DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kto and Med12l

DIOPT Version :9

Sequence 1:NP_524786.1 Gene:kto / 44830 FlyBaseID:FBgn0001324 Length:2531 Species:Drosophila melanogaster
Sequence 2:XP_030108505.1 Gene:Med12l / 329650 MGIID:2139916 Length:2196 Species:Mus musculus


Alignment Length:2637 Identity:914/2637 - (34%)
Similarity:1244/2637 - (47%) Gaps:709/2637 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 EKRPLKRTRLGPPDIYPQDAKQREDELTPTNVKHGFTTTPPLS-DEFGTAHNSNVNASKVSAFFS 70
            |:|||||.||||||:||||.||:|||||..|||.||...|..: ||.|:|.|..:|.||:.|:||
Mouse    10 EQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFS 74

  Fly    71 GVLAKKEELMTLPDTGRKKQQINCKDNFWPVSPRRKCTVDAWFKDLAGNKPLLSLAKR------- 128
            .:||:|.:|.|..|||:||.|:|.|||:|.|:.|.:..:.:||.||||||||..|||:       
Mouse    75 SILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKELPLAKS 139

  Fly   129 ----APSFNKKEEIFITLCENQVNMQRATWFIKLSAAYTLSFTESKNKKRSIYDPAAEWTGNMIK 189
                .|..:|||::|..|.:..|.|.||||.||::.||..:.:|:|.|||...||..|||....:
Mouse   140 GVPQVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQAPDPNLEWTQISTR 204

  Fly   190 FMKELLPKLQEYYQQNHDKSSSNGTTSGSLTAAGNGPASNGSTGTSSINSVTGSSASTNVIPVPS 254
            :::|.|.|:.::|   |..||:           |:||.                           
Mouse   205 YLREQLVKISDFY---HMASST-----------GDGPV--------------------------- 228

  Fly   255 MASPLPPIHSPANGQQAAPGGGVNAGSVMPTTGSLGGVVGGPGSSVVGGAAGAGAAVPPGSTISG 319
               |:||                                                          
Mouse   229 ---PVPP---------------------------------------------------------- 232

  Fly   320 IGSQFEDSRNALKYWKYCHQLSKYMYEESLLDRQEFLNWILDLLDKMRTQASFDEPLKKLVLSFA 384
                  :...|:|.|:|..:|:.:|::|.:|::.|:|.||||:|:|:|   ..|:.|.||:|...
Mouse   233 ------EVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIR---PVDDSLLKLLLPLM 288

  Fly   385 LQYMHDFVQSERLCRKMAYIVSKKLAQLLNTVVEQQTIKELDEPKL------------------- 430
            |||..:||||..|.|::||..:::|:.||:           |.|.|                   
Mouse   289 LQYSDEFVQSAYLSRRLAYFCARRLSLLLS-----------DSPNLLAAHSPHMIIGTNNTSIGT 342

  Fly   431 --------QQDPYELALQEQMSCPHHRDIVLYLSTILQIITIECPTALVWSGIAAHRAPSSLLGS 487
                    ...|.:||..:.:||..|..:|..||.:||.:|:.||:||||: .:.:....|..||
Mouse   343 PSPGTPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWN-YSTNENKISNPGS 406

  Fly   488 PLDHLPLAPSVLPMPTRCPRTNHEIRRQLRAAESDIVLRTQHAEQRWFAAKW--LSAGKNQYTSV 550
            |||.|.:|||.||||......|.::|.::...|..|..|.:..|.||...|.  .:||.. .:.|
Mouse   407 PLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVT-ISRV 470

  Fly   551 LATLDHLDTHCFDRMEHNNSIDTLYAQIFPSPTVSRRREEDQVEPRPPYEPKQDKDTVRILCEWA 615
            |.||:.||.|||||.:.:||::|||.:||   ..::.::..:|.|       .|:..|.:|||||
Mouse   471 LHTLEVLDRHCFDRTDSSNSMETLYHKIF---WANQNKDNQEVAP-------NDEAVVTLLCEWA 525

  Fly   616 VSGQRWGEHRAMVVAILLDKRQIDVTSTPADQQSSDKDDKDSLASGAGLIDGLPVFQHVLMHFLD 680
            ||.:|.|:||||.||.||:|||.::.:.... :|...|:|:|::|.:.....|||||:||:.|||
Mouse   526 VSCKRSGKHRAMAVAKLLEKRQAEIEAERCG-ESEVLDEKESISSASLAGSSLPVFQNVLLRFLD 589

  Fly   681 HDAPVLDEHVSSPQQRTEFTNLVQLFSALIRHDVFSHNAYMHTLISRGDLLLESVLVIKSGTTAT 745
            ..||.|.: .:|..::.||.|||.||...||||||||:|||.||||||||.:.:...::|     
Mouse   590 TQAPALSD-PNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTGLRS----- 648

  Fly   746 KTSPPPPAPPPTTTHGFDDD-------------GFGGGLDFKHNEFDDSNVDDDLDKLVQNIKEK 797
                  ||...:..|...|.             |.|.|.         :::.||:|      |..
Mouse   649 ------PAGENSDEHYSKDHDMKMEEHSVMARLGLGSGA---------THIFDDVD------KSD 692

  Fly   798 GQQHEAPDSPKIGP-PGDGETNPGGSIS----------------------------RHYVYTKHF 833
            .:...|.:.|...| ||:...|...|:|                            ||..|..||
Mouse   693 FKSDPASEFPIFSPMPGESCENINPSLSRRLSVNGEKLLKREKPRELIFPSNYDLLRHLQYATHF 757

  Fly   834 PIPQDDPSMSSYSSESNQRYILLFGVGKERDEKKHAVKKMSKEIGKLFTKKFSID--VAAAGHVK 896
            |||.|:.|    |.|.|||.|||:||||||||.:|.:||::|:|.|:..||.:.:  |...|...
Mouse   758 PIPLDESS----SHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKGTTESGVGDEGQKA 818

  Fly   897 KHSRNEF--NFEATTSKCQQMAYFDQHVVTAQCAANVLEQLNGFALGNNNYLPVQEHVAFLFDLM 959
            :.::.|.  ..|...:|.|.::|||||.||:|.:.|||||:..||.|.:.:||:..|:..:||||
Mouse   819 RKTKQEVFPTPENVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLM 883

  Fly   960 ELALNIYSLLELCDSLLKELPEVEHQLQLKKSNLVRSYTTSLALYIVSILRRYHSCLLLSPEQTL 1024
            |.||||..|::....||.||..||.:|.||.|:|..||||.|.:.||::||||||||:|:|:||.
Mouse   884 EPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTA 948

  Fly  1025 SVFEGVCRTIRHVSNPSECTSAERCIIAYLSDLHESCVLLQGKEQSTEYYQQL---QCIKRFKDI 1086
            .||||:|..::||.|||||:|.||||:|||.||:.||..|:.|      :..|   .|.|..:.|
Mouse   949 QVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSK------FGDLFSSACSKVKQTI 1007

  Fly  1087 FNT--PEQLDLPPQGYNPLLLQELFMAPRRGGKLDPHWLG-TLHESPANVYSFVSNALIAVCR-E 1147
            :|.  |...:|   .::|..:.:....| ....::...|| .|:::.||.||||.|.|:.||. .
Mouse  1008 YNNVMPANSNL---RWDPDFMMDFIENP-SARSINYSMLGKILNDNAANRYSFVCNTLMNVCMGH 1068

  Fly  1148 TDNERLNDVALACAELTASCNVLSEEWIYALQSLCSGSKSPRYPHLGG------QVDIGQLKTHN 1206
            .|..|:||:|...:||||.|.|||.||:..|::||..|.     |:.|      .||:..|..|:
Mouse  1069 QDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSN-----HVWGFNDVLCTVDVSDLSFHD 1128

  Fly  1207 ALAVFVCILVARHCFSLADFVSKFALPTLARSVSAGGAELSVDAEAGARLTCHLVLKLFKTLEIP 1271
            :||.|:.||:||.||||.|.|...|||:|. :.:.|.|    |||.|||:||.|:|.||:.   |
Mouse  1129 SLATFIAILIARQCFSLEDVVQHVALPSLL-AAACGDA----DAEPGARMTCRLLLHLFRA---P 1185

  Fly  1272 QPGMYSVSTSPNPLHAVGNDF-SIRLSCDRHLLVGAHKTIPIAAVLAVLKAILIVVDNAALKTPL 1335
            |...:...|        |..| .||.|||||||..||.:|.:.||.||||||:::.| |.:.:..
Mouse  1186 QACFFPQGT--------GKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGD-AKIGSNN 1241

  Fly  1336 ASGSGTSSGGLGGAFGSGKRSGFNTPVHPGSTPKSNEQRPADLSQILGTSDLQLGSSLTSEPEAL 1400
            .:.......|:.|.    :|.|             |.:.....||    :....|.|::      
Mouse  1242 VNTMKNEDFGMRGL----RRDG-------------NAEDAWATSQ----NSKSYGKSIS------ 1279

  Fly  1401 QQPSVGGMEQISLLEFAQAVLKQICAQEHVLERCLKNAEQLC---DMIIDEMLTAKQAQRVLHMI 1462
                   :|..:|.|:|:.||:.||.||.|.|.|||..|:||   ::|:|.:|:..|||::|.:|
Mouse  1280 -------IETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLI 1337

  Fly  1463 CYPEPEFNIISELD--QRSMIVRILENLGQWTLRISWLDLQLMYRQSLSNN-----AELNVWLDT 1520
            |||. .....:|.|  ||..|.|||:||.|||||.|||:||||.:|.|.:.     ||:|..||.
Mouse  1338 CYPH-GIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPSSGSVAEMNNLLDN 1401

  Fly  1521 VARAAIDVFHMEE--------------------VVLPGAVK-------ATHKPKPSTWLVAPLIA 1558
            :|:|.|:||....                    .|.|.:.:       .:...:...||||||||
Mouse  1402 IAKATIEVFQQSADLNNNASNSGMSLFNPNTIGSVDPSSTRQNGIKTFLSSSERRGVWLVAPLIA 1466

  Fly  1559 KLTPAVQGRILRVAGQVLESMNYFSKVSKSDCNSSGSGDEREKSNSCHSSNSYGLGGVPARNKKM 1623
            :|..:||||:|:.||:.||...:.           ||..::|:......|.|.            
Mouse  1467 RLPTSVQGRVLKAAGEELEKGQHL-----------GSSSKKERDRQKQKSMSL------------ 1508

  Fly  1624 PLDYQPFLGLILTCLKGQDEYKENLLVSLYAQLSQCLQSFAELDTIGGIDEPQAREEILDALQLR 1688
             |..||||.|:|||||||||.:|.||.||..|::|.|.::.|...   .|:.:||:.:.:|||||
Mouse  1509 -LSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERY---QDDTKARQMMHEALQLR 1569

  Fly  1689 FSLVGGMFEAIQKNSTPTTDWAILLAQLVCQGVVDLSCNRELFTTVVDMLATLVHSTLVSD---- 1749
            .:||||||:.:|:::..|||||:||.|::..|.||:..|.||||||:|||..|::.||.||    
Mouse  1570 LNLVGGMFDTVQRSTQGTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSSA 1634

  Fly  1750 -------DERHYMNLMKKLKKEIGEKNNASIRVIRQLLPLYKQPTEVIACEHSG--MDTKGNKIC 1805
                   ::|.||||:||||||:|:|.:.||..:||||||.||..:||.||..|  :|||||||.
Mouse  1635 SPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIA 1699

  Fly  1806 ---DIDKKQ-LRISDKQRISVWDILEGHKNPAPLSWVWFGAVKLERKPLTYEEAHRNLKYHTHSL 1866
               .||||| |::|.||::|.||:.||.||||||||.|||.|:::||.:.|||....|.||||::
Mouse  1700 GFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVIKYEEQQHFLLYHTHTM 1764

  Fly  1867 VKPSSYYYEPLPLPPEDIEPVPEKICIKDEMKADTPSSVDQSP---SAVVGGTGRGRG---KGTT 1925
            .||.|||.||||||||             |.:.:..|.|.|.|   ||.:...|:...   |.|.
Mouse  1765 PKPRSYYLEPLPLPPE-------------EEEEELTSPVSQEPERKSAELSDQGKATADEEKKTK 1816

  Fly  1926 TRKRKPKN----------------PKTPPVVNTQQQQPQ-------LAQQPQQP----QN----- 1958
            .||||.|:                |...|:.:.....||       |..|||||    ||     
Mouse  1817 GRKRKTKSSSRIDEYQQTNLYRVPPNYSPMSSQMTHHPQPALWGYNLVSQPQQPSFFLQNPSLNP 1881

  Fly  1959 -------------------------------VQQQQLQQQQQQQQHMQQQHMQQQQMQPNQMGQM 1992
                                           :|...|.....|||.:|.:.:||||.|..|.   
Mouse  1882 GGSRLDPAGSFVPTNTKQALSNMLQRRSGAMLQPPSLHAVTSQQQLLQMKLLQQQQQQQQQQ--- 1943

  Fly  1993 PMNMPMNMQQFAPNPNNMMQQNAMLQQQQQQQMQQMGNNPMQQQLNVGGGNGQPNPQMNFMQQGP 2057
                                     |||||:.::|....|.|                       
Mouse  1944 -------------------------QQQQQRLLRQAQTRPFQ----------------------- 1960

  Fly  2058 GGGGAGPQGMPGQQQQWHNAPQQQQPPQPYHNQYAPHQQNMQSNRIERPPLNANSKQALSQ---M 2119
                   ||.||.|.....|   |..|.|...||...||                .|.:.|   |
Mouse  1961 -------QGQPGDQAALFTA---QARPSPQLPQYPGLQQ----------------AQTMPQGYTM 1999

  Fly  2120 LRQRQPFQQQAQQGPGG-----GFNPMQQQPQASQQQPG-----PQQQMNPNQMRQQQMNPQQNP 2174
            ...:.|.||.|||.|||     .:|  .:...|:...|.     .|.|..|:...|||.:|...|
Mouse  2000 YGTQMPLQQAAQQQPGGVVLSPSYN--SRAYPAAHSSPALMERLRQLQQQPSGYVQQQASPYLQP 2062

  Fly  2175 QSVAAFNAMQQQPQQNAQQQQMNPNQQQQQQFMRGGNMRPGMAPNQMNQMNMGGQGMSQNPM--M 2237
            .               |..|::| :|..||..:.||.:...:.|   ...|:....:.|:||  .
Mouse  2063 V---------------AGSQRLN-HQALQQSPLVGGGIDAVLTP---AHPNLPSVPLPQDPMRPR 2108

  Fly  2238 QQQIPQNMVGMVNPNANQMMQSGGAQGGNGVGVGVGVGVGGAGNNPNMGMGGMPQQGMIQ-QQPQ 2301
            |||:.|                                                ||.::| ||||
Mouse  2109 QQQVRQ------------------------------------------------QQRLLQMQQPQ 2125

  Fly  2302 Q--QPQQ--QVQFQNFQNQYQQQQQ-----QGMQQQGGGAGVGVGVGMAPNQQQQQQANMMGNFN 2357
            |  ||||  |.|.|....|..|.||     ||:||               .|||||         
Mouse  2126 QAPQPQQPSQTQSQALGLQAMQPQQPLFPRQGLQQ---------------TQQQQQ--------- 2166

  Fly  2358 PQMQQGNRNNPDFMAAAAVAQQQQQ---QQQQQRVVP 2391
                          .||.|.|.|:|   .|.||.|.|
Mouse  2167 --------------TAALVRQLQKQLSSNQPQQGVTP 2189

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ktoNP_524786.1 Med12 99..157 CDD:286572 28/68 (41%)
Med12-LCEWAV 390..856 CDD:288959 180/536 (34%)
Med12lXP_030108505.1 Med12 106..172 CDD:370531 26/65 (40%)
Med12-LCEWAV 294..776 CDD:371921 180/536 (34%)
Med12-PQL 1849..2073 CDD:371920 69/318 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167831284
Domainoid 1 1.000 707 1.000 Domainoid score I121
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H43143
Inparanoid 1 1.050 1247 1.000 Inparanoid score I180
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45902
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0004348
OrthoInspector 1 1.000 - - otm44219
orthoMCL 1 0.900 - - OOG6_105637
Panther 1 1.100 - - O PTHR46007
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2630
SonicParanoid 1 1.000 - - X4125
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1413.930

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