DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment g and Ap3d1

DIOPT Version :9

Sequence 1:	NP_524785.2	Gene:	g / 44819	FlyBaseID:	FBgn0001087	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	NP_001094189.1	Gene:	Ap3d1 / 314633	RGDID:	1308659	Length:	1204	Species:	Rattus norvegicus

Alignment Length:	1035	Identity:	571/1035 - (55%)
Similarity:	722/1035 - (69%)	Gaps:	110/1035 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALKKVKGNFFERMFDKNLTDLVRGIRNNKDNEAKYISTCIEEIKQELRQDNISVKCNAVAKLTY 65
            ||||.|||: .:|||||||.||||||||:|::||||||.||:||||||:||||:||.|||.||||
  Rat     1 MALKMVKGS-IDRMFDKNLQDLVRGIRNHKEDEAKYISQCIDEIKQELKQDNIAVKANAVCKLTY 64

  Fly    66 IQMLGYDISWAGFNIIEVMSSSRFTCKRIGYLAASQCFHPDSELLMLTTNMIRKDLNSQNQYDAG 130
            :||||||||||.||||||||:|:||.||:||||||||||..::::|||||.|||||:|.:|||.|
  Rat    65 LQMLGYDISWAAFNIIEVMSASKFTFKRVGYLAASQCFHEGTDVIMLTTNQIRKDLSSPSQYDTG 129

  Fly   131 VALSGLSCFISPDLSRDLANDIMTLMSSTKPYLRMKAVLMMYKVFLRYPEALRPAFPKLKEKLED 195
            |||:|||||::|||:||||||||||||.||||:|.||||:||||||:|||:||||||:|||||||
  Rat   130 VALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLED 194

  Fly   196 PDPGVQSAAVNVICELARKNPKNYLPLAPIFFKLMTTSTNNWMLIKIIKLFGALTPLEPRLGKKL 260
            ||||||||||||||||||:||||||.|||:||||||:|||||:||||||||||||||||||||||
  Rat   195 PDPGVQSAAVNVICELARRNPKNYLSLAPLFFKLMTSSTNNWVLIKIIKLFGALTPLEPRLGKKL 259

  Fly   261 IEPLTNLIHSTSAMSLLYECINTVIAVLISISSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGL 325
            ||||||||||||||||||||:|||||||||:||||||||||||||||||||||||||||||||||
  Rat   260 IEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGL 324

  Fly   326 LAMSKILKTHPKSVQAHKDLILACLDDKDESIRLRALDLLYGMVSKKNLMEIVKRLLGHMERAEG 390
            |||||||||||||||:||||||.|||||||||||||||||||||||||||||||:|:.|:::|||
  Rat   325 LAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEG 389

  Fly   391 SAYRDELLYKVIEICAQSSYLYVTNFEWYLTVLVELIQLEAGSRHGRLIAEQLLDVAIRVPVVRQ 455
            :.||||||.|:|:||:||:|.::||||||:::||||.:|| |:|||.|||.|:|||||||..:|:
  Rat   390 TTYRDELLTKIIDICSQSNYQHITNFEWYISILVELTRLE-GTRHGHLIAAQMLDVAIRVKAIRK 453

  Fly   456 FAVNEMTNLLDT---FTVSAQSNSMYEVLYAAAWIVGEFAGELEDAEKTLNILLRPRL--LPGHI 515
            |||::|::|||:   ...|.|.|.:.|||||||||.|||:..|:..::||..:|||::  |||||
  Rat   454 FAVSQMSSLLDSAHLVASSTQRNGICEVLYAAAWICGEFSEHLQGPQQTLEAMLRPKVTTLPGHI 518

  Fly   516 QGVYVQNVIKLFARLATTCLELQDLPGLVTLCDHVLDKLQHFNGSSDIEVQERANSACMLIEMLR 580
            |.||||||:||:|.:.....:..|..|...:...::::|..|..|:|:||||||:....|::.::
  Rat   519 QAVYVQNVVKLYASILQQKEQAADTEGAQEVTQLLVERLPQFVQSADLEVQERASCILQLVKHVQ 583

  Fly   581 NQLSTSTDAMAMDTTTEGGIPPLAIEIVQEMTLLFTGELIPVAPKAQRKVPLPDGLDLDEWINAP 645
            ...:.             |:|     :.:|::.||.|||.|||||||:|||:|:|||||.|||.|
  Rat   584 KLQAK-------------GVP-----VAEEVSALFAGELNPVAPKAQKKVPVPEGLDLDAWINEP 630

  Fly   646 PPEDAASSSSSEHDKDE-LFVSATQAGTGADGGEKRRQSLELTPEQLERQRMARLIEQSNNPHYL 709
            |     |.|.||.:|.: :|.......|       ||:..|...|:|.|:|.||..||:|||.|:
  Rat   631 P-----SDSESEDEKPKAIFHEEEPRHT-------RRRQPEEDEEELARRREARKQEQANNPFYI 683

  Fly   710 KSTPTASGASNADQYDN---IDDIPITELPLDMEGVAALRVGITKRSDKY--LQEQQAAQGSKDG 769
            ||:|     |...:|.:   ::.||:.::.|.:    .|:|.....||:|  |:||:..:...:.
  Rat   684 KSSP-----SPQKRYQDAPGVEHIPVVQIDLSV----PLKVPGMPMSDQYVKLEEQRRHRQRLEK 739

  Fly   770 KKKHKKGKKSKKAKNKVAYNSSSESEGEPKPLHIVN-TTLDMPEGVSMSDSEDKDGKYDPNDPHR 833
            .||.||.:|.|:..:.:    .:||:.:..|...|: .|.:|||....||.:||    |||||:|
  Rat   740 DKKRKKKEKGKRRHSSL----PTESDEDIAPAQRVDIITEEMPENALPSDEDDK----DPNDPYR 796

  Fly   834 ALDIELDITEFEAPAVRSASKKSAADKENL-----------KTPADSAGGGNAAKKDRKKDKDKD 887
            ||||:||              |..||.|.|           |:|......|    .::|..|.|.
  Rat   797 ALDIDLD--------------KPLADSEKLPVQKHRNAETVKSPEKEGVPG----VEKKSKKPKK 843

  Fly   888 KERKVKREHRESKRERKEAAVQSVIDLIDADTPTPSPSHISATSNNNNTSTVLPDAPKHHKKKKN 952
            ||:|.|...||.|.::.|.     :|...:.||.|:.:.:.|.|.....:::: ..||...:...
  Rat   844 KEKKPKEREREKKDKKGED-----LDFWLSTTPPPAAAPVPAPSTEGLAASIV-TPPKGECEVLK 902

  Fly   953 KEKTTDEAPDALATATGSSIIDVGGEEASEVASKVHKKKHKKEKSQR-KEKKKASESASV 1011
            .|:..||.             |....:....:|:..||||:|||.:| ::||||.....|
  Rat   903 GEEPQDEE-------------DHMDHDQERKSSRHKKKKHRKEKEERPRDKKKAKRKQVV 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
g	NP_524785.2	Adaptin_N	33..578	CDD:279882	406/549 (74%)
		HEAT repeat	152..173	CDD:293787	16/20 (80%)
		HEAT repeat	185..213	CDD:293787	26/27 (96%)
		Cnd1	<193..266	CDD:289487	67/72 (93%)
		HEAT repeat	221..263	CDD:293787	37/41 (90%)
		HEAT repeat	272..290	CDD:293787	16/17 (94%)
		HEAT repeat	302..331	CDD:293787	28/28 (100%)
		BLVR	687..840	CDD:283923	56/158 (35%)
Ap3d1	NP_001094189.1	Adaptin_N	32..581	CDD:279882	406/549 (74%)
		HEAT repeat	151..172	CDD:293787	16/20 (80%)
		Cnd1	155..265	CDD:289487	97/109 (89%)
		HEAT repeat	184..212	CDD:293787	26/27 (96%)
		HEAT repeat	220..262	CDD:293787	37/41 (90%)
		HEAT repeat	271..292	CDD:293787	18/20 (90%)
		HEAT repeat	301..330	CDD:293787	28/28 (100%)
		HEAT repeat	335..364	CDD:293787	26/28 (93%)
		BLVR	661..803	CDD:283923	56/158 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346138
Domainoid	1	1.000	805	1.000	Domainoid score	I69
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1006	1.000	Inparanoid score	I275
OMA	1	1.010	-	-		QHG52588
OrthoDB	1	1.010	-	-		D163216at33208
OrthoFinder	1	1.000	-	-		FOG0005167
OrthoInspector	1	1.000	-	-		oto96245
orthoMCL	1	0.900	-	-		OOG6_102126
Panther	1	1.100	-	-	LDO	PTHR22781
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3686
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770