Protein Alignment g and Ap2a1

DIOPT Version :10

• Sequence 1: NP_524785.2
• Gene: g / 44819
• FlyBaseID: FBgn0001087
• Length: 1034
• Species: Drosophila melanogaster
• Sequence 2: XP_063118046.1
• Gene: Ap2a1 / 308578
• RGDID: 1306254
• Length: 982
• Species: Rattus norvegicus
• Alignment Length: 979
• Identity: 220/979 - (22%)
• Similarity: 390/979 - (39%)
• Gaps: 248/979 - (25%)

  Fly    17 KNLTDLVRGIRNNKDNEAKYISTCIEEIKQELRQ-----------DNISVKCNAVAKLTYIQMLG 70
            :.|...:..|||.|..||:     |:.|.:||..           |..|.| ..|.||.:|.:||
  Rat    11 RGLAVFISDIRNCKSKEAE-----IKRINKELANIRSKFKGDKALDGYSKK-KYVCKLLFIFLLG 69

  Fly    71 YDISWAGFNIIEVMSSSRFTCKRIGYLAASQCFHPDSELLMLTTNMIRKDLNSQNQYDAGVALSG 135
            :||.:.....:.::||:::|.|:||||..|...:.:|||:.|..|.|:.||.|:|.....:||..
  Rat    70 HDIDFGHMEAVNLLSSNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMCLALHC 134

  Fly   136 LSCFISPDLSRDLANDIMTLM--SSTKPYLRMKAVLMMYKVFLRYPEALRPA---FPKLKEKLED 195
            ::...|.::....|.||..::  ..:...::..|.|.:.:::...|: |.|.   ..::...|.|
  Rat   135 IANVGSREMGEAFAADIPRILVAGDSMDSVKQSAALCLLRLYKASPD-LVPMGEWTARVVHLLND 198

  Fly   196 PDPGVQSAAVNVICELARKNPKNY-----LPLAPIFFKLMTTSTN-----------NWMLIKIIK 244
            ...||.:|||::|..|.:|||.::     |.::.:...:.:.||:           .|:.:|:::
  Rat   199 QHMGVVTAAVSLITCLCKKNPDDFKTCVSLAVSRLSRIVSSASTDLQDYTYYFVPAPWLSVKLLR 263

  Fly   245 LFGALTPLEPRLGK-KLIEPLTNLI-------------HSTSAMSLLYECINTVIAVLISISSGM 295
            |.....|.|....| :|:|.|..::             ||.:..::|:|.|:.:|..     ...
  Rat   264 LLQCYPPPEDAAVKGRLVECLETVLNKAQEPPKSKKVQHSNAKNAILFETISLIIHY-----DSE 323

  Fly   296 PNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTH--PKSVQAHKDLILACL-DDKDESI 357
            ||  ..::.|.| |...::..:.||:||.|.:|..:..:.  .::|:.|.|.::..| .::|.|:
  Rat   324 PN--LLVRACNQ-LGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIDTVINALKTERDVSV 385

  Fly   358 RLRALDLLYGMVSKKNLMEIVKRLLGHMERAEGSAYRDELLYKVIEICAQSSYLYVTNFEWYLTV 422
            |.||.||||.|..:.|..:||..:|.::|.|: .|.|:|::.|| .|.|:.   |..::.||:..
  Rat   386 RQRAADLLYAMCDRSNAKQIVSEMLRYLETAD-YAIREEIVLKV-AILAEK---YAVDYSWYVDT 445

  Fly   423 LVELIQLEAGSRHGRLIAEQLLDVAIRVPVVRQFAVNEMTNLLDTFTVSAQSNSMYEVLYAAA-- 485
            ::.||::.     |..::|::....:::          :||..|....:|:  :::|.|.|.|
  Rat   446 ILNLIRIA-----GDYVSEEVWYRVLQI----------VTNRDDVQGYAAK--TVFEALQAPACH 493

  Fly   486 --------WIVGEF----AGE-----------LEDAEKTLNILLRPRLLPGHIQGV--------Y 519
                    :|:|||    ||:           |.......::..|..||..:|:.:        .
  Rat   494 ENMVKVGGYILGEFGNLIAGDPRSSPPVQFSLLHSKFHLCSVATRALLLSTYIKFINLFPETKAT 558

  Fly   520 VQNVIKLFARLATTCLELQ-----------------------DLPGLVTLCDHVLDKLQHFNG-- 559
            :|.|::..::|....:|||                       ::|........:|.||:...|
  Rat   559 IQGVLRAGSQLRNADVELQQRAVEYLTLSSVASTDVLATVLEEMPPFPERESSILAKLKRKKGPG 623

  Fly   560 -SSDIEVQERANSACML---IEMLRNQLST---STDAMAMDTTTEGGIPP------LAIEIVQEM 611
             :|.::...|..|:..:   :|...:.:||   |.|.:.:........||      |.:::..:.
  Rat   624 AASALDDSRRDTSSNDINGGVEPTPSNVSTPSPSADLLGLRAAPPPAAPPAPVGGNLLVDVFSDG 688

  Fly   612 TL-----------LFTGELIPVAPKAQRKV---PLPDGLDLDEWINAPPPEDAASSSSSEHDKDE 662
            ..           .|..||.|.||::...:   |.|......|.|..|.||           .||
  Rat   689 PTAQPSLGPTPEEAFLSELEPPAPESPMTLLADPAPAADPGPEDIGPPIPE-----------ADE 742

  Fly   663 L---FVSATQAGTGADGGEKRRQSLELTPEQLERQRMARLI----------EQSNNP-------- 706
            |   ||...      .|.....|.|::..:...||.:.|:.          .||..|
  Rat   743 LLNKFVCKN------SGVLFENQLLQIGVKSEFRQNLGRMYLFYGNKTSVQFQSFLPTVVHPGDL 801

  Fly   707 --HYLKS---------TPTASGASNADQYDNIDDI------PITELPLDMEGVA---ALRVGITK 751
              |.|.|         .....|.:...|..||:.:      |:..:.....|.|   .|::.:|
  Rat   802 QTHILCSCLAVQTKRVAAQVDGGAQVQQVLNIECLRDFLTPPLLSVRFRYGGTAQSLTLKLPVT- 865

  Fly   752 RSDKYLQEQQAA----------------QGSKDGKKKHKKGKKSKKAKNKVAYNSSSESEGEPKP 800
             .:|:.|..:.|                :..|..|..|....:..||| .:.:.|:.....:|.|
  Rat   866 -INKFFQPTEMAAQDFFQRWKQLSLPLQEAQKIFKANHPMDAEVTKAK-LLGFGSALLDNVDPNP 928

  Fly   801 LHIV 804
            .:.|
  Rat   929 ENFV 932

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
g	NP_524785.2	Adaptin_N	33..578	CDD:396262	155/655 (24%)
		AP3D1	687..840	CDD:461889	31/172 (18%)
Ap2a1	XP_063118046.1	None