DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kto and Med12l

DIOPT Version :9

Sequence 1:	NP_524786.1	Gene:	kto / 44830	FlyBaseID:	FBgn0001324	Length:	2531	Species:	Drosophila melanogaster
Sequence 2:	XP_038959614.1	Gene:	Med12l / 690752	RGDID:	1592212	Length:	2199	Species:	Rattus norvegicus

Alignment Length:	2498	Identity:	896/2498 - (35%)
Similarity:	1220/2498 - (48%)	Gaps:	601/2498 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 EKRPLKRTRLGPPDIYPQDAKQREDELTPTNVKHGFTTTPPLS-DEFGTAHNSNVNASKVSAFFS 70
            |:|||||.||||||:||||.||:|||||..|||.||...|..: ||.|:|.|..:|.||:.|:||
  Rat    10 EQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFS 74

  Fly    71 GVLAKKEELMTLPDTGRKKQQINCKDNFWPVSPRRKCTVDAWFKDLAGNKPLLSLAKR------- 128
            .:||:|.:|.|..|||:||.|:|.|||:|.|:.|.:..:.:||.||||||||..|||:
  Rat    75 SILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKELPLAKS 139

  Fly   129 ----APSFNKKEEIFITLCENQVNMQRATWFIKLSAAYTLSFTESKNKKRSIYDPAAEWTGNMIK 189
                .|..:|||::|..|.:..|.|.||||.||::.||..:.:|:|.|||...||..|||....:
  Rat   140 GVPQVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQAPDPNLEWTQISTR 204

  Fly   190 FMKELLPKLQEYYQQNHDKSSSNGTTSGSLTAAGNGPASNGSTGTSSINSVTGSSASTNVIPVPS 254
            :::|.|.|:.::|   |..||:           |:||.
  Rat   205 YLREQLVKISDFY---HMASST-----------GDGPV--------------------------- 228

  Fly   255 MASPLPPIHSPANGQQAAPGGGVNAGSVMPTTGSLGGVVGGPGSSVVGGAAGAGAAVPPGSTISG 319
               |:||
  Rat   229 ---PVPP---------------------------------------------------------- 232

  Fly   320 IGSQFEDSRNALKYWKYCHQLSKYMYEESLLDRQEFLNWILDLLDKMRTQASFDEPLKKLVLSFA 384
                  :...|:|.|:|..:|:.:|::|.:|::.|:|:||||:|:|:|   ..|:.|.||:|...
  Rat   233 ------EVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLSWILDVLEKIR---PVDDSLLKLLLPLM 288

  Fly   385 LQYMHDFVQSERLCRKMAYIVSKKLAQLLNTVVEQQTIKELDEPKL------------------- 430
            |||..:||||..|.|::||..:::|:.||:           |.|.|
  Rat   289 LQYSDEFVQSAYLSRRLAYFCARRLSLLLS-----------DSPNLLAAHSPHMIIGANNTSIGT 342

  Fly   431 --------QQDPYELALQEQMSCPHHRDIVLYLSTILQIITIECPTALVWSGIAAHRAPSSLLGS 487
                    ...|.:||..:.:||..|..:|..||.:||.:|:.||:||||: .:.:....:..||
  Rat   343 PSPGTPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWN-YSTNENKIANPGS 406

  Fly   488 PLDHLPLAPSVLPMPTRCPRTNHEIRRQLRAAESDIVLRTQHAEQRWFAAKW--LSAGKNQYTSV 550
            |||.|.:|||.||||......|.::|.::...|..|..|.:..|.||...|.  .:||.. .:.|
  Rat   407 PLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVT-ISRV 470

  Fly   551 LATLDHLDTHCFDRMEHNNSIDTLYAQIFPSPTVSRRREEDQVEPRPPYEPKQDKDTVRILCEWA 615
            |.||:.||.|||||.:.:||::|||.:||   ..::.::..:|.|       .|:..|.:|||||
  Rat   471 LHTLEVLDRHCFDRTDSSNSMETLYHKIF---WANQNKDNQEVAP-------NDEAVVTLLCEWA 525

  Fly   616 VSGQRWGEHRAMVVAILLDKRQIDVTSTPADQQSSDKDDKDSLASGAGLIDGLPVFQHVLMHFLD 680
            ||.:|.|:||||.||.||:|||.:|.:.... :|...|:|:|::|.:.....|||||:||:.|||
  Rat   526 VSCKRSGKHRAMAVAKLLEKRQAEVEAERCG-ESEVLDEKESISSASLAGSSLPVFQNVLLRFLD 589

  Fly   681 HDAPVLDEHVSSPQQRTEFTNLVQLFSALIRHDVFSHNAYMHTLISRGDLLLESVLVIKSGTTAT 745
            ..||.|.: .:|..::.||.|||.||...||||||||:|||.||||||||.:.:...::|
  Rat   590 TQAPSLSD-PNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTGLRS----- 648

  Fly   746 KTSPPPPAPPPTTTHGFDDD-------------GFGGGLDFKHNEFDDSNVDDDLDKLVQNIKEK 797
                  ||...:..|...|.             |.|.|.....:|.|.|:...|.
  Rat   649 ------PAGENSDEHYSKDHEMKMEEHAVMAHMGLGSGTTNIFDEVDKSDFKSDF---------- 697

  Fly   798 GQQHEAPDSPKIGP-PGDGETNPGGSIS----------------------------RHYVYTKHF 833
                 ..:.|...| ||:...|...|:|                            ||..|..||
  Rat   698 -----GSEFPIFSPMPGESCENINPSLSRRMSGNGEKLGKREKPRELIFPSNYDLLRHLQYATHF 757

  Fly   834 PIPQDDPSMSSYSSESNQRYILLFGVGKERDEKKHAVKKMSKEIGKLFTKKFSIDVAAAGHVKKH 898
            |||.|:.|    |.|.|||.|||:||||||||.:|.:||::|:|.|:..||.:.:.......:|.
  Rat   758 PIPLDESS----SHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTESGVGDEGQKA 818

  Fly   899 SRNEFNF----EATTSKCQQMAYFDQHVVTAQCAANVLEQLNGFALGNNNYLPVQEHVAFLFDLM 959
            .:|:...    |...:|.|.::|||||.||:|.:.|||||:..||.|.:.:||:..|:..:||||
  Rat   819 RKNKQEVFPTPENVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLM 883

  Fly   960 ELALNIYSLLELCDSLLKELPEVEHQLQLKKSNLVRSYTTSLALYIVSILRRYHSCLLLSPEQTL 1024
            |.||||..|::....||.||..||.:|.||.|:|..||||.|.:.||::||||||||:|:|:||.
  Rat   884 EPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTA 948

  Fly  1025 SVFEGVCRTIRHVSNPSECTSAERCIIAYLSDLHESCVLLQGKEQSTEYYQQL---QCIKRFKDI 1086
            .||||:|..::||.|||||:|.||||:|||.||:.||..|:.|      :..|   .|.|..:.|
  Rat   949 QVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSK------FGDLFSSACSKVKQTI 1007

  Fly  1087 FNT--PEQLDLPPQGYNPLLLQELFMAPRRGGKLDPHWLG-TLHESPANVYSFVSNALIAVCR-E 1147
            :|.  |...:|   .::|..:.:....| ....::...|| .|:::.||.||||.|.|:.||. .
  Rat  1008 YNNVMPANSNL---RWDPDFMMDFIENP-SARSINYSMLGKVLNDNAANRYSFVCNTLMNVCMGH 1068

  Fly  1148 TDNERLNDVALACAELTASCNVLSEEWIYALQSLCSGSKSPRYPHLGG------QVDIGQLKTHN 1206
            .|..|:||:|...:||||.|.|||.||:..|::||..|.     |:.|      .||:..|..|:
  Rat  1069 QDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSN-----HVWGFNDVLCTVDVSDLSFHD 1128

  Fly  1207 ALAVFVCILVARHCFSLADFVSKFALPTLARSVSAGGAELSVDAEAGARLTCHLVLKLFKTLEIP 1271
            :||.|:.||:||.||||.|.|...|||:|. :.:.|.|    |||.|||:||.|:|.||:.   |
  Rat  1129 SLATFIAILIARQCFSLEDVVQHVALPSLL-AAACGDA----DAEPGARMTCRLLLHLFRA---P 1185

  Fly  1272 QPGMYSVSTSPNPLHAVGNDF-SIRLSCDRHLLVGAHKTIPIAAVLAVLKAILIVVDNAALKTPL 1335
            |...:.        .|.|..| .||.|||||||..||.:|.:.||.||||||:::
  Rat  1186 QACFFP--------QATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMML---------- 1232

  Fly  1336 ASGSGTSSGGLGGAFGSGKRSGFNTPVHPGSTPKSNEQRPADLSQILGTSDLQLGSSLTSEPEAL 1400
                           |..|....|.     :|.|:.:.....|.:. |:::....:|..|:|..
  Rat  1233 ---------------GDAKIGSNNV-----NTLKNEDFSMRGLRRD-GSAEDAWATSQNSKPYG- 1275

  Fly  1401 QQPSVGGMEQISLLEFAQAVLKQICAQEHVLERCLKNAEQLC---DMIIDEMLTAKQAQRVLHMI 1462
              .|: .:|..:|.|:|:.||:.||.||.|.|.|||..|:||   ::|:|.:|:..|||::|.:|
  Rat  1276 --KSI-SIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLI 1337

  Fly  1463 CYPEPEFNIISELD--QRSMIVRILENLGQWTLRISWLDLQLMYRQSLSNN-----AELNVWLDT 1520
            |||. .....:|.|  ||..|.|||:||.|||||.|||:||||.:|.|.:.     ||:|..||.
  Rat  1338 CYPH-GIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPSSGSVAEMNNLLDN 1401

  Fly  1521 VARAAIDVFHMEE--------------------VVLPGAVK-------ATHKPKPSTWLVAPLIA 1558
            :|:|.|:||....                    .|.|.:.:       .:...:...||||||||
  Rat  1402 IAKATIEVFQQSADLNNNASSSGMSLFNPNTIGSVDPSSTRQNGIKTFLSSSERRGVWLVAPLIA 1466

  Fly  1559 KLTPAVQGRILRVAGQVLESMNYFSKVSKSDCNSSGSGDEREKSNSCHSSNSYGLGGVPARNKKM 1623
            :|..:||||:|:.||:.||...:.           ||..::|:......|.|.
  Rat  1467 RLPTSVQGRVLKAAGEELEKGQHL-----------GSSSKKERDRQKQKSMSL------------ 1508

  Fly  1624 PLDYQPFLGLILTCLKGQDEYKENLLVSLYAQLSQCLQSFAELDTIGGIDEPQAREEILDALQLR 1688
             |..||||.|:|||||||||.:|.||.||..|::|.|.::.|...   .|:.:||:.:.:|||||
  Rat  1509 -LSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERY---QDDTKARQMMHEALQLR 1569

  Fly  1689 FSLVGGMFEAIQKNSTPTTDWAILLAQLVCQGVVDLSCNRELFTTVVDMLATLVHSTLVSD---- 1749
            .:||||||:.:|:::..|||||:||.|::..|.||:..|.||||||:|||..|::.||.||
  Rat  1570 LNLVGGMFDTVQRSTQGTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSTA 1634

  Fly  1750 -------DERHYMNLMKKLKKEIGEKNNASIRVIRQLLPLYKQPTEVIACEHSG--MDTKGNKIC 1805
                   ::|.||||:||||||:|:|.:.||..:||||||.||..:||.||..|  :|||||||.
  Rat  1635 SPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIA 1699

  Fly  1806 ---DIDKKQ-LRISDKQRISVWDILEGHKNPAPLSWVWFGAVKLERKPLTYEEAHRNLKYHTHSL 1866
               .||||| |::|.||::|.||:.||.||||||||.|||.|:::|:.:.|||.|..|.||||::
  Rat  1700 GFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEEQHHFLLYHTHTM 1764

  Fly  1867 VKPSSYYYEPLPLPPEDIEPVPEKICIKDEMKADTPSSVDQSP---SAVVGGTGRGRG---KGTT 1925
            .||.|||.||||||||:.|..|             .|.|.|.|   ||.:...|:...   |.|.
  Rat  1765 PKPRSYYLEPLPLPPEEEEEEP-------------TSPVSQEPERKSAELSDHGKSAADEEKKTK 1816

  Fly  1926 TRKRKPKN----------------PKTPPVVNTQQQQPQ-------LAQQPQQP----QN----- 1958
            .||||.|:                |...|:.:......|       |..|||||    ||
  Rat  1817 GRKRKTKSSSRIDEYQQTNIYRLPPNYSPMSSQMMHHTQPALWGYNLVSQPQQPSFFLQNQSLNA 1881

  Fly  1959 ---------------------------------------------------VQQQQLQQQQQQQQ 1972
                                                               :||||.||||||||
  Rat  1882 GGSRLDPAGSFVPTNTKQALSNMLQRRSGAMLQPPSLHAVTSQQQLLQMKLLQQQQQQQQQQQQQ 1946

  Fly  1973 HMQQQHMQQQQMQPNQMGQMPMNMPMNMQQFAPNPNNMMQQNAMLQQQQQQQMQ-------QMGN 2030
            ..||:.::|.|.:|.|.||......:...|..|:|  .:.|...||||.|...|       ||
  Rat  1947 QQQQRLLRQAQTRPFQQGQPGDQAALFTAQARPSP--QLPQYPGLQQQAQTMPQGYTMYGTQM-- 2007

  Fly  2031 NPMQQQLNVGGGNGQPNPQMNFMQQGPGGGGAGPQGMPGQQQQWHNAP-------QQQQPPQPYH 2088
             |:||.                .||.|||....|..........|::|       |.||.|..|.
  Rat  2008 -PLQQA----------------AQQQPGGVVLSPSYSSRAYPAAHSSPALMERLRQLQQQPGGYV 2055

  Fly  2089 NQYA-PHQQNMQSNRIERPPLNANSKQALSQMLRQRQPFQQQAQQGP--GGGFN----------- 2139
            .|.| |:.|.:                |.||.|.     .|..||.|  ||..:
  Rat  2056 QQQASPYLQPV----------------AGSQRLN-----HQALQQSPLVGGAIDAVLTPAHPNLP 2099

  Fly  2140 --PMQQQP-QASQQQPGPQQQMNPNQMRQQQMNPQQ--NPQSVA-AFNAMQ-QQP-------QQN 2190
              |:.|.| :..|||...||::...|..||...|||  .|||.| ...||| |||       ||.
  Rat  2100 SVPLAQDPMRPRQQQVRQQQRLLQMQQPQQAPQPQQPSQPQSQALGLQAMQPQQPLFPRQGLQQT 2164

  Fly  2191 AQQQQMNPNQQQQQQFMRGGNMRPGMAP 2218
            .||||.....:|.|:.:.....:.|:.|
  Rat  2165 QQQQQTAALVRQLQKQLSSNQPQQGVTP 2192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kto	NP_524786.1	Med12	99..157	CDD:286572	28/68 (41%)
kto	NP_524786.1	Med12-LCEWAV	390..856	CDD:288959	179/536 (33%)
Med12l	XP_038959614.1	Med12	106..172	CDD:401449	26/65 (40%)
		Med12-LCEWAV	294..776	CDD:403388	179/536 (33%)
		Med12-PQL	1849..2078	CDD:403387	66/270 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335015
Domainoid	1	1.000	237	1.000	Domainoid score	I2247
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004348
OrthoInspector	1	1.000	-	-		otm46315
orthoMCL	1	0.900	-	-		OOG6_105637
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.740