DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kto and MED12L

DIOPT Version :9

Sequence 1:	NP_524786.1	Gene:	kto / 44830	FlyBaseID:	FBgn0001324	Length:	2531	Species:	Drosophila melanogaster
Sequence 2:	XP_016861165.1	Gene:	MED12L / 116931	HGNCID:	16050	Length:	2197	Species:	Homo sapiens

Alignment Length:	2581	Identity:	902/2581 - (34%)
Similarity:	1241/2581 - (48%)	Gaps:	592/2581 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 EKRPLKRTRLGPPDIYPQDAKQREDELTPTNVKHGFTTTPPLS-DEFGTAHNSNVNASKVSAFFS 70
            |:|||||.||||||:||||.||:|||||..|||.||...|..: ||.|:|.|..:|.||:.|:||
Human    10 EQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFS 74

  Fly    71 GVLAKKEELMTLPDTGRKKQQINCKDNFWPVSPRRKCTVDAWFKDLAGNKPLLSLAKRAPSFNKK 135
            .:||:|.:|.|..|||:||.|:|.|||:|.|:.|.:..:.:||.||||||||..|||:.|..:||
Human    75 SILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLSILAKKVPILSKK 139

  Fly   136 EEIFITLCENQVNMQRATWFIKLSAAYTLSFTESKNKKRSIYDPAAEWTGNMIKFMKELLPKLQE 200
            |::|..|.:..|.|.||||.||::.||..:.:|:|.|||...||..|||....::::|.|.|:.:
Human   140 EDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQAPDPNLEWTQISTRYLREQLAKISD 204

  Fly   201 YYQQNHDKSSSNGTTSGSLTAAGNGPASNGSTGTSSINSVTGSSASTNVIPVPSMASPLPPIHSP 265
            :|   |..||:           |:||.                              |:||
Human   205 FY---HMASST-----------GDGPV------------------------------PVPP---- 221

  Fly   266 ANGQQAAPGGGVNAGSVMPTTGSLGGVVGGPGSSVVGGAAGAGAAVPPGSTISGIGSQFEDSRNA 330
                                                                        :...|
Human   222 ------------------------------------------------------------EVEQA 226

  Fly   331 LKYWKYCHQLSKYMYEESLLDRQEFLNWILDLLDKMRTQASFDEPLKKLVLSFALQYMHDFVQSE 395
            :|.|:|..:|:.:|::|.:|::.|:|.||||:|:|:|   ..|:.|.||:|...|||..:||||.
Human   227 MKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIR---PMDDDLLKLLLPLMLQYSDEFVQSA 288

  Fly   396 RLCRKMAYIVSKKLAQLLNTVVEQQTIKELDEPKL---------------------------QQD 433
            .|.|::||..:::|:.||:           |.|.|                           ...
Human   289 YLSRRLAYFCARRLSLLLS-----------DSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMS 342

  Fly   434 PYELALQEQMSCPHHRDIVLYLSTILQIITIECPTALVWSGIAAHRAPSSLLGSPLDHLPLAPSV 498
            |.:||..:.:||..|..:|..||.:||.:|:.||:||||: .:.:...|:..|||||.|.:|||.
Human   343 PVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWN-YSTNENKSANPGSPLDLLQVAPSS 406

  Fly   499 LPMPTRCPRTNHEIRRQLRAAESDIVLRTQHAEQRWFAAKW--LSAGKNQYTSVLATLDHLDTHC 561
            ||||......|.::|.::...|..|..|.:..|.||...|.  .:||.. .:.||.||:.||.||
Human   407 LPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVT-ISRVLHTLEVLDRHC 470

  Fly   562 FDRMEHNNSIDTLYAQIFPSPTVSRRREEDQVEPRPPYEPKQDKDTVRILCEWAVSGQRWGEHRA 626
            |||.:.:||::|||.:||   ..::.::..:|.|       .|:..|.:|||||||.:|.|:|||
Human   471 FDRTDSSNSMETLYHKIF---WANQNKDNQEVAP-------NDEAVVTLLCEWAVSCKRSGKHRA 525

  Fly   627 MVVAILLDKRQIDVTSTPADQQSSDKDDKDSLASGAGLIDGLPVFQHVLMHFLDHDAPVLDEHVS 691
            |.||.||:|||.::.:.... :|...|:|:|::|.:.....|||||:||:.|||..||.|.: .:
Human   526 MAVAKLLEKRQAEIEAERCG-ESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSD-PN 588

  Fly   692 SPQQRTEFTNLVQLFSALIRHDVFSHNAYMHTLISRGDLLLESVLVIKSGTTATKTSPPPPAPPP 756
            |..::.||.|||.||...||||||||:|||.||||||||           :....|.|..|....
Human   589 SECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDL-----------SVTASTRPRSPVGEN 642

  Fly   757 TTTHGFDDDGFGGGLDFK--------HNEFDD--SNVDDDLDKLVQNIK-EKGQQHEAPDSPKIG 810
            ...|...|.      |.|        |...|.  :|:.|::||  .:.| :.|.:.     |...
Human   643 ADEHYSKDH------DVKMEEQSIMAHMGIDSGTTNIFDEVDK--SDFKTDFGSEF-----PIFS 694

  Fly   811 P-PGDGETNPGGSIS----------------------------RHYVYTKHFPIPQDDPSMSSYS 846
            | ||:...|...|:.                            ||..|..|||||.|:.|    |
Human   695 PMPGESCENANTSLGRRMSVNCEKLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESS----S 755

  Fly   847 SESNQRYILLFGVGKERDEKKHAVKKMSKEIGKLFTKKFSIDVAAAGHVKKHSRNEF----NFEA 907
            .|.|||.|||:||||||||.:|.:||::|:|.|:..||.:.:.......:|..:|:.    ..|.
Human   756 HECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLET 820

  Fly   908 TTSKCQQMAYFDQHVVTAQCAANVLEQLNGFALGNNNYLPVQEHVAFLFDLMELALNIYSLLELC 972
            ..:|.|.::|||||.||:|.:.|||||:..||.|.:.:||:..|:..:|||||.||||..|::..
Human   821 VFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFA 885

  Fly   973 DSLLKELPEVEHQLQLKKSNLVRSYTTSLALYIVSILRRYHSCLLLSPEQTLSVFEGVCRTIRHV 1037
            ..||.||..||.:|.||.|:|..||||.|.:.||::||||||||:|:|:||..||||:|..::||
Human   886 IQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHV 950

  Fly  1038 SNPSECTSAERCIIAYLSDLHESCVLLQGKEQSTEYYQQL---QCIKRFKDIFNT--PEQLDLPP 1097
            .|||||:|.||||:|||.||:.||..|:.|      :..|   .|.|..:.|:|.  |...:|
Human   951 VNPSECSSPERCILAYLYDLYVSCSHLRSK------FGDLFSSACSKVKQTIYNNVMPANSNL-- 1007

  Fly  1098 QGYNPLLLQELFMAPRRGGKLDPHWLG-TLHESPANVYSFVSNALIAVCR-ETDNERLNDVALAC 1160
             .::|..:.:....| ....::...|| .|.::.||.||||.|.|:.||. ..|..|:||:|...
Human  1008 -RWDPDFMMDFIENP-SARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFS 1070

  Fly  1161 AELTASCNVLSEEWIYALQSLCSGSKSPRYPHLGG------QVDIGQLKTHNALAVFVCILVARH 1219
            :||||.|.|||.||:..|::||..|.     |:.|      .||:..|..|::||.|:.||:||.
Human  1071 SELTACCTVLSSEWLGVLKALCCSSN-----HVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQ 1130

  Fly  1220 CFSLADFVSKFALPTLARSVSAGGAELSVDAEAGARLTCHLVLKLFKTLE---IPQPGMYSVSTS 1281
            ||||.|.|...|||:|. :.:.|.|    |||.|||:||.|:|.||:..:   :||
Human  1131 CFSLEDVVQHVALPSLL-AAACGDA----DAEPGARMTCRLLLHLFRAPQACFLPQ--------- 1181

  Fly  1282 PNPLHAVGNDF-SIRLSCDRHLLVGAHKTIPIAAVLAVLKAILIVVDNAALKTPLASGSGTSSGG 1345
                 |.|..| .||.|||||||..||.:|.:.||.||||||:::.| |.:.....|........
Human  1182 -----ATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGD-AKIGNNSVSSLKNDDFT 1240

  Fly  1346 LGGAFGSGKRSGFNTPVHPGSTPKSNEQRPADLSQILGTSDLQLGSSLTSEPEALQQPSVGGMEQ 1410
            :.|....|......|   ....|||                  .|.|::             :|.
Human  1241 MRGLRCDGNADDIWT---ASQNPKS------------------CGKSIS-------------IET 1271

  Fly  1411 ISLLEFAQAVLKQICAQEHVLERCLKNAEQLC---DMIIDEMLTAKQAQRVLHMICYPEPEFNII 1472
            .:|.|:|:.||:.||.||.|.|.|||..|:||   ::|:|.:|:..|||::|.:||||. .....
Human  1272 ANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPH-GIKEC 1335

  Fly  1473 SELD--QRSMIVRILENLGQWTLRISWLDLQLMYRQSLSNN-----AELNVWLDTVARAAIDVFH 1530
            :|.|  ||..|.|||:||.|||||.|||:||||.:|.|.:.     ||:|..||.:|:|.|:||.
Human  1336 TEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQ 1400

  Fly  1531 ME-----------EVVLPGAVKA---------------THKPKPSTWLVAPLIAKLTPAVQGRIL 1569
            ..           .:..|.::.:               :...:...||||||||:|..:||||:|
Human  1401 QSADLNNSSNSGMSLFNPNSIGSADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVL 1465

  Fly  1570 RVAGQVLESMNYFSKVSKSDCNSSGSGDEREKSNSCHSSNSYGLGGVPARNKKMPLDYQPFLGLI 1634
            :.||:.||...:.           ||..::|:......|.|.             |..||||.|:
Human  1466 KAAGEELEKGQHL-----------GSSSKKERDRQKQKSMSL-------------LSQQPFLSLV 1506

  Fly  1635 LTCLKGQDEYKENLLVSLYAQLSQCLQSFAELDTIGGIDEPQAREEILDALQLRFSLVGGMFEAI 1699
            |||||||||.:|.||.||..|::|.|.::.|...   .|:.:||:.:.:|||||.:||||||:.:
Human  1507 LTCLKGQDEQREGLLTSLQNQVNQILSNWREERY---QDDIKARQMMHEALQLRLNLVGGMFDTV 1568

  Fly  1700 QKNSTPTTDWAILLAQLVCQGVVDLSCNRELFTTVVDMLATLVHSTLVSD-----------DERH 1753
            |:::..|||||:||.|::..|.||:..|.||||||:|||..|::.||.||           ::|.
Human  1569 QRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRA 1633

  Fly  1754 YMNLMKKLKKEIGEKNNASIRVIRQLLPLYKQPTEVIACEHSG--MDTKGNKIC---DIDKKQ-L 1812
            ||||:||||||:|:|.:.||..:||||||.||..:||.||..|  :|||||||.   .||||| |
Human  1634 YMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGL 1698

  Fly  1813 RISDKQRISVWDILEGHKNPAPLSWVWFGAVKLERKPLTYEEAHRNLKYHTHSLVKPSSYYYEPL 1877
            ::|.||::|.||:.||.||||||||.|||.|:::|:.:.|||.|..|.||||.:.||.|||.:||
Human  1699 QVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYHTHPMPKPRSYYLQPL 1763

  Fly  1878 PLPPEDIEPVPEKICIKDEMKADTPSSVDQSP---SAVV---GGTGRGRGKGTTTRKRKPKN--- 1933
            |||||:.|..|             .|.|.|.|   ||.:   |.|.....|.|..||||.|:
Human  1764 PLPPEEEEEEP-------------TSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSR 1815

  Fly  1934 -------------PKTPPVVNTQQQQPQ-------LAQQPQQPQ-NVQQQQLQQQQQQ------- 1970
                         |...|:.:.....||       |..|||||. .:|.|.|.....:
Human  1816 VDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGFFLQNQSLTPGGSRLDPAGSF 1880

  Fly  1971 -QQHMQQQHMQQQQMQPNQMGQMPMNMPMNMQQFAPNPNNMMQQNAMLQQQQQQQMQQMGNNPMQ 2034
             ..:.:|......|.:...|.|.|....:..||      .::|...:.|||||:.::|....|.|
Human  1881 VPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQ------QLIQMKLLQQQQQQRLLRQAQTRPFQ 1939

  Fly  2035 QQLNVGGGNGQPNPQMNFMQQGPGGGGAGPQGMPGQQQQWHNAPQQQQPPQPYHNQYAPHQQNMQ 2099
            |..        .|..::.::...     ...|.||.|.....|   |..|.|...||
Human  1940 QDF--------CNSAVSLLEDFD-----NIMGQPGDQAALFAA---QARPSPQLPQY-------- 1980

  Fly  2100 SNRIERPPLNANSKQALSQMLRQRQPFQQQAQQGPGGGFNPMQQQP--QASQQQPGPQQQMNPNQ 2162
                                     |..||||..|.|......|.|  |.||||.| ...::|:.
Human  1981 -------------------------PGLQQAQTMPQGYTMYGTQMPLQQTSQQQAG-SVVLSPSY 2019

  Fly  2163 MRQQQMNPQQNPQSVAAFNAMQQQPQQNAQQQQMNPNQQQQQQFMRGGNMRPGMAPNQMNQMNMG 2227
            ..:.......||..:.....:||||....|||                 ..|.:.|...:| .:.
Human  2020 NSRAYPAAHSNPVLMERLRQIQQQPSGYVQQQ-----------------ASPYLQPLTGSQ-RLN 2066

  Fly  2228 GQGMSQNPMMQQQIPQNMVGMVNPNANQMMQSGGAQGGNGVGVGVGVGVGGAGNNPNMGMGGMPQ 2292
            .|.:.|:|:                                 ||.|:.......:||:....:||
Human  2067 HQALQQSPL---------------------------------VGGGIDAVLTSAHPNLPSVPLPQ 2098

  Fly  2293 QGMIQQQPQQQPQQQVQFQNFQNQYQQQQQQGMQQQGGGAGVGVGVGMAPNQQQQQQANMMG--N 2355
            ..|..:|||.:.||::.      |.||.||...||.           ..|.|..|.|:..:|  .
Human  2099 DPMRPRQPQVRQQQRLL------QMQQPQQPQPQQP-----------PQPQQSSQSQSQTLGLQA 2146

  Fly  2356 FNPQM----QQGNRNNPDFMAAAAVAQQQQQQ----QQQQRVVPGG 2393
            ..||.    :||.:........||:.:|.|:|    |.||.|.|.|
Human  2147 MQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYG 2192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kto	NP_524786.1	Med12	99..157	CDD:286572	28/57 (49%)
kto	NP_524786.1	Med12-LCEWAV	390..856	CDD:288959	181/534 (34%)
MED12L	XP_016861165.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141343
Domainoid	1	1.000	714	1.000	Domainoid score	I117
eggNOG	1	0.900	-	-		E1_KOG3598
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H43143
Inparanoid	1	1.050	1250	1.000	Inparanoid score	I178
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45902
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004348
OrthoInspector	1	1.000	-	-		otm42165
orthoMCL	1	0.900	-	-		OOG6_105637
Panther	1	1.100	-	-	O	PTHR46007
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2630
SonicParanoid	1	1.000	-	-		X4125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790