DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment g and Ap3d1

DIOPT Version :9

Sequence 1:	NP_524785.2	Gene:	g / 44819	FlyBaseID:	FBgn0001087	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	NP_031486.1	Gene:	Ap3d1 / 11776	MGIID:	107734	Length:	1199	Species:	Mus musculus

Alignment Length:	1061	Identity:	577/1061 - (54%)
Similarity:	729/1061 - (68%)	Gaps:	136/1061 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALKKVKGNFFERMFDKNLTDLVRGIRNNKDNEAKYISTCIEEIKQELRQDNISVKCNAVAKLTY 65
            ||||.|||: .:|||||||.||||||||:|::||||||.||:||||||:||||:||.|||.||||
Mouse     1 MALKMVKGS-IDRMFDKNLQDLVRGIRNHKEDEAKYISQCIDEIKQELKQDNIAVKANAVCKLTY 64

  Fly    66 IQMLGYDISWAGFNIIEVMSSSRFTCKRIGYLAASQCFHPDSELLMLTTNMIRKDLNSQNQYDAG 130
            :||||||||||.||||||||:|:||.||:||||||||||..::::|||||.|||||:|.:|||.|
Mouse    65 LQMLGYDISWAAFNIIEVMSASKFTFKRVGYLAASQCFHEGTDVIMLTTNQIRKDLSSPSQYDTG 129

  Fly   131 VALSGLSCFISPDLSRDLANDIMTLMSSTKPYLRMKAVLMMYKVFLRYPEALRPAFPKLKEKLED 195
            |||:|||||::|||:||||||||||||.||||:|.||||:||||||:|||:||||||:|||||||
Mouse   130 VALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLED 194

  Fly   196 PDPGVQSAAVNVICELARKNPKNYLPLAPIFFKLMTTSTNNWMLIKIIKLFGALTPLEPRLGKKL 260
            ||||||||||||||||||:||||||.|||:||||||:|||||:||||||||||||||||||||||
Mouse   195 PDPGVQSAAVNVICELARRNPKNYLSLAPLFFKLMTSSTNNWVLIKIIKLFGALTPLEPRLGKKL 259

  Fly   261 IEPLTNLIHSTSAMSLLYECINTVIAVLISISSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGL 325
            ||||||||||||||||||||:|||||||||:||||||||||||||||||||||||||||||||||
Mouse   260 IEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGL 324

  Fly   326 LAMSKILKTHPKSVQAHKDLILACLDDKDESIRLRALDLLYGMVSKKNLMEIVKRLLGHMERAEG 390
            |||||||||||||||:||||||.|||||||||||||||||||||||||||||||:|:.|:::|||
Mouse   325 LAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEG 389

  Fly   391 SAYRDELLYKVIEICAQSSYLYVTNFEWYLTVLVELIQLEAGSRHGRLIAEQLLDVAIRVPVVRQ 455
            :.||||||.|:|:||:||:|.::||||||:::||||.:|| |:|||.|||.|:|||||||..:|:
Mouse   390 TTYRDELLTKIIDICSQSNYQHITNFEWYISILVELTRLE-GTRHGHLIAAQMLDVAIRVKAIRK 453

  Fly   456 FAVNEMTNLLDT---FTVSAQSNSMYEVLYAAAWIVGEFAGELEDAEKTLNILLRPRL--LPGHI 515
            |||::|::|||:   ...|.|.|.:.|||||||||.|||:..|:..::||..:|||::  |||||
Mouse   454 FAVSQMSSLLDSAHLVASSTQRNGICEVLYAAAWICGEFSEHLQGPQQTLEAMLRPKVTTLPGHI 518

  Fly   516 QGVYVQNVIKLFARLATTCLELQDLPGLVTLCDHVLDKLQHFNGSSDIEVQERANSACMLIEMLR 580
            |.||||||:||:|.:.....:..|......:...::::|..|..|:|:||||||:....|::.::
Mouse   519 QAVYVQNVVKLYASILQQKEQAADTEAAQEVTQLLVERLPQFVQSADLEVQERASCILQLVKHVQ 583

  Fly   581 NQLSTSTDAMAMDTTTEGGIPPLAIEIVQEMTLLFTGELIPVAPKAQRKVPLPDGLDLDEWINAP 645
            ...:.             |:|     :.:|::.||.|||.|||||||:|||:|:|||||.|||.|
Mouse   584 KLQAK-------------GVP-----VAEEVSALFAGELNPVAPKAQKKVPVPEGLDLDAWINEP 630

  Fly   646 PPEDAASSSSSEHDKDE-LFVSATQAGTGADGGEKRRQSLELTPEQLERQRMARLIEQSNNPHYL 709
            |     |.|.||.:|.: :|.......|       ||:..|...|:|.|:|.||..||:|||.|:
Mouse   631 P-----SDSESEDEKPKAIFHEEEPRHT-------RRRQPEEDEEELARRREARKQEQANNPFYI 683

  Fly   710 KSTPTASGASNADQYDN---IDDIPITELPLDMEGVAALRVGITKRSDKY--LQEQQAAQGSKDG 769
            ||:|     |...:|.:   ::.||:.::.|.:    .|:|.....||:|  |:||:..:...:.
Mouse   684 KSSP-----SPQKRYQDAPGVEHIPVVQIDLSV----PLKVPGMPMSDQYVKLEEQRRHRQRLEK 739

  Fly   770 KKKHKKGKKSKKAKNKVAYNSSSESEGEPKPLHIVN-TTLDMPEGVSMSDSEDKDGKYDPNDPHR 833
            .||.||.:|.|:..:.:    .:||:.:..|...|: .|.:|||....||.:||    |||||:|
Mouse   740 DKKRKKKEKGKRRHSSL----PTESDEDIAPAQRVDIITEEMPENALPSDEDDK----DPNDPYR 796

  Fly   834 ALDIELDITEFEAPAVRSASKKSAADKENLKTPADSAGGGNAAKK---------DRKKDKDKDKE 889
            ||||:||              |..||.|  |.|........|.|.         ::|..|.|.||
Mouse   797 ALDIDLD--------------KPLADSE--KLPVQKHRNAEAVKSPEKEGVLGVEKKSKKPKKKE 845

  Fly   890 RKVKREHRESKRERKEAAVQSVIDLIDADTPTPSPSHISATSNNNNTSTVLPDAPKHHKKKKNKE 954
            :|.|...||.|.::.|.     :|...:.||.|:.:.|.|.|
Mouse   846 KKTKEREREKKDKKGED-----LDFWLSTTPPPAAAPIPAPS----------------------- 882

  Fly   955 KTTDEAPDALATATGSSIID----VGGEEASEV-------ASKVHKKKHKKEKSQR---KEKKKA 1005
              |:|    ||.:|.:|..|    :.|||...|       :|:..||||:|||.:.   ::||||
Mouse   883 --TEE----LAASTITSPKDECEVLKGEEEDHVDHDQERKSSRHKKKKHRKEKEKEERPRDKKKA 941

  Fly  1006 SES--ASVSAIVSIGDYEQPL 1024
            .:.  |.:....:..:.|:|:
Mouse   942 KKKQVAPLENGAAAEEEEEPI 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
g	NP_524785.2	Adaptin_N	33..578	CDD:279882	405/549 (74%)
		HEAT repeat	152..173	CDD:293787	16/20 (80%)
		HEAT repeat	185..213	CDD:293787	26/27 (96%)
		Cnd1	<193..266	CDD:289487	67/72 (93%)
		HEAT repeat	221..263	CDD:293787	37/41 (90%)
		HEAT repeat	272..290	CDD:293787	16/17 (94%)
		HEAT repeat	302..331	CDD:293787	28/28 (100%)
		BLVR	687..840	CDD:283923	56/158 (35%)
Ap3d1	NP_031486.1	Adaptin_N	32..581	CDD:279882	405/549 (74%)
		HEAT 1	34..71		29/36 (81%)
		HEAT 2	142..179		30/36 (83%)
		HEAT repeat	151..172	CDD:293787	16/20 (80%)
		Cnd1	155..265	CDD:289487	97/109 (89%)
		HEAT 3	180..216		32/35 (91%)
		HEAT repeat	184..212	CDD:293787	26/27 (96%)
		HEAT 4	218..254		31/35 (89%)
		HEAT repeat	220..262	CDD:293787	37/41 (90%)
		HEAT 5	257..296		36/38 (95%)
		HEAT repeat	271..292	CDD:293787	18/20 (90%)
		HEAT 6	298..336		37/37 (100%)
		HEAT repeat	301..330	CDD:293787	28/28 (100%)
		HEAT repeat	335..364	CDD:293787	26/28 (93%)
		HEAT 7	337..373		33/35 (94%)
		HEAT 8	375..409		21/33 (64%)
		HEAT 9	521..558		10/36 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..695		34/88 (39%)
		BLVR	661..803	CDD:283923	56/158 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	724..963		86/297 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842676
Domainoid	1	1.000	809	1.000	Domainoid score	I70
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	997	1.000	Inparanoid score	I297
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52588
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102126
Panther	1	1.100	-	-	LDO	PTHR22781
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R64
SonicParanoid	1	1.000	-	-		X3686
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.790