Protein Alignment kto and dpy-22

DIOPT Version :9

• Sequence 1: NP_524786.1
• Gene: kto / 44830
• FlyBaseID: FBgn0001324
• Length: 2531
• Species: Drosophila melanogaster
• Sequence 2: NP_509645.1
• Gene: dpy-22 / 181194
• WormBaseID: WBGene00001081
• Length: 3498
• Species: Caenorhabditis elegans
• Alignment Length: 3703
• Identity: 714/3703 - (19%)
• Similarity: 1120/3703 - (30%)
• Gaps: 1514/3703 - (40%)

  Fly    11 LKRT--RLGPPDIYPQDAKQREDELTPTNVKHGFTTTPPLSD------EFGTAHNSNVNASKV-- 65
            |::|  |:|..|:|.|:..|.||.||...:|.|:..  ||:.      .|..:.|..:...|.
 Worm     2 LRKTNLRMGTADVYKQNKNQEEDMLTTERLKKGYQM--PLTQYELQSLVFNASENKLIRLEKAQK 64

  Fly    66 --SAFFSGVLAKKEELMTLPDTGRK--KQQINCKDNFWP------VSPRRKCTVDAWFKDLAGNK 120
              .:..:.|:.||.|.....|..||  |:|:.|   |.|      :|.|.|     :|..||...
 Worm    65 RSQSMIASVIHKKGEFHMNYDRERKIPKEQLPC---FAPHNWKRILSDRVK-----FFSALARGT 121

  Fly   121 PLLSLAKRAPSFNKKEEIFITLCENQVNMQRATWFIKLSAAYTLSF-TESKNKKRSIYDPAA--- 181
            ||..|::|.|.|.:||.:|:...:..::..||.|.:||..  .|.| :.||.:|:::.|.|.
 Worm   122 PLQQLSQRIPGFRRKELLFLEFSDYNISYDRAIWCVKLLC--ILGFNSSSKTQKKTLLDVATLEL 184

  Fly   182 ------------------------------EW---TGNMIKFM--------KELLPKLQEYYQQ- 204
                                          .|   ||.| |:|        :|.|..|.|.:.|
 Worm   185 SQACNKTTIWLVTQLYKSFRNPIKRREATKTWNYLTGFM-KYMFDDGVLDKQEFLNDLTEVFNQL 248

  Fly   205 --------------------------------------------------NHDK-------SSSN 212
                                                              ..||       .|:|
 Worm   249 FLQKNFKNPSVLSTFMKYYVYFVEDLSSSLVLARRSSTLLCQALGFLFEMAQDKRKIDAYYDSAN 313

  Fly   213 GT--------------------------------------------------------TSGSLTA 221
            .|                                                        .:|||..
 Worm   314 KTFIKKEFENEDGEIYEFEDYDDFIDMLDEIPDVPYFDETDKTPEAQAEELIKQHEKRKAGSLKK 378

  Fly   222 A----------------GNGPASNGST------------------GTSSINSVTGSSASTNVIPV 252
            :                ...|::..|.                  |..|.||:...|.|....|
 Worm   379 SERRRRRGLSKNRPKKMPQNPSNEASLDHDKVQIKQEPMDYDEYGGQQSDNSMDYDSFSHQYDP- 442

  Fly   253 PSMASPLP--PIHS----PANGQQAAPGGGVNAGSVMPTT-----GSL--------GGV-VGGPG 297
              ...|||  |:|:    .....:......:...||.|..     ||:        ||| :..|.
 Worm   443 --SYEPLPFKPLHTDIPKKLTDDEEFKYMKIGKRSVTPERISGRYGSMTYPFWIQQGGVGIDPPK 505

  Fly   298 SSVVGGAAGAGA------------AVPPGSTISGIGSQFE------------------------- 325
            ..|:..:.....            :.|..|....:..:.|
 Worm   506 DEVLDFSNPTPTETVNTQPQIDFESSPSASPALSVDKENECEKKEDESKTKEKNKDKEKDKEKEK 570

  Fly   326 ------------------------DSRNALKYWKYCHQ-----------LSKYMYEESLLDRQEF 355
                                    |..:|.:..|...:           .||.....:..::.|.
 Worm   571 SVDEHTNDLDVPINPDDAEMADANDKTDASEKQKLVEEEPTGKENEDDTSSKTAKTSTSAEKSEA 635

  Fly   356 LNWILDLLDKM-----------------------------------RTQASFDEPLKKLVLSFAL 385
            .: |:|..||:                                   .|:.:.:|||:       :
 Worm   636 PS-IVDSNDKIDKEPNASSTSNDETSKDDTVPMESDPPAATEKPKESTEITTEEPLE-------V 692

  Fly   386 QYMHDFVQSERLCRKMAYIV-SKKLAQLLNTVV--------------------EQQTIKELDEPK 429
            ....:..:||:.......|: |.|.|...:.||                    |::..|..|...
 Worm   693 DKAPEVDKSEKEHEDDIMIIESNKKADEDDCVVIAVVDPDQEQTPESEKKKDGEEERDKNKDTDV 757

  Fly   430 LQQDPYELALQEQMS-------------------------------------------CPHHRDI 451
            ...:|.::...|:::                                           |....:.
 Worm   758 ADNEPEKIYTDEELAEIKIRKEKEMKIATLASHIKEKMVSDKKWKEKTSHAGWRTLDQCSQFSEA 822

  Fly   452 VLYLSTILQIITIECPTALVWSGIAA------HRAPSSLLGSPLDHLPLAPSVLPMPTRCPRTNH 510
            :..||:::|.:....|.:.||:.::.      ||....|.|||||:||.....||:....    .
 Worm   823 LHLLSSMVQYMACVTPESFVWNDLSVQQEERRHRILPQLCGSPLDYLPCELHKLPVMEGV----E 883

  Fly   511 EIRRQLRAAESDIVLRTQHAEQRWF--AAKWLSAGK--NQYTSVLATLDHLDTHCFDRMEHNNSI 571
            |:...||....:||.|:|.||.||.  ||...|.|:  :....|:..:|::|      :|..|:|
 Worm   884 EVVDCLRLRHCEIVRRSQAAEDRWLPNAAFLQSFGRIIDTCVDVIGIMDNID------VEKPNAI 942

  Fly   572 DTLYAQIFPSPTVSRRREEDQVEPRPPYEPKQDKDTVRILCEWAVSGQRWGEHRAMVVAILLDKR 636
            .....::|..              |..:|.::......::.:|.::.:|.|..||..:|.||
 Worm   943 TNAGLRLFAF--------------REKFEKQEALLKTMLMFKWCITEEREGSFRATYIAKLL--- 990

  Fly   637 QIDVTSTPADQQSSDKDDKDSLASGAGLIDGLPVFQHVLMHFLDHDAPVLDEHVSSPQQRTEFTN 701
                      :...|::.:::: .|..::|       :...|:..:.|   :| .|...:..|.:
 Worm   991 ----------RFGMDQNPENTI-GGWQVMD-------LFFKFMSTEGP---KH-GSKMYQAHFDS 1033

  Fly   702 LVQLFSALIRHDVFSHNAYMHTLISRGDLLLESVLVIKSGTTATKTSPPPPAPPPTTTHGFDDDG 766
            .|.:...::|..:||....:..|....||
 Worm  1034 TVAIMIEMMREKIFSITDILRELEKDSDL------------------------------------ 1062

  Fly   767 FGGGLDFKHNEFDDSNVDDDLDKLVQNIKEKGQQHEAPDSPKIGPPGDGETNPGGSISRHYVYTK 831
                      :::...::....:.:..|.::.::.|.||..|:               .|:. |:
 Worm  1063 ----------DYNAPLMERQRKQKIPKISKRHRKPETPDDTKL---------------VHFT-TE 1101

  Fly   832 HFP------------------IPQDDPSMSSYSSESNQRYILLFGVGKERDEKKHAVKKMSKEIG 878
            :.|                  :||.|  :...:.|...|.:||||:....:......:.:.|.|.
 Worm  1102 YTPKRLFMGKKMDLLERMIIILPQLD--VDEDTDEYRLRRLLLFGLKPAANVYFRRARAIYKSIT 1164

  Fly   879 KLFTKKFSIDVAAAGHV----KKHSRNEFN-----FEATTSKCQQMAYFDQHVVTAQCAANVLEQ 934
            |.||.:..|:...:..|    ||.::|..:     |.|.|       |.|||::..:...|.::.
 Worm  1165 KEFTTRLYIEFDRSSKVTTAHKKINQNRLDDLLRQFRAQT-------YHDQHLILERIVYNFIDG 1222

  Fly   935 LNGFALGNNNYLPVQEHVAFLFDLMELALNIYSLLELCDSLLKELPEVEHQL-QLKKSNLVRSYT 998
            :.||...|.:.:|..|....:.::.|.:::|.|:.:..:.:...|..|:.:: ..:...|...|.
 Worm  1223 IGGFLKKNCDDVPAPEVANIICEMYEFSMDITSIFDFFEMVNPYLKAVDDKIAHFRMDVLPDMYY 1287

  Fly   999 TSLALYIVSILRRYHSCLLLSP------EQTLSVFEGVCRTIRHVSNPSECTSAERCIIAYLSDL 1057
            |..|...||...::....||.|      .|...:.:.:.|...|:     .|...|.:..::  .
 Worm  1288 TETAFIFVSFFMKHWQRFLLHPRACAIVNQCFVLIQDMIRADDHM-----ITCWGRTVAIFV--F 1345

  Fly  1058 HESCVLLQGKEQSTEYYQQLQCIKRFKDIFNTPEQLDLPPQGYNPLLLQELFMAPR---RGGKL- 1118
            |....:.....|:.|:..:   ...|..:|...:.:||....:|     |.|...:   |||.|
 Worm  1346 HARKAIANAGLQNEEFLAE---DSHFWRVFPNAQHVDLDVGYFN-----EDFAGVKLQLRGGTLR 1402

  Fly  1119 -----DPHWLGT---------LH-ESPANVYSFVSNALIAVCRETDN-ERLNDVALACAELTASC 1167
                 |..||.:         .| :.|...||||..|.:...:...| :|:|::|..||.:||:.
 Worm  1403 YDSYNDFKWLVSNMKPNLKKKPHLKRPNTRYSFVVRAFMEARQHGRNFDRINELANYCANITAND 1467

  Fly  1168 NVLSEEWIYALQSLCSGSKSPRYP--HLGGQVDIGQLKTHNALAVFVCILVARHCF----SLADF 1226
            ..|||.||.|::.||..|....||  .:..|:||....||.:|..|:..|..:..|    .||:
 Worm  1468 PPLSEYWIGAIKGLCFLSLDAPYPFKEMSQQIDISDCSTHYSLTTFITCLAGKSAFYIPRLLAE- 1531

  Fly  1227 VSKFALPTLAR------------------SVSAGGAELSVDAEAGARLTCHLVLKLFKTLEIPQP 1273
            ::|...|.:.|                  |.:.....|| :||.|..| |.|::          .
 Worm  1532 LTKHVFPLMLRHDGRLTSQKTHDVKRKVASKTTESRTLS-EAEPGVCL-CLLII----------C 1584

  Fly  1274 GMYSVSTSPNPL--HAVG---------NDFSIRLSCDRHLLVGAH---KTI-PIAAVLAVLK--- 1320
            |:..|...|..|  |..|         |....|:....|.....|   :|: .|:.:|..|:
 Worm  1585 GLCCVGDEPFGLSVHYRGIEKKKKRFNNTADERIMHLFHWFEMDHAMFRTLGHISQLLEALQSRC 1649

  Fly  1321 --AILIVVDNAALKTPLASGSGTSSGGLGGAFGSGKRSGFNTPVHPGSTPKSNEQ--------RP 1375
              |.|::..|..:|.|                                 ||..::        ||
 Worm  1650 RDANLVLPKNFPIKNP---------------------------------PKHQQELHREKAPYRP 1681

  Fly  1376 ADLSQILGTSDLQLGSSLTSEPEALQQPSVGGMEQISLLEFAQAVLKQICAQEHVLERCLKNAEQ 1440
            ..|..|..|....:          .:|..|    .:.:..|.|....:...|:.:.:.||  .:|
 Worm  1682 QYLFNIAKTVQFVI----------CEQDWV----TLRMFRFFQTRKMEAFNQDKLKQNCL--GQQ 1730

  Fly  1441 LCDMIIDEMLTAKQAQRVLHMICYPEPEFNIISELDQRSMIVRILENLGQWTLRISWLDLQLMYR 1505
            :..|.:......:...::..           ..::.:::.:.::|..:..|..|.:..||.||.:
 Worm  1731 ILRMALRRRTERENVHKLFE-----------AHKISKKATVDKVLSFMNLWNFRATLFDLMLMIK 1784

  Fly  1506 Q----SLSNNAE-----LNVWLDTVARAAIDVF---HMEEVVLPGAVKATH---KPKPSTWLVAP 1555
            :    ..|.:|:     .:..:..:.:...|:|   :..::.:|.|...|.   ......||:||
 Worm  1785 EISPDGNSRHAQQGAIAADALMSEIGKCCRDMFLSAYKTKIKMPIAKTLTDFRLSDINKFWLIAP 1849

  Fly  1556 LIAKLTP---------------AVQGRILRVAGQVLESMNYFSKVSKSDCNSSGSGDEREKSNSC 1605
            |: ::.|               .|..:.||.|..::::.....|.....|
 Worm  1850 LV-RMCPKPINIPPQYANTTVGTVAAKFLREAALLMDTPPTTPKERLLQC--------------- 1898

  Fly  1606 HSSNSYGLGGVPARNKKMPLDYQPFLGLILTCLKGQ--DEYKENLLVSLYAQLSQCLQSFAELDT 1668
                |:.:..|            ||:.:|||||:.:  .:.|:..|.|||.||.:        :|
 Worm  1899 ----SWAMSKV------------PFINMILTCLQCEKMQQSKDVFLQSLYTQLQR--------ET 1939

  Fly  1669 IGGIDEPQA-----REEILDALQLRFSLVGGMFEAIQKNSTPTTDWAILLAQLVCQGVVDLSCNR 1728
            :.  |..:.     |.|..|....|.:|:|.:::.|.| :|....|.:|:.||:..|:::....:
 Worm  1940 LR--DHHRRSNWTNRREHRDCTIFRITLIGYIYKEILK-ATHVETWGLLIFQLMFHGIINPVREK 2001

  Fly  1729 ELFTTVVDMLATLVHSTLVSDDERH--------------YMNLMKKLKKEIGEKNNASIR-VIRQ 1778
            .::.|..|||..:|..|||..|..:              |..||||::||:.|:.....| .:.:
 Worm  2002 LIYETCFDMLHHMVLWTLVDGDSMNQHDRYGSIRVRWPQYAGLMKKIRKEMQERFTDQTRNSLHR 2066

  Fly  1779 LLPLYKQPTEVIACEHSGMDTKGNKICDIDKKQLR------------ISDKQRISVWD------- 1824
            .||:.|.....|:.:......|.|:  .:.||.|.            ..:|.:.:.::
 Worm  2067 FLPIGKMQMSTISYKKYQKRPKVNQ--KMSKKFLAGEGLKNGKYSFLPEEKAKTNAFEHTDHLGD 2129

  Fly  1825 -ILEGHKNPAPLSWVW--FGAVKLERKPLTYEEAHRNLKYHTHSLV--KP----SSYYYEPLPLP 1880
             |::|       .|.:  |...:|::.....:...|:..:|||.|.  :|    |...::.:.|.
 Worm  2130 LIVKG-------GWKFRMFQTTRLDKVAKNVQNVLRSNMHHTHVLEFNRPQLLMSDNMFDDIFLA 2187

  Fly  1881 PEDIE-------PVP-------------------------------------------------- 1888
            |.|||       |||
 Worm  2188 PPDIEITKIIEQPVPVIDEEEAKKRAEEEKEAAEKKEESKNAEDEKNKNNAENKKDTKEGEKGKS 2252

  Fly  1889 -------EKICIKDEMKAD----------------------------------TPSSVDQSPSAV 1912
                   ||...||..|.|                                  .|:.|.:||:..
 Worm  2253 KDKEKDGEKEKCKDASKKDDVTSEKNELEKRASDAAAATNAPETNKDMDTSTPKPAPVTRSPATR 2317

  Fly  1913 VGGTGRGRGKG----------------------TTTRKRKP----KNP------------KTPPV 1939
            ..|.||.|..|                      .||:...|    .||            ..||:
 Worm  2318 GRGGGRKRNSGARGGGPRAKRANSRADTAQAAAATTQWNAPIANTSNPAAGGNFHAAMRGNQPPM 2382

  Fly  1940 VN-----------------TQQQQPQLAQQ----------------------PQQPQNVQQ---- 1961
            .|                 .::::..||..                      |..|.....
 Worm  2383 SNGSSDETKVHIRNLLNRKKEEKRNSLADASAAAAAANSNAMGNTSSMPPSGPPMPMGSSMQSAG 2447

  Fly  1962 --QQLQQQQQQQQHMQQQHMQQQQ--MQPNQMGQMP--------MNMPMNMQQF------APNPN 2008
              ||||..|:.|.......|.|..  |..:...|.|        ||.|: |.|:      ||||.
 Worm  2448 ATQQLQGMQKHQMGGSMSGMNQNMGGMNQSMSHQAPPPYSSTNEMNRPL-MNQYGGPHFAAPNPG 2511

  Fly  2009 NM-------------------------------------------------------MQQNAMLQ 2018
            .:                                                       ||:.|.::
 Worm  2512 PLNRSSGPVSSETRQQIMEQQMREKLAAHHQLVEQQKQRDAREREAREREAREHQERMQREAYMK 2576

  Fly  2019 QQQ-------------------------------------------------------------- 2021
            :||
 Worm  2577 EQQLLERKRAIEENNRIMEEQQREREMEAARKEAARRAAEEAYAAEQQRLELLRRQEEERLRKEA 2641

  Fly  2022 ---------------QQQMQ--------------------------------------------- 2026
                           |:||:
 Worm  2642 EERMRIQRENEERVRQEQMRLEAEERERIRRAEEERIQKELEDKVRREKEEAARQEKERQEQEAR 2706

  Fly  2027 -------QMGNNPMQQQLNVGGGNGQPNPQMNFMQQGPGGGGAGPQGMPGQQQQWHNAPQQQQPP 2084
                   ::....|:||     ...|.||.||                  ||.|:     .||||
 Worm  2707 MREAREAELSRQRMEQQ-----RRSQQNPYMN------------------QQGQY-----SQQPP 2743

  Fly  2085 QPYH-----NQYAPHQQNMQSNRIERPP-------LNANSKQALSQM---LRQRQPFQ----QQA 2130
            ..|.     |.|.|.||..|....::|.       ..|..:|..:||   ::|:|..|    ||:
 Worm  2744 PSYQQSSYPNNYQPGQQGNQPPNYQQPSHQSMQQGHQAGYQQTSNQMQMNMQQQQNRQQGGPQQS 2808

  Fly  2131 QQGPGG----------GFN---------PMQQQ-----PQASQQQPGPQQQMN--PNQMRQQQMN 2169
            ..||||          |:|         .||||     .|...||||..:.|:  ||:...||..
 Worm  2809 FSGPGGINQPSQPGYSGYNQQGGQGQQGQMQQQRNPFGNQQDMQQPGAAKLMHAKPNEAHAQQYQ 2873

  Fly  2170 PQQNPQSVAA-------FNAMQ-QQPQQNAQQQQM--------------NPNQQQQ--QQFMRGG 2210
            ..||..|:|.       |.|.. |..|.||||||.              .|..|||  .....|.
 Worm  2874 HTQNQLSLAQKEKEKQYFQAKNLQASQANAQQQQQRFGDVVAGNVAGYGRPYGQQQLGASDQMGT 2938

  Fly  2211 NMRPGMAPNQMNQMNMGGQG-----MSQNPMM------------QQQIPQNMVGMVN-------- 2250
            :..||.:.::|||.:...||     ..|.|::            |||||.......|
 Worm  2939 SQLPGASTSRMNQGSSNPQGGMQSYQQQQPVLGQPGPIQTGQSTQQQIPAQSQQQYNSGRPQMHT 3003

  Fly  2251 -PNANQM--MQSGGAQG--GNGVGVGVG-VGVGGAGNN------------------------PNM 2285
             |..|.|  ....||.|  .|.:|.|.. .|.|..|.|                        ||.
 Worm  3004 TPTKNDMSARAPSGAMGQIANRMGHGTNPQGYGSTGQNVPGGYQQGQQQSGQGSYPQAQQQQPNQ 3068

  Fly  2286 GMGGMPQQGMIQQQPQQQP--------QQQVQF----------QNFQNQ-----YQQ--QQQQGM 2325
            ..|...|.|...||.||||        |...||          |:..||     ||:  |||||.
 Worm  3069 YSGSNQQVGQQAQQQQQQPLNQNVSQSQSAAQFGRPSQDSAYQQSGYNQTGNQSYQRPDQQQQGA 3133

  Fly  2326 QQQGGGAGVGVGVGMAPN----QQQQQQANMMGNFNPQMQQGNRNNPDFMAAAAV------AQQQ 2380
            ||....     |...|.|    |||.||.......:.|.||..:...:.||.:|.      .||.
 Worm  3134 QQNQWS-----GSNQAQNQLRSQQQAQQPLQQPQQSQQFQQPAQQAKNPMAQSAQYGGFGGQQQG 3193

  Fly  2381 QQQQQQQRVVPGGMMAGNRNQYMNQAPNVTMSTMMGPGPGGVV---------------------- 2423
            ..||||.::.|  ..|.|.....:.....|.....|.|..|..
 Worm  3194 YDQQQQGQIAP--QQAQNPQASQSYGQQQTQQNRYGMGSSGYTANSGGSSNILNQSMEESGLNQG 3256

  Fly  2424 ---------GQVPPYARQQSAGGGKPGVLNTQQQFQQQQQQQQQLRHQMMQLQGMGGGAGGGMGA 2479
                     .|....::.|.:|.|.||     .|.|.||.|:||::..|.  .|||....|..|.
 Worm  3257 FSGASSNASSQQGGSSQMQQSGYGMPG-----NQMQMQQNQKQQVQRGMP--TGMGQTNMGQSGM 3314

  Fly  2480 GPQQGGGAVG---GGAGGGMVPQQQSMNQQQTPNLVAQLQRQNMM-----------GQQQYQP 2528
            | |.|.|..|   .|.|||:..|.|...|.|.|. |:|.|.|..|           ||||:||
 Worm  3315 G-QSGMGQTGMSRSGLGGGIGQQGQQSQQPQQPQ-VSQQQNQRGMNPGAQLPPYSTGQQQHQP 3375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kto	NP_524786.1	Med12	99..157	CDD:286572	19/63 (30%)
		Med12-LCEWAV	390..856	CDD:288959	92/557 (17%)
dpy-22	NP_509645.1	Med12	99..158	CDD:286572	19/63 (30%)
		Med12-LCEWAV	815..>990	CDD:288959	49/198 (25%)
		ARGLU	<2523..2662	CDD:291991	8/138 (6%)
		MAP7	<2623..2729	CDD:283355	7/110 (6%)
		GBP_C	<2630..2728	CDD:303769	6/102 (6%)
		PHA00671	2690..>2760	CDD:106979	19/97 (20%)
		coiled coil	2710..2721	CDD:293879	0/10 (0%)
		RCR	<2728..2784	CDD:304939	20/78 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156338
Domainoid	1	1.000	232	1.000	Domainoid score	I1370
eggNOG	1	0.900	-	-		E1_KOG3598
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	359	1.000	Inparanoid score	I1292
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004348
OrthoInspector	1	1.000	-	-		oto20213
orthoMCL	1	0.900	-	-		OOG6_105637
Panther	1	1.100	-	-	LDO	PTHR46007
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2630
SonicParanoid	1	1.000	-	-		X4125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.910