DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment g and ap2a1

DIOPT Version :9

Sequence 1:	NP_524785.2	Gene:	g / 44819	FlyBaseID:	FBgn0001087	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	XP_009297842.1	Gene:	ap2a1 / 558153	ZFINID:	ZDB-GENE-090302-2	Length:	984	Species:	Danio rerio

Alignment Length:	1039	Identity:	223/1039 - (21%)
Similarity:	407/1039 - (39%)	Gaps:	239/1039 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 KNLTDLVRGIRNNKDNEAKYISTCIEEIKQELRQ-----------DNISVKCNAVAKLTYIQMLG 70
            :.|...:..|||.|..||:     |:.|.:||..           |..|.| ..|.||.:|.:||
Zfish    11 RGLAVFISDIRNCKSKEAE-----IKRINKELANIRSKFKGDKALDGYSKK-KYVCKLLFIFLLG 69

  Fly    71 YDISWAGFNIIEVMSSSRFTCKRIGYLAASQCFHPDSELLMLTTNMIRKDLNSQNQYDAGVALSG 135
            :||.:.....:.::||:::|.|:||||..|...:.:|||:.|..|.|:.||:|:|.....:||..
Zfish    70 HDIDFGHMEAVNLLSSNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLSSRNPTFMCLALHC 134

  Fly   136 LSCFISPDLSRDLANDIMTLM--SSTKPYLRMKAVLMMYKVFLRYPEALRPA--FPKLKEKLEDP 196
            ::...|.:::...|.:|..::  ..|...::..|.|.:.:::...|:.:...  ..::...|.|.
Zfish   135 IANVGSREMAEAFAGEIPRILVAGDTMDSVKQSAALCLLRLYKTSPDLVLMGEWTSRVVHLLNDQ 199

  Fly   197 DPGVQSAAVNVICELARKNP---KNYLPLAPIFFKLMTTSTNN-------------WMLIKIIKL 245
            ..||.:||:::|..|::|||   |..:.||......:.:|.:.             |:..|:::|
Zfish   200 HMGVVTAAISLITCLSQKNPDEFKTCVSLAVSRLSRIVSSASTDLQDYTYYFVPAPWLSCKLLRL 264

  Fly   246 FGALTPLEPRLGK-KLIEPLTNLI-------------HSTSAMSLLYECINTVIAVLISISSGMP 296
            .....|.|....| :|:|.|..::             ||.:..::|:|.|:.:|..     ...|
Zfish   265 LQCYPPPEDGAVKGRLVECLETILNKAQEPPKSKKVQHSNAKNAILFEAISLIIHY-----DSEP 324

  Fly   297 NHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKI---------LKTHPKSVQAHKDLILACLDD 352
            |  ..::.|.| |...::..:.||:||.|.:|..:         :|||.::|      |.|...:
Zfish   325 N--LLVRACNQ-LGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIETV------INALKTE 380

  Fly   353 KDESIRLRALDLLYGMVSKKNLMEIVKRLLGHMERAEGSAYRDELLYKVIEICAQSSYLYVTNFE 417
            :|.|:|.||.||||.|..:.|..:||..:|.::|.|:.| .|:|::.|| .|.|:.   |..::.
Zfish   381 RDVSVRQRAADLLYAMCDRSNAKQIVAEMLSYLETADYS-IREEMVLKV-AILAEK---YAVDYS 440

  Fly   418 WYLTVLVELIQLEAGSRHGRLIAEQLLDVAIRVPVVRQFAVNEMTNLLDTFTVSAQSNSMYE-VL 481
            ||:..::.||:: ||......:..:::.:.|....|:.:|...:...|       |:.:.:| ::
Zfish   441 WYVDTILNLIRI-AGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEAL-------QAPACHENMV 497

  Fly   482 YAAAWIVGEF----AGE-----------LEDAEKTLNILLRPRLLPGHIQGV--------YVQNV 523
            ....:|:|||    ||:           |.......::..|..||..:|:.:        .:|.|
Zfish   498 KVGGYILGEFGNLIAGDPRSSPLVQFNLLHSKFHLCSVPTRALLLSAYIKFINLFPETKSTIQEV 562

  Fly   524 IKLFARLATTCLELQ-----------------------DLPGLVTLCDHVLDKLQHFNGSSDIEV 565
            ::..:::..:.:|||                       ::|........:|.||:...|...:.|
Zfish   563 LRSDSQIRNSDVELQQRAVEYLKLSSIASTDVLATVLEEMPPFPERESSILAKLKKKKGPGAVSV 627

  Fly   566 Q-----------------ERANSACMLIEMLRNQLSTSTDAMAMDTTTE-GGIPP----LAIEIV 608
            .                 ||......:.....:..|.|.|.:.:.|..: ...||    |.:::.
Zfish   628 NELEEGKREGGELNGGGGERGGDNSTIAASNASTPSPSADLLGLRTGPQVSAAPPSAGSLLVDVF 692

  Fly   609 QEMTLLFTGELIPVAPKAQRKVPL----PDGLDLDEWINAPP---PEDAASSSSSEHDKDELFVS 666
            .|..:...|.|..:.|..:....|    |...|     :|||   .||||......::....||.
Zfish   693 SEAGVNDDGFLRDLEPPTESSDSLLAEGPGDSD-----SAPPSAVSEDAAPPLPESNELLNKFVC 752

  Fly   667 ATQAGTGADGGEKRRQSLELTPEQLERQRMARLIEQSNN---------------PHYLKS----- 711
            ..      :|.....|.|::..:...||.:.|:.....|               |..|:|
Zfish   753 KN------NGVLFENQLLQIGIKSEYRQNLGRMYLFYGNKTSVQFVTFTTTVSCPGELQSQLNVQ 811

  Fly   712 ----TPTASGASNADQYDNID------DIPITELPLDMEGV---AALRVGITKRSDKYLQEQQAA 763
                .|...|.:...|..||:      :.|:..:.....|.   .:|::.:|  .:|:.|..:.|
Zfish   812 AKPVEPLIEGGAQVQQVINIECLGDFCEAPLLNIKFRYGGALQNLSLKLPVT--INKFFQPTEMA 874

  Fly   764 QGSKDGKKKHKKGKKSKKAKNKVAYNSSSESEGEPKPLHIVNTTLDMPE--GVSMSDSEDKDGKY 826
              |.|..::.|:..:.::...|:.           |..|.::|.:...:  |:.|:..|:    .
Zfish   875 --SHDFFQRWKQLSQPQQEAQKIF-----------KASHAMDTEVIKAKLLGLGMALLEN----V 922

  Fly   827 DPNDPHRALDIELDITEFEAPAVRSASKKSAADKENLKTPADSAGGGNAAKKDRKKDKDKDKER 890
            |||..:           |....|.....:.......|:..|.:..|....:...:..||...:|
Zfish   923 DPNPEN-----------FVCAGVIQTKAQQVGSLLRLEPNAQAQSGEQMYRLTLRSSKDTVSKR 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
g	NP_524785.2	Adaptin_N	33..578	CDD:279882	152/662 (23%)
		HEAT repeat	152..173	CDD:293787	4/22 (18%)
		HEAT repeat	185..213	CDD:293787	8/29 (28%)
		Cnd1	<193..266	CDD:289487	24/89 (27%)
		HEAT repeat	221..263	CDD:293787	10/55 (18%)
		HEAT repeat	272..290	CDD:293787	4/17 (24%)
		HEAT repeat	302..331	CDD:293787	9/28 (32%)
		BLVR	687..840	CDD:283923	32/187 (17%)
ap2a1	XP_009297842.1	Adaptin_N	29..591	CDD:279882	142/594 (24%)
		RIX1	141..>292	CDD:285390	30/150 (20%)
		Alpha_adaptinC2	758..861	CDD:197886	17/102 (17%)
		Alpha_adaptin_C	867..979	CDD:280460	23/137 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810