DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment g and ap3d1

DIOPT Version :9

Sequence 1:	NP_524785.2	Gene:	g / 44819	FlyBaseID:	FBgn0001087	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	XP_031760928.1	Gene:	ap3d1 / 493202	XenbaseID:	XB-GENE-494144	Length:	1238	Species:	Xenopus tropicalis

Alignment Length:	1032	Identity:	568/1032 - (55%)
Similarity:	727/1032 - (70%)	Gaps:	92/1032 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALKKVKGNFFERMFDKNLTDLVRGIRNNKDNEAKYISTCIEEIKQELRQDNISVKCNAVAKLTY 65
            |||:.|||: .:|||||||.||||||||:|::||||||.||:||||||:||||:||.|||.||||
Frog     1 MALRIVKGS-IDRMFDKNLQDLVRGIRNHKEDEAKYISHCIDEIKQELKQDNIAVKANAVCKLTY 64

  Fly    66 IQMLGYDISWAGFNIIEVMSSSRFTCKRIGYLAASQCFHPDSELLMLTTNMIRKDLNSQNQYDAG 130
            :||||||||||.||||||||:|:||.|||||||||||||..::::|||||.|||||:|.||||.|
Frog    65 LQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAASQCFHEATDVIMLTTNQIRKDLSSPNQYDTG 129

  Fly   131 VALSGLSCFISPDLSRDLANDIMTLMSSTKPYLRMKAVLMMYKVFLRYPEALRPAFPKLKEKLED 195
            |||:|||||::|||:||||||||||||.||||:|.||||:||||||:|||:||||||:|||||||
Frog   130 VALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLED 194

  Fly   196 PDPGVQSAAVNVICELARKNPKNYLPLAPIFFKLMTTSTNNWMLIKIIKLFGALTPLEPRLGKKL 260
            ||||||||||||||||||:||||||.|||:||||||:|||||:||||||||||||||||||||||
Frog   195 PDPGVQSAAVNVICELARRNPKNYLSLAPLFFKLMTSSTNNWVLIKIIKLFGALTPLEPRLGKKL 259

  Fly   261 IEPLTNLIHSTSAMSLLYECINTVIAVLISISSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGL 325
            ||||||||||||||||||||:|||||||||:||||||||||||||||||||||||||||||||||
Frog   260 IEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGL 324

  Fly   326 LAMSKILKTHPKSVQAHKDLILACLDDKDESIRLRALDLLYGMVSKKNLMEIVKRLLGHMERAEG 390
            |||||||||||||||:||||||.|||||||||||||||||||||||||||||||:|:.|:::|||
Frog   325 LAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMIHVDKAEG 389

  Fly   391 SAYRDELLYKVIEICAQSSYLYVTNFEWYLTVLVELIQLEAGSRHGRLIAEQLLDVAIRVPVVRQ 455
            :|||||||.|:|:||:||:|.|:||||||:::||||.:|| |:|||.|||.|:|||||||..:|:
Frog   390 TAYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLE-GTRHGHLIAAQMLDVAIRVKAIRR 453

  Fly   456 FAVNEMTNLLDT---FTVSAQSNSMYEVLYAAAWIVGEFAGELEDAEKTLNILLRPRL--LPGHI 515
            |||::|..|||.   ...:.|.|.:.|||||||||.|||:..|.:..:||..:|||::  |||||
Frog   454 FAVSQMATLLDNAHLLASNTQRNGICEVLYAAAWICGEFSEHLLEPNQTLEAMLRPKVTTLPGHI 518

  Fly   516 QGVYVQNVIKLFARLATTCLELQDLPGLVTLCDHVLDKLQHFNGSSDIEVQERANSACMLIEMLR 580
            |.||||||:||::.:..:..:..|......:...::|:|..|..|:|:||||||:....||:.::
Frog   519 QAVYVQNVVKLYSCILQSKEQAGDQEAAQEITQLMIDRLPQFVQSADLEVQERASCILQLIKYIQ 583

  Fly   581 NQLSTSTDAMAMDTTTEGGIPPLAIEIVQEMTLLFTGELIPVAPKAQRKVPLPDGLDLDEWINAP 645
            ...|..                  :.:.:|:..||.|||.|||||||:|||:|:||||:.|||.|
Frog   584 KLQSKE------------------VPVAEEVMALFAGELNPVAPKAQKKVPVPEGLDLEAWINEP 630

  Fly   646 PPEDAASSSSSEHDKDE-LFVSATQAGTGADGGEKRRQSLELTPEQLERQRMARLIEQSNNPHYL 709
            |     |.|.||.:|.: :|....|:     .|:..|.  |:..|:|.|:|.||..||:|||.|:
Frog   631 P-----SDSESEEEKPKAIFQDEKQS-----HGKTSRP--EIDEEELARRRAARKEEQANNPFYI 683

  Fly   710 KSTPTASGASNADQYDN---IDDIPITELPLDMEGVAALRVGITKRSDKY--LQEQQAAQGSKDG 769
            |::|     |....|.:   ::.||:.::.|.:    .|:|.....||:|  |:|::.::..::.
Frog   684 KASP-----SPQKLYQDSPGVEHIPVVQIDLSV----PLKVPGLPISDQYVKLEEERRSKQRQEK 739

  Fly   770 KKKHKKGKKSKKAKNKVAYNSSSESEGEPKPLHIVN-TTLDMPEGVSMSDSEDKDGKYDPNDPHR 833
            .||.||.|..|.:|.:..::..:||:.:..|.|.|: .|.:|||....||.:||    |||||:|
Frog   740 DKKKKKEKDKKGSKTRRHHSLHTESDEDITPAHHVDIITEEMPENALPSDEDDK----DPNDPYR 800

  Fly   834 ALDIELD--ITEFE---------APAVRSASKKSAADKENLKTPADSAGGGNAAKKDRKKDKDKD 887
            ||||:||  :.:.|         |..::|...::....:.:|..:......:.|::.:||:|.|.
Frog   801 ALDIDLDKPLADTEKLPVQRHRNAEILKSPENETPTSDQKIKKMSKKEKKQSEAERVKKKEKKKS 865

  Fly   888 KERKVKREHRES----KRERKEAAVQSVIDLIDADTPTPSPSHISATSNNNNTSTVLPDAPKHHK 948
            ||::.|.:|::|    .:|::....:....:.:.....||.......||    ||:...|....:
Frog   866 KEKEEKSKHKKSVSHTTKEKESPLKEEEFQVDEQVNEAPSEDMDFWLSN----STLPSQAESQPE 926

  Fly   949 KKKNKEKTTDEAPDALATATGSSIIDVGG--EEASEVASKVHKKKHKKEKSQRKEKK 1003
            ....:|:..:|              ||.|  ||..|..|..|||||||||..:::||
Frog   927 VNPTREEPKEE--------------DVEGEREEEQEKKSHRHKKKHKKEKELKEDKK 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
g	NP_524785.2	Adaptin_N	33..578	CDD:279882	409/549 (74%)
		HEAT repeat	152..173	CDD:293787	16/20 (80%)
		HEAT repeat	185..213	CDD:293787	26/27 (96%)
		Cnd1	<193..266	CDD:289487	67/72 (93%)
		HEAT repeat	221..263	CDD:293787	37/41 (90%)
		HEAT repeat	272..290	CDD:293787	16/17 (94%)
		HEAT repeat	302..331	CDD:293787	28/28 (100%)
		BLVR	687..840	CDD:283923	56/158 (35%)
ap3d1	XP_031760928.1	Adaptin_N	32..580	CDD:396262	408/548 (74%)
		HEAT repeat	151..172	CDD:293787	16/20 (80%)
		HEAT repeat	184..212	CDD:293787	26/27 (96%)
		HEAT repeat	220..262	CDD:293787	37/41 (90%)
		HEAT repeat	271..292	CDD:293787	18/20 (90%)
		HEAT repeat	301..330	CDD:293787	28/28 (100%)
		HEAT repeat	335..364	CDD:293787	26/28 (93%)
		AP3D1	661..807	CDD:399400	56/158 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	810	1.000	Domainoid score	I76
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H137722
Inparanoid	1	1.050	1008	1.000	Inparanoid score	I294
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D163216at33208
OrthoFinder	1	1.000	-	-		FOG0005167
OrthoInspector	1	1.000	-	-		oto102970
Panther	1	1.100	-	-	LDO	PTHR22781
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3686
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160