DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment g and AP-1gamma

DIOPT Version :9

Sequence 1:	NP_524785.2	Gene:	g / 44819	FlyBaseID:	FBgn0001087	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	NP_788891.2	Gene:	AP-1gamma / 31842	FlyBaseID:	FBgn0030089	Length:	982	Species:	Drosophila melanogaster

Alignment Length:	944	Identity:	220/944 - (23%)
Similarity:	356/944 - (37%)	Gaps:	283/944 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LTDLVRGIRNNKDNEAKYISTCIEE----------IKQELRQDNISVKCNAVAKLTYIQMLGYDI 73
            |.||:|.||..:        |..||          |:...|:::...:|..:|||.||.||||..
  Fly    48 LRDLIRQIRAAR--------TAAEERAVVNKECAYIRSTFREEDSVWRCRNIAKLLYIHMLGYPA 104

  Fly    74 SWAGFNIIEVMSSSRFTCKRIGYLAASQCFHPDSELLMLTTNMIRKDLNSQNQYDAGVALSGLSC 138
            .:.....:::.:|:|||.||||||.|........::.:|.||.::.||||..|:..|:||..|..
  Fly   105 HFGQLECLKLTASTRFTDKRIGYLGAMLLLDERQDVHLLITNCLKNDLNSSTQFVVGLALCTLGA 169

  Fly   139 FISPDLSRDLANDIMTLMSSTKPYLRMKAVLMMYKVFLRYPEALRPAFPKLKEKLEDPDPGVQSA 203
            ..||:::||||:::..||.|...|:|.||.|..::|..|.||.:....|..:..|.:.:.|:...
  Fly   170 IASPEMARDLASEVERLMKSPNTYIRKKATLCAFRVIRRVPELMEIFLPATRSLLSEKNHGILIT 234

  Fly   204 AVNVICELARKNPKNYLPLAPIFFKLMTTSTNNWM---LIKIIK--LFGALTP-------LEPRL 256
            .|.:|.|:. :|..:.|    :.||  ..|.|..:   |::|:|  :.|..:|       .:|.|
  Fly   235 GVTLITEMC-ENSSDTL----MHFK--KDSGNREIVPNLVRILKNLILGGYSPEHDVSGVSDPFL 292

  Fly   257 GKKLIEPLTNLIH----STSAM-------------------SLLYECINTVIAVLISISSGMPNH 298
            ..|::..|..|.|    ::.||                   ::|||   ||::::...|.|
  Fly   293 QVKILRLLRILGHNDPDASEAMNDILAQVATNTETSKNVGNTILYE---TVLSIMDIRSEG---- 350

  Fly   299 SASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQAHKDLILACLDDKDESIRLRALD 363
             ....|.|..|...:.:||:|::|:.|..:.:.:.....:||.|:..||.||.|.|.|||.||::
  Fly   351 -GLRVLAVNILGRFLLNSDKNIRYVALNTLLRTVHADTSAVQRHRTTILECLKDPDVSIRRRAME 414

  Fly   364 LLYGMVSKKNLMEIVKRLLGHMERAEGSAYRDELLYKVIEICAQSSYL----YVTNFEWYLTVLV 424
            |.:.:::.:|:..:.|.||..:|:|:..       :|.  .|:....|    |.....|:|..
  Fly   415 LSFALINAQNIRTMTKELLLFLEKADAE-------FKA--QCSSGMILAAERYSPTTRWHLDT-- 468

  Fly   425 ELIQLEAGSRHGRLIAEQLLDVAIRVPVVRQFAVNEMTNLLDTFTVSAQSNSMYE----VLYAAA 485
               ||......|..:.:.:  |:..:.:|....|.|.|.:.:.|..|.|..:..|    :|..|.
  Fly   469 ---QLSVLIAAGNYVRDDV--VSSTIQLVSSSPVPEQTYITNRFWESLQVANHCEDKQPLLQVAV 528

  Fly   486 WIVGEFA-----GELED-----AEKTLNILLRPRLLPGHIQGVYVQNVIKLFARLAT---TCLEL 537
            |.:||:.     |..||     .|..|..:....|....:.....|..:...|:|:|   .|:|
  Fly   529 WAIGEYGDLFMYGANEDEFERPTESDLIAVYYKFLTSAQVSTTSKQYALVSLAKLSTRLQQCVE- 592

  Fly   538 QDLPGLVTLCDHVLDKLQHFNGSSDIEVQERANSACMLIEMLRNQLSTSTDAMAMDTTTEGGIPP 602
             ::..|:|          .|....::::|:|                              |:
  Fly   593 -EIQALIT----------SFGSHLNVDLQQR------------------------------GV-- 614

  Fly   603 LAIEIVQEMTLLFTGELIPVAPKAQRKVPLPDGLDLDEWINAPPPEDAASSSSSEHDKD-ELFVS 666
                   |.|.|| |....:.|....|:|...       |:....::..|...|..|.. ::..:
  Fly   615 -------EFTQLF-GHYKHLRPPLLEKMPAMQ-------ISRISSQNGESGGGSFDDNSPDVIEN 664

  Fly   667 ATQAGTGADGGEKRRQSLELTPEQLERQRMARLIEQSNNPHYLKSTPTASGASNADQYDNIDDIP 731
            ..:.|.|  ||..                   |||.:.|         ..|       ||
  Fly   665 GVEGGGG--GGHS-------------------LIESNMN---------TLG-------DN----- 687

  Fly   732 ITELPLDMEGVAALRVGITKRSDKYLQEQQAAQGSKD-------GKKKHKKGKKSKKAKNKVAYN 789
             |.:.||:.|...|..|                |:.|       ....||  |.|:.|.:.||..
  Fly   688 -TNILLDLLGSTDLSAG----------------GAGDLVAATDLSNAVHK--KNSRNANDVVAPV 733

  Fly   790 SSSESEGEPKPLHIVNTTLDMPEGVSMSDSEDKDGKYDPNDPHRALDIELDI---TEFEAPA--- 848
            |:::.            .||:                        ||::|..   |...|||
  Fly   734 SNNQD------------LLDL------------------------LDLDLSAPSSTTTGAPAGGG 762

  Fly   849 --------VRSASKKSAADKENLKTPADSAGGGN 874
                    |...::.|||:..|:....|..|.|:
  Fly   763 GGGGIVALVGDNNQSSAANMNNMLGGLDLGGFGS 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
g	NP_524785.2	Adaptin_N	33..578	CDD:279882	157/610 (26%)
		HEAT repeat	152..173	CDD:293787	8/20 (40%)
		HEAT repeat	185..213	CDD:293787	6/27 (22%)
		Cnd1	<193..266	CDD:289487	20/84 (24%)
		HEAT repeat	221..263	CDD:293787	12/53 (23%)
		HEAT repeat	272..290	CDD:293787	7/36 (19%)
		HEAT repeat	302..331	CDD:293787	8/28 (29%)
		BLVR	687..840	CDD:283923	27/159 (17%)
AP-1gamma	NP_788891.2	Adaptin_N	68..624	CDD:279882	160/638 (25%)
AP-1gamma	NP_788891.2	Alpha_adaptinC2	869..972	CDD:197886
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810