Protein Alignment g and AP1G1

DIOPT Version :10

• Sequence 1: NP_524785.2
• Gene: g / 44819
• FlyBaseID: FBgn0001087
• Length: 1034
• Species: Drosophila melanogaster
• Sequence 2: NP_001025178.1
• Gene: AP1G1 / 164
• HGNCID: 555
• Length: 825
• Species: Homo sapiens
• Alignment Length: 878
• Identity: 207/878 - (23%)
• Similarity: 347/878 - (39%)
• Gaps: 187/878 - (21%)

  Fly    19 LTDLVRGIR--NNKDNEAKYISTCIEEIKQELRQDNISVKCNAVAKLTYIQMLGYDISWAGFNII 81
            |.:|:|.||  ..:..|.:.|......|:...|:::.:.:|..||||.|:.||||...:.....:
Human     7 LRELIRTIRTARTQAEEREMIQKECAAIRSSFREEDNTYRCRNVAKLLYMHMLGYPAHFGQLECL 71

  Fly    82 EVMSSSRFTCKRIGYLAASQCFHPDSELLMLTTNMIRKDLNSQNQYDAGVALSGLSCFISPDLSR 146
            ::::|.:||.||||||.|........::.:|.||.|:.|||...|:..|:||..|.|..|.::.|
Human    72 KLIASQKFTDKRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQGLALCTLGCMGSSEMCR 136

  Fly   147 DLANDIMTLMSSTKPYLRMKAVLMMYKVFLRYPEALRPAFPKLKEKLEDPDPGVQSAAVNVICEL 211
            |||.::..|:.::..|||.||.|....|..:.||.:....|..|..|.:.:.||...:|.::.|:
Human   137 DLAGEVEKLLKTSNSYLRKKAALCAVHVIRKVPELMEMFLPATKNLLNEKNHGVLHTSVVLLTEM 201

  Fly   212 A----------RKNPKNYLPLAPIFFKLMTTS----------TNNWMLIKIIKLFGALTPLEPRL 256
            .          |||.|....|..|...|:.:.          ::.::.::|::|...|...:...
Human   202 CERSPDMLAHFRKNEKLVPQLVRILKNLIMSGYSPEHDVSGISDPFLQVRILRLLRILGRNDDDS 266

  Fly   257 GKKLIEPLTNLIHSTSAM-----SLLYECINTVIAVLISISSGMPNHSASIQLCVQKLRILIEDS 316
            .:.:.:.|..:..:|...     ::|||.:.|::.  |...||:.      .|.:..|...:.::
Human   267 SEAMNDILAQVATNTETSKNVGNAILYETVLTIMD--IKSESGLR------VLAINILGRFLLNN 323

  Fly   317 DQNLKYLGLLAMSKILKTHPKSVQAHKDLILACLDDKDESIRLRALDLLYGMVSKKNLMEIVKRL 381
            |:|::|:.|.::.|.::|...:||.|:..|:.||.|.|.||:.||::|.:.:|:..|:..::|.|
Human   324 DKNIRYVALTSLLKTVQTDHNAVQRHRSTIVDCLKDLDVSIKRRAMELSFALVNGNNIRGMMKEL 388

  Fly   382 LGHMERAEGSAYRDELLYKVIEICAQSSYL----YVTNFEWYLTVLVELIQLEAGSRHGRLIAEQ 442
            |..::..|.....|         ||...:|    |..:..|::..::.:: ..|||
Human   389 LYFLDSCEPEFKAD---------CASGIFLAAEKYAPSKRWHIDTIMRVL-TTAGS--------- 434

  Fly   443 LLDVAIRVPVVRQFAVNEMTNLLDTFTVSAQSN---------------SMYEVLYAAAWIVGEF- 491
                     .||..||   .||:...|.|.:.:               |...::..|||.:||:
Human   435 ---------YVRDDAV---PNLIQLITNSVEMHAYTVQRLYKAILGDYSQQPLVQVAAWCIGEYG 487

  Fly   492 ----AGELEDAE-------KTLNIL---LRPRLLPGHIQGVYVQNVIKLFARLATTCLELQDLPG 542
                :|:.|:.|       :.|:||   |...:.....:|..:..::||..|...|...::.:..
Human   488 DLLVSGQCEEEEPIQVTEDEVLDILESVLISNMSTSVTRGYALTAIMKLSTRFTCTVNRIKKVVS 552

  Fly   543 LVTLCDHVLDKLQHFNGSSDIEVQERA---NSACMLIEMLRNQLSTSTDAMAMDTT--------T 596
            :             :..|.|:|:|:||   |:.....:.:|:.|......|...||        |
Human   553 I-------------YGSSIDVELQQRAVEYNALFKKYDHMRSALLERMPVMEKVTTNGPTEIVQT 604

  Fly   597 EGGIPPLAIEIVQE-------------MTLLFTGELIPVAPKAQRKVPLPDG---LDLDEWIN-- 643
            .|...|..:|....             :.||...::.||.|.|....|...|   |||...||
Human   605 NGETEPAPLETKPPPSGPQPTSQANDLLDLLGGNDITPVIPTAPTSKPSSAGGELLDLLGDINLT 669

  Fly   644 -----APPPEDAASSSSSEH-----DKDELFVSATQAGTGADGGEKRRQSLELTPEQLERQRMAR 698
                 ||.|......|....     ....||..............|....:|.|
Human   670 GAPAAAPAPASVPQISQPPFLLDGLSSQPLFNDIAAGIPSITAYSKNGLKIEFT----------- 723

  Fly   699 LIEQSN-NPHYLKSTPTASGASNADQYDNIDD--IPIT-ELPL---DMEGVAALRVGITKRSDKY 756
             .|:|| ||.....|..||.::..|..|.:..  :|.| :|.|   ....|.|...|...:..|.
Human   724 -FERSNTNPSVTVITIQASNSTELDMTDFVFQAAVPKTFQLQLLSPSSSIVPAFNTGTITQVIKV 787

  Fly   757 LQEQQAAQGSKDGKKKHKKGKKSKKAKNKVAYN 789
            |..|                |:..:.:.|:.||
Human   788 LNPQ----------------KQQLRMRIKLTYN 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
g	NP_524785.2	Adaptin_N	33..578	CDD:396262	147/606 (24%)
		AP3D1	687..840	CDD:461889	25/110 (23%)
AP1G1	NP_001025178.1	Adaptin_N	23..577	CDD:396262	147/605 (24%)
		HEAT repeat	142..163	CDD:293787	7/20 (35%)
		HEAT repeat	175..203	CDD:293787	7/27 (26%)
		HEAT repeat	246..276	CDD:293787	4/29 (14%)
		HEAT repeat	287..319	CDD:293787	9/39 (23%)
		Herpes_BLLF1	<593..>654	CDD:282904	13/60 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	600..631		4/30 (13%)
		Alpha_adaptinC2	712..820	CDD:197886	27/121 (22%)