DRSC/TRiP Functional Genomics Resources

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Protein Alignment g and AP4E1

DIOPT Version :9

Sequence 1:NP_524785.2 Gene:g / 44819 FlyBaseID:FBgn0001087 Length:1034 Species:Drosophila melanogaster
Sequence 2:NP_031373.2 Gene:AP4E1 / 23431 HGNCID:573 Length:1137 Species:Homo sapiens


Alignment Length:938 Identity:215/938 - (22%)
Similarity:373/938 - (39%) Gaps:178/938 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 FDKNLTDLVRGIR--NNKDNEAKYISTCIEEIKQELRQDNISVKC--NAVAKLTYIQMLGYDISW 75
            |...|..|||||.  .:|..|.|.|...:..:|..:.....::|.  ..:.:|.|.:|||||.|:
Human    32 FSSRLGSLVRGITALTSKHEEEKLIQQELSSLKATVSAPTTTLKMMKECMVRLIYCEMLGYDASF 96

  Fly    76 AGFNIIEVMSSSRFTCKRIGYLAASQCFHPDSELLMLTTNMIRKDLNSQNQYDAGVALSGLSCFI 140
            ...:.|::........||:||||.|...|...|||:|..|.:.|||.|.|..:..:||:.:|...
Human    97 GYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKDLQSTNLVEVCMALTVVSQIF 161

  Fly   141 SPDLSRDLANDIMTLMSSTKPYLRMKAVLMMYKVFLRYPEALRPAFPKLKEKLEDPDPGVQSAAV 205
            ..::...:...|...:..:|..:|.||||.:||..|..|..::....|.::.|.|.|.||.:|::
Human   162 PCEMIPAVLPLIEDKLQHSKEIVRRKAVLALYKFHLIAPNQVQHIHIKFRKALCDRDVGVMAASL 226

  Fly   206 NVICELARKNPKNYLPLAPIFFKLMTTSTNN--------------WMLIKIIKLFGALTPLEPRL 256
            ::...:.::|...|..|...|..::......              |:.|:::::.|.|...:.|.
Human   227 HIYLRMIKENSSGYKDLTGSFVTILKQVVGGKLPVEFNYHSVPAPWLQIQLLRILGLLGKDDQRT 291

  Fly   257 GKKLIEPL------TNLIHSTSAMSLLYECINTVIAVLISISSGMPNHSASIQLCVQKLRILIED 315
            .:.:.:.|      ..|.|:.: .::|:||::||.:  |...|.:...:|.   |:.|   .:..
Human   292 SELMYDVLDESLRRAELNHNVT-YAILFECVHTVYS--IYPKSELLEKAAK---CIGK---FVLS 347

  Fly   316 SDQNLKYLGLLAMSKILKTHPKSVQAHKDLILACLDDKDESIRLRALDLLYGMVSKKNLMEIVKR 380
            ...|||||||.|::.:::..|.....|:..|:.|||..|..|:...|:|||.:.:.:|:..||::
Human   348 PKINLKYLGLKALTYVIQQDPTLALQHQMTIIECLDHPDPIIKRETLELLYRITNAQNITVIVQK 412

  Fly   381 LLGHMERAEGSAYRDELLYKVIEICAQSSYLYVTNFEWYLTVLVELIQLEAGSRHG-------RL 438
            :|.::.:::.......|:.|:.|:..:    |..:..|::..:..:..:.....|.       ||
Human   413 MLEYLHQSKEEYVIVNLVGKIAELAEK----YAPDNAWFIQTMNAVFSVGGDVMHPDIPNNFLRL 473

  Fly   439 IAEQLLDVAIRVPVVRQFAVNEMTNLLDTFTVSAQSNSMY--EVLYAAAWIVGEFAGELEDAEKT 501
            :||. .|.......:|.:||.....|||      ..|..|  ..|...:|::||:: .|.|.|..
Human   474 LAEG-FDDETEDQQLRLYAVQSYLTLLD------MENVFYPQRFLQVMSWVLGEYS-YLLDKETP 530

  Fly   502 LNILLRPRLLPGHIQGVYVQNVIKLFARLATTCLELQDLPGLVTLCDHVLDKLQH-FNGSSDIEV 565
            ..::.:...|   :....|.:..|.:...|.|.|..|      ....:.:::|.| |..|.|..:
Human   531 EEVIAKLYKL---LMNDSVSSETKAWLIAAVTKLTSQ------AHSSNTVERLIHEFTISLDTCM 586

  Fly   566 QERANSACMLIEMLRNQLSTSTDAMAMDTTTEGGIPPLAIEIVQEMTLLFTGELI---------P 621
            ::.|    ..::.|...:......:.:|.:.|        ::|.:.:|.|....:         |
Human   587 RQHA----FELKHLHENVELMKSLLPVDRSCE--------DLVVDASLSFLDGFVAEGLSQGAAP 639

  Fly   622 VAPKAQRKVPLPDGLDLDEWINAPPPEDAASSS--SSEHDKDELFVSATQAGTGADGGEKRRQSL 684
            ..|..||:   .:.|..::.:|..|...:.|||  :.......:.:.:..:|..|:.|.|...||
Human   640 YKPPHQRQ---EEKLSQEKVLNFEPYGLSFSSSGFTGRQSPAGISLGSDVSGNSAETGLKETNSL 701

  Fly   685 ELTPEQLERQRMARLIEQSNNPHYLKSTPTASGASNADQYDNIDDIPITELPLDMEGVAALRVGI 749
            :|       :.:.:|..:..   ||....:.:|       |....:|:.:..: ||.|..   .|
Human   702 KL-------EGIKKLWGKEG---YLPKKESKTG-------DESGALPVPQESI-MENVDQ---AI 745

  Fly   750 TKRSDKYLQEQQAAQGSKDGKKK---------------------------HKKGKKSKKAKNKVA 787
            ||:     .:.|....||:.|:|                           ||..:|||..:.|  
Human   746 TKK-----DQSQVLTQSKEEKEKQLLASSLFVGLGSESTINLLGKADTVSHKFRRKSKVKEAK-- 803

  Fly   788 YNSSSESEGEPKPLHIVNTTLDMPEGVSMSDSEDKDGKYDPNDPHRALDIEL------------- 839
                   .||....|  |.|......:|....||   .|..|..|...|.||             
Human   804 -------SGETTSTH--NMTCSSFSSLSNVAYED---DYYSNTLHDTGDKELKKFSLTSELLDSE 856

  Fly   840 DITEFEAPAVRSASKKSAADKENLKTPA 867
            .:||.  |.|...|..|      |.||:
Human   857 SLTEL--PLVEKFSYCS------LSTPS 876

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
gNP_524785.2 Adaptin_N 33..578 CDD:279882 138/576 (24%)
HEAT repeat 152..173 CDD:293787 7/20 (35%)
HEAT repeat 185..213 CDD:293787 7/27 (26%)
Cnd1 <193..266 CDD:289487 16/92 (17%)
HEAT repeat 221..263 CDD:293787 7/55 (13%)
HEAT repeat 272..290 CDD:293787 5/17 (29%)
HEAT repeat 302..331 CDD:293787 10/28 (36%)
BLVR 687..840 CDD:283923 37/192 (19%)
AP4E1NP_031373.2 Adaptin_N 52..596 CDD:331138 138/577 (24%)
Interaction with TEPSIN. /evidence=ECO:0000269|PubMed:26542808 727..1137 41/181 (23%)
AP4E_app_platf 1033..1132 CDD:317244
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG4354
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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