DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment m and ram-5

DIOPT Version :9

Sequence 1:	NP_572747.1	Gene:	m / 44835	FlyBaseID:	FBgn0002577	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_510422.2	Gene:	ram-5 / 181550	WormBaseID:	WBGene00004301	Length:	711	Species:	Caenorhabditis elegans

Alignment Length:	813	Identity:	147/813 - (18%)
Similarity:	261/813 - (32%)	Gaps:	248/813 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LRFSSCIFILHLMFSLVIAGNELWPMERPDGMPNIVSLEVMCGKDHMDVHLTFSHPFEGIVSSKG 78
            :::|:...|.::...:|:|.:..:......|:|     :|.|....:.|....:.||:|.:|...
Worm     1 MQYSTKHVIGYIFSFVVLATSTDFDNAHVMGVP-----QVTCSAKLITVSFNTNIPFQGRISVFD 60

  Fly    79 QHSDPRCVYVPPSTGKTFFSFRISYSRCGTKPDLNGQFYENTVVVQYDKDLLEVWDEAKRLRCEW 143
            :...|.|.:...:..:...:|::...:|.     |..|.:|      ...||..:.|.      .
Worm    61 KLFIPACNHDYSTNIQKNATFQMDILKCA-----NPMFLKN------GSRLLRAYVEI------G 108

  Fly   144 FNDYEKTASKPPMVIADLD--VIQLDFRGDN-VDC---------W---MEIQHGKG---PWAPPV 190
            |:....|.|....::..||  ::.:..|..: .||         |   .|.|.|..   .|:..:
Worm   109 FHPLVMTNSDRTFLVECLDNTIMPIVNRAQSFADCTHLVRMASEWSSMSEFQVGDAIVHEWSCKL 173

  Fly   191 SGIVPLGSTLTLVVAINDYRGEFDMRVKSCVASDGSGHVINLSDEFGCVLRPKMISRFLKA-RAP 254
            .......:.||                 :|.|...:|.:|:|.||.|||:..:::...:.: ..|
Worm   174 PNPAKTQTFLT-----------------NCNALSQNGQIIHLIDENGCVIDSELMGDIVYSDHVP 221

  Fly   255 DERATVITYAFFHAFKFPDALSVHIKCKVEICRHG--CLDH-----CQNT--------------- 297
            .      .||....|||.......|:|.:|.|.:|  |.|.     |..|
Worm   222 K------LYARARIFKFLTDDKYRIECTLEFCNNGSPCKDRVFPPKCAFTKEEITSRSTKNQLEQ 280

  Fly   298 -------GVGGGGGGSGESLGLG-LGLGLTNANERKDVHMSDALGSSSNDLLRDLALPPGGQHGM 354
                   |:......|...:... |.:.|....|.|.:|....|.:..:..|.:...|....|.:
Worm   281 SGMTTMPGIPSSAYDSRLKISSAWLTIKLNQYTETKGLHPRYHLKTFLDPTLHETISPNDADHFL 345

  Fly   355 GMGMG----------------PD----------HDIFYEDI----IHDHKQTLG----GGGMPAG 385
             ||:.                ||          |...::.|    |..|::.:.    |..:.:.
Worm   346 -MGISYREPIPKLSSQSELSHPDNNRVEGARILHSSAFQPIISPPIDSHEEFIETITFGSNLNSE 409

  Fly   386 GDYGHEKSVNLQPRPVHEEQEEADLSDLFGDEDLADLDMEGGEGERYLGLK--KSGKFPHGPR-Q 447
            .....:|.::||..|||:         :|..:|    .::..:.|:::.|.  ::....||.. :
Worm   410 PIVNVQKEMHLQKEPVHK---------VFTHKD----PLKTEKTEKFMKLVQIENEDRNHGAALE 461

  Fly   448 LEAQKRM-------------GVPMAGPRSLEPHGHGDEDVPRPVYRPQAEALKQPRE--DHIDLD 497
            ...|.||             ..||......:                     |.|.|  :|.:||
Worm   462 TTQQSRMFTTTMPSTMISTTTTPMTSSSRTD---------------------KLPSEHFNHPELD 505

  Fly   498 KEEEEEKEKEEKTQQEDKLTGEGGAAASN-------------------------------DSSKS 531
             ..|:.|:..||:....::|....|.|:|                               :|:|.
Worm   506 -TFEKPKKSFEKSHSLVQMTETTTAPAANLKFYSTTASTKKLTPTTPYASAPPESSTQTPNSTKP 569

  Fly   532 RRRRSLVISDRKVRSADVGVSGLYD------VISEADLAFSPDSKQEAVTVFQGKISEEVVYGIC 590
            ...|::..|...|:..|..|:...|      .|:::|:.   ..||.:.......||.:   ..|
Worm   570 TSIRNVTHSVPTVKKYDKFVNNNADWRFDDKAINDSDIV---SEKQTSACYNATIISSQ---RQC 628

  Fly   591 MPVPGFSILFIVVISTTIVSALVAGSLLYRYQLQKEALEKQTPMPVTGTLASWMTLRLFRLRHMQ 655
            .......:|.|...::.||..::....||||..:|               ..|:..|...||.:.
Worm   629 KWSGVEHLLLIWSFASLIVWMMLIALFLYRYSSRK---------------PQWIGFREQELRRVA 678

  Fly   656 QQQQQQQQQ--------QQQQQQVRQPSSGHET 680
            |.:...|..        :::.|...:....|.|
Worm   679 QSRVLSQDHPWLHADAFEERNQSKNEIEINHFT 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
m	NP_572747.1	ZP	55..286	CDD:214579	50/249 (20%)
m	NP_572747.1	Zona_pellucida	<194..287	CDD:278526	21/93 (23%)
ram-5	NP_510422.2	Zona_pellucida	36..264	CDD:391783	55/267 (21%)
ram-5	NP_510422.2	PRK13042	522..>590	CDD:183854	10/67 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910