DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment g and apl5

DIOPT Version :9

Sequence 1:	NP_524785.2	Gene:	g / 44819	FlyBaseID:	FBgn0001087	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	NP_594667.2	Gene:	apl5 / 2542857	PomBaseID:	SPAC144.06	Length:	825	Species:	Schizosaccharomyces pombe

Alignment Length:	920	Identity:	324/920 - (35%)
Similarity:	501/920 - (54%)	Gaps:	140/920 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 MFDKNLTDLVRGIRNNKDNEAKYISTCIEEIKQELRQDNISVKCNAVAKLTYIQMLGYDISWAGF 78
            :|::.|.||::|||::.::|..:|:||:.|.::|....:..:|..|:.||.|::|||.|||||.|
pombe     2 VFERTLIDLIKGIRSHANDEEAFIATCLLECRKEATSQDADLKSEAILKLAYLEMLGVDISWASF 66

  Fly    79 NIIEVMSSSRFTCKRIGYLAASQCFHPDSELLMLTTNMIRKDLNSQNQYDAGVALSGLSCFISPD 143
            .|:||||||:...|:.|||||.|.|.||:::||||||:::|||.|....:..:|:.|||.|.:..
pombe    67 QIVEVMSSSKILQKQKGYLAAVQSFKPDTDVLMLTTNLLKKDLMSSKVPEITLAIDGLSHFSTLG 131

  Fly   144 LSRDLANDIMTLMSSTKPYLRMKAVLMMYKVFLRYPEALRPAFPKLKEKLEDPDPGVQSAAVNVI 208
            |:|||..|::.|::.:.||:|.:.:|::|::.|:||||:....|||:|:|:|||..|.:|||:||
pombe   132 LARDLYRDVLILLNHSVPYVRKRTILLLYRLCLQYPEAISACIPKLRERLDDPDTSVVNAAVSVI 196

  Fly   209 CELARKNPKNYLPLAPIFFKLMTTSTNNWMLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHSTSA 273
            |||||:.|||||..||..|.|:|||:|||||||:||||.:|||.||||.||||..||::|.:|.|
pombe   197 CELARRAPKNYLEFAPDLFHLLTTSSNNWMLIKLIKLFASLTPYEPRLVKKLIPSLTDIIENTHA 261

  Fly   274 MSLLYECINTVIAVLISISSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTHPKS 338
            ||||||||||:::..:.:.....:..||  ||..|||...||:||||||:.||.:.|:..|||..
pombe   262 MSLLYECINTIVSGNMLVGHSQCDKLAS--LCASKLRGFFEDTDQNLKYIALLCLRKLANTHPSL 324

  Fly   339 VQAHKDLILACLDDKDESIRLRALDLLYGMVSKKNLMEIVKRLLGHM----ERAEGSAYRDELLY 399
            |.|..|:||.||.|.|.|||||||||:..:|:|:|:..|||.|:..:    :.:.....|:....
pombe   325 VSAQLDIILKCLVDTDTSIRLRALDLVNEIVNKENIRTIVKTLMLQLIVSSDESAVEDIRNSTAT 389

  Fly   400 KVIEICAQSSYLYVTNFEWYLTVLVELIQLEAGSRHGRLIAEQLLDVAIRVPVVRQFAVNEMTN- 463
            ::||:.::|:|:.:.:|||.|||.|:|..: .|...|.|:..|::|:.:||..:|.|:|:..:.
pombe   390 RIIEMTSKSTYMNIADFEWLLTVYVDLANI-PGIDTGTLLNNQIIDLCVRVKALRPFSVDIFSQA 453

  Fly   464 LLDTFTVSAQSNSMYE----VLYAAAWIVGEFAGELEDAEKTLNILLRP----------RLLPGH 514
            :||...||....|:.|    :|.|..|.:||:|..:|:....|:.|.||          |||
pombe   454 ILDPSYVSTTDCSVSEKRTDILPAIIWCLGEYAEFIEEYLDILDALTRPSFKKCSNLAHRLL--- 515

  Fly   515 IQGVYVQNVIKLFARLATTCLELQ-----DLPGLVTL-CDHVLDKLQHFNGSSDIEVQERANSAC 573
                 :|.:.|:|.:   .|||.:     :..|||.| .:.::..::.|....|:|:|.||:...
pombe   516 -----LQAITKIFCQ---WCLEEEPTWGVEKFGLVKLWVEKIVSFIEQFLNFQDMEIQRRASEFY 572

  Fly   574 MLIEMLRNQLSTSTDAMAMDTTTEGGIPPLAIEIVQEMTLLFTGE-LIPVAPKAQRKVPLPDGLD 637
            :|...:.:.::||.....::...:   ||..::  ..|..||.|| |.|||.||||||...:.||
pombe   573 ILFNQVSDIVNTSDTMEVLELQKK---PPYIVQ--NTMYKLFFGEPLNPVAVKAQRKVMPDENLD 632

  Fly   638 LDEWINA---PPPEDAASSSSSEHDKDELFVSATQA-GTGADGGEKRR-QSLELTPEQLERQRMA 697
            |:..||.   .|.|...:...|:   |.|....|:. .:|.|...|:: .|||..|.|
pombe   633 LNCPINGVIEVPKELLENIIQSD---DSLINFDTEVPSSGIDTFSKKQFNSLESVPVQ------- 687

  Fly   698 RLIEQSNNPHYLKSTPTASGASNADQYDNIDDIPITELPLDMEGVAALRVGITKRSDKYLQEQQA 762
               ...::|.||.|....:..::..:..|::                     |..||:.....:.
pombe   688 ---RDLSSPFYLSSNQHTTTTNSEPENLNVE---------------------TSMSDEAFNADKV 728

  Fly   763 AQGSKDGKKKHKKGKKSKKAKNKVAYNSSSESEGEPKPLHIVNTTLDMPEGVSMSDSEDKDGKYD 827
            .:.:|:            |.:.|:..:.|.::        :|....::|||:|::|.|:|:   :
pombe   729 TKVTKN------------KRRRKIFTSPSLQA--------MVVAQDEVPEGISLADIENKE---N 770

  Fly   828 PNDPHRALDIELD-------------ITEFEAPAVRSASKKSAADKENLKTPADSAGGGNAAKKD 879
            |::.:....|.||             :.|.::| :|...|||                   .||.
pombe   771 PSNSNVYSLISLDPPLSTNQGSMGDIVLETKSP-IRVEKKKS-------------------KKKK 815

  Fly   880 RKKDKDKDKE 889
            :||:|...||
pombe   816 KKKEKTSGKE 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
g	NP_524785.2	Adaptin_N	33..578	CDD:279882	242/569 (43%)
		HEAT repeat	152..173	CDD:293787	5/20 (25%)
		HEAT repeat	185..213	CDD:293787	17/27 (63%)
		Cnd1	<193..266	CDD:289487	50/72 (69%)
		HEAT repeat	221..263	CDD:293787	29/41 (71%)
		HEAT repeat	272..290	CDD:293787	11/17 (65%)
		HEAT repeat	302..331	CDD:293787	15/28 (54%)
		BLVR	687..840	CDD:283923	24/152 (16%)
apl5	NP_594667.2	Adaptin_N	21..577	CDD:279882	242/569 (43%)
		ARM	140..>206	CDD:237987	31/65 (48%)
		HEAT repeat	140..161	CDD:293787	5/20 (25%)
		HEAT repeat	173..201	CDD:293787	17/27 (63%)
		HEAT repeat	212..236	CDD:293787	17/23 (74%)
		HEAT repeat	248..279	CDD:293787	17/30 (57%)
		HEAT repeat	289..320	CDD:293787	17/32 (53%)
		HEAT repeat	329..353	CDD:293787	16/23 (70%)
		HEAT repeat	364..394	CDD:293787	5/29 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	420	1.000	Domainoid score	I88
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	467	1.000	Inparanoid score	I278
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005167
OrthoInspector	1	1.000	-	-		oto100820
orthoMCL	1	0.900	-	-		OOG6_102126
Panther	1	1.100	-	-	LDO	PTHR22781
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R64
SonicParanoid	1	1.000	-	-		X3686
TreeFam	1	0.960	-	-
	12	11.850