Protein Alignment kto and SRB8

DIOPT Version :10

• Sequence 1: NP_524786.1
• Gene: kto / 44830
• FlyBaseID: FBgn0001324
• Length: 2531
• Species: Drosophila melanogaster
• Sequence 2: NP_010004.1
• Gene: SRB8 / 850442
• SGDID: S000000677
• Length: 1427
• Species: Saccharomyces cerevisiae
• Alignment Length: 775
• Identity: 134/775 - (17%)
• Similarity: 248/775 - (32%)
• Gaps: 271/775 - (34%)

  Fly    19 PDIYPQDAKQREDELTPTNVKHGFTTTPPLSDEF----GTAHNSNVNASKV-SAFFSGVLAKKEE 78
            ||..|.:....||::....|..||..||.::.|.    .:.|.|.|..|.: |..|..::..:|:
Yeast    31 PDFKPWEHTAAEDQILANFVAKGFYHTPMVNFESISARSSVHESLVTQSNILSQQFDKIIKIRED 95

  Fly    79 ---------LMTLPDTG-RKKQQINCKDNFWPVSPRRKCTVDAWFKDL-AGNKPLLSLAKRAPSF 132
                     ..||...| :...:|...|:       ||   :.|..:| :.:..|:.:.|..|..
Yeast    96 HINKIPSNSTTTLHGPGFQLPNRITLTDH-------RK---ETWLHELSSSHTSLVKIGKFIPHG 150

  Fly   133 NKKEEIFITLCENQVNMQRATWFIKLSAAYTLSFTESKNKKRSIYDPA---------AEWTGNMI 188
            .|:.::........:.::||.|.||  ..|.:.:..:..||||....|         .:||...:
Yeast   151 LKRRQVIEQCYLKFIPLKRAIWLIK--CCYFIEWKSNHKKKRSNAAGADDAISMHLLKDWTDTFV 213

  Fly   189 KFMKELLPKLQEYYQQNHDKSSSNGTTSGSLTAAGNGPASNGSTGTSSINSVTGSSASTNVIPVP 253
            ..:::|:     :...||
Yeast   214 YILEKLI-----FDMTNH----------------------------------------------- 226

  Fly   254 SMASPLPPIHSPANGQQAAPGGGVNAGSVMPTTGSLGGVVGGPGSSVVGGAAGAGAAVPPGSTIS 318
                                                                             
Yeast   227 ----------------------------------------------------------------- 226

  Fly   319 GIGSQFEDSRNALKYWKYCHQLSKYM------YEESLLDRQEFLNWILDLLDKMRTQASFDEPLK 377
                 :.||:. |:.||  .|:|.::      |...|::::.|.:|:::.::||.   :|:  ..
Yeast   227 -----YNDSQQ-LRTWK--RQISYFLKLLGNCYSLRLINKEIFHHWLVEFINKME---NFE--FL 278

  Fly   378 KLVLSFALQYMHDFVQSERLCRKMAYIVSKK------LAQLLNTVVEQQTIKELDEPKLQQDPYE 436
            .|.|...:.:.:|..|.:......|.|.|.:      :.::.:.::.:..|....:..:..:.|.
Yeast   279 PLSLHILMIFWNDICQIDTNAPVAATITSSQKEPFFLVTKITDMLLHKYYIVSSSKSMINDENYI 343

  Fly   437 LALQEQMSCPHHRDIVLYLSTILQIITIECPTALVWSGIAAHRAPSSLLGSPLDHLPLAPSVLPM 501
            :           .||.......|.|:.|                .|||:........|...:.
Yeast   344 I-----------NDIKKNNKIKLNILKI----------------LSSLILKIFQEQSLEVFIF-- 379

  Fly   502 PTRCPRTNHEIRRQL---------RAAESDIVLRTQHAEQRWFAAKWLSAGKNQYTSVLATLDHL 557
                |.:|.||.:.|         ....||:..:.:....|..:.|..|:.:|...|.....|..
Yeast   380 ----PTSNWEIYKPLLFEIVSNADTNQNSDMKKKLELISYRNESLKNNSSIRNVIMSASNANDFQ 440

  Fly   558 DT--HC--FDRME--HNNSIDTLYAQIF-PSPTVSRRREEDQVEPRPPYEPKQDKDTVRI--LCE 613
            .|  .|  |.::.  ..|.|||.:.::. .:||     |.|.    |.|..:......:|  |..
Yeast   441 LTIVTCKQFPKLSCIQLNCIDTQFTKLLDDNPT-----EFDW----PTYVDQNPLTMHKIIQLIL 496

  Fly   614 WAVSGQRWGEH---RAMVVAILLDKRQIDVTSTPADQQSSDKDDKDSLASGAGLIDGLPVFQHVL 675
            |::...|..:|   ..:|..:||    :.:.||  |:...:...:|::.|        .|||
Yeast   497 WSIHPSRQFDHYESNQLVAKLLL----LRINST--DEDLHEFQIEDAIWS--------LVFQ--- 544

  Fly   676 MHFLDHDAPVLDEHVSSPQQRTEF--TNLVQLFSALIRHDVFSHNAYMHTLISRGDLLLE 733
                      |.::.|:.::...:  .:|.:|.:.||.:.:.....|:..|||.|.|.|:
Yeast   545 ----------LAKNFSAQKRVVSYMMPSLYRLLNILITYGIIKVPTYIRKLISSGLLYLQ 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kto	NP_524786.1	Med12	97..157	CDD:462818	11/60 (18%)
		Med12-LCEWAV	390..856	CDD:463472	71/373 (19%)
SRB8	NP_010004.1	Med12	113..175	CDD:462818	13/71 (18%)