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Protein Alignment g and AP2A2

DIOPT Version :9

Sequence 1:	NP_524785.2	Gene:	g / 44819	FlyBaseID:	FBgn0001087	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	NP_001229766.1	Gene:	AP2A2 / 161	HGNCID:	562	Length:	940	Species:	Homo sapiens

Alignment Length:	961	Identity:	226/961 - (23%)
Similarity:	386/961 - (40%)	Gaps:	254/961 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 KNLTDLVRGIRNNKDNEAKYISTCIEEIKQELRQ-----------DNISVKCNAVAKLTYIQMLG 70
            :.|...:..|||.|..||:     |:.|.:||..           |..|.| ..|.||.:|.:||
Human    11 RGLAVFISDIRNCKSKEAE-----IKRINKELANIRSKFKGDKALDGYSKK-KYVCKLLFIFLLG 69

  Fly    71 YDISWAGFNIIEVMSSSRFTCKRIGYLAASQCFHPDSELLMLTTNMIRKDLNSQNQYDAGVALSG 135
            :||.:.....:.::||:|:|.|:||||..|...:.:|||:.|..|.|:.||.|:|....|:||..
Human    70 HDIDFGHMEAVNLLSSNRYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHC 134

  Fly   136 LSCFISPDLSRDLANDI--MTLMSSTKPYLRMKAVLMMYKVFLRYPEALRPA---FPKLKEKLED 195
            ::...|.:::...|.:|  :.:...|...::..|.|.:.:::...|: |.|.   ..::...|.|
Human   135 IASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSPD-LVPMGDWTSRVVHLLND 198

  Fly   196 PDPGVQSAAVNVICELARKNPKNY---LPLAPIFFKLMTTSTNN-------------WMLIKIIK 244
            ...||.:||.::|..||:|||:.:   :.||......:.||.:.             |:.:|:::
Human   199 QHLGVVTAATSLITTLAQKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLR 263

  Fly   245 LFGALTPLE-PRLGKKLIEPLTNLI-------------HSTSAMSLLYECINTVIAVLISISSGM 295
            |.....|.| |.:..:|.|.|..::             ||.:..::|:|.|:.:|
Human   264 LLQCYPPPEDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLII---------- 318

  Fly   296 PNHSASIQLCVQ---KLRILIEDSDQNLKYLGLLAMSKI---------LKTHPKSVQAHKDLILA 348
             :|.:...|.|:   :|...::..:.||:||.|.:|..:         :|||.::|      |.|
Human   319 -HHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIETV------INA 376

  Fly   349 CLDDKDESIRLRALDLLYGMVSKKNLMEIVKRLLGHMERAEGSAYRDELLYKVIEICAQSSYLYV 413
            ...::|.|:|.||:||||.|..:.|..:||..:|.::|.|:.| .|:|::.|| .|.|:.   |.
Human   377 LKTERDVSVRQRAVDLLYAMCDRSNAPQIVAEMLSYLETADYS-IREEIVLKV-AILAEK---YA 436

  Fly   414 TNFEWYLTVLVELIQLEAGSRHGRLIAEQLLDVAIRVPVVRQFAVNEMTNLLDTFTVSAQSNSMY 478
            .::.||:..::.||:: ||......:..:::.:.|....|:.:|...:...|       |:.:.:
Human   437 VDYTWYVDTILNLIRI-AGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEAL-------QAPACH 493

  Fly   479 E-VLYAAAWIVGEFAGELEDAEKTLNILLRPRLLPG--HIQGV---------YVQNVIKLFARLA 531
            | ::....:|:||| |.|...:...:.|::..||..  |:..|         |:: .:.||..:.
Human   494 ENLVKVGGYILGEF-GNLIAGDPRSSPLIQFHLLHSKFHLCSVPTRALLLSTYIK-FVNLFPEVK 556

  Fly   532 TTCLELQDLPGLVTLCDHVLDKLQHFNGSSDIEVQERANSACMLIEMLRNQLSTSTDAMAM---- 592
            .|   :||    |...|..|       .::|:|:|:||      :|.||.....|||.:|.
Human   557 PT---IQD----VLRSDSQL-------RNADVELQQRA------VEYLRLSTVASTDILATVLEE 601

  Fly   593 ---------------------DTTTE-------------GGIPPLAIEIVQEMTLLFTGELIPV- 622
                                 .|.|:             ||..|.........|...:.:|:.:
Human   602 MPPFPERESSILAKLKKKKGPSTVTDLEDTKRDRSVDVNGGPEPAPASTSAVSTPSPSADLLGLG 666

  Fly   623 -APKAQRKVPLPDGLDLDEWINAPPPEDAASSSSSEHDKDELFVSATQAGTGADGGEK------- 679
             ||      |.|.|         |||....|....:...|...|.|..|....|...:
Human   667 AAP------PAPAG---------PPPSSGGSGLLVDVFSDSASVVAPLAPGSEDNFARFVCKNNG 716

  Fly   680 ---RRQSLELTPEQLERQRMARLI---EQSNNPHYLKST---------------------PTASG 717
               ..|.|::..:...||.:.|:.   ....:..:|..|                     ||..|
Human   717 VLFENQLLQIGLKSEFRQNLGRMFIFYGNKTSTQFLNFTPTLICSDDLQPNLNLQTKPVDPTVEG 781

  Fly   718 ASNADQYDNIDDI-PITELP-LDMEGVAALRVGITKRS---------DKYLQEQQAAQGSKD--- 768
            .:...|..||:.: ..||.| |:::    .|.|.|.::         :|:.|..:.|  |:|
Human   782 GAQVQQVVNIECVSDFTEAPVLNIQ----FRYGGTFQNVSVQLPITLNKFFQPTEMA--SQDFFQ 840

  Fly   769 ---------------GKKKHKKGKKSKKAKNKVAYNSSSESEGEPKPLHIV 804
                           .|.||....:..||| .:.:.|:...|.:|.|.:.|
Human   841 RWKQLSNPQQEVQNIFKAKHPMDTEVTKAK-IIGFGSALLEEVDPNPANFV 890

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.