DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kto and CCT

DIOPT Version :9

Sequence 1:	NP_524786.1	Gene:	kto / 44830	FlyBaseID:	FBgn0001324	Length:	2531	Species:	Drosophila melanogaster
Sequence 2:	NP_001319832.1	Gene:	CCT / 827954	AraportID:	AT4G00450	Length:	2235	Species:	Arabidopsis thaliana

Alignment Length:	2763	Identity:	471/2763 - (17%)
Similarity:	825/2763 - (29%)	Gaps:	1080/2763 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LQEKRP-------LK------RTRLGPPDIYPQDAKQREDELTPTNVKHGFTTTPPLSDEFGTAH 56
            |..:||       ||      .:||||||.:|..:...|:.||...|:.|:..|..     |...
plant    39 LNSRRPPPLTPYKLKCEKDGLNSRLGPPDFHPPTSNSPEENLTKEYVQFGYKETVD-----GLKE 98

  Fly    57 NSNVNASKVSAFFSGVLAKKEE-----LMTLPDT---GRKKQQIN---------CKDNFWPVSPR 104
            :..:..|:|..|...|:.|.:|     |..:.::   .||..|:.         ||..|   ..:
plant    99 SEEIILSQVHTFSKPVVHKCKEAVRKCLRAINESRALKRKAGQVYGVPLSGSLLCKPGF---PEQ 160

  Fly   105 RKC---TVDAWFKDLA-GNKPLLSLAKRAPSFNKKEEIFITLCENQVNMQRATWFIKL------- 158
            |.|   |...|.:.|: .:|.|.|||...|.:.:| .:|..|..|.|.:.|||||||:
plant   161 RSCGEETKKRWIESLSQQHKRLRSLADNIPGYRRK-TLFEVLIRNNVPLLRATWFIKVTYLNQVR 224

  Fly   159 -SAAYTLSFTESKNKKRSIYDPAAEWTGNMIKFMKELLPKLQEY-----YQQNHDKSSSNGTTSG 217
             |.|...|.|..|.:.    ....:||.::|::::.||.:|...     .||..|:|.....| |
plant   225 PSPAAISSGTPDKTQA----SRCEQWTKDVIEYLQYLLDELLSRNSSFPAQQTRDRSPQMLYT-G 284

  Fly   218 SLTAAGNGPASNGSTGTSSINSVTGSSASTNVIPVPSMASPLPPIHSPANGQQAAPGGGVNAGSV 282
            |:..  |.|||....|
plant   285 SMQK--NSPASTSLYG------------------------------------------------- 298

  Fly   283 MPTTGSLGGVVGGPGSSVVGGAAGAGAAVPPGSTISGIGSQFEDSRNALKYWKYCHQLSKYMYEE 347
                                                      |::....|:| |..:|.::.:.|
plant   299 ------------------------------------------EETSLHFKWW-YMVRLLQWHHAE 320

  Fly   348 SLLDRQEFLNWILDLLDKMRTQASFDEPLKKL--VLSFALQYMHDFVQSERLCRKMAYIVSKKLA 410
            .||.....::|:|.||.:           |::  :|...|..::..::|        .::|:...
plant   321 GLLFPNLIVDWVLKLLQE-----------KEIFEILQLLLPIVYGVLES--------IVLSQTYV 366

  Fly   411 QLLNTVVEQQTIKELDEPKLQQDPYELALQEQMSCPHHRDIV------LYLSTILQIITIECPTA 469
            |.|..:    .::.:.||                .|...|:|      ..||.:::::..
plant   367 QSLVAI----AVRFIQEP----------------APGGSDLVDNSRRAYTLSALIEMVRY----- 406

  Fly   470 LVWSGIAAHRAPSSLLGSPLDHLPLAPSVL---PMPTRCPRTNHEIRRQLRAAESDIVLRTQ--- 528
            ||.:      ||.:.:.|  |..||.|||.   |.........:|...:||:..::|..:.|
plant   407 LVLA------APDTFVAS--DFFPLPPSVAACGPNDVSYTSKAYENLEKLRSNSAEISAQFQGRG 463

  Fly   529 -------------------HAEQRWFAAKWLSAGKNQYTSVLATLDHLDTHCFDRMEHNNSIDTL 574
                               .|:.   .||..|||..|:....|      ....|:...:..|...
plant   464 VLSRFEFLSFDYTISTIQRSADD---LAKIASAGYPQHNVAKA------VQALDKALSDGDIRAA 519

  Fly   575 YAQIFPSPTVSRRREEDQVEPRPPYEPKQDKDTVRILCEWAV-------------SGQRW----G 622
            |:.:|          ||                   ||..||             |..||    .
plant   520 YSYLF----------ED-------------------LCNGAVDEAWITDVSPCLRSSLRWIGAIS 555

  Fly   623 EHRAMVVAILLDKRQIDV----TSTPADQQSSDKDD-----------KDSLASG----------- 661
            ......|..|::....|.    ...|.|.:.|.:.|           |..:..|
plant   556 TSFVCSVFFLIEWATCDFRDFRAGVPKDIKFSGRKDCSQVYLVIQLLKQKILGGEFTARKGKNCR 620

  Fly   662 ---------AGLIDGL----PVFQHVLMHFLDHDAPV--LDEHVSSPQQRTEFTNLVQLFSALIR 711
                     :|.:|..    |:          ||..|  :|:|   ...:.....|..|...|||
plant   621 NNFLGVSKPSGSMDAFESPGPL----------HDIIVCWIDQH---EVHKGGAKRLQLLVFELIR 672

  Fly   712 HDVFSHNAYMHTLISR-----------------------------------------GDLLLESV 735
            ..:|:..||:..||..                                         ||.|.|:|
plant   673 SGIFNPIAYVRQLIVSGMIDVIQPAVDPERRMRHHRILKQLPGCFVHETLEEAQLFGGDKLSEAV 737

  Fly   736 -------------LVIKSG-----------------TTATKTSPPPPAPPPTTTHGFDDDGFGGG 770
                         |:::.|                 |:.:....|......:.:.|
plant   738 RTYSNERRLLLRELLVEKGKYWNNLVLSDQKSKKISTSLSSVIFPRACNAKSNSKG--------- 793

  Fly   771 LDFKHNEFDDSNVDDDLDKLVQNIKEK------------------------------GQQHEAPD 805
             ..||.:   |:||      ::.:||:                              |..:...|
plant   794 -PRKHTK---SSVD------IRELKERISALLQFPGMSCGVETPVRDEFQNSVKRSSGSVYSKMD 848

  Fly   806 SPKIGPPGDG---ETNPGGSISRHYVYTKHFPIPQDDP-----SMSSYSSESNQRYILLFGVGKE 862
            .|:..|..:.   ...|..:..:...|..:.||..|:.     ...|.:.||:.:......:.|:
plant   849 QPEATPGCEDCRRAKRPKMNDEKSSCYQGNSPIASDEEDNWWIKKGSKTVESSLKVDPQIEITKQ 913

  Fly   863 --RDEKKHAVKKMS--------------------------------------KEIGKLFTKKFSI 887
              |..:|.|.|..|                                      :::..:|.....:
plant   914 VPRGRQKMARKTQSLAQLQAARIEGSQGASTSHVCDNKVSCPHHGPGVEGENQKVVDVFRTSTPV 978

  Fly   888 DVAAAGHVKKHSRNEFNFEATTSKCQQMAYFDQHVVTAQCAANVLE-----QLNGFALGN-NNYL 946
            |:.:.|:..|                |:.:.|:..:.......|.:     |.:...:|. |...
plant   979 DMVSVGNSLK----------------QLQFVDKRSIAVWLTTAVRQLVEEPQKSSVRVGQFNRGA 1027

  Fly   947 PVQEHVAFLFDLMELALNIYSLLELCDSLLKELPEVEHQL-QLKKSNLVRSYTTSLALYIVSILR 1010
            ||:|.....:.|.  |..:||:|.|.|..|..:..|:..| .|.|:|...|:.......:|::
plant  1028 PVEEKNTIRWKLG--ADELYSILFLLDISLDLVSAVKFLLWLLPKANSTPSFAVQGGRNLVTV-- 1088

  Fly  1011 RYHSCLLLSPEQTLSVFEGVCRTIRHVSNPSECTSAERCIIAYLSDLHESCVLLQGKEQSTEYYQ 1075
                     |              |:|.| :.|...|..:::.|
plant  1089 ---------P--------------RNVEN-NMCEIGEAILVSSL--------------------- 1108

  Fly  1076 QLQCIKRFKDIFNTPEQLDLPPQGYNPLLLQELFMAPRRGGKLDPHWLGTLHESPANVYS-FV-- 1137
                 :|:::|..:   .||.|:....|:.:...:....         |.:..|.|.||: ::
plant  1109 -----RRYENILLS---ADLVPEAMTALMNRAASLMSSN---------GKISGSAALVYTRYILK 1156

  Fly  1138 -SNALIAVCRETDNERLNDVALACAELTASCNVLSEEWIYALQSLCSGSKSPRYP---------- 1191
             ..:|.:|....:|          .:.|:...:|||     |....||:.....|
plant  1157 RYGSLPSVVEWHNN----------FKATSEKKLLSE-----LDHTRSGNGEYGNPLGVPAGVDNP 1206

  Fly  1192 --HLGGQVDIGQLKTHNALAVFVCILVARHCFSLADFVSKFALPTLARSVSAG--GAELSVDAEA 1252
              :|..::.||..:. :.:.:.:..::.||......::.|.        :..|  .|.|:...:.
plant  1207 DDYLRKKISIGGARP-SRVGLSMRDVLQRHVEEATHYLKKL--------IGTGTMKASLAEKNDD 1262

  Fly  1253 GARLTCHLVLKLFKTL-------EIPQPGMYSVSTSPNPLHAVG------NDFSIRLSCDRH--- 1301
            |.::...:|:.|...:       :...|.:.|.:.|. .:::||      .|||:......|
plant  1263 GYQVAQQIVVGLMDCIRQTGGAAQEGDPSLVSSAVSA-IINSVGLSVARITDFSLGNIYQNHPSG 1326

  Fly  1302 --------LLVGAHKTIPIAAVLAVLKAILIVVDNAALKTPLASGSGTSSGGLGGAFGSGKRSGF 1358
                    .::..|.|     .|.:||..|....:...:..||:.|.|:   |.|.|...|.|..
plant  1327 VDSSNIARYILRIHIT-----CLCLLKEALGERQSRVFEIALATESSTA---LTGVFAPVKGSRG 1383

  Fly  1359 NTPVHPGSTPKSNEQRPADLSQILGTSDLQLGSSLTSEPEALQQPS-----------VGGMEQIS 1412
            ...:.|.|...:......|:|...|...|...:.:|:...||...|           ||.:....
plant  1384 QHQLSPESYDSNANNSTIDMSNGTGKMALSRATKITAAVSALVIGSITHGVITLERIVGLLRLKD 1448

  Fly  1413 LLEFAQAVLK-------------------QICAQEHVLERCLKNAEQLCDMIIDEM------LTA 1452
            .|:|.|.|.:                   .|....|.....:.|.:.:.:.::.|:      :..
plant  1449 YLDFVQFVRRTKSSSNGSARSMGASKVESPIEVYVHWFRLLVGNCKTVSEGLVLELVGESSVVAI 1513

  Fly  1453 KQAQRVLHM-ICYPEPEFNIISELDQRSMIVRILENLGQWTLRISWLDLQLMYRQSLSN-NAELN 1515
            .:.||:|.: :.:| |.::||:                           .:::|..:|| |:..:
plant  1514 SRMQRMLPLKLVFP-PAYSIIA---------------------------FVLWRPFVSNSNSNSS 1550

  Fly  1516 VWLDT--VARAAIDVFHMEEVVLPGAVKATHKP------KPSTWLVAPLIAKLTPA--------- 1563
            |..||  :.::....||  :|:       .|.|      :.:..|...::|..|.|
plant  1551 VHEDTHRLYQSLTMAFH--DVI-------KHLPFRDVCFRDTQGLYELIVADSTDAEFASVFESH 1606

  Fly  1564 -VQGRILRVAGQVLESMNYFSKVSKSDCNSSGSGDERE---KSNSCHSSNSYGLGGVPARNKKMP 1624
             :...:..||...|.:..:.:  |..||....||...|   ::.:.|..|     |....:|
plant  1607 GLDMHLKSVAFAPLRARLFLN--SLIDCKVPSSGYSHEGVSEAKNRHQGN-----GTKLVDK--- 1661

  Fly  1625 LDYQPFLGLILTCLKGQDEYKENLLVSLYAQLSQCLQSFAELDTIGGIDEPQAREEILDALQLRF 1689
                  |..:|.||:....:.:      :.:|...|...|..:.:...|.|     :.||:
plant  1662 ------LVSVLDCLQPAKFHWQ------WVELRLLLNEQALAEKLENHDMP-----LTDAI---- 1705

  Fly  1690 SLVGGMFEAIQKNSTPTTD-----------WAILLAQLVCQ-GVVDLSCNRELFTTVVDMLATLV 1742
                       ::|.||::           ..|||.:|:.: ..|      .||:.||.:....|
plant  1706 -----------RSSCPTSEKPDASENEKNFIQILLTRLLVRPDAV------PLFSEVVHLFGRSV 1753

  Fly  1743 HSTLVSDDERHYMNLMKKLKKEIGEKNNASIRVIRQLLPLYKQPTEVIACEHSGMDTKGNKICDI 1807
            ..:::...|...          .|:......:.|||.|        :|..|..|:.||.
plant  1754 EDSMLKQAEWFL----------AGQDVLFGRKTIRQKL--------IIVGESKGLPTKP------ 1794

  Fly  1808 DKKQLRISDKQRISVWDILEGHKNPAPLSWVWFGAVKLERKPLTYEEAHRNLKYHTHSLVKPSSY 1872
                         ..|.           .|.|..:...:.  :|..:|.:..|:...|:
plant  1795 -------------QFWK-----------PWGWCNSSSSDH--ITANKAGKKRKFEITSI------ 1827

  Fly  1873 YYEPLPLPPEDIEPVPEKICIKDEMKADTPSSVDQ-SPSAVVGGTGRGRGKGTTTRKRKPKNPKT 1936
                     |:.|.:.|.   ....|...|..:|: |||.         |.|.||.:
plant  1828 ---------EEGEVIEEG---SGSRKVLLPRVLDENSPSV---------GYGITTER-------- 1863

  Fly  1937 PPVVNTQQQQPQLAQQPQQPQNVQQQQLQQQQQQQQHMQQQHMQQQQMQPNQMGQMPMNMPMNMQ 2001
               ...|...|.:.|...:.::....:|                                   ::
plant  1864 ---AFVQLVLPCIDQSSDESRSTFVNEL-----------------------------------VR 1890

  Fly  2002 QFAPNPNNMMQQNAMLQQQQQQQMQQMGNNPMQQQLNVGGGNGQPNPQMNFMQQGPGGGGAGPQG 2066
            ||    :|:.||.:.:..:.....:|||......:::...|:         .::|..||.
plant  1891 QF----SNIEQQLSSVTNRSTTSNKQMGTASSGSEISSNKGS---------TRKGLRGGS----- 1937

  Fly  2067 MPG-QQQQWHNAPQQQQPPQPYHNQYAPHQQNMQSNRIE----------RPPLNANSKQALS--- 2117
             |. .::...|......||.|     |..:.:| |.|::          ..|...|::.||:
plant  1938 -PSLARRSSANTTDTSPPPSP-----AALRASM-SLRLQFLLRLLPVICGEPSFKNTRHALASTI 1995

  Fly  2118 -QMLRQRQPFQQQAQQGPGGGFNPMQQQPQASQQQPGPQQQMNPNQMRQQQMNPQQNPQSVAAFN 2181
             ::|..|..::..|           ...|::...:...:..::|:.|        .:..|...|:
plant  1996 VRLLGSRVVYEDYA-----------VCSPRSELSKAETESTIDPSSM--------ADLSSEVLFD 2041

  Fly  2182 AM---------QQQPQQNAQQQQMNPNQQQQQQFMRGGNMRPGMAPNQMNQMNMGGQGMSQNPMM 2237
            .:         ..||:....:...|.:.:....|.|.       |...:           ||.:.
plant  2042 RLLFVLHGLLSNHQPKWLKPRPSSNESSKDFTLFDRD-------AAESL-----------QNELS 2088

  Fly  2238 QQQIPQNM-----VGM-----------------VNPNANQMMQSGGAQGGNGVGVGVGVGVGGAG 2280
            :.|:|..:     ..|                 |.|.|..::|..|:....|.         ...
plant  2089 RMQLPDTIRWRIQAAMPILLPSLRCSLSCQPHSVPPTALTLVQPSGSTAAAGT---------NQR 2144

  Fly  2281 NNPNMGMGG-MPQQGMIQQQPQQQPQQQVQFQN 2312
            |:|.:...| ...||.: :.....|.||.:..|
plant  2145 NSPAISKSGTAAAQGKL-KPTMLAPHQQQEADN 2176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kto	NP_524786.1	Med12	99..157	CDD:286572	21/61 (34%)
kto	NP_524786.1	Med12-LCEWAV	390..856	CDD:288959	105/663 (16%)
CCT	NP_001319832.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004348
OrthoInspector	1	1.000	-	-		oto3197
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000