DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment g and APL3

DIOPT Version :9

Sequence 1:	NP_524785.2	Gene:	g / 44819	FlyBaseID:	FBgn0001087	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	NP_009516.1	Gene:	APL3 / 852243	SGDID:	S000000133	Length:	1025	Species:	Saccharomyces cerevisiae

Alignment Length:	990	Identity:	196/990 - (19%)
Similarity:	347/990 - (35%)	Gaps:	310/990 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LTDLVRGIRNNKDNEAKYISTCIEEIKQEL-----RQDNIS-----VKCNAVAKLTYIQMLG--- 70
            :.|| |..:..::.| |.|.:.|.:|||..     :|.|..     .:...||||.||.:..
Yeast    26 IADL-RSAQQAQEQE-KRIQSEIVKIKQHFDAAKKKQGNHDRLGGYQRKKYVAKLAYIYITSNTT 88

  Fly    71 --YDISWAGFNIIEVMSSSRFTCKRIGYLAASQCFH----------------------PDSELLM 111
              .:|.:.....:|::.||.|:.|.|||:.....:.                      .|...:|
Yeast    89 KLNEILFGLEQTVELLKSSIFSEKFIGYMTLELLYERSEVVAKVNDEVNYQLMKDLSSSDDNFVM 153

  Fly   112 LTTNMIR--KDLNSQNQYD----AGV-----------------ALSGLS------CFISPDLSRD 147
            |..|.:.  .:|.::..|:    .||                 |||.|:      ..::.||.|.
Yeast   154 LALNFVGVVGELTNRLAYNDDITTGVFKILRSPTSSIYLKKKSALSFLALLKSNHSILTEDLQRK 218

  Fly   148 --LANDIMTLMSSTKPYLRMKAVLMMYKVFLRY--PEALRPAFPKLKEKLEDPDPGVQSAAVNVI 208
              ....|::|:..|:.|....|.:.:.:...:|  |.......|:|.|.|           .|.:
Yeast   219 QLWIQRILSLLDDTENYRLTLATIPLIEFIAKYIDPSYCTRLLPQLTEIL-----------YNCV 272

  Fly   209 CELARKNPKNYLPLAPIFFKLMTTSTNNWMLIKIIKLFGAL--TPLEPRLGKKLIEPLTNLIHST 271
            .....::..|..||...|..:    .|.|::.|::.|...|  :|.|...|..|   .||.| ..
Yeast   273 VVGTSRSSDNQFPLEYTFANM----PNPWLITKVVSLLSILIASPTERDSGSLL---QTNNI-DN 329

  Fly   272 SAMSLLYECI--------------------NTVIAVLISISSGMPNHSASIQLCVQKLRILIEDS 316
            ..::.|.:|:                    |||:..||:.:|.:.....:|...|..|..|:...
Yeast   330 ELLNKLRKCVSVAIELGTRQAQDPMERIVQNTVLFSLINFASKLDPSDEAISNSVTALCSLLTSK 394

  Fly   317 DQNLKYLGLLAMSKILKTHPK-SVQA----HKDLILACLD-DKDESIRLRALDLLYGMVSKKNLM 375
            :.|::||.|.::.|:..:..| ::.|    :.|:|...|: ::|.||..:.:||||.....:|:.
Yeast   395 EINIRYLTLDSLVKLCSSSGKPAIDAVRYKNLDMIFHLLNTERDSSIVRKVVDLLYTFTDVENVK 459

  Fly   376 EIVKRLLGHMERAEGSA---YRDELLYKVIEICAQSSYLYVTNFEWYLTVLVELIQLEAGSR-HG 436
            .||..||.::...:..|   .:.::..|:..:..:    |.|:..|::.:.::|:.|.:.:. :.
Yeast   460 IIVDGLLQYILSPKNLAEPQIKSDIAVKIAILTEK----YATDINWFVIISLQLLSLTSNTTIND 520

  Fly   437 RLIAEQLLDVAIRVPVVRQFAVNEMTNLLDTFTVSAQSNSMYEVLYAAAWIVGEFAGELEDAEKT 501
            ..|.::|..:.:..|.:.:.....:.:.|      .:..:...::.|||:::||::..:.|...:
Yeast   521 DEIWQRLCQIVVNNPSLHRITCERLVDYL------CKKQASEAIIKAAAFLLGEYSSLITDRISS 579

  Fly   502 LNILL--------RPRLLPGHIQGVYVQ----------NVIKLFARLATTCLELQDLPGLVTLCD 548
            .|:..        .|.:....|....::          ||||.|.      |||..|
Yeast   580 ANLFTLFAEKYFSAPNVAKAMILTTMIKLYKTSPEIGSNVIKFFQ------LELNSL-------- 630

  Fly   549 HVLDKLQHFNGSSDIEVQERANSACMLIEMLRNQLSTSTDAMAMDTTTEGGIPPLAIEIVQEMTL 613
                         |||:|.|:.....:|::.:  ::.:||               .::|:.|...
Yeast   631 -------------DIELQTRSFEYLNIIQLAK--VNGNTD---------------ILQILFEPMP 665

  Fly   614 LFTGELIPVAPKAQRKVPLPDGLDLDEWINAPPPEDAASSSSSEHDKDELFVSATQAGTGADGGE 678
            .|..:..|:   .:|...||........||.|   ..||||
Yeast   666 PFNSKSNPL---LKRLGSLPASAGSTTLINTP---SEASSS------------------------ 700

  Fly   679 KRRQSLELTPEQL-ERQRMARLIEQSNNPHYLKSTPTASGASNADQYDNIDD----IPITELPLD 738
                    ||:.| :|...:|.|.....|...::|              |||    |..:|   |
Yeast   701 --------TPDLLSKRANSSRSIMVPMPPPSRRNT--------------IDDVNSKISSSE---D 740

  Fly   739 MEGVAALRVGITKRSDKYLQEQQAAQGSKDGKKK---HKKGKKSKKAKNKVAYNSSSESEGEPKP 800
            ..|           .|.|...|..|...::|..:   ||:|.....:..||.|..::....:|..
Yeast   741 FSG-----------KDSYYSRQILAPNWREGFTRMISHKQGVLFTSSLMKVFYRITTPDAQQPYV 794

  Fly   801 LHI----VNTTLDMPEGVSMSDSEDKDGKYDPNDPHRALDIELDITEFEAPAVRSASKKSAADKE 861
            .||    :|.|                              |.:||......:.|   |:..:.|
Yeast   795 FHISLAFINLT------------------------------EWEITGLSTQIIPS---KTQGNPE 826

  Fly   862 ----NLKTPADSAGG 872
                |:.||:.:..|
Yeast   827 YLIMNINTPSTATIG 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
g	NP_524785.2	Adaptin_N	33..578	CDD:279882	136/664 (20%)
		HEAT repeat	152..173	CDD:293787	5/20 (25%)
		HEAT repeat	185..213	CDD:293787	5/27 (19%)
		Cnd1	<193..266	CDD:289487	15/74 (20%)
		HEAT repeat	221..263	CDD:293787	12/43 (28%)
		HEAT repeat	272..290	CDD:293787	6/37 (16%)
		HEAT repeat	302..331	CDD:293787	8/28 (29%)
		BLVR	687..840	CDD:283923	32/164 (20%)
APL3	NP_009516.1	Adaptin_N	38..649	CDD:396262	136/667 (20%)
APL3	NP_009516.1	Alpha_adaptin_C	901..1018	CDD:367023
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810