Protein Alignment g and Ap3d1

DIOPT Version :10

• Sequence 1: NP_524785.2
• Gene: g / 44819
• FlyBaseID: FBgn0001087
• Length: 1034
• Species: Drosophila melanogaster
• Sequence 2: XP_063119492.1
• Gene: Ap3d1 / 314633
• RGDID: 1308659
• Length: 1227
• Species: Rattus norvegicus
• Alignment Length: 1035
• Identity: 571/1035 - (55%)
• Similarity: 722/1035 - (69%)
• Gaps: 110/1035 - (10%)

  Fly     1 MALKKVKGNFFERMFDKNLTDLVRGIRNNKDNEAKYISTCIEEIKQELRQDNISVKCNAVAKLTY 65
            ||||.|||: .:|||||||.||||||||:|::||||||.||:||||||:||||:||.|||.||||
  Rat     1 MALKMVKGS-IDRMFDKNLQDLVRGIRNHKEDEAKYISQCIDEIKQELKQDNIAVKANAVCKLTY 64

  Fly    66 IQMLGYDISWAGFNIIEVMSSSRFTCKRIGYLAASQCFHPDSELLMLTTNMIRKDLNSQNQYDAG 130
            :||||||||||.||||||||:|:||.||:||||||||||..::::|||||.|||||:|.:|||.|
  Rat    65 LQMLGYDISWAAFNIIEVMSASKFTFKRVGYLAASQCFHEGTDVIMLTTNQIRKDLSSPSQYDTG 129

  Fly   131 VALSGLSCFISPDLSRDLANDIMTLMSSTKPYLRMKAVLMMYKVFLRYPEALRPAFPKLKEKLED 195
            |||:|||||::|||:||||||||||||.||||:|.||||:||||||:|||:||||||:|||||||
  Rat   130 VALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLED 194

  Fly   196 PDPGVQSAAVNVICELARKNPKNYLPLAPIFFKLMTTSTNNWMLIKIIKLFGALTPLEPRLGKKL 260
            ||||||||||||||||||:||||||.|||:||||||:|||||:||||||||||||||||||||||
  Rat   195 PDPGVQSAAVNVICELARRNPKNYLSLAPLFFKLMTSSTNNWVLIKIIKLFGALTPLEPRLGKKL 259

  Fly   261 IEPLTNLIHSTSAMSLLYECINTVIAVLISISSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGL 325
            ||||||||||||||||||||:|||||||||:||||||||||||||||||||||||||||||||||
  Rat   260 IEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGL 324

  Fly   326 LAMSKILKTHPKSVQAHKDLILACLDDKDESIRLRALDLLYGMVSKKNLMEIVKRLLGHMERAEG 390
            |||||||||||||||:||||||.|||||||||||||||||||||||||||||||:|:.|:::|||
  Rat   325 LAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEG 389

  Fly   391 SAYRDELLYKVIEICAQSSYLYVTNFEWYLTVLVELIQLEAGSRHGRLIAEQLLDVAIRVPVVRQ 455
            :.||||||.|:|:||:||:|.::||||||:::||||.:|| |:|||.|||.|:|||||||..:|:
  Rat   390 TTYRDELLTKIIDICSQSNYQHITNFEWYISILVELTRLE-GTRHGHLIAAQMLDVAIRVKAIRK 453

  Fly   456 FAVNEMTNLLDT---FTVSAQSNSMYEVLYAAAWIVGEFAGELEDAEKTLNILLRPRL--LPGHI 515
            |||::|::|||:   ...|.|.|.:.|||||||||.|||:..|:..::||..:|||::  |||||
  Rat   454 FAVSQMSSLLDSAHLVASSTQRNGICEVLYAAAWICGEFSEHLQGPQQTLEAMLRPKVTTLPGHI 518

  Fly   516 QGVYVQNVIKLFARLATTCLELQDLPGLVTLCDHVLDKLQHFNGSSDIEVQERANSACMLIEMLR 580
            |.||||||:||:|.:.....:..|..|...:...::::|..|..|:|:||||||:....|::.::
  Rat   519 QAVYVQNVVKLYASILQQKEQAADTEGAQEVTQLLVERLPQFVQSADLEVQERASCILQLVKHVQ 583

  Fly   581 NQLSTSTDAMAMDTTTEGGIPPLAIEIVQEMTLLFTGELIPVAPKAQRKVPLPDGLDLDEWINAP 645
            ...:.             |:|     :.:|::.||.|||.|||||||:|||:|:|||||.|||.|
  Rat   584 KLQAK-------------GVP-----VAEEVSALFAGELNPVAPKAQKKVPVPEGLDLDAWINEP 630

  Fly   646 PPEDAASSSSSEHDKDE-LFVSATQAGTGADGGEKRRQSLELTPEQLERQRMARLIEQSNNPHYL 709
            |     |.|.||.:|.: :|.......|       ||:..|...|:|.|:|.||..||:|||.|:
  Rat   631 P-----SDSESEDEKPKAIFHEEEPRHT-------RRRQPEEDEEELARRREARKQEQANNPFYI 683

  Fly   710 KSTPTASGASNADQYDN---IDDIPITELPLDMEGVAALRVGITKRSDKY--LQEQQAAQGSKDG 769
            ||:|     |...:|.:   ::.||:.::.|.:    .|:|.....||:|  |:||:..:...:.
  Rat   684 KSSP-----SPQKRYQDAPGVEHIPVVQIDLSV----PLKVPGMPMSDQYVKLEEQRRHRQRLEK 739

  Fly   770 KKKHKKGKKSKKAKNKVAYNSSSESEGEPKPLHIVN-TTLDMPEGVSMSDSEDKDGKYDPNDPHR 833
            .||.||.:|.|:..:.:    .:||:.:..|...|: .|.:|||....||.:||    |||||:|
  Rat   740 DKKRKKKEKGKRRHSSL----PTESDEDIAPAQRVDIITEEMPENALPSDEDDK----DPNDPYR 796

  Fly   834 ALDIELDITEFEAPAVRSASKKSAADKENL-----------KTPADSAGGGNAAKKDRKKDKDKD 887
            ||||:||              |..||.|.|           |:|......|    .::|..|.|.
  Rat   797 ALDIDLD--------------KPLADSEKLPVQKHRNAETVKSPEKEGVPG----VEKKSKKPKK 843

  Fly   888 KERKVKREHRESKRERKEAAVQSVIDLIDADTPTPSPSHISATSNNNNTSTVLPDAPKHHKKKKN 952
            ||:|.|...||.|.::.|.     :|...:.||.|:.:.:.|.|.....:::: ..||...:...
  Rat   844 KEKKPKEREREKKDKKGED-----LDFWLSTTPPPAAAPVPAPSTEGLAASIV-TPPKGECEVLK 902

  Fly   953 KEKTTDEAPDALATATGSSIIDVGGEEASEVASKVHKKKHKKEKSQR-KEKKKASESASV 1011
            .|:..||.             |....:....:|:..||||:|||.:| ::||||.....|
  Rat   903 GEEPQDEE-------------DHMDHDQERKSSRHKKKKHRKEKEERPRDKKKAKRKQVV 949

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
g	NP_524785.2	Adaptin_N	33..578	CDD:396262	406/549 (74%)
		AP3D1	687..840	CDD:461889	56/158 (35%)
Ap3d1	XP_063119492.1	None