DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment g and delta-ADR

DIOPT Version :9

Sequence 1:	NP_524785.2	Gene:	g / 44819	FlyBaseID:	FBgn0001087	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	NP_001031156.1	Gene:	delta-ADR / 841298	AraportID:	AT1G48760	Length:	869	Species:	Arabidopsis thaliana

Alignment Length:	1052	Identity:	299/1052 - (28%)
Similarity:	501/1052 - (47%)	Gaps:	231/1052 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NFFERMFDKNLTDLVRGIRNNKDNEAKYISTCIEEIKQELRQDNISVKCNAVAKLTYIQML-GYD 72
            :..:.:|.::|.||::|.|.....|:.:||..:|||::|::..::|.|..|:.||:|:..| |.|
plant     7 SIMDNLFQRSLEDLIKGFRLQLLGESNFISRAVEEIRREIKATDLSTKSTALHKLSYLAALHGVD 71

  Fly    73 ISWAGFNIIEVMSSSRFTCKRIGYLAASQCFHPDSELLMLTTNMIRKDLNSQNQYDAGVALSGLS 137
            :|||.|:.:||:|||||..|||||.|.:|.|:..:.:::|.||.:||||||.|:|:..:||..||
plant    72 MSWAAFHAVEVVSSSRFQHKRIGYQAITQSFNDQTSVMLLITNQVRKDLNSANEYEVSLALECLS 136

  Fly   138 CFISPDLSRDLANDIMTLMSSTKPYLRMKAVLMMYKVFLRYPEALRPAFPKLKEKLEDPDPGVQS 202
            ...:.||:|||..::.||:.|:|.:::.||:.::.:||.:|.:|::..|.:|.|.||..||.:.|
plant   137 RIGTHDLARDLTPEVFTLLGSSKSFVKKKAIGVVLRVFEKYHDAVKVCFKRLVENLETSDPQILS 201

  Fly   203 AAVNVICELARKNPKNYLPLAPIFFKLMTTSTNNWMLIKIIKLFGALTPLEPRLGKKLIEPLTNL 267
            |.|.|.||||.|:|::.|||||.|:|::..|.|||:|||::|:|..|..:|||||||:.||:...
plant   202 AVVGVFCELATKDPQSCLPLAPEFYKVLVDSRNNWVLIKVLKIFAKLALIEPRLGKKVAEPICEH 266

  Fly   268 IHSTSAMSLLYECINTVIAVLISISSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKIL 332
            :..|.|.||::||:.||:       |.:.::.|:::|.|.|:|..:.:.|.|||||||.|:|.:.
plant   267 MRRTVAKSLVFECVRTVV-------SSLSDNEAAVKLAVAKIREFLVEDDPNLKYLGLNALSIVA 324

  Fly   333 KTHPKSVQAHKDLILACLDDKDESIRLRALDLLYGMVSKKNLMEIVKRLLGHMERAEGSAYRDEL 397
            ..|..:|..:|::::..:.|:|.:::|.||.||..||::.|:.||.:.|:.:..::: ..:.:|:
plant   325 PKHLWAVLENKEVVVKAMSDEDPNVKLEALHLLMAMVNEDNVSEISRILMNYALKSD-PLFCNEI 388

  Fly   398 LYKVIEICAQSSYLYVTNFEWYLTVLVELIQLEAGSRHGRLIAEQLLDVAIRVPVVR-QFAVNEM 461
            ::.|:..|::::|..:.:|:|||::|.|:.::....| |..|..||:|:.:||...| |......
plant   389 IFSVLSACSRNAYEIIVDFDWYLSLLGEMARIPHCQR-GEDIEHQLIDIGMRVRDARPQLVRVSW 452

  Fly   462 TNLLDTFTVSAQSNSMYEVLYAAAWIVGEFAGELEDAEKTLNILLRPR--LLPGHIQGVYVQNVI 524
            ..|:|...:.  :..::.:|.||||:.||:....::..:|:..||:||  |||..|:.:|:.:..
plant   453 ALLIDPALLG--NLFLHPILSAAAWVSGEYVEFSKNPYETVEALLQPRTDLLPPSIKAIYIHSAF 515

  Fly   525 KL--------FARLATTCLEL----------------QDLPGLVTLCDHVLDKLQHFNGSSDIEV 565
            |:        |:....|...|                :.:..||.:.:..|..|   :|..|:||
plant   516 KVLVFCLGSYFSSQEPTSSSLAQESSSGSLLVNVFTHESILSLVNVIELGLGPL---SGYHDVEV 577

  Fly   566 QERANSACMLIEMLRNQLSTSTDAMAMDTTTEGGIPPLAIEIVQEMTLLFTGELIPVAPKAQRKV 630
            ||||.:....|.:::.:::...:  ..|..||      |..:...|..:|:.|..|::..||.||
plant   578 QERAKNVLGYISVIKQEIAEQLN--LQDNETE------ASRVTAFMEDVFSEEFGPISATAQEKV 634

  Fly   631 PLPDGLDLDEWI---------NAPPPEDAASSSSSEHDKDELFVSATQAGTGADGGEKRRQSLEL 686
            .:||||:|.|.:         :..|.|   |.|.|..||....||..:.          |...|.
plant   635 CVPDGLELKENLGDLEEICGEHLKPVE---SDSVSYTDKISFSVSKLRI----------RDQQEA 686

  Fly   687 TPEQLERQRMARLIEQSNNPH---YLKSTPTASGASNADQYDNIDDIPITELPLDMEGVAALRVG 748
            |.........:.|:.:....|   ||.|       ...||              |..|.:
plant   687 TSSSSPPHEASSLLAEHRKRHGMYYLTS-------QKEDQ--------------DSNGTS----- 725

  Fly   749 ITKRSDKYLQEQQAAQGSKDGKKKHKKGKKSKKAKNKVAYNSSSESEGEPKPLHIVNTTLDMPEG 813
                ||..|..:.|.:.|:|.....:|..:||                 |:|:.:
plant   726 ----SDYPLANELANEISQDSFNPKRKPNQSK-----------------PRPVVV---------- 759

  Fly   814 VSMSDSEDKDGKYDPNDPHRALDIELDITEFEAPAVRSASKKSAADKENLKTPADSAGGGNAAKK 878
                       |.|..|..|       ||    |..:: :.::|.|.|:|.....||    ...|
plant   760 -----------KLDDGDESR-------IT----PQAKT-NIQTANDDESLSRAIQSA----LLVK 797

  Fly   879 DRKKDKDKDKERKVKREHRESKRERKEAAVQSVIDLIDADTPTPSPSHISATSNNNNTSTVLPDA 943
            ::.|:||     :.:......::|::|:                     |...|:.|:
plant   798 NKGKEKD-----RYEGNPNSGQQEKEES---------------------SRIENHQNS------- 829

  Fly   944 PKHHKKKKNKEKTTDEAPDALATATGSSIIDVGGEEASEVASKVHKKKHKKEKSQRKEKKKASES 1008
                :|||.|                                   |||.|.|.|.:.:.::.:|.
plant   830 ----EKKKKK-----------------------------------KKKKKGEGSSKHKSRRQNEV 855

  Fly  1009 ASVSAIVSIGDY 1020
            ||.|..|.|.|:
plant   856 ASASEQVIIPDF 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
g	NP_524785.2	Adaptin_N	33..578	CDD:279882	204/572 (36%)
		HEAT repeat	152..173	CDD:293787	6/20 (30%)
		HEAT repeat	185..213	CDD:293787	14/27 (52%)
		Cnd1	<193..266	CDD:289487	40/72 (56%)
		HEAT repeat	221..263	CDD:293787	23/41 (56%)
		HEAT repeat	272..290	CDD:293787	7/17 (41%)
		HEAT repeat	302..331	CDD:293787	14/28 (50%)
		BLVR	687..840	CDD:283923	25/155 (16%)
delta-ADR	NP_001031156.1	Adaptin_N	31..482	CDD:279882	177/461 (38%)
		HEAT repeat	259..286	CDD:293787	10/33 (30%)
		HEAT repeat	296..326	CDD:293787	14/29 (48%)
		HEAT repeat	335..359	CDD:293787	8/23 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	352	1.000	Domainoid score	I214
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	421	1.000	Inparanoid score	I432
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D598949at2759
OrthoFinder	1	1.000	-	-		FOG0005167
OrthoInspector	1	1.000	-	-		oto3407
orthoMCL	1	0.900	-	-		OOG6_102126
Panther	1	1.100	-	-	LDO	PTHR22781
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3686
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830