DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment g and Ap4e1

DIOPT Version :9

Sequence 1:	NP_524785.2	Gene:	g / 44819	FlyBaseID:	FBgn0001087	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	NP_001178671.1	Gene:	Ap4e1 / 311404	RGDID:	1562199	Length:	1130	Species:	Rattus norvegicus

Alignment Length:	960	Identity:	211/960 - (21%)
Similarity:	379/960 - (39%)	Gaps:	202/960 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FFERMFDKNLTDLVRGIR--NNKDNEAKYISTCIEEIKQELRQDNISVKC--NAVAKLTYIQMLG 70
            ||.|     |..|:||:.  ::|..|.|.|...:..:|..:.....::|.  ..:.:|.|.:|||
  Rat    31 FFSR-----LGGLIRGVTALSSKHEEEKLIQQELSSLKATVSAPTTTLKMMKECMVRLIYCEMLG 90

  Fly    71 YDISWAGFNIIEVMSSSRFTCKRIGYLAASQCFHPDSELLMLTTNMIRKDLNSQNQYDAGVALSG 135
            ||.|:...:.|::........||:||||.|...|...|||:|..|.:.|||.|.|..:..:||:
  Rat    91 YDASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKDLQSTNLVEVCMALT- 154

  Fly   136 LSCFISPDLSRDLANDIMTL----MSSTKPYLRMKAVLMMYKVFLRYPEALRPAFPKLKEKLEDP 196
               .:|....|::...::.|    :..:|..:|.||||.:||.:|..|..::....|.::.|.|.
  Rat   155 ---VVSQIFPREMIPAVLPLIEEKLQHSKEIIRRKAVLALYKFYLIAPNQVQHIHTKFRKALCDR 216

  Fly   197 DPGVQSAAVNVICELARKNPKNYLPLAPIFFKLMTTSTNN--------------WMLIKIIKLFG 247
            |.||.:|::::...:.::|...|..|...|..::......              |:.|:::::.|
  Rat   217 DVGVMAASLHIYLRMIKENSSGYKDLTESFVTILKQVVGGKLPVEFSYHSVPAPWLQIQLLRILG 281

  Fly   248 ALTPLEPRLGKKLIEPL------TNLIHSTSAMSLLYECINTVIAVLISISSGMPNHSASIQLCV 306
            .|...:.|..:.:.:.|      ..|.|:.: .::|:||::|:.:  |...|.:...:|.   |:
  Rat   282 LLGKDDERTSELMYDVLDESLRRAELNHNVT-YAILFECVHTIYS--IYPKSELLEKAAK---CI 340

  Fly   307 QKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQAHKDLILACLDDKDESIRLRALDLLYGMVSK 371
            .|   .:.....|||||||.|::.:::..|.....|:..|:.|||..|..|:...|:|||.:.:.
  Rat   341 GK---FVLSPKINLKYLGLKALTYVIQQDPSLALQHQITIIECLDHPDPIIKRETLELLYRITNA 402

  Fly   372 KNLMEIVKRLLGHMERAEGSAYRDELLYKVIEICAQSSYLYVTNFEWYLTVLVELIQLEAGSRHG 436
            :|::.||:::|.::.:::.......|:.|:.|:..:    |..:..|::..:..:..:.....|.
  Rat   403 QNVVVIVQKMLEYLHQSKEEYIIINLVGKIAELAEK----YAPDNVWFIQTMNAVFSVGGDVMHP 463

  Fly   437 -------RLIAEQLLDVAIRVPVVRQFAVNEMTNLLDTFTVSAQSNSMY--EVLYAAAWIVGEFA 492
                   ||:||. .|.......:|.:||.....|||      ..|:.|  ..|...:|::||::
  Rat   464 DILSNFLRLLAEG-FDDETEDQQLRLYAVQSYLTLLD------MENTFYPQRFLQVMSWVLGEYS 521

  Fly   493 GELEDAEKTLNILLR----------------------PRLLPGHIQGVYVQNVIKLFARLATTCL 535
             .|.|.|....::.|                      .:|.|.......|:|:|:.|.....|||
  Rat   522 -YLLDRESPEAVMTRLYKLLRSDSISSETKAWLFAAVTKLTPQAHSSPIVENLIQEFTVSLNTCL 585

  Fly   536 ELQDLPGLVTLCDHVLDKLQHFNGSSDIEVQERANSACMLIEMLRNQLSTSTDAMAMDTTTEGGI 600
            .           .|..: |:|.:.:.:: ::....||....:::.:...:..|....:..::|.
  Rat   586 R-----------QHAFE-LKHLHENEEL-MKSLLQSAQNCDDIMADASLSFLDGFVAEGLSQGA- 636

  Fly   601 PPLAIEIVQEMTLLFTGELIPVAPKAQRKVPLPDGLDLDEWINAPPPEDAASSSSSEHDKDELFV 665
                               .|..|:.||:   .:.|..::.:|..|...:.|||.....:....|
  Rat   637 -------------------APYKPRHQRQ---EEQLSQEKVLNFEPYGLSFSSSGFTGRQSPAGV 679

  Fly   666 S--ATQAGTGADGGEKRRQSLELTPEQLERQRMARLIEQSNNPHYLKSTPTASGASNADQYDNID 728
            |  :..:|..|:.|.|...||          :|..:.:......||..  ..|||:        |
  Rat   680 SLGSDISGNSAETGLKEAGSL----------KMDGIKKLWGKEGYLPK--KESGAA--------D 724

  Fly   729 DIPITELPLD---MEGVAALRVGITKRSDKYLQEQQAAQGSKDGKKKHKK--------------- 775
            .:.....|.:   ||.|           |:.:..:..|||.....::.:|
  Rat   725 KLEAAHAPAESAMMENV-----------DQAMTRKDQAQGHTPSTEEKEKQLLASSLFVGLGPEN 778

  Fly   776 -----GKKS-------KKAKNKVAYNSSSESEGEPKPLHIVNTTLDMPEGVSMSDSEDKDGKYDP 828
                 ||..       :|:|.|||     :|:..|......::||.....|:..| ||.....|.
  Rat   779 TINLLGKADVVSYKFRRKSKPKVA-----QSDKMPSAHAAPSSTLSPVSDVAGGD-EDSLSAADR 837

  Fly   829 NDPHRALDIELDITEFEAPAVRSASKKS--------AADKENLKTPADSA 870
            .|.....::....:..|.|:|.:.|..|        ..|.|....|:.||
  Rat   838 GDGELGSELLGSESVLELPSVENLSSVSLPVSSLFAGNDMEVFHPPSSSA 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
g	NP_524785.2	Adaptin_N	33..578	CDD:279882	140/601 (23%)
		HEAT repeat	152..173	CDD:293787	7/24 (29%)
		HEAT repeat	185..213	CDD:293787	7/27 (26%)
		Cnd1	<193..266	CDD:289487	16/92 (17%)
		HEAT repeat	221..263	CDD:293787	7/55 (13%)
		HEAT repeat	272..290	CDD:293787	4/17 (24%)
		HEAT repeat	302..331	CDD:293787	10/28 (36%)
		BLVR	687..840	CDD:283923	33/182 (18%)
Ap4e1	NP_001178671.1	Adaptin_N	51..595	CDD:279882	137/580 (24%)
Ap4e1	NP_001178671.1	AP4E_app_platf	1026..1125	CDD:291473
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810