Protein Alignment g and AP3D1

DIOPT Version :9

• Sequence 1: NP_524785.2
• Gene: g / 44819
• FlyBaseID: FBgn0001087
• Length: 1034
• Species: Drosophila melanogaster
• Sequence 2: NP_001248755.1
• Gene: AP3D1 / 8943
• HGNCID: 568
• Length: 1215
• Species: Homo sapiens
• Alignment Length: 1060
• Identity: 582/1060 - (54%)
• Similarity: 733/1060 - (69%)
• Gaps: 108/1060 - (10%)

  Fly     1 MALKKVKGNFFERMFDKNLTDLVRGIRNNKDNEAKYISTCIEEIKQELRQDNISVKCNAVAKLTY 65
            ||||.|||: .:|||||||.||||||||:|::||||||.||:||||||:||||:||.|||.||||
Human     1 MALKMVKGS-IDRMFDKNLQDLVRGIRNHKEDEAKYISQCIDEIKQELKQDNIAVKANAVCKLTY 64

  Fly    66 IQMLGYDISWAGFNIIEVMSSSRFTCKRIGYLAASQCFHPDSELLMLTTNMIRKDLNSQNQYDAG 130
            :||||||||||.||||||||:|:||.||||||||||.||..::::|||||.|||||:|.:|||.|
Human    65 LQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTG 129

  Fly   131 VALSGLSCFISPDLSRDLANDIMTLMSSTKPYLRMKAVLMMYKVFLRYPEALRPAFPKLKEKLED 195
            |||:|||||::|||:||||||||||||.||||:|.||||:||||||:|||:||||||:|||||||
Human   130 VALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLED 194

  Fly   196 PDPGVQSAAVNVICELARKNPKNYLPLAPIFFKLMTTSTNNWMLIKIIKLFGALTPLEPRLGKKL 260
            ||||||||||||||||||:||||||.|||:||||||:|||||:||||||||||||||||||||||
Human   195 PDPGVQSAAVNVICELARRNPKNYLSLAPLFFKLMTSSTNNWVLIKIIKLFGALTPLEPRLGKKL 259

  Fly   261 IEPLTNLIHSTSAMSLLYECINTVIAVLISISSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGL 325
            ||||||||||||||||||||:|||||||||:||||||||||||||||||||||||||||||||||
Human   260 IEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGL 324

  Fly   326 LAMSKILKTHPKSVQAHKDLILACLDDKDESIRLRALDLLYGMVSKKNLMEIVKRLLGHMERAEG 390
            |||||||||||||||:||||||.|||||||||||||||||||||||||||||||:|:.|:::|||
Human   325 LAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEG 389

  Fly   391 SAYRDELLYKVIEICAQSSYLYVTNFEWYLTVLVELIQLEAGSRHGRLIAEQLLDVAIRVPVVRQ 455
            :.||||||.|:|:||:||:|.|:||||||:::||||.:|| |:|||.|||.|:|||||||..:|:
Human   390 TTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLE-GTRHGHLIAAQMLDVAIRVKAIRK 453

  Fly   456 FAVNEMTNLLDT---FTVSAQSNSMYEVLYAAAWIVGEFAGELEDAEKTLNILLRPRL--LPGHI 515
            |||::|:.|||:   ...|.|.|.:.|||||||||.|||:..|::...||..:||||:  |||||
Human   454 FAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQEPHHTLEAMLRPRVTTLPGHI 518

  Fly   516 QGVYVQNVIKLFARLATTCLELQDLPGLVTLCDHVLDKLQHFNGSSDIEVQERANSACMLIEMLR 580
            |.||||||:||:|.:.....:..:..|...:...::|:|..|..|:|:||||||:....|::.::
Human   519 QAVYVQNVVKLYASILQQKEQAGEAEGAQAVTQLMVDRLPQFVQSADLEVQERASCILQLVKHIQ 583

  Fly   581 NQLSTSTDAMAMDTTTEGGIPPLAIEIVQEMTLLFTGELIPVAPKAQRKVPLPDGLDLDEWINAP 645
            .       ..|.|           :.:.:|::.||.|||.|||||||:|||:|:|||||.|||.|
Human   584 K-------LQAKD-----------VPVAEEVSALFAGELNPVAPKAQKKVPVPEGLDLDAWINEP 630

  Fly   646 PPEDAASSSSSEHDKDE-LFVSATQAGTGADGGEKRRQSLELTPEQLERQRMARLIEQSNNPHYL 709
                 .|.|.||.::.. :|....|.      ..|.|.| |...|:|.|:|.||..||:|||.|:
Human   631 -----LSDSESEDERPRAVFHEEEQR------RPKHRPS-EADEEELARRREARKQEQANNPFYI 683

  Fly   710 KSTPTASGASNADQYDN---IDDIPITELPLDMEGVAALRVGITKRSDKYLQ-EQQAAQGSKDGK 770
            ||:|     |...:|.:   ::.||:.::.|.:    .|:|.....||:|:: |::.....|..|
Human   684 KSSP-----SPQKRYQDTPGVEHIPVVQIDLSV----PLKVPGLPMSDQYVKLEEERRHRQKLEK 739

  Fly   771 KKHKKGKKSKKAKNKVAYNS-SSESEGEPKPLHIVN-TTLDMPEGVSMSDSEDKDGKYDPNDPHR 833
            .|.:|.:|.|:.|.|..::| .:||:.:..|...|: .|.:|||....||.:||    |||||:|
Human   740 DKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDK----DPNDPYR 800

  Fly   834 ALDIELDITEFEAPAVRSASKKSAADKENL-----------KTPADSAGGGNAAKKDRKKDKDKD 887
            ||||:||              |..||.|.|           |:|....   ...:|..||.|.|:
Human   801 ALDIDLD--------------KPLADSEKLPIQKHRNTETSKSPEKDV---PMVEKKSKKPKKKE 848

  Fly   888 KERKVKREHRESKRERKEAAVQSVIDLIDADTPTPSPSHISA---TSNNNNTSTVLPDAPKHHKK 949
            |:.|.|...:|.|:|:::.|..  :|...:.||.|:|:...|   ::...:.:||  ..||
Human   849 KKHKEKERDKEKKKEKEKKAED--LDFWLSTTPPPAPAPAPAPVPSTGELSVNTV--TTPK---- 905

  Fly   950 KKNKEKTTDEAPDALATATGSSIIDVGGEEASEVASKVHKKKHKKEKSQRKEKKKASESASVSAI 1014
                    ||..||...|.|.. .|..|::..:.:.|..||||:|||.:|.:.||.|:.....:.
Human   906 --------DECEDAKTEAQGEE-DDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSE 961

  Fly  1015 VSIGDYEQPLGISTPSKEIL 1034
            .:.|   :|:....|.:|.|
Human   962 EAAG---EPVQNGAPEEEQL 978

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
g	NP_524785.2	Adaptin_N	33..578	CDD:279882	408/549 (74%)
		HEAT repeat	152..173	CDD:293787	16/20 (80%)
		HEAT repeat	185..213	CDD:293787	26/27 (96%)
		Cnd1	<193..266	CDD:289487	67/72 (93%)
		HEAT repeat	221..263	CDD:293787	37/41 (90%)
		HEAT repeat	272..290	CDD:293787	16/17 (94%)
		HEAT repeat	302..331	CDD:293787	28/28 (100%)
		BLVR	687..840	CDD:283923	57/158 (36%)
AP3D1	NP_001248755.1	Adaptin_N	32..581	CDD:279882	408/549 (74%)
		HEAT repeat	151..172	CDD:293787	16/20 (80%)
		Cnd1	155..265	CDD:289487	97/109 (89%)
		HEAT repeat	184..212	CDD:293787	26/27 (96%)
		HEAT repeat	220..262	CDD:293787	37/41 (90%)
		HEAT repeat	271..292	CDD:293787	18/20 (90%)
		HEAT repeat	301..330	CDD:293787	28/28 (100%)
		HEAT repeat	335..364	CDD:293787	26/28 (93%)
		BLVR	661..807	CDD:283923	57/158 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152617
Domainoid	1	1.000	805	1.000	Domainoid score	I72
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	984	1.000	Inparanoid score	I310
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52588
OrthoDB	1	1.010	-	-		D163216at33208
OrthoFinder	1	1.000	-	-		FOG0005167
OrthoInspector	1	1.000	-	-		oto89116
orthoMCL	1	0.900	-	-		OOG6_102126
Panther	1	1.100	-	-	LDO	PTHR22781
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R64
SonicParanoid	1	1.000	-	-		X3686
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.900