DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment g and APL5

DIOPT Version :9

Sequence 1:NP_524785.2 Gene:g / 44819 FlyBaseID:FBgn0001087 Length:1034 Species:Drosophila melanogaster
Sequence 2:NP_015129.1 Gene:APL5 / 855906 SGDID:S000006116 Length:932 Species:Saccharomyces cerevisiae


Alignment Length:965 Identity:280/965 - (29%)
Similarity:482/965 - (49%) Gaps:141/965 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 FERMFDKNLTDLVRGIRNNKDNEAK---YISTCIEEIKQELRQDNISVKCNAVAKLTYIQMLGYD 72
            |...|:|:|.||::|||::.:...|   :....:.|.::|:...:::.|.|||.||||::|.|:|
Yeast    19 FGFFFEKSLKDLIKGIRSHNETPEKLDQFFKQVLSECREEVNSPDLNSKTNAVLKLTYLEMYGFD 83

  Fly    73 ISWAGFNIIEVMSSSRFTCKRIGYLAASQCFHPDSELLMLTTNMIRKDLNSQNQYD---AGVALS 134
            ::|..|:|:|||||::...||:|||||||.|:.||::|||.||:::|||......|   .|:|||
Yeast    84 MAWCNFHILEVMSSNKLQQKRVGYLAASQSFYKDSDILMLATNLLKKDLKYDGNNDVVKVGIALS 148

  Fly   135 GLSCFISPDLSRDLANDIMTLMSSTKPYLRMKAVLMMYKVFLRYPEALRPAFPKLKEKLEDPDPG 199
            |||..|:|.|:||:|:|:.|:::||:||:|.||:..::||||:||||||..|.|...||:|.|..
Yeast   149 GLSTIITPSLARDIADDLFTMLNSTRPYIRKKAITALFKVFLQYPEALRDNFDKFVSKLDDDDIS 213

  Fly   200 VQSAAVNVICELARKNPKNYLPLAPIFFKLMTTSTNNWMLIKIIKLFGALTPLEPRLGKKLIEPL 264
            |.||||:|||||::|||:.::.|:|:.::::.|..|||::|:::|||..|:.:||:|..||:..:
Yeast   214 VVSAAVSVICELSKKNPQPFIQLSPLLYEILVTIDNNWIIIRLLKLFTNLSQVEPKLRAKLLPKI 278

  Fly   265 TNLIHSTSAMSLLYECINTVIAVLISISSGM--PNHSASIQLCVQKLRILIEDSDQNLKYLGLLA 327
            ..|:.||.|.|::||.:|.:      :...|  .:...:...|:::|....:..|.||:|:..:.
Yeast   279 LELMESTVATSVIYESVNCI------VKGNMLEEDDFETAMACLERLHTFCDSQDPNLRYISCIL 337

  Fly   328 MSKILKTHPKSVQAHKDLILACLDDKDESIRLRALDLLYGMVSKKNLMEIVKRLLGHMERAE--- 389
            ..||.|.:...:.....||:..|.|.|.|||.:|::|:.|:|.:.||..||:.|:......:   
Yeast   338 FYKIGKINTDFISRFDQLIIRLLSDVDVSIRSKAIELVEGIVDEDNLKAIVQTLMKQFVDEDVVI 402

  Fly   390 ---GSA---------------YRDELLYKVIEICAQSSYLYVTNFEWYLTVLVELIQL------- 429
               ||.               |:.:::..:|.||:..:|..|.:||||..|:::|..|       
Yeast   403 LQTGSIVYEKSKRIPIIIPENYKIKMVNVIISICSADNYSSVNDFEWYNAVIMDLAMLCQDISDK 467

  Fly   430 EAGSRHGRLIAEQLLDVAIRVPVVRQFAVNEMTNLLDTFTVSAQSNSMYEVLYAAAWIVGEFAGE 494
            ..||:    |.||..::.|:||.:|:..:..:..|:....::.|   :..||....|.:|||:..
Yeast   468 SLGSK----IGEQFRNLMIKVPSMREVTIANIIKLISNDNINKQ---LPTVLRECIWCLGEFSTL 525

  Fly   495 LEDAEKTLNILLRPRLLPGH-IQGVYVQNVIKLFARLATTCLELQDLPGLVTLCDHVLDKLQHFN 558
            :|:....:.|:........| :|.|.:..::|:|:.......|.:... :..:...:::..::.:
Yeast   526 VENGNDLIKIMTENISYYSHSVQEVLILALVKVFSNWCNNFQEDKRFE-IKMVLKELIEFFENLS 589

  Fly   559 GSSDIEVQERANSACMLIEMLRNQLSTSTDAMAMDTTTEGGIPPLAIEIVQEMTLLFTGELIPVA 623
            .||..|||||   :..::|.||..|.      |::..|| |:|.|..|::......:  ||.|:|
Yeast   590 YSSTFEVQER---SVEVLEFLRLSLE------ALEEDTE-GLPMLLSEVLPSFFNAY--ELAPIA 642

  Fly   624 PKAQRKVPLPDGLDL----------DEWINAPPPEDAASSSSSEHDKDE----LFVSATQAGTGA 674
            ...|.|:.:.:.|||          ||.:: ....||.|...|:...||    .||.      .:
Yeast   643 RGTQLKLAVDENLDLETPFLTKEAADELLD-EQKSDAISDLMSDISMDEQVELKFVD------DS 700

  Fly   675 DGGEKRRQSLE--LTPEQLERQRMARLIEQSNNPHYLKSTPTASGASNADQYDNIDDIPITELPL 737
            |...:.::.|:  ..|.::||::     |:.:||:||       |..:.::..|..|:    |.|
Yeast   701 DTSYEEKEKLDDFENPFEIEREK-----ERMSNPYYL-------GEEDEERTKNSKDL----LDL 749

  Fly   738 DMEGVA-----ALRVGITKRSDKYLQEQQAAQGSKDGKKKHKKGKKSKKA-------------KN 784
            :.|..:     .:|:   .|:|..|  ...:..:.:..:|.|||||..:.             |.
Yeast   750 NEEESSDKKPETIRL---NRTDNSL--NSLSLSTTEISRKKKKGKKKNRVQVLSDEPVIEAAPKR 809

  Fly   785 KVAYNSSSESEGEPKPLHIVNTTLDMPEGVSMSD-----SEDKDGKYDPNDPHRALDIELDITEF 844
            |.|:....::.....||......|.|...:...|     .....|:....:.:...:.||:::..
Yeast   810 KDAFQKPHDNHSTQNPLKKDKINLRMHSQLENFDFSNFGQSSNAGRGSQEEGNLRKEDELELSRL 874

  Fly   845 EAPAVRSASKKSAADKENLKTPADSAGGGNAAKKDRKKDKDKDKERKVKREHRES 899
            ||..:....|.:.:|.|.:           ...|.:||.|....:.|:|.:.:.|
Yeast   875 EANLIVKDEKDNLSDTEEV-----------IVIKKKKKGKKSKSKNKLKTKAKNS 918

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
gNP_524785.2 Adaptin_N 33..578 CDD:279882 192/581 (33%)
HEAT repeat 152..173 CDD:293787 8/20 (40%)
HEAT repeat 185..213 CDD:293787 16/27 (59%)
Cnd1 <193..266 CDD:289487 32/72 (44%)
HEAT repeat 221..263 CDD:293787 16/41 (39%)
HEAT repeat 272..290 CDD:293787 5/17 (29%)
HEAT repeat 302..331 CDD:293787 6/28 (21%)
BLVR 687..840 CDD:283923 34/175 (19%)
APL5NP_015129.1 Adaptin_N 45..610 CDD:396262 194/581 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157344844
Domainoid 1 1.000 337 1.000 Domainoid score I161
eggNOG 1 0.900 - - E1_COG4354
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 386 1.000 Inparanoid score I333
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0005167
OrthoInspector 1 1.000 - - oto99258
orthoMCL 1 0.900 - - OOG6_102126
Panther 1 1.100 - - LDO PTHR22781
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R64
SonicParanoid 1 1.000 - - X3686
TreeFam 1 0.960 - -
1312.780

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