Protein Alignment g and apa-2

DIOPT Version :10

• Sequence 1: NP_524785.2
• Gene: g / 44819
• FlyBaseID: FBgn0001087
• Length: 1034
• Species: Drosophila melanogaster
• Sequence 2: NP_001370626.1
• Gene: apa-2 / 181163
• WormBaseID: WBGene00000161
• Length: 925
• Species: Caenorhabditis elegans
• Alignment Length: 786
• Identity: 199/786 - (25%)
• Similarity: 344/786 - (43%)
• Gaps: 147/786 - (18%)

  Fly     6 VKGNFFERMFDKNLTDLVRGIRNNKDNEA--KYISTCIEEIKQELRQDNI---SVKCNAVAKLTY 65
            |||:..     :.|...:..|||.|..||  |.|:..:..|:.:.:.|..   ..|...|.||.:
 Worm     4 VKGDGM-----RGLAVFISDIRNCKSKEAELKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLF 63

  Fly    66 IQMLGYDISWAGFNIIEVMSSSRFTCKRIGYLAASQCFHPDSELLMLTTNMIRKDLNSQNQYDAG 130
            |.:||.||.:.....:.::||:::|.|:||||..|......|:|:.|....||.||.|:|.....
 Worm    64 IFLLGNDIDFGHMEAVNLLSSNKYTEKQIGYLFISVLIEQQSDLMKLIVQGIRNDLTSRNPVHVN 128

  Fly   131 VALSGLSCFISPDLSRDLANDIMTLMSS--TKPYLRMKAVLMMYKVFLRYPEALRPA--FPKLKE 191
            :||..:|...|.::......|:..|:.|  |..:::..|.|.:.|:|...|::.:|.  ..::..
 Worm   129 LALQCISNMGSREMVEAFCTDLPKLLVSGETIDFVKQSAALCILKLFRNSPDSFQPGDYASRIVH 193

  Fly   192 KLEDPDPGVQSAAVNVICELARKNPKNY---LPLAPIFFKLMTTSTNN-------------WMLI 240
            .|.|...||.::|.::|..|::|.|:.|   :|||......:.|:|..             |:.:
 Worm   194 LLNDSHMGVVTSAASLIEALSKKWPEEYKGAVPLAISRLSRIVTATYTDLQDYTYYFVPAPWLCV 258

  Fly   241 KIIKLFGALTPL-EPRLGKKLIEPLTNLI-------------HSTSAMSLLYECINTVIAVLISI 291
            |:::|.....|. :|....:|:|.|..::             ||.:..::|:|    .||::|.:
 Worm   259 KLLRLLQNYPPPDDPSNKARLLECLEGILNKAQDAPKSKKVQHSNAKNAVLFE----AIALIIHM 319

  Fly   292 SSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTHPKS---VQAHKDLILACL-DD 352
            .|   .....::.|.| |...:...:.||:||.|.:|. :|.|...|   |:.|:|.|:..| .:
 Worm   320 DS---EPQLLVRACNQ-LGTFLSHRETNLRYLALESMC-LLATSEFSHDAVKKHQDTIINSLKTE 379

  Fly   353 KDESIRLRALDLLYGMVSKKNLMEIVKRLLGHMERAEGSAYRDELLYKVIEICAQSSYLYVTNFE 417
            :|.|:|.||:||||.|..:.|..:||..:|.::|.|:.| .|:|::.|| .|.|:.   |.|::.
 Worm   380 RDVSVRQRAVDLLYAMCDRSNANQIVAEMLAYLETADYS-IREEMVLKV-AILAEK---YATDYT 439

  Fly   418 WYLTVLVELIQLEAGSRHGRLIAEQLLDVAIRVPVVRQ----FAVNEMTNLLDTFTVSAQSNSMY 478
            ||:.|:::||::.     |..::|::....|::.|.|:    :|...:...|       |..:.:
 Worm   440 WYVDVILKLIRIA-----GDYVSEEVWYRVIQIVVNREDVQGYAAKTVFEAL-------QRPACH 492

  Fly   479 E-VLYAAAWIVGEF----AGELEDAEKTLNILLRPRLLPGHIQGVYVQNVIKLFARLATTCLELQ 538
            | ::....:|:|||    ||:.....|....||..:.   |:..:..:      ..|.||.::..
 Worm   493 ENMVKVGGYILGEFGNFIAGDERSTAKIQFELLHSKF---HLCSITTR------CLLLTTYIKFC 548

  Fly   539 DL-PGLVTLCDHVLDKLQHFNGSSDIEVQERANSACMLIEMLRNQLSTSTDAMAMDTTTEGGIPP 602
            :| |.:..|...|. :..|...:.|.|:|:|:      ||.|:.....|.|.:|  |..|  :.|
 Worm   549 NLFPEIKPLVQQVF-QTDHNLRNPDAELQQRS------IEYLQMTKLASNDVLA--TILE--VMP 602

  Fly   603 LAIEIVQEMTLLFTGELIPVAPKAQRKVPLPDGLDLDEWINAPPPEDAASSSS-------SEHDK 660
            ...|  :|.:||         .|.::..|..:.::.:|......|....|..|       |.:|.
 Worm   603 AFAE--KESSLL---------AKLKKSKPQLEEIEREEKEKRSKPTAVMSEGSTSLVDFDSTNDT 656

  Fly   661 D----ELFVSATQAGTGADGGEKRRQSLELTPEQLERQRMARLIEQSNNPHYLKSTPTASGASNA 721
            .    ::|.:.:..|.||.|.|                     :|.:|...|||....::.....
 Worm   657 TASLADVFANNSGTGLGAQGDE---------------------VEIANKDDYLKFVTKSNAILWE 700

  Fly   722 DQYDNI 727
            |.|..|
 Worm   701 DDYIQI 706

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
g	NP_524785.2	Adaptin_N	33..578	CDD:396262	157/597 (26%)
		AP3D1	687..840	CDD:461889	8/41 (20%)
apa-2	NP_001370626.1	Adaptin_N	28..590	CDD:396262	157/603 (26%)
		Alpha_adaptinC2	698..806	CDD:197886	3/9 (33%)
		Alpha_adaptin_C	812..920	CDD:426707