|
Fly 7 EKRPLKRTRLGPPDIYPQDAKQREDELTPTNVKHGFTTTPPLS-DEFGTAHNSNVNASKVSAFFS 70
|.|||||.||||||:||||.||:|||||..|||.||...|.:| ||.|:|.|.|.|.:|:|:.||
Rat 10 EHRPLKRLRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFS 74
Fly 71 GVLAKKEELMTLPDTGRKKQQINCKDNFWPVSPRRKCTVDAWFKDLAGNKPLLSLAKRAPSFNKK 135
.::|:|....||.||||:|..:|.|||||.|:.|.:..::.||.||||.|||..|||:.|.|:||
Rat 75 SIIAEKLRCNTLSDTGRRKSLMNQKDNFWLVTARSQSAINTWFTDLAGTKPLTHLAKKVPIFSKK 139
Fly 136 EEIFITLCENQVNMQRATWFIKLSAAYTLSFTESKNKKRSIYDPAAEWTGNMIKFMKELLPKLQE 200
||:|..|.:..|.:.||.|.||::.||..:.:|:|.||::..||..|||..:.|::.|.|.|:.|
Rat 140 EEVFGYLAKYTVPVMRAAWLIKMTCAYYAAMSETKVKKKNTADPFTEWTQIITKYLWEQLQKMAE 204
Fly 201 YYQQNHDKSSSNGTTSGSLTAAGNGPASNGSTGTSSINSVTGSSASTNVIPVPSMASPLPPIHSP 265
||:. |||.:|..| |...|||
Rat 205 YYRP--------------------GPAGSGVCG--------------------SAIGPLP----- 224
Fly 266 ANGQQAAPGGGVNAGSVMPTTGSLGGVVGGPGSSVVGGAAGAGAAVPPGSTISGIGSQFEDSRNA 330
.|...|
Rat 225 -----------------------------------------------------------HDVEMA 230
Fly 331 LKYWKYCHQLSKYMYEESLLDRQEFLNWILDLLDKMRTQASFDEPLKKLVLSFALQYMHDFVQSE 395
::.|.|..:|:.:|:::.:|||.|||.|:|:..:|:|.. ::.|.||:|...|:|..:||||.
Rat 231 IRQWDYNEKLALFMFQDGMLDRHEFLTWVLECFEKIRPG---EDELLKLLLPLLLRYSGEFVQSA 292
Fly 396 RLCRKMAYIVSKKLAQLL-------NTVVEQQTIKELDEPKLQQDPY----ELALQEQMSCPHHR 449
.|.|::||..:::||..| :.|:..|:...|......|.|. .....:.:.||.||
Rat 293 YLSRRLAYFCTRRLALQLDGVNSHSSHVISAQSTSSLPTTPAPQPPTSNTPSTPFSDLLMCPQHR 357
Fly 450 DIVLYLSTILQIITIECPTALVWS-GIAAHRAPSSLLGSPLDHLPLAPSVLPMPTRCPRTNHEIR 513
.:|..||.|||.|.:.||:||||. .:...|..: ||||||||:|||.||||........::|
Rat 358 PLVFGLSCILQTILLCCPSALVWHYSLTDSRIKT---GSPLDHLPIAPSNLPMPEGNSAFTQQVR 419
Fly 514 RQLRAAESDIVLRTQHAEQRWFAAKWLSAGKNQYT--SVLATLDHLDTHCFDRMEHNNSIDTLYA 576
.:||..|..|..|.|..|.||...|...|... :| .||.||:.||:|.|:|.:.:||:|:|..
Rat 420 AKLREIEQQIKERGQAVEVRWSFDKCQEATAG-FTIGRVLHTLEVLDSHSFERSDFSNSLDSLCN 483
Fly 577 QIF---PSPTVSRRREEDQVEPRPPYEPKQDKD-TVRILCEWAVSGQRWGEHRAMVVAILLDKRQ 637
:|| || :..:|...|.| .|.:|||||||.:|.|.|||||||.||:|||
Rat 484 RIFGLGPS--------------KDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQ 534
Fly 638 IDVTSTPADQQSSDKDDKDSLASGAGLIDGLPVFQHVLMHFLDHDAPVLDEHVSSPQQRTEFTNL 702
.::.:.... :|...|:|.|:|||:......|:||.||:.|||..||:|.: ..|..:|.||.||
Rat 535 AEIEAERCG-ESEAADEKGSVASGSLSAPSAPIFQDVLLQFLDTQAPMLTD-PRSESERVEFFNL 597
Fly 703 VQLFSALIRHDVFSHNAYMHTLISRGDLLLESVLVIKSGTTATKTSPPPPAPPP----------- 756
|.||..||||||||||.|..||||||||.. ||...: ||.|...|
Rat 598 VLLFCELIRHDVFSHNMYTCTLISRGDLAF--------GTPGPR--PPSPFDDPADDPERKEAEG 652
Fly 757 TTTHGFDDDGFGGGLDFKHNE---FDDSNVDDDLDKLVQNIKEKGQQHEAPDSPKI-----GPPG 813
:::...:|.|....:|...:. |:|.. ..|.......:..:|:...:|:.|.: .||.
Rat 653 SSSSKLEDPGLSESMDIDPSSSVLFEDME-KPDFSLFSPTMPCEGKGSPSPEKPDVEKDVKPPPK 716
Fly 814 DGETNPGGSI---SRHYVYTKHFPIPQDDPSMSSYSSESNQRYILLFGVGKERDEKKHAVKKMSK 875
:......|.: .||..|..||||||:: |.|.|.|||.::||||||:||:.:||:||::|
Rat 717 EKIEGTLGILYDQPRHVQYATHFPIPQEE----SCSHECNQRLVVLFGVGKQRDDARHAIKKITK 777
Fly 876 EIGKLFTKKFSIDV------------------AAAGHVKKHSRNEF--NFEATTSKCQQMAYFDQ 920
:|.|:..:|.:.:. ...|..::.:|.|. ..|...:|.|.::::||
Rat 778 DILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQ 842
Fly 921 HVVTAQCAANVLEQLNGFALGNNNYLPVQEHVAFLFDLMELALNIYSLLELCDSLLKELPEVEHQ 985
|.||||.:.|||||:..||||.:.:||:.:||.|:|||||.:|:|..|::....||.||..||.:
Rat 843 HQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFVFDLMEYSLSISGLIDFAIQLLNELSVVEAE 907
Fly 986 LQLKKSNLVRSYTTSLALYIVSILRRYHSCLLLSPEQTLSVFEGVCRTIRHVSNPSECTSAERCI 1050
|.||.|:||.||||||.|.||::||.||:||:|:.:|...||||:|..::|..|.|:.:||||||
Rat 908 LLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCI 972
Fly 1051 IAYLSDLHESCVLLQGK--EQSTEYYQQLQCIKRFKDIFNTPEQLDLPPQG---YNPLLLQELFM 1110
:|||.||:.||..|:.| |..::: |.|....|:...| |.:. :.|..:.:...
Rat 973 LAYLYDLYTSCSHLKSKFGELFSDF-----CSKVKNTIYCNVE----PSESNMRWAPEFMIDTLE 1028
Fly 1111 APRRG-------GKLDPHWLGTLHESPANVYSFVSNALIAVC-RETDNERLNDVALACAELTASC 1167
.|... || :|.|:|||.||||.|||:.|| ...|.:|:||:|:.|||||..|
Rat 1029 NPAAHTFTYTGLGK-------SLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYC 1086
Fly 1168 NVLSEEWIYALQSLCSGSKSPR--YPHLGGQVDIGQLKTHNALAVFVCILVARHCFSLADFVSKF 1230
..||.||:..|::||..|.:.. :..|...||:..|..|::||.||.||:||.|..|.|.:...
Rat 1087 KSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCA 1151
Fly 1231 ALPTLARSVSAGGAELSVDAEAGARLTCHLVLKLFKTLEIPQPGMYSVSTSPNPLHAVGN--DFS 1293
|:|:|..:..: ..|:|.||||||.::|.||||.:: ||..:.|| ...
Rat 1152 AIPSLLNAACS-----EQDSEPGARLTCRILLHLFKTPQL------------NPCQSDGNKPTVG 1199
Fly 1294 IRLSCDRHLLVGAHKTIPIAAVLAVLKAILIVVDNAALKTPLASGSG-TSSGGL-------GGAF 1350
||.|||||||..:...|...||.|||||:.::.| |.|| ||| |..||. ||..
Rat 1200 IRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGD-AELK-----GSGFTVPGGTEELPEEEGGGG 1258
Fly 1351 GSGKRSGFNTPVHPGSTPKSNEQRPADLSQILGTSDLQLGSSLTSEPEALQQPSVGGMEQISLLE 1415
.||:|.| |.::: :|..||..
Rat 1259 SSGRRQG--------------------------------GRNIS-------------VETASLDV 1278
Fly 1416 FAQAVLKQICAQEHVLERCLKNAEQLCDMIIDEMLTAKQAQRVLHMICYPEPEFNIISELD---- 1476
:|:.||:.||.||.|.|||||:..:..:.:.|.:|::.||||::.:||||. .::...|
Rat 1279 YAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPH---RLLDSEDGENP 1340
Fly 1477 QRSMIVRILENLGQWTLRISWLDLQLMYRQSLSNNAELNVWLDTVARAAIDVFHMEEVV------ 1535
||..|.|||:||.|||:|.|.|:||||.:| :.|.|:|..|:.:|:|.|:||......
Rat 1341 QRQRIKRILKNLDQWTMRQSSLELQLMIKQ--TPNTEMNSLLENIAKATIEVFQQSAETGSSSGS 1403
Fly 1536 ----LPGAVKATHKP------KPSTWLVAPLIAKLTPAVQGRILRVAGQVLESMNYFSKVSKSDC 1590
:|.:.|| || :...||||||||||..:|||.:|:.||:.||...:.
Rat 1404 TASNMPSSSKA--KPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHL-------- 1458
Fly 1591 NSSGSGDEREKSNSCHSSNSYGLGGVPARNKKMPLDYQPFLGLILTCLKGQDEYKENLLVSLYAQ 1655
||...:|:......|.|. |..||||.|:|||||||||.:|.||.||::|
Rat 1459 ---GSSSRKERDRQKQKSMSL-------------LSQQPFLSLVLTCLKGQDEQREGLLASLHSQ 1507
Fly 1656 LSQCLQSFAELDTIGGIDEPQAREEILDALQLRFSLVGGMFEAIQKNSTPTTDWAILLAQLVCQG 1720
:.|.:.::.|... :|:.:.::.:.:||:||.:||||||:.:|:::..||:||.||.:::..|
Rat 1508 VHQIVINWRENQY---LDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAQLLLEIIISG 1569
Fly 1721 VVDLSCNRELFTTVVDMLATLVHSTLVSD-----------DERHYMNLMKKLKKEIGEKNNASIR 1774
.||:..|.||||||:|||:.|::.||.:| ::|.||||:|||:|::||:.:.|:.
Rat 1570 TVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLQKDLGERQSDSLE 1634
Fly 1775 VIRQLLPLYKQPTEVIACEHSG--MDTKGNKICDID----KKQLRISDKQRISVWDILEGHK-NP 1832
.:.|||||.||..:||.||..| :|||||||...| |:.|::|.||:||.|::.||.| :.
Rat 1635 KVHQLLPLPKQNRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWELFEGLKPST 1699
Fly 1833 APLSWVWFGAVKLERKPLTYEEAHRNLKYHTHSLVKPSSYYYEPLPLPPEDIEPVPEKICIKDEM 1897
|||||.|||.|:::|:....||..|.|.||||...:|.:||.|||||||||.|| |....::.|.
Rat 1700 APLSWAWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEP-PAPALLEPEK 1763
Fly 1898 KADTPSSVDQSPSAVVGGTGRGRGKGTTTRKRKPKNPKTPPVVNTQQQQPQLAQQPQQPQNVQQQ 1962
||..|...|:..:| ..:|.:||.|:.| ..::.||....
Rat 1764 KAPEPPKTDKPGTA-----------PPSTEERKKKSTK-----GKKRSQPATKS----------- 1801
Fly 1963 QLQQQQQQQQHMQQQHMQQQQMQPNQMGQMPMNMPMNMQQFAPNPNNMMQQNAMLQQQQQQQMQQ 2027
:...|.|.:.|...:.:|.::...| ||.:: :.|..:| ..
Rat 1802 -----------------EDYGMGPGRSGPYGVTVPPDLLHHA-NPGSI----SHLSYRQ----SS 1840
Fly 2028 MGNNPMQQQLNVGGGNGQPNPQMNFMQQGPGGGGAGPQGMPGQQQQWHNAPQQQQPPQPYHNQYA 2092
||.....|.|..||....|...:.. |.|:.|.:|.:....
Rat 1841 MGLYTQNQPLPAGGPRVDPYRPVRL-------------------------PMQKLPTRPTYPGVL 1880
Fly 2093 PHQQNMQSNRIERPPLNANSKQALSQMLRQRQP-------FQQQAQ-----QGPGGGFNPMQQQP 2145
|........ |..:|.: :.:.||:|| .:||.| ||..|..:..|..|
Rat 1881 PTTMTTVMG------LEPSSYK--TSVYRQQQPTVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTP 1937
Fly 2146 QAS------------------QQQPGPQQQMNP---NQMRQQQMNPQQNPQSVAAFNAMQQQPQQ 2189
.:| ||..||...|.| :....|..:|..||..|.....:||:|..
Rat 1938 SSSYGLQSSQGYTSYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSG 2002
Fly 2190 NAQQQQMNPNQQQQQQFMRGGNMRPGMAPNQMNQMNMGGQGMSQNPMMQQQIPQN--MVGMVNPN 2252
...|| ||.. |.|::.......|..|. |:|.:.|.
Rat 2003 YVHQQ----------------------APTY-------GHGLTSTQRFSHQTLQQTPMMGTMTPL 2038
Fly 2253 ANQMMQSGGAQGGNGVGVGVGVGVGGAGNNPNMGMGGMPQQGMIQQQPQQQPQQQVQFQNFQNQY 2317
:.| ||..||......|. |||.|||.|||.|.|..|.|.
Rat 2039 SAQ---------------GVQAGVRSTSILPE------------QQQQQQQQQQQQQQQQQQQQQ 2076
Fly 2318 QQQQQQGMQQQGGGAGVGVGVGMAPNQQQQQQANMMGNFNPQMQQGNRNNPDFMAAAAVAQQQQQ 2382
||||||..||| ....||||||..:. |.|| |||||
Rat 2077 QQQQQQQQQQQ-----------YHIRQQQQQQQILR-----QQQQ---------------QQQQQ 2110
Fly 2383 QQQQQRVVPGGMMAGNRNQYMNQAPNVTMSTMMGPGPGGVVGQVPPYARQQSAGGGKPGVLNTQQ 2447
||||| ||
Rat 2111 QQQQQ----------------------------------------------------------QQ 2117
Fly 2448 QFQQQQQQQQQLRHQMMQLQGMGGGAGGGMGAGPQQGGGAVGGGAGGGMVPQ------------Q 2500
|.|||||.|||..||..| ..|.|| || |
Rat 2118 QQQQQQQPQQQQPHQQQQ-----------QAAPPQ---------------PQPQSQPQFQRQGLQ 2156
Fly 2501 QSMNQQQTPNLVAQLQRQNMMGQQQYQP 2528
|:..||||..||.|||:| :...|.||
Rat 2157 QTQQQQQTAALVRQLQQQ--LSNTQPQP 2182
| 
