DRSC/TRiP Functional Genomics Resources

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Protein Alignment m and COL6A5

DIOPT Version :9

Sequence 1:NP_572747.1 Gene:m / 44835 FlyBaseID:FBgn0002577 Length:682 Species:Drosophila melanogaster
Sequence 2:NP_001265227.1 Gene:COL6A5 / 256076 HGNCID:26674 Length:2614 Species:Homo sapiens


Alignment Length:572 Identity:120/572 - (20%)
Similarity:197/572 - (34%) Gaps:156/572 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 CIFIL--------HLMFSLVIAGN--ELWPMERPDGMPNI-----VSLEV--MCGKDH--MDVHL 64
            |:.:|        ||   |.|.||  ::...:..|.:.|:     :..|:  .|||.:  ||:.:
Human  1136 CVLVLGIGDVYKEHL---LPITGNSEKIITFQDFDKLKNVDVKKRIIREICQSCGKTNCFMDIVV 1197

  Fly    65 TF-------------SHP---------FEGIVSSKGQHSDPRCVYVPPSTG---KTFFSFRISYS 104
            .|             .||         .|.|.|.||         |....|   :...:|::: |
Human  1198 GFDISTHVQGQPLFQGHPQLESYLPGILEDISSIKG---------VSCGAGTEAQVSLAFKVN-S 1252

  Fly   105 RCGTKPDLNGQFYENTVVVQYDKDLLEV------WDEAKRLRCEWFNDYEKTASKPPMVIADLDV 163
            ..|.....  |.|:..|   :| .||:|      ...|:.||..|....:|:||:..:::...|.
Human  1253 DQGFPAKF--QIYQKAV---FD-SLLQVNVSGPTHLNAQFLRSLWDTFKDKSASRGQVLLIFSDG 1311

  Fly   164 IQLDFRGDNVDCWMEIQHGKGPWAPPVSGIVPLGSTLTLVVAIN----------DYRGEFDMRVK 218
            :|.:   .|:  .:|.|..:         :...|....|||::|          ::...||.|. 
Human  1312 LQSE---SNI--MLENQSDR---------LREAGLDALLVVSLNTTAHHEFSSFEFGKRFDYRT- 1361

  Fly   219 SCVASDGSGHVINLSDEFGCVLRPKMISRFLKARAPDERATVITYAFFHAFKFPDALSVHIKCKV 283
                     |:.....|.|     |.:|::|...|  ||....|:.               ||..
Human  1362 ---------HLTIGMRELG-----KKLSQYLGNIA--ERTCCCTFC---------------KCPG 1395

  Fly   284 EICRHGC--LDHCQNT-GVGGGGGGSGESLGLGLGLGLTNANERKDVHMSDALGSSSNDLLRDLA 345
            ....||.  |...:.: |:.|..|..||....|:   ..:...:.|..::...|:.....|:..:
Human  1396 IPGPHGTRGLQAMKGSQGLKGSRGHRGEDGNPGV---RGDTGPQGDKGIAGCPGAWGQKGLKGFS 1457

  Fly   346 LPPGGQHGMGM-GMGPDHDIFYEDIIHDHKQTLGGGGMP----AGGDYGHEKSVNLQPRPVHEEQ 405
            .|.||....|: |:..:........|...|...|..|.|    |.|.|| ||.....|....:..
Human  1458 GPKGGHGDDGIDGLDGEEGCHGFPGIKGEKGDPGSQGSPGSRGAPGQYG-EKGFPGDPGNPGQNN 1521

  Fly   406 EEADLSDLFGDEDLADLDMEGGEGERYLGLKKSGKFPHGPRQLEAQKRMGVPMAGPRSLEPHGHG 470
            .........|::     ..:|..|::  |::.|.. ..|.|..|.|:       |.|.:.    |
Human  1522 NIKGQKGSKGEQ-----GRQGRSGQK--GVQGSPS-SRGSRGREGQR-------GLRGVS----G 1567

  Fly   471 DEDVPRPVYRPQAEALKQPREDHIDLDKEEEEEKEKEEKTQQEDKLTGEGGA 522
            :...|.|.....||.|:.|:....:..::.|:..:.::..|....|.|..|:
Human  1568 EPGNPGPTGTLGAEGLQGPQGSQGNPGRKGEKGSQGQKGPQGSPGLMGAKGS 1619

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mNP_572747.1 ZP 55..286 CDD:214579 57/273 (21%)
Zona_pellucida <194..287 CDD:278526 20/102 (20%)
COL6A5NP_001265227.1 Nonhelical region 19..1394 67/322 (21%)
vWFA 29..195 CDD:294047
VWA 236..404 CDD:278519
vWA_collagen 441..590 CDD:238749
YfbK 445..>593 CDD:225187
vWA_collagen 627..787 CDD:238749
YfbK 813..>980 CDD:225187
VWA 814..985 CDD:278519
VWA 1005..1172 CDD:278519 9/38 (24%)
Collagen 1394..1447 CDD:189968 10/55 (18%)
Triple-helical region 1395..1728 52/248 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1404..1693 50/239 (21%)
Cell attachment site. /evidence=ECO:0000255 1430..1432 0/1 (0%)
Collagen 1443..1520 CDD:189968 19/77 (25%)
Collagen 1485..1576 CDD:189968 25/110 (23%)
Collagen 1564..1623 CDD:189968 12/60 (20%)
Collagen 1597..1657 CDD:189968 5/23 (22%)
Collagen 1645..1730 CDD:189968
VWA 1759..1918 CDD:278519
vWFA_subfamily_ECM 1962..2137 CDD:238727
vWFA_subfamily_ECM 2290..2467 CDD:238727
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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