELAQVK 1243
            ::..|.| .||.|:           ||.|  :||.:|...::.:   |.....||:|.:.|   |
Human   157 ILGQLLV-AEKSRR-----------QTIL--ELEEEKRKHKEYMEKSDEFICLLEQECERL---K 204

  Fly  1244 SVIEAQTKLSDDLQREKESAQQLVDNLKVELDKERKELAQVNSAFEAQTKLSDDLQRQKESAQQL 1308
            .:|:.:.|..::.::|||   :.|..||.||.|.:.....|   .:.|.:|:..|..|::..|:|
Human   205 KLIDQEIKSQEEKEQEKE---KRVTTLKEELTKLKSFALMV---VDEQQRLTAQLTLQRQKIQEL 263

  Fly  1309 VDNLKVELDKERKELAQVNSAFEAQTKLSDDLQREKESAQQLVDNLKVELDKERKELAQVKSVIE 1373
            ..|.|....|.....|:|....:..|:|..:||.:.....|..|.:..:|..|..:..|::..:.
Human   264 TTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLA 328

  Fly  1374 AQTKLSDDLQ---RQKESAQQLVDNLKVELDKERKELAKVKSVIEAQTKLSDDLQRQKESAQQLE 1435
            |.::..|:|:   |....|::.:.::|.::.|.....|.:.:.:|...|...|::.:.|...::|
Human   329 ALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKME 393

  Fly  1436 AQTKLSDDLQRQKESAQQLVDNLKVELDKERKELAQVKSVIEAQTKLSDDLQRQKESAQQLVDNL 1500
            .|.:   ||.::.|.......:.|:|::|..|.       |.|..||.|...:.|:...    :|
Human   394 EQCR---DLNKRLERETLQSKDFKLEVEKLSKR-------IMALEKLEDAFNKSKQECY----SL 444

  Fly  1501 KMELDKERKELAQVKSAIGAQTKLSDDLECQKESVQQLVDNLKVELEKERKELAKVNSAFEAQTK 1565
            |..|:|||....|          ||.:||           :|||.:    |||..:.|
Human   445 KCNLEKERMTTKQ----------LSQELE-----------SLKVRI----KELEAIES------- 477

  Fly  1566 LSDDLKLQKEDAQREVFLVKERLVKEKREFEVKLATLEDIIETLEMRCTQMEEERATAYEQINKL 1630
                 :|:|.:     |.:||.|.|               ::||.:   ...:||.|..|::.|.
Human   478 -----RLEKTE-----FTLKEDLTK---------------LKTLTV---MFVDERKTMSEKLKKT 514

  Fly  1631 ENRCQEKDNVKSSQLQVETFKVECLHHQLKSEMATHNSLVEDLNRKLAEKVSKLDFVQSRLMTEI 1695
            |::.|    ..|||||||..||..:..:          |:|:..|.|..|..    |:.::.:..
Human   515 EDKLQ----AASSQLQVEQNKVTTVTEK----------LIEETKRALKSKTD----VEEKMYSVT 561

  Fly  1696 AEHNQVKDQLAQITD-----IPKVVELQHRLEA-ETAEREEAQNKLAVVTGRLDEITRELDNARL 1754
            .|.:.:|::|....:     :.:|..|::||:: |..|::..:|||...:|:......:.:|
Human   562 KERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENN--- 623

  Fly  1755 EHGAQILRMEETAREVGNKNAELCELIEFYRNRVEALERLLLASNQELEELNSIQSNQAEGVRDL 1819
                   :::|.::||        |.::.....::|:|..|:.:..|.|.|....:|:.:..:.|
Human   624 -------KIKELSQEV--------ERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFL 673

  Fly  1820 GD----------TYSAAEGRQTESDQDKERYQKLALDCKILQAKYRDAKDEIKRCEKKI------ 1868
            ..          .|..||  :||:..::..:::|..:    :||......|:...::||
Human   674 SKELEHVKMELAKYKLAE--KTETSHEQWLFKRLQEE----EAKSGHLSREVDALKEKIHEYMAT 732

  Fly  1869 KDQRLEMEGKLEKMKNKMRSLYTAEVTRMKEKQERDAAKSASELEALTAQNAKYEEHTRKLSNQI 1933
            :|....::|....::.|:         ..:|.:.||..:   |:|.||.:..:|...::.|...:
Human   733 EDLICHLQGDHSVLQKKL---------NQQENRNRDLGR---EIENLTKELERYRHFSKSLRPSL 785

  Fly  1934 --VRLNE-KILEQQKQ------------------HAIISTNLRHLQMQPISETKPSSTTLTVSSS 1977
              .|::: ::..::.|                  .|:|:..|.........:.....:.|:...|
Human   786 NGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPNDEGSVLSFKCS 850

  Fly  1978 SSAP----NDDWQPFKRPNVPSSNLAMEDEEGEVFNNTYLT----------DLKLGRVPADMTAE 2028
            .|.|    ...|.|:           |:.:||.:.|....|          ||.|...|.
Human   851 QSTPCPVNRKLWIPW-----------MKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPG----- 899

  Fly  2029 ELIYRNSLQPPHLKST-----YAAQYDLGSQDEDLKDGPHSLDDSMSALLSSSSTGTRKKSMGTH 2088
                    ||.|:|.|     ..|..::.|   ...:.|||.  :.:|::  .:.||.|:.:...
Human   900 --------QPLHIKVTPDHVQNTATLEITS---PTTESPHSY--TSTAVI--PNCGTPKQRITIL 949

  Fly  2089 YKRPGPPTPSKNGGR--------------LSFGSSEPPREILREFGDHNNTSKTPARFKFLTQRF 2139
            ......|..||....              .:|..::.|...         .|.||.|.....|..
Human   950 QNASITPVKSKTSTEDLMNLEQGMSPITMATFARAQTPESC---------GSLTPERTMSPIQVL 1005

  Fly  2140 SV-GSSGLPRDEPIPQLPRRKRPNLLTGIHRRRLRHAVDIFCTSTPRKSRSYYDQQRMIGASDAD 2203
            :| ||:..|.....|:      |..::.      :||  ||..|..|:|...:.:      |:::
Human  1006 AVTGSASSPEQGRSPE------PTEISA------KHA--IFRVSPDRQSSWQFQR------SNSN 1050

  Fly  2204 KSEAVETEDEVIEV-----------------EPDAVPELEPLEDADQQGTPHLSTAALLALTKGN 2251
            .|..:.|||..|.:                 .|.|     ||:|...||   |...||...|...
Human  1051 SSSVITTEDNKIHIHLGSPYMQAVASPVRPASPSA-----PLQDNRTQG---LINGALNKTTNKV 1107

  Fly  2252 TRRLTGTTKSKKGRVSLSLHGNIFAKSRPASFVAGKRVQLR-RKLRRDRIMGRFDEARHLDQMRL 2315
            |..:|.|                     |.:....::.|:. :::.:.||..|..:.:.....::
Human  1108 TSSITIT---------------------PTATPLPRQSQITIKEVCKQRIPARIPKPKSTGITKI 1151

  Fly  2316 SHSAQAAKSP---------ENNNYSLHNRNEEEHLPSENNVMGKTVVLVGKRR 2359
            |     .|:|         :|....||         ....|...|.:.||.||
Human  1152 S-----TKAPTVPMDKPIYQNGCGKLH---------IVRTVTSNTFLHVGGRR 1190

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mud	NP_727769.3	SMC_prok_B	319..1178	CDD:274008	26/125 (21%)
		SCP-1	853..1571	CDD:114219	122/524 (23%)
		Smc	1234..>1944	CDD:224117	161/737 (22%)
		DUF948	1392..1517	CDD:295114	29/124 (23%)
FILIP1L	NP_001374779.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..65		6/31 (19%)
		CortBP2	66..248	CDD:401608	52/210 (25%)
		SMC_prok_B	224..>773	CDD:274008	150/679 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000