DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kto and kto

DIOPT Version :10

Sequence 1:NP_524786.1 Gene:kto / 44830 FlyBaseID:FBgn0001324 Length:2531 Species:Drosophila melanogaster
Sequence 2:XP_061506997.1 Gene:kto / 1273438 VectorBaseID:AGAMI1_013264 Length:2833 Species:Anopheles gambiae


Alignment Length:2991 Identity:1410/2991 - (47%)
Similarity:1711/2991 - (57%) Gaps:629/2991 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 RPLKRTRLGPPDIYPQDAKQREDELTPTNVKHGFTTTPPLSDEFGTAHNSNVNASKVSAFFSGVL 73
            |||||.||||||:|||:|||||||||.|:|||||.|...||:|||||.|.||:||||.|:|:.:|
Mosquito     4 RPLKRPRLGPPDVYPQEAKQREDELTSTHVKHGFATEHKLSEEFGTARNCNVSASKVGAYFNAIL 68

  Fly    74 AKKEELMTLPDTGRKKQQINCKDNFWPVSPRRKCTVDAWFKDLAGNKPLLSLAKRAPSFNKKEEI 138
            |||||||||||:||||||||.|||||||:.|.|.|:|.|||||||.|||.||||:||||||||||
Mosquito    69 AKKEELMTLPDSGRKKQQINPKDNFWPVTARNKTTLDTWFKDLAGTKPLSSLAKKAPSFNKKEEI 133

  Fly   139 FITLCENQVNMQRATWFIKLSAAYTLSFTESKNKKRSIYDPAAEWTGNMIKFMKELLPKLQEYYQ 203
            |..||||||.||||.||||||:|||::.:|:|.|||.:.|||.||||.||||||:|:|||.|:|.
Mosquito   134 FAMLCENQVTMQRAAWFIKLSSAYTVAVSEAKIKKRQMPDPATEWTGTMIKFMKDLIPKLHEHYH 198

  Fly   204 QN--HDKSSSNGTTSGSLTAAGNGPASNG-STGTSSINSVTGSSASTNVIPVPSMASPLPPIHSP 265
            |.  .:|.|:.|  :||....|:|.:..| |:|....|:||        || |.::||...:|||
Mosquito   199 QGPLQEKPSTGG--AGSSGGLGSGASGLGLSSGAGGTNAVT--------IP-PPLSSPAGSMHSP 252

  Fly   266 ANGQQAAPGGGVNAGSVMPTTGSLGGVVGGPGSSVVGGAAGAGAAVPPGSTISGIGSQFEDSRNA 330
            |.                             |:.||||:..|..............|..|:.|.|
Mosquito   253 AG-----------------------------GNPVVGGSMHAQQQQQQQQQQQQPISPQEEQRIA 288

  Fly   331 LKYWKYCHQLSKYMYEESLLDRQEFLNWILDLLDKMRTQASFDEPLKKLVLSFALQYMHDFVQSE 395
            .|.|.|..||.||||||.|||:|||||||:|||:||::..:.|:.|.::.|..|:||::|.||||
Mosquito   289 QKQWNYSTQLCKYMYEEGLLDKQEFLNWIIDLLEKMKSSPNADDGLLRIYLPLAMQYLYDLVQSE 353

  Fly   396 RLCRKMAYIVSKKLAQLLNTVVEQQTI-------------------------KELDEPKLQ---- 431
            |.||::||.||||||||:|.:.|...|                         |:.|:|..:    
Mosquito   354 RFCRRLAYAVSKKLAQLINQMAESHNINLSSPEPQDASGKQPSIEAPDSKSEKQNDKPSKEGTAG 418

  Fly   432 ------------QDPYELALQEQMSCPHHRDIVLYLSTILQIITIECPTALVWSGIAAHRAPSSL 484
                        .:|||:...|.:.|.||||::|.||:|||:||:||||||||.|:...|:.|.|
Mosquito   419 TVAQPADSKPPKVNPYEMIFTEYLQCSHHRDVILQLSSILQVITLECPTALVWCGVGETRSSSVL 483

  Fly   485 LGSPLDHLPLAPSVLPMPTRCPRTNHEIRRQLRAAESDIVLRTQHAEQRWFAAKWLSAGKNQYTS 549
            .||||||||:|||.||:|||..::|.:|||||..||..|.:|::|||.||...||.:|..|....
Mosquito   484 SGSPLDHLPVAPSALPIPTRYEKSNEDIRRQLFEAEESIKVRSRHAESRWCIDKWQTAAGNASLK 548

  Fly   550 VLATLDHLDTHCFDRMEHNNSIDTLYAQIFPSPTVSRRREEDQVEPRPP---------------- 598
            :|||||.||.||||||:.|||:|:||::|||         ..||:|..|                
Mosquito   549 ILATLDALDGHCFDRMDSNNSLDSLYSKIFP---------PFQVQPLKPAESASATGGSGGSGTG 604

  Fly   599 --------------------YEPKQDKDTVRILCEWAVSGQRWGEHRAMVVAILLDKRQIDV-TS 642
                                |..:||...|:||||||||.||||||||||||.||||||.:| |:
Mosquito   605 NTASGLAVVDGKDAATKQFEYNVEQDSSIVKILCEWAVSWQRWGEHRAMVVAWLLDKRQNEVLTA 669

  Fly   643 TPADQQS---SDKDDKDSLASGAGLIDGLPVFQHVLMHFLDHDAPVLDEHVSSPQQRTEFTNLVQ 704
            ...|..:   ::.|||||:.||:||..|.|||||:||:||||||||||| ..|||.:::|||||.
Mosquito   670 LENDSYTNNLNNSDDKDSVLSGSGLNGGQPVFQHILMNFLDHDAPVLDE-AGSPQNKSQFTNLVH 733

  Fly   705 LFSALIRHDVFSHNAYMHTLISRGDLL--------LESVLVIKSGT-TATKTSPPPPAPPPTTTH 760
            |||.|||||||||:|||..||||||||        |:|..:..:|. |...::.|..:..|....
Mosquito   734 LFSELIRHDVFSHDAYMCCLISRGDLLTGAGGMLSLDSQGICNAGLGTGPISNKPATSSSPNGGG 798

  Fly   761 GFDDDGFGGGLDFKHNEFDDSNVDDDLDKLVQNIKEKGQQH-EAPDSPK----IGPPGDGETNPG 820
            |.:||........|..:.||||||||||||:|:|||..|.. :||||||    ..|...| ....
Mosquito   799 GVEDDVLQTDFKAKLEDLDDSNVDDDLDKLLQHIKEDQQNSMDAPDSPKDPEHAAPSVTG-LGKA 862

  Fly   821 GSISRHYVYTKHFPIPQDDPSMSSYSSESNQRYILLFGVGKERDEKKHAVKKMSKEIGKLFTKKF 885
            .|.|||::||:|||:.|||| :|.:  :.|||||||:||||||||||||||||||||.|||:|||
Mosquito   863 ESSSRHFLYTEHFPLCQDDP-ISQH--DCNQRYILLYGVGKERDEKKHAVKKMSKEICKLFSKKF 924

  Fly   886 SIDVAAAGHVKKHSRNEFNFEATTSKCQQMAYFDQHVVTAQCAANVLEQLNGFALGNNNYLPVQE 950
            |||||..|.||||||:|||||:|::|||.|:||||||||.|||..|.|.||.||:||:|||||||
Mosquito   925 SIDVAEGGKVKKHSRSEFNFESTSNKCQAMSYFDQHVVTWQCAVQVQEMLNAFAIGNSNYLPVQE 989

  Fly   951 HVAFLFDLMELALNIYSLLELCDSLLKELPEVEHQLQLKKS-NLVRSYTTSLALYIVSILRRYHS 1014
            ||||||||||.|.|||.|::.|..:|:||||||.||..|.| .|||||||||:||:|.:|||||.
Mosquito   990 HVAFLFDLMESAFNIYGLIDTCIQILRELPEVELQLIGKSSMALVRSYTTSLSLYVVGVLRRYHC 1054

  Fly  1015 CLLLSPEQTLSVFEGVCRTIRHVSNPSECTSAERCIIAYLSDLHESCVLLQGKEQSTEYYQQLQC 1079
            |||||.|||.::|||:||.::||||||:|:||||||:|||.||:.:|..|:.:.|...::   ..
Mosquito  1055 CLLLSQEQTTAIFEGLCRIVKHVSNPSDCSSAERCILAYLYDLYSACSSLKARPQQEPFH---NA 1116

  Fly  1080 IKRFKDIFNTPEQLDLPPQGYNPLLLQELFMAPRRGGKLDPHWLGTLHESPANVYSFVSNALIAV 1144
            ..:.|....||.|.......|||..:.::...||||||::..|...|:||.:|.||||.||::||
Mosquito  1117 YPKIKQALYTPLQPTPSAHTYNPQFMLDIITNPRRGGKIESGWARQLNESASNRYSFVCNAVVAV 1181

  Fly  1145 CRETDNERLNDVALACAELTASCNVLSEEWIYALQSLCSGSK-SPRYPHLGGQVDIGQLKTHNAL 1208
            .|:.||:.|||:|..||||||.||.||.||:..|.:||..:: :..|..:..|||:.....||||
Mosquito  1182 TRDIDNDCLNDIAAMCAELTACCNSLSTEWLGVLIALCGSNRDAGYYVDVLTQVDVQNTNIHNAL 1246

  Fly  1209 AVFVCILVARHCFSLADFVSKFALPTLARSVSAGGAELSVDAEAGARLTCHLVLKLFKTLEIPQP 1273
            :||..||||||||||.:||:..|||:|.::.. |..|.:.:.||||||:|||:|:||||:|.|||
Mosquito  1247 SVFTSILVARHCFSLENFVAHVALPSLVQACK-GRGETTPEIEAGARLSCHLLLRLFKTIECPQP 1310

  Fly  1274 GMYSVSTSPNPLHAVGNDFSIRLSCDRHLLVGAHKTIPIAAVLAVLKAILIVVDNAALKTPLASG 1338
            |:|||||||||: .|||..:|:||||||||..|||.|.:|.||||||.||:|.|..|.|      
Mosquito  1311 GLYSVSTSPNPI-TVGNAHNIKLSCDRHLLAAAHKNIGVAPVLAVLKGILVVGDATAHK------ 1368

  Fly  1339 SGTSSGGLGGAFGSGKRSGFNTPVHPGSTPKSNEQRPADLSQILGTSDLQLGSSLTSEPEALQQP 1403
                   :...||||||||.|||||||||||| .....|||.|||||||   |.|.:..|::...
Mosquito  1369 -------VSSIFGSGKRSGLNTPVHPGSTPKS-MAGSGDLSHILGTSDL---SILGNPDESMLDV 1422

  Fly  1404 SVGGMEQI------------------------SLLEFAQAVLKQICAQEHVLERCLKNAEQLCD- 1443
            |:..:.::                        ||.:|||.||:|||:||.||||||::||:||. 
Mosquito  1423 SMIELGELSPTASARLYSSRQQNSHLNQDNATSLSDFAQHVLRQICSQEWVLERCLQHAEELCQH 1487

  Fly  1444 -MIIDEMLTAKQAQRVLHMICYPEPEFNIISELDQRSMIVRILENLGQWTLRISWLDLQLMYRQS 1507
             |:||.:||||||||:||||||||.|.|:|:||||:::||||||||.||:|||||||||||::|:
Mosquito  1488 GMLIDNLLTAKQAQRLLHMICYPEHESNLIAELDQKAIIVRILENLEQWSLRISWLDLQLMFKQT 1552

  Fly  1508 LSNNAELNVWLDTVARAAIDVFHMEEVVLPGAVKATHKPKPSTWLVAPLIAKLTPAVQGRILRVA 1572
            ..::.:|:.|||.|||||||||.:.|.:|........|.||||||||||::||..|||||||:|:
Mosquito  1553 NCSSPDLSNWLDMVARAAIDVFRVNEFILNSPDVKQEKVKPSTWLVAPLVSKLPSAVQGRILKVS 1617

  Fly  1573 GQVLESMNYFSKVSKSDCNSSGSGDEREKSNSCH----------SSNSYGLGGVPARNKKMPLDY 1627
            ||||||.:.|||      :..|:|.....||:.|          |||....|.    .:...|::
Mosquito  1618 GQVLESTSMFSK------HKDGNGGNNSSSNNSHNHGANSNSSVSSNGSTFGS----KQSAQLNH 1672

  Fly  1628 QPFLGLILTCLKGQDEYKENLLVSLYAQLSQCLQSFAE-LDTIGGIDEPQAREEILDALQLRFSL 1691
            ||||||:|||||||||.||.||.|||:||||.||:..: |:|||||::|...|::|||||||:||
Mosquito  1673 QPFLGLVLTCLKGQDEQKEGLLQSLYSQLSQFLQNRDQSLETIGGIEDPCGFEKMLDALQLRYSL 1737

  Fly  1692 VGGMFEAIQKNSTPTTDWAILLAQLVCQGVVDLSCNRELFTTVVDMLATLVHSTLVSD------- 1749
            |||:|:||.||:|.|||||||.|||:.|||:|||.|.|||||.:||||||:|||||||       
Mosquito  1738 VGGLFDAIMKNATSTTDWAILFAQLISQGVIDLSNNSELFTTTLDMLATLIHSTLVSDSQTERDE 1802

  Fly  1750 DERHYMNLMKKLKKEIGEKNNASIRVIRQLLPLYKQPTEVIACEHSG--MDTKGNKIC--DIDKK 1810
            :::.|.||||||:||:|:||..||:.:||||||.||..||:.|:.:|  .|.|||||.  .|:||
Mosquito  1803 NKKLYTNLMKKLRKELGDKNGPSIKYVRQLLPLAKQTCEVLTCDSAGSSTDAKGNKIAIDSIEKK 1867

  Fly  1811 Q-LRISDKQRISVWDILEGHKNPAPLSWVWFGAVKLERKPLTYEEAHRNLKYHTHSLVKPSSYYY 1874
            . ||:.||||:||||:||||||||||||.||||||:|||||.|||.||.||||||||.|||||||
Mosquito  1868 NGLRLGDKQRVSVWDLLEGHKNPAPLSWAWFGAVKIERKPLAYEETHRLLKYHTHSLFKPSSYYY 1932

  Fly  1875 EPLPLPPEDIEPVPEKICIKDEMKADTPSSVDQSPSAVVGGTGRGRGKGTTTRKRK--------- 1930
            ||||||||:::|:|:|  :||:|||||||| ||||:.   .||..:.| |||||||         
Mosquito  1933 EPLPLPPEEVDPLPDK--LKDDMKADTPSS-DQSPAP---STGSKKSK-TTTRKRKTKATAAAQV 1990

  Fly  1931 ----PKNPKTPPVV--------------NTQQQQPQLAQQPQQ----PQNVQQQQLQQQQ--QQQ 1971
                |:.|..|.:|              ..||||.|..||.||    .|..||||:||||  |||
Mosquito  1991 QQSQPQQPVMPAIVPQPAAGPQQMQQMQQQQQQQQQQQQQQQQHQQHQQQQQQQQMQQQQTLQQQ 2055

  Fly  1972 QHMQQQ----HMQQQQ-------MQPNQMGQMPMNMPMNMQQFAPNPNNMM-----------QQN 2014
            ||:|||    |:||||       .|..|:.|:.......:||.....|.||           ||.
Mosquito  2056 QHLQQQQQQLHLQQQQAQQQQQLQQQQQLQQLQQQQQQQLQQQQQQQNQMMMQQQQQPNIPQQQQ 2120

  Fly  2015 AMLQQQQ-----------------QQQMQQMGNNP-----------------MQQQLNVGGGNGQ 2045
            :.|||||                 ||.:|||.||.                 ||||.      ||
Mosquito  2121 SALQQQQLGSQQGQQQQQQVTMTPQQTLQQMQNNSMGGMQMGGPMSSMNQQHMQQQY------GQ 2179

  Fly  2046 PNP-------QMNFMQQGPGGGGAGPQG--MPGQQQQWHNAPQQQQPPQPYHNQYAPHQQNMQSN 2101
            .||       .|..||.|.||.|||..|  |..||||.....|||||||....|.|...|..|..
Mosquito  2180 ANPAQLVGQGNMGGMQTGMGGLGAGMGGGMMNQQQQQQQQQQQQQQPPQQQQPQQAQQAQQAQQA 2244

  Fly  2102 RIERPPLNAN-------------------SKQ-----ALSQMLRQRQPFQQQAQQGPGGGFNPMQ 2142
            :.::|..|.|                   ::|     :|.|..:|:|..|||.||.........|
Mosquito  2245 QQQQPQGNPNMGFVGNVNPMAQLAQQQGGNQQWGGYGSLQQQQQQQQQQQQQQQQQQQQQQQQQQ 2309

  Fly  2143 QQPQASQQQPGPQQQMNPNQMRQQQMNPQQNPQSVAAFNAMQQQPQQNAQ-----QQQMNPNQQQ 2202
            ||.|..|||...|||...:|::|||..|||. |..:.....||.|||.||     |||:...|||
Mosquito  2310 QQQQQQQQQQQQQQQQTQSQVQQQQQTPQQG-QQASQQQGPQQGPQQGAQQGPQTQQQLQQQQQQ 2373

  Fly  2203 QQQFMRG---------------------------------------------------------- 2209
            ||.|..|                                                          
Mosquito  2374 QQMFYSGMGQATMNRFDRPQLNTNSKQALSNMLRSKLPINAGHPASFMQQQQQQQQAQQQQAQRN 2438

  Fly  2210 -------GNMRPGMAPNQ-------MNQMN------------------MGGQGMSQNPMM-QQQI 2241
                   |.:|.||..|.       |..||                  ||.|||....|| .||.
Mosquito  2439 PQQPFLRGPLRAGMPGNPIVGAQAGMGPMNPAMAGGTAGIGTAGGGAVMGAQGMGAGGMMGAQQT 2503

  Fly  2242 PQN--------------------------------MVGMVNPNANQ------------------- 2255
            .|.                                ..||:||..|.                   
Mosquito  2504 AQGQQGAGGIMNQTTPAMMGTTGGSIMSQSGGSMIQTGMMNPQQNPALVGQGMGGSGGLGGASGM 2568

  Fly  2256 --------------------MMQSGG-----------------AQGGNGVGVGVGVGV---GGAG 2280
                                |:.|||                 ..||.|.|:|...|:   .|.|
Mosquito  2569 AGNSGMGASAGGMGGTSGGGMVTSGGMVTGGMGSAGIGNTAPMGAGGQGGGMGGNAGMPNAAGMG 2633

  Fly  2281 N----NPNMGMGGMPQQGMIQQQPQQQPQQQVQFQNFQNQYQQQQQQGMQQQGGGAGVGVGVGMA 2341
            |    ||.|||..|.|.|.:|.....| .|.|.:||....|.....|||.||.|..|        
Mosquito  2634 NPAMGNPGMGMQNMQQSGNMQGGGMFQ-GQNVPYQNVNQNYPNYGNQGMGQQSGQGG-------- 2689

  Fly  2342 PNQQQQQQANMMGNFNPQMQQGNRNNPDFMAAAAVAQQQQQQQQQQRVVPGGMMAGNRNQYMNQA 2406
                     .|||||||..||......:|:|             |||..    ||..|.||...|
Mosquito  2690 ---------GMMGNFNPMAQQQRNTQAEFLA-------------QQRAA----MAAGRGQYGQHA 2728

  Fly  2407 PNVTMSTMMGPGPGGVVGQVPPYARQQSAGGGKPGVLNTQQQFQQQQQQQQQLRHQMMQLQGMGG 2471
            |||||..|     |...|.||||.||    ||||||.....|.||||.|||::|..|.|..||| 
Mosquito  2729 PNVTMGNM-----GVNQGAVPPYPRQ----GGKPGVGGNMPQNQQQQFQQQRMRLIMQQHSGMG- 2783

  Fly  2472 GAGGGMGAGPQQGGGAVGGGAGGGMVPQQQSMNQQQTPNLVAQLQRQ-----NMMGQQ-QYQPPP 2530
                            .||.|.|.|..|.|.|:.|||||||||||||     |||||| .:|||.
Mosquito  2784 ----------------QGGNAQGMMQNQGQGMSTQQTPNLVAQLQRQMPNQNNMMGQQYPHQPPQ 2832

  Fly  2531 Y 2531
            |
Mosquito  2833 Y 2833

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ktoNP_524786.1 Med12 97..157 CDD:462818 46/59 (78%)
Med12-LCEWAV 390..856 CDD:463472 260/560 (46%)
ktoXP_061506997.1 None

Return to query results.
Submit another query.