Protein Alignment g and ap2a2

DIOPT Version :9

• Sequence 1: NP_524785.2
• Gene: g / 44819
• FlyBaseID: FBgn0001087
• Length: 1034
• Species: Drosophila melanogaster
• Sequence 2: XP_031755830.1
• Gene: ap2a2 / 407867
• XenbaseID: XB-GENE-486024
• Length: 1011
• Species: Xenopus tropicalis
• Alignment Length: 1005
• Identity: 221/1005 - (21%)
• Similarity: 392/1005 - (39%)
• Gaps: 271/1005 - (26%)

  Fly    17 KNLTDLVRGIRNNKDNEAKYISTCIEEIKQELRQ-----------DNISVKCNAVAKLTYIQMLG 70
            :.|...:..|||.|..||:     |:.|.:||..           |..|.| ..|.||.:|.:||
 Frog    11 RGLAVFISDIRNCKSKEAE-----IKRINKELANIRSKFKGDKALDGYSKK-KYVCKLLFIFLLG 69

  Fly    71 YDISWAGFNIIEVMSSSRFTCKRIGYLAASQCFHPDSELLMLTTNMIRKDLNSQNQYDAGVALSG 135
            :||.:.....:.::||:::|.|:||||..|...:.:|||:.|..|.|:.||:|:|....|:||..
 Frog    70 HDIDFGHMEAVNLLSSNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLSSRNPTFMGLALHC 134

  Fly   136 LSCFISPDLSRDLANDIMTLM--SSTKPYLRMKAVLMMYKVFLRYPEAL--RPAFPKLKEKLEDP 196
            ::...|.:::...|.:|..::  ..|...::..|.|.:.:::...|:.:  .....::...|.|.
 Frog   135 IANVGSREMAEAFAGEIPRILVAGDTMDSVKQSAALCLLRLYRTSPDLVLTNEWTSRVVHLLNDQ 199

  Fly   197 DPGVQSAAVNVICELARKNPKNY---LPLAPIFFKLMTTSTNN-------------WMLIKIIKL 245
            ..||.:||.::|..||:|||:.:   :.||......:.||.:.             |:.:|:::|
 Frog   200 HLGVVTAATSLITTLAQKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRL 264

  Fly   246 FGALTPLE-PRLGKKLIEPLTNLI-------------HSTSAMSLLYECINTVIAVLISISSGMP 296
            .....|.| |.:..:|.|.|..::             ||.:..::|:|.|:     ||......|
 Frog   265 LQCYPPPEDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAIS-----LIIYHDSEP 324

  Fly   297 NHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKI---------LKTHPKSVQAHKDLILACLDD 352
            |  ..::.|.| |...::..:.||:||.|.:|..:         :|||.::|      |.|...:
 Frog   325 N--LLVRACNQ-LGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIETV------INALKTE 380

  Fly   353 KDESIRLRALDLLYGMVSKKNLMEIVKRLLGHMERAEGSAYRDELLYKVIEICAQSSYLYVTNFE 417
            :|.|:|.||:||||.|..:.|..:||..:|.::|.|:.| .|:|::.|| .|.|:.   |..::.
 Frog   381 RDVSVRQRAVDLLYAMCDRSNAQQIVAEMLSYLETADYS-IREEIVLKV-AILAEK---YAVDYT 440

  Fly   418 WYLTVLVELIQLEAGSRHGRLIAEQLLDVAIRVPVVRQFAVNEMTNLLDTFTVSAQSNSMYE-VL 481
            ||:..::.||:: ||......:..:::.:.|....|:.:|...:...|       |:.:.:| ::
 Frog   441 WYVDTILNLIRI-AGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEAL-------QAPACHENLV 497

  Fly   482 YAAAWIVGEF----AGE-----------LEDAEKTLNILLRPRLLPGHIQGV--------YVQNV 523
            ....:|:|||    ||:           |.......::..|..||..:|:.:        .:|:|
 Frog   498 KVGGYILGEFGNLIAGDPRSSPLIQFNLLHSKFHLCSVPTRALLLSAYIKFINLFPEIKTTIQDV 562

  Fly   524 IKLFARLATTCLELQ-----------------------DLPGLVTLCDHVLDKLQHFNGSS---D 562
            ::..::|....:|||                       ::|........:|.||:...|.|   |
 Frog   563 LRSDSQLRNADVELQQRAVEYLRLSSIASNDILATVLEEMPPFPERESSILAKLKKKKGPSTVTD 627

  Fly   563 IE--VQERANSACMLIEMLRNQLSTSTDAMAMDTTTEGGIPPLAIEIVQEMTLLFTGELIPVAPK 625
            :|  .:|::||          .|:..|:...:.||.:......|...|::..|..   |:|....
 Frog   628 LEETKKEKSNS----------DLNGITEHAPLSTTQQPVFEDKATYAVRQRPLSL---LVPTLSS 679

  Fly   626 AQ--------RKVPLPDGLDLDEWINAPPPE------DAASSSSS-------------------- 656
            :|        |...||      ...:.|.|.      .|||.|||
 Frog   680 SQSLYSGTSHRVAALP------FCQSTPSPSADLLGLGAASGSSSTPTTAPSAGSLLVDVFAEPS 738

  Fly   657 ------EHDKDELFVSATQAGTGADGGEK-----------------------RRQSLELTPEQLE 692
                  ..:.|:.|.|..|.......||.                       ..|.|::..:...
 Frog   739 LPVAAVTTEADDNFPSDVQTPLEGASGEPDPSVDNAEDFFDKFICKNNGVLFENQLLQIGIKSEF 803

  Fly   693 RQRMARL------------------------IEQSNNPHYLKSTPTASGASNADQYDNID----- 728
            ||.:.|:                        :..|.|.....:.||..|.:...|..|::
 Frog   804 RQNLGRMFIFFGNKMSSQFQNFTTTLICSDELSASLNLQSKPAEPTIDGGAQVQQVVNVECVQEF 868

  Fly   729 -DIPITELPLDMEGV---AALRVGITKRSDKYLQ-----EQQAAQGSKDGKKKHKKGKKSKKAKN 784
             |:|:..:.....|.   .::::.||  .:|:.|     .|...|..|.....:::.:|..||||
 Frog   869 TDLPLLNIQFRYGGAFQNVSVKLPIT--LNKFFQPTEMNSQDFFQRWKQLSSPNQEVQKIFKAKN 931

  Fly   785 K----------VAYNSSSESEGEPKPLHIV 804
            .          :.:..:.....:|.|.:.|
 Frog   932 PMDTDITKARLIGFGPAVMDNVDPNPSNYV 961

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
g	NP_524785.2	Adaptin_N	33..578	CDD:279882	159/650 (24%)
		HEAT repeat	152..173	CDD:293787	4/22 (18%)
		HEAT repeat	185..213	CDD:293787	8/27 (30%)
		Cnd1	<193..266	CDD:289487	25/89 (28%)
		HEAT repeat	221..263	CDD:293787	11/55 (20%)
		HEAT repeat	272..290	CDD:293787	4/17 (24%)
		HEAT repeat	302..331	CDD:293787	9/28 (32%)
		BLVR	687..840	CDD:283923	28/166 (17%)
ap2a2	XP_031755830.1	Adaptin_N	29..591	CDD:396262	146/594 (25%)
		HEAT repeat	332..355	CDD:293787	8/23 (35%)
		HEAT repeat	369..398	CDD:293787	14/34 (41%)
		HEAT repeat	408..434	CDD:293787	10/27 (37%)
		Alpha_adaptinC2	789..892	CDD:197886	15/102 (15%)
		Alpha_adaptin_C	898..1006	CDD:367023	12/64 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910