Protein Alignment g and ap3d1

DIOPT Version :10

• Sequence 1: NP_524785.2
• Gene: g / 44819
• FlyBaseID: FBgn0001087
• Length: 1034
• Species: Drosophila melanogaster
• Sequence 2: XP_009294540.1
• Gene: ap3d1 / 563359
• ZFINID: ZDB-GENE-050208-437
• Length: 1262
• Species: Danio rerio
• Alignment Length: 1059
• Identity: 580/1059 - (54%)
• Similarity: 729/1059 - (68%)
• Gaps: 127/1059 - (11%)

  Fly     1 MALKKVKGNFFERMFDKNLTDLVRGIRNNKDNEAKYISTCIEEIKQELRQDNISVKCNAVAKLTY 65
            ||||.|||: .:|||||||.||||||||:|::|||||||||:||||||:||||:||.|||.||||
Zfish     1 MALKIVKGS-IDRMFDKNLQDLVRGIRNHKEDEAKYISTCIDEIKQELKQDNIAVKANAVCKLTY 64

  Fly    66 IQMLGYDISWAGFNIIEVMSSSRFTCKRIGYLAASQCFHPDSELLMLTTNMIRKDLNSQNQYDAG 130
            :||||||:|||.|||:||||||:||.|||||||||||||..::::|||||.|||||:|.||||.|
Zfish    65 LQMLGYDVSWAAFNIVEVMSSSKFTYKRIGYLAASQCFHEGTDVIMLTTNQIRKDLSSPNQYDTG 129

  Fly   131 VALSGLSCFISPDLSRDLANDIMTLMSSTKPYLRMKAVLMMYKVFLRYPEALRPAFPKLKEKLED 195
            |||:|||||::|||:||||||||||||.||||:|.||||:||||||:|||:||||||:|||||||
Zfish   130 VALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLED 194

  Fly   196 PDPGVQSAAVNVICELARKNPKNYLPLAPIFFKLMTTSTNNWMLIKIIKLFGALTPLEPRLGKKL 260
            ||||||||||||||||||:||||||.|||:||||||:|||||:||||||||||||||||||||||
Zfish   195 PDPGVQSAAVNVICELARRNPKNYLSLAPLFFKLMTSSTNNWVLIKIIKLFGALTPLEPRLGKKL 259

  Fly   261 IEPLTNLIHSTSAMSLLYECINTVIAVLISISSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGL 325
            ||||||||||||||||||||:|||||||||:||||||||||||||||||||||||||||||||||
Zfish   260 IEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGL 324

  Fly   326 LAMSKILKTHPKSVQAHKDLILACLDDKDESIRLRALDLLYGMVSKKNLMEIVKRLLGHMERAEG 390
            |||||||||||||||:||||||.|||||||||||||||||||||||||||||||:|:.|:::|||
Zfish   325 LAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMLHVDKAEG 389

  Fly   391 SAYRDELLYKVIEICAQSSYLYVTNFEWYLTVLVELIQLEAGSRHGRLIAEQLLDVAIRVPVVRQ 455
            :.||||||.|:|:||:||:|.|:||||||:::||||.:|| |:|||.|||.|:|||||||..:|.
Zfish   390 TTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLE-GTRHGHLIASQMLDVAIRVKAIRA 453

  Fly   456 FAVNEMTNLLDT---FTVSAQSNSMYEVLYAAAWIVGEFAGELEDAEKTLNILLRPRL--LPGHI 515
            |||.:|..|||.   .|.:.|.|.:.|||||||||.||||..|||...||..:|||::  |||||
Zfish   454 FAVAQMATLLDNAHLLTGNTQRNGICEVLYAAAWICGEFAEHLEDPMLTLEAMLRPKVATLPGHI 518

  Fly   516 QGVYVQNVIKLFARL------ATTCLELQDLPGLVTLCDHVLDKLQHFNGSSDIEVQERANSACM 574
            |.|||||..||||.:      .|.....|:...|      ::|:|..|..|:::||||||:....
Zfish   519 QAVYVQNAAKLFATVLQKHEGETDSQAAQETSQL------LIDRLPLFVQSANLEVQERASCILQ 577

  Fly   575 LIEMLRNQLSTSTDAMAMDTTTEGGIPPLAIEIVQEMTLLFTGELIPVAPKAQRKVPLPDGLDLD 639
            |::.::.                  :....:|:.:|:|.||.|||.|||||||:|||:|:|||||
Zfish   578 LVKYIQK------------------LQQKNVEVAEEVTALFAGELNPVAPKAQKKVPIPEGLDLD 624

  Fly   640 EWINAPPPEDAASSSSSEHDKDELFVSATQAGTGADGGEKRRQSLELTPEQLERQRMARLIEQSN 704
            .|||.||     |.|.||.:|.:...:..:.      ...|.:..|:..::|.|:|.||..||:|
Zfish   625 AWINEPP-----SESESEDEKPKAVFAKEEP------KHSRSRHTEVDEKELARRREARKQEQAN 678

  Fly   705 NPHYLKSTPTASGASNADQYD--NIDDIPITELPLDMEGVAALRVGITKRSDKY--LQEQQAAQG 765
            ||.|:|::|     |:...||  .::.||:.::.|.:    .|:|.....||:|  |:|::..:.
Zfish   679 NPFYIKASP-----SSQKVYDAPGVEHIPVVQIDLSV----PLKVPGMPMSDQYVKLEEERRQKE 734

  Fly   766 SKDGKKKHKKGKKSKKAKNKVAYNSSSESEGEPKPLHIVN-TTLDMPEGVSMSDSEDKDGKYDPN 829
            ..|.|||.||.|:.|:.|.:.. :|..|||.:..|.|.|: .|.:|||....||.:||    |||
Zfish   735 KADKKKKEKKKKREKRGKGRKG-DSGPESEEDITPAHHVDIVTEEMPENALPSDDDDK----DPN 794

  Fly   830 DPHRALDIELD----------ITEFEAPAVRS----ASKKSAADKENLKTPADSAGGGNAAKKDR 880
            |||:||||:||          :.:.|...||:    ..|..|.|:::...|.::....:..||::
Zfish   795 DPHKALDIDLDNLLSGAGSRPLADSEKLPVRTHRPEVLKSPAEDRDDNTIPQETKKKSSKDKKEK 859

  Fly   881 KKDKDKDKER-----KVKREHRESKRERKEAAVQSVI---------------DLIDAD-----TP 920
            ||||:||::|     |.|::|::.:.|..|:..:.|:               |..|.|     .|
Zfish   860 KKDKEKDRKRSKEDKKKKKKHKDVEEELPESLPEEVVQSEETKEVAVPPTSADASDLDFWLSSAP 924

  Fly   921 TPSPSHISATSNNNNTSTVLPDAPKHHKKKKNKEKTTDEAPDALATATGSSIIDVGGEEASEVAS 985
            .|..:.:...|::...:||  |:......:...|:..|..||                   :..|
Zfish   925 VPPVAQVVTVSSSAAAATV--DSSSAAAAESEPEELKDTEPD-------------------DTKS 968

  Fly   986 KVHKKKHKKEKSQRKEKKK 1004
            ..||||.:|::.:.|||||
Zfish   969 SKHKKKKQKKEKEEKEKKK 987

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
g	NP_524785.2	Adaptin_N	33..578	CDD:396262	413/555 (74%)
		AP3D1	687..840	CDD:461889	60/157 (38%)
ap3d1	XP_009294540.1	Adaptin_N	32..580	CDD:396262	413/554 (75%)
		HEAT repeat	151..172	CDD:293787	16/20 (80%)
		HEAT repeat	184..212	CDD:293787	26/27 (96%)
		HEAT repeat	220..262	CDD:293787	37/41 (90%)
		HEAT repeat	271..292	CDD:293787	18/20 (90%)
		HEAT repeat	301..330	CDD:293787	28/28 (100%)
		HEAT repeat	335..364	CDD:293787	26/28 (93%)
		AP3D1	661..805	CDD:461889	60/157 (38%)