DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment m and cutl-8

DIOPT Version :9

Sequence 1:	NP_572747.1	Gene:	m / 44835	FlyBaseID:	FBgn0002577	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_001250721.1	Gene:	cutl-8 / 3565740	WormBaseID:	WBGene00013960	Length:	625	Species:	Caenorhabditis elegans

Alignment Length:	716	Identity:	133/716 - (18%)
Similarity:	241/716 - (33%)	Gaps:	209/716 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LHLMFSLVIAGNELWPMERPDGMPNIVSL--------EVMCGKDHMDVHLTFSHPFEGIVSSKGQ 79
            :|.:..|:||    |...|   :.|.:|:        ::.|.:|.:.:.:.....|.|.:.:||:
Worm     1 MHFLKILIIA----WTGWR---VANAISIDNEIIGEPDIECLEDEIRIWVKTRKIFAGRIYAKGR 58

  Fly    80 HSDPRCV---YVPPSTGKTFFSFRISYSRCGTKP----DLNGQFYENTVVVQYDKDLLEVWDEAK 137
            .....|.   :....|.|..|.  :.:..||.|.    |..|.:|..||||.:....:...|:|.
Worm    59 AELEDCYKDDFGNQKTRKPHFD--LQFGACGMKSLRSVDPRGMYYGITVVVSFHPLFITKVDQAY 121

  Fly   138 RLRCEWFNDYEK--TASKPPMVIADLDVIQLDFRGDNVDCWMEIQHG------KGPWAPPVSGIV 194
            .::| :|.:..|  ||.   :.::.:...:|:.|.....|...|...      .|..|..|....
Worm   122 HVKC-FFEEANKGLTAE---LGVSMIPTTELEARHGIPGCTYSIHRSTIDELDAGRPAGNVIQFA 182

  Fly   195 PLGSTLTLVVAINDYRGEFDMRVKSCVASDGSGHVINLSDEFGCVLRPKMISRFLKARAPDERAT 259
            .:|..:......||..  :.:.:.:|..:||.|...::.|:.||.:.|.:|:. ::..:..:||
Worm   183 RVGERVLHQWHCNDQM--YGVLINNCYVTDGFGKKADVIDDKGCPIDPILITG-IRYSSDLQRA- 243

  Fly   260 VITYAFFHAFKFPDALSVHIKCKVEIC--RHGCLDHCQNTGVGGGGGGSGESLGLGLGLGLTNAN 322
               ||....|||.|...|...|:|::|  :||..|                        |:|
Worm   244 ---YAESSVFKFADKPGVWFFCQVQMCMKKHGMCD------------------------GIT--- 278

  Fly   323 ERKDVHMSDALGSSSNDLLRDLALPPGGQHGMGMGMGPDHDIFYED--IIHDHKQTLGGGGMPAG 385
                   ..:.||.|.      .:..||:         |:..|.|:  .....::|.   ..|:|
Worm   279 -------PPSCGSMSR------VISVGGE---------DNGGFEEEEKAPSSRRKTT---PKPSG 318

  Fly   386 GDYGHEKSVNLQPRPVHEEQEEADLSDLFGDEDLADLDMEGGEGERYLGLKKSGKFPHGPRQLEA 450
            .||.:|.. ..|.:..:..:....:|        .|.|.:          .:|.|. |.|.. .:
Worm   319 SDYDYENE-KPQQKTTNAPRRSTTVS--------RDYDYD----------NESPKL-HSPNS-HS 362

  Fly   451 QKRMGVPM------------------AGPRSLEPHGHGDEDVPRPVYRPQAEALKQPREDHIDLD 497
            ...:..|:                  .|..|:......::|:......|:.::.|..:.|:.|.|
Worm   363 YNSVTPPLDYESVTLTAFSPPINPATVGIESVSKTFETEDDLASSSVTPEPKSKKIGKSDYNDYD 427

  Fly   498 K-------------------EEEEEKEKEEKTQQEDKLTGEGGAAASNDSSKSRRR------RSL 537
            :                   .:..:|...:.......|..|.|....|...|:.|:      |.|
Worm   428 EVTIPPNLTDLLANLPDDISSDSIQKMLRDSVDNPKALLAEFGKLMKNKKLKAERKNRSRNLREL 492

  Fly   538 VISDRK--------------VRSADV------------------GVSGLYDVISEA--DLAFSPD 568
            ...|.:              .|..||                  |...::|:..|.  |:....:
Worm   493 KPGDLRSGEKIDQIEVDWTSTRRRDVPAIPEFDGNSKYDKPMLAGQLLIFDLDEEPPNDVGLDKN 557

  Fly   569 SKQEAVTVFQGKISEEVVYGICMPVPGFSILFIVVISTTIVSALVAGSLLYRYQLQKEALEKQTP 633
            |.::|.|..  .::::   |:.....||..:...:||       ..|.|:.|.:.|...:::.||
Worm   558 STKDASTAC--SVTKD---GLLAIFAGFGAILAALIS-------AIGFLIIRLKSQTTPIDQATP 610

  Fly   634 M 634
            :
Worm   611 I 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
m	NP_572747.1	ZP	55..286	CDD:214579	57/245 (23%)
m	NP_572747.1	Zona_pellucida	<194..287	CDD:278526	24/94 (26%)
cutl-8	NP_001250721.1	ZP	33..285	CDD:214579	64/298 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	78	1.000	Inparanoid score	I3815
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14807
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X161
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.960