|
Fly 7 EKRPLKRTRLGPPDIYPQDAKQREDELTPTNVKHGFTTTPPLS-DEFGTAHNSNVNASKVSAFFS 70
|:|||||.||||||:||||.||:|||||..|||.||...|..: ||.|:|.|..:|.||:.|:||
Mouse 10 EQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFS 74
Fly 71 GVLAKKEELMTLPDTGRKKQQINCKDNFWPVSPRRKCTVDAWFKDLAGNKPLLSLAKR------- 128
.:||:|.:|.|..|||:||.|:|.|||:|.|:.|.:..:.:||.||||||||..|||:
Mouse 75 SILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKELPLAKS 139
Fly 129 ----APSFNKKEEIFITLCENQVNMQRATWFIKLSAAYTLSFTESKNKKRSIYDPAAEWTGNMIK 189
.|..:|||::|..|.:..|.|.||||.||::.||..:.:|:|.|||...||..|||....:
Mouse 140 GVPQVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQAPDPNLEWTQISTR 204
Fly 190 FMKELLPKLQEYYQQNHDKSSSNGTTSGSLTAAGNGPASNGSTGTSSINSVTGSSASTNVIPVPS 254
:::|.|.|:.::| |..||: |:||.
Mouse 205 YLREQLVKISDFY---HMASST-----------GDGPV--------------------------- 228
Fly 255 MASPLPPIHSPANGQQAAPGGGVNAGSVMPTTGSLGGVVGGPGSSVVGGAAGAGAAVPPGSTISG 319
|:||
Mouse 229 ---PVPP---------------------------------------------------------- 232
Fly 320 IGSQFEDSRNALKYWKYCHQLSKYMYEESLLDRQEFLNWILDLLDKMRTQASFDEPLKKLVLSFA 384
:...|:|.|:|..:|:.:|::|.:|::.|:|.||||:|:|:| ..|:.|.||:|...
Mouse 233 ------EVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIR---PVDDSLLKLLLPLM 288
Fly 385 LQYMHDFVQSERLCRKMAYIVSKKLAQLLNTVVEQQTIKELDEPKL------------------- 430
|||..:||||..|.|::||..:::|:.||: |.|.|
Mouse 289 LQYSDEFVQSAYLSRRLAYFCARRLSLLLS-----------DSPNLLAAHSPHMIIGTNNTSIGT 342
Fly 431 --------QQDPYELALQEQMSCPHHRDIVLYLSTILQIITIECPTALVWSGIAAHRAPSSLLGS 487
...|.:||..:.:||..|..:|..||.:||.:|:.||:||||: .:.:....|..||
Mouse 343 PSPGTPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWN-YSTNENKISNPGS 406
Fly 488 PLDHLPLAPSVLPMPTRCPRTNHEIRRQLRAAESDIVLRTQHAEQRWFAAKW--LSAGKNQYTSV 550
|||.|.:|||.||||......|.::|.::...|..|..|.:..|.||...|. .:||.. .:.|
Mouse 407 PLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVT-ISRV 470
Fly 551 LATLDHLDTHCFDRMEHNNSIDTLYAQIFPSPTVSRRREEDQVEPRPPYEPKQDKDTVRILCEWA 615
|.||:.||.|||||.:.:||::|||.:|| ..::.::..:|.| .|:..|.:|||||
Mouse 471 LHTLEVLDRHCFDRTDSSNSMETLYHKIF---WANQNKDNQEVAP-------NDEAVVTLLCEWA 525
Fly 616 VSGQRWGEHRAMVVAILLDKRQIDVTSTPADQQSSDKDDKDSLASGAGLIDGLPVFQHVLMHFLD 680
||.:|.|:||||.||.||:|||.::.:.... :|...|:|:|::|.:.....|||||:||:.|||
Mouse 526 VSCKRSGKHRAMAVAKLLEKRQAEIEAERCG-ESEVLDEKESISSASLAGSSLPVFQNVLLRFLD 589
Fly 681 HDAPVLDEHVSSPQQRTEFTNLVQLFSALIRHDVFSHNAYMHTLISRGDLLLESVLVIKSGTTAT 745
..||.|.: .:|..::.||.|||.||...||||||||:|||.||||||||.:.:...::|
Mouse 590 TQAPALSD-PNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTGLRS----- 648
Fly 746 KTSPPPPAPPPTTTHGFDDD-------------GFGGGLDFKHNEFDDSNVDDDLDKLVQNIKEK 797
||...:..|...|. |.|.|. :::.||:| |..
Mouse 649 ------PAGENSDEHYSKDHDMKMEEHSVMARLGLGSGA---------THIFDDVD------KSD 692
Fly 798 GQQHEAPDSPKIGP-PGDGETNPGGSIS----------------------------RHYVYTKHF 833
.:...|.:.|...| ||:...|...|:| ||..|..||
Mouse 693 FKSDPASEFPIFSPMPGESCENINPSLSRRLSVNGEKLLKREKPRELIFPSNYDLLRHLQYATHF 757
Fly 834 PIPQDDPSMSSYSSESNQRYILLFGVGKERDEKKHAVKKMSKEIGKLFTKKFSID--VAAAGHVK 896
|||.|:.| |.|.|||.|||:||||||||.:|.:||::|:|.|:..||.:.: |...|...
Mouse 758 PIPLDESS----SHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKGTTESGVGDEGQKA 818
Fly 897 KHSRNEF--NFEATTSKCQQMAYFDQHVVTAQCAANVLEQLNGFALGNNNYLPVQEHVAFLFDLM 959
:.::.|. ..|...:|.|.::|||||.||:|.:.|||||:..||.|.:.:||:..|:..:||||
Mouse 819 RKTKQEVFPTPENVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLM 883
Fly 960 ELALNIYSLLELCDSLLKELPEVEHQLQLKKSNLVRSYTTSLALYIVSILRRYHSCLLLSPEQTL 1024
|.||||..|::....||.||..||.:|.||.|:|..||||.|.:.||::||||||||:|:|:||.
Mouse 884 EPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTA 948
Fly 1025 SVFEGVCRTIRHVSNPSECTSAERCIIAYLSDLHESCVLLQGKEQSTEYYQQL---QCIKRFKDI 1086
.||||:|..::||.|||||:|.||||:|||.||:.||..|:.| :..| .|.|..:.|
Mouse 949 QVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSK------FGDLFSSACSKVKQTI 1007
Fly 1087 FNT--PEQLDLPPQGYNPLLLQELFMAPRRGGKLDPHWLG-TLHESPANVYSFVSNALIAVCR-E 1147
:|. |...:| .::|..:.:....| ....::...|| .|:::.||.||||.|.|:.||. .
Mouse 1008 YNNVMPANSNL---RWDPDFMMDFIENP-SARSINYSMLGKILNDNAANRYSFVCNTLMNVCMGH 1068
Fly 1148 TDNERLNDVALACAELTASCNVLSEEWIYALQSLCSGSKSPRYPHLGG------QVDIGQLKTHN 1206
.|..|:||:|...:||||.|.|||.||:..|::||..|. |:.| .||:..|..|:
Mouse 1069 QDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSN-----HVWGFNDVLCTVDVSDLSFHD 1128
Fly 1207 ALAVFVCILVARHCFSLADFVSKFALPTLARSVSAGGAELSVDAEAGARLTCHLVLKLFKTLEIP 1271
:||.|:.||:||.||||.|.|...|||:|. :.:.|.| |||.|||:||.|:|.||:. |
Mouse 1129 SLATFIAILIARQCFSLEDVVQHVALPSLL-AAACGDA----DAEPGARMTCRLLLHLFRA---P 1185
Fly 1272 QPGMYSVST-SPNPLHAVGNDFSIRLSCDRHLLVGAHKTIPIAAVLAVLKAILIVVDNAALKTPL 1335
|...:...| .|.| .||.|||||||..||.:|.:.||.||||||:::.| |.:.:..
Mouse 1186 QACFFPQGTGKPFP--------GIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGD-AKIGSNN 1241
Fly 1336 ASGSGTSSGGLGGAFGSGKRSGFNTPVHPGSTPKSNEQRPADLSQILGTSDLQLGSSLTSEPEAL 1400
.:.......|:.|. :|.| |.:.....|| :....|.|::
Mouse 1242 VNTMKNEDFGMRGL----RRDG-------------NAEDAWATSQ----NSKSYGKSIS------ 1279
Fly 1401 QQPSVGGMEQISLLEFAQAVLKQICAQEHVLERCLKNAEQLC---DMIIDEMLTAKQAQRVLHMI 1462
:|..:|.|:|:.||:.||.||.|.|.|||..|:|| ::|:|.:|:..|||::|.:|
Mouse 1280 -------IETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLI 1337
Fly 1463 CYPEPEFNIISELD--QRSMIVRILENLGQWTLRISWLDLQLMYRQSLSNN-----AELNVWLDT 1520
|||. .....:|.| ||..|.|||:||.|||||.|||:||||.:|.|.:. ||:|..||.
Mouse 1338 CYPH-GIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPSSGSVAEMNNLLDN 1401
Fly 1521 VARAAIDVFHMEE--------------------VVLPGAVK-------ATHKPKPSTWLVAPLIA 1558
:|:|.|:||.... .|.|.:.: .:...:...||||||||
Mouse 1402 IAKATIEVFQQSADLNNNASNSGMSLFNPNTIGSVDPSSTRQNGIKTFLSSSERRGVWLVAPLIA 1466
Fly 1559 KLTPAVQGRILRVAGQVLESMNYFSKVSKSDCNSSGSGDEREKSNSCHSSNSYGLGGVPARNKKM 1623
:|..:||||:|:.||:.||...:. ||..::|:......|.|.
Mouse 1467 RLPTSVQGRVLKAAGEELEKGQHL-----------GSSSKKERDRQKQKSMSL------------ 1508
Fly 1624 PLDYQPFLGLILTCLKGQDEYKENLLVSLYAQLSQCLQSFAELDTIGGIDEPQAREEILDALQLR 1688
|..||||.|:|||||||||.:|.||.||..|::|.|.::.|... .|:.:||:.:.:|||||
Mouse 1509 -LSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERY---QDDTKARQMMHEALQLR 1569
Fly 1689 FSLVGGMFEAIQKNSTPTTDWAILLAQLVCQGVVDLSCNRELFTTVVDMLATLVHSTLVSD---- 1749
.:||||||:.:|:::..|||||:||.|::..|.||:..|.||||||:|||..|::.||.||
Mouse 1570 LNLVGGMFDTVQRSTQGTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSSA 1634
Fly 1750 -------DERHYMNLMKKLKKEIGEKNNASIRVIRQLLPLYKQPTEVIACEHSG--MDTKGNKIC 1805
::|.||||:||||||:|:|.:.||..:||||||.||..:||.||..| :|||||||.
Mouse 1635 SPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIA 1699
Fly 1806 ---DIDKKQ-LRISDKQRISVWDILEGHKNPAPLSWVWFGAVKLERKPLTYEEAHRNLKYHTHSL 1866
.||||| |::|.||::|.||:.||.||||||||.|||.|:::||.:.|||....|.||||::
Mouse 1700 GFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVIKYEEQQHFLLYHTHTM 1764
Fly 1867 VKPSSYYYEPLPLPPEDIEPVPEKICIKDEMKADTPSSVDQSP---SAVVGGTGRGRG---KGTT 1925
.||.|||.|||||||| |.:.:..|.|.|.| ||.:...|:... |.|.
Mouse 1765 PKPRSYYLEPLPLPPE-------------EEEEELTSPVSQEPERKSAELSDQGKATADEEKKTK 1816
Fly 1926 TRKRKPKN----------------PKTPPVVNTQQQQPQ-------LAQQPQQP----QN----- 1958
.||||.|: |...|:.:.....|| |..||||| ||
Mouse 1817 GRKRKTKSSSRIDEYQQTNLYRVPPNYSPMSSQMTHHPQPALWGYNLVSQPQQPSFFLQNPSLNP 1881
Fly 1959 -------------------------------VQQQQLQQQQQQQQHMQQQHMQQQQMQPNQMGQM 1992
:|...|.....|||.:|.:.:||||.|..|.
Mouse 1882 GGSRLDPAGSFVPTNTKQALSNMLQRRSGAMLQPPSLHAVTSQQQLLQMKLLQQQQQQQQQQ--- 1943
Fly 1993 PMNMPMNMQQFAPNPNNMMQQNAMLQQQQQQQMQQMGNNPMQQQLNVGGGNGQPNPQMNFMQQGP 2057
|||||:.::|....|.|
Mouse 1944 -------------------------QQQQQRLLRQAQTRPFQ----------------------- 1960
Fly 2058 GGGGAGPQGMPGQQQQWHNAPQQQQPPQPYHNQYAPHQQNMQSNRIERPPLNANSKQALSQ---M 2119
||.||.|.....| |..|.|...||...|| .|.:.| |
Mouse 1961 -------QGQPGDQAALFTA---QARPSPQLPQYPGLQQ----------------AQTMPQGYTM 1999
Fly 2120 LRQRQPFQQQAQQGPGG-----GFNPMQQQPQASQQQPG-----PQQQMNPNQMRQQQMNPQQNP 2174
...:.|.||.|||.||| .:| .:...|:...|. .|.|..|:...|||.:|...|
Mouse 2000 YGTQMPLQQAAQQQPGGVVLSPSYN--SRAYPAAHSSPALMERLRQLQQQPSGYVQQQASPYLQP 2062
Fly 2175 QSVAAFNAMQQQPQQNAQQQQMNPNQQQQQQFMRGGNMRPGMAPNQMNQMNMGGQGMSQNPM--M 2237
. |..|::| :|..||..:.||.:...:.| ...|:....:.|:|| .
Mouse 2063 V---------------AGSQRLN-HQALQQSPLVGGGIDAVLTP---AHPNLPSVPLPQDPMRPR 2108
Fly 2238 QQQIPQNMVGMVNPNANQMMQSGGAQGGNGVGVGVGVGVGGAGNNPNMGMGGMPQQGMIQ-QQPQ 2301
|||:.| ||.::| ||||
Mouse 2109 QQQVRQ------------------------------------------------QQRLLQMQQPQ 2125
Fly 2302 Q--QPQQ--QVQFQNFQNQYQQQQQ-----QGMQQQGGGAGVGVGVGMAPNQQQQQQANMMGNFN 2357
| |||| |.|.|....|..|.|| ||:|| .|||||
Mouse 2126 QAPQPQQPSQTQSQALGLQAMQPQQPLFPRQGLQQ---------------TQQQQQ--------- 2166
Fly 2358 PQMQQGNRNNPDFMAAAAVAQQQQQ---QQQQQRVVP 2391
.||.|.|.|:| .|.||.|.|
Mouse 2167 --------------TAALVRQLQKQLSSNQPQQGVTP 2189
| 
