DRSC/TRiP Functional Genomics Resources

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Protein Alignment g and Ap2a2

DIOPT Version :9

Sequence 1:NP_524785.2 Gene:g / 44819 FlyBaseID:FBgn0001087 Length:1034 Species:Drosophila melanogaster
Sequence 2:NP_001343997.1 Gene:Ap2a2 / 11772 MGIID:101920 Length:939 Species:Mus musculus


Alignment Length:960 Identity:229/960 - (23%)
Similarity:394/960 - (41%) Gaps:253/960 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 KNLTDLVRGIRNNKDNEAKYISTCIEEIKQELRQ-----------DNISVKCNAVAKLTYIQMLG 70
            :.|...:..|||.|..||:     |:.|.:||..           |..|.| ..|.||.:|.:||
Mouse    11 RGLAVFISDIRNCKSKEAE-----IKRINKELANIRSKFKGDKALDGYSKK-KYVCKLLFIFLLG 69

  Fly    71 YDISWAGFNIIEVMSSSRFTCKRIGYLAASQCFHPDSELLMLTTNMIRKDLNSQNQYDAGVALSG 135
            :||.:.....:.::||:|:|.|:||||..|...:.:|||:.|..|.|:.||.|:|....|:||..
Mouse    70 HDIDFGHMEAVNLLSSNRYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHC 134

  Fly   136 LSCFISPDLSRDLANDIMTLM--SSTKPYLRMKAVLMMYKVFLRYPEALRPA---FPKLKEKLED 195
            ::...|.:::...|.:|..::  ..|...::..|.|.:.:::...|: |.|.   ..::...|.|
Mouse   135 IANVGSREMAEAFAGEIPKILVAGDTMDSVKQSAALCLLRLYRTSPD-LVPMGDWTSRVVHLLND 198

  Fly   196 PDPGVQSAAVNVICELARKNPKNY---LPLAPIFFKLMTTSTNN-------------WMLIKIIK 244
            ...||.:||.::|..||:|||:.:   :.||......:.||.:.             |:.:|:::
Mouse   199 QHLGVVTAATSLITTLAQKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLR 263

  Fly   245 LFGALTPLE-PRLGKKLIEPLTNLI-------------HSTSAMSLLYECINTVIAVLISISSGM 295
            |.....|.| |.:..:|.|.|..::             ||.:..::|:|.|:.:|          
Mouse   264 LLQCYPPPEDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLII---------- 318

  Fly   296 PNHSASIQLCVQ---KLRILIEDSDQNLKYLGLLAMSKI---------LKTHPKSVQAHKDLILA 348
             :|.:...|.|:   :|...::..:.||:||.|.:|..:         :|||.::|      |.|
Mouse   319 -HHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIETV------INA 376

  Fly   349 CLDDKDESIRLRALDLLYGMVSKKNLMEIVKRLLGHMERAEGSAYRDELLYKVIEICAQSSYLYV 413
            ...::|.|:|.||:||||.|..:.|..:||..:|.::|.|:.| .|:|::.|| .|.|:.   |.
Mouse   377 LKTERDVSVRQRAVDLLYAMCDRSNAQQIVAEMLSYLETADYS-IREEIVLKV-AILAEK---YA 436

  Fly   414 TNFEWYLTVLVELIQLEAGSRHGRLIAEQLLDVAIRVPVVRQFAVNEMTNLLDTFTVSAQSNSMY 478
            .::.||:..::.||:: ||......:..:::.:.|....|:.:|...:...|       |:.:.:
Mouse   437 VDYTWYVDTILNLIRI-AGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEAL-------QAPACH 493

  Fly   479 E-VLYAAAWIVGEFAGELEDAEKTLNILLRPRLLPG--HIQGV---------YVQNVIKLFARLA 531
            | ::....:|:||| |.|...:...:.|::..||..  |:..|         |:: .:.||..:.
Mouse   494 ENLVKVGGYILGEF-GNLIAGDPRSSPLIQFNLLHSKFHLCSVPTRALLLSTYIK-FVNLFPEVK 556

  Fly   532 TTCLELQDLPGLVTLCDHVLDKLQHFNGSSDIEVQERANSACMLIEMLRNQLSTSTDAMAMDTTT 596
            .|   :||    |...|..|.       ::|:|:|:||      :|.||.....|||.:|   |.
Mouse   557 AT---IQD----VLRSDSQLK-------NADVELQQRA------VEYLRLSTVASTDILA---TV 598

  Fly   597 EGGIPPLAIEIVQEMTLLFTGELIPVAPKAQRKVPLPDGLDLDEW-------INA---PPPEDAA 651
            ...:||..   .:|.::|         .|.::|.......||:|.       :|.   |.|...:
Mouse   599 LEEMPPFP---ERESSIL---------AKLKKKKGPSTVTDLEETKRERSIDVNGGPEPVPASTS 651

  Fly   652 SSSSSEHDKDELFVSAT-QAGTG------------------------ADGGEK------------ 679
            ::|:.....|.|.:.|. .|.||                        |.|.|.            
Mouse   652 AASTPSPSADLLGLGAVPPAPTGPPPSSGGGLLVDVFSDSASAVAPLAPGSEDNFARFVCKNNGV 716

  Fly   680 --RRQSLELTPEQLERQRMARLI---EQSNNPHYLKST---------------------PTASGA 718
              ..|.|::..:...||.:.|:.   ....:..:|..|                     ||..|.
Mouse   717 LFENQLLQIGLKSEFRQNLGRMFIFYGNKTSTQFLNFTPTLICADDLQTNLNLQTKPVDPTVDGG 781

  Fly   719 SNADQYDNIDDI-PITELP-LDMEGVAALRVGITKRS---------DKYLQEQQAAQGSKD---- 768
            :...|..||:.| ..||.| |:::    .|.|.|.::         :|:.|..:.|  |:|    
Mouse   782 AQVQQVVNIECISDFTEAPVLNIQ----FRYGGTFQNVSVKLPITLNKFFQPTEMA--SQDFFQR 840

  Fly   769 --------------GKKKHKKGKKSKKAKNKVAYNSSSESEGEPKPLHIV 804
                          .|.||....:..||| .:.:.|:...|.:|.|.:.|
Mouse   841 WKQLSNPQQEVQNIFKAKHPMDTEITKAK-IIGFGSALLEEVDPNPANFV 889

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
gNP_524785.2 Adaptin_N 33..578 CDD:279882 157/614 (26%)
HEAT repeat 152..173 CDD:293787 4/22 (18%)
HEAT repeat 185..213 CDD:293787 8/30 (27%)
Cnd1 <193..266 CDD:289487 25/89 (28%)
HEAT repeat 221..263 CDD:293787 11/55 (20%)
HEAT repeat 272..290 CDD:293787 4/17 (24%)
HEAT repeat 302..331 CDD:293787 9/31 (29%)
BLVR 687..840 CDD:283923 35/171 (20%)
Ap2a2NP_001343997.1 Lipid-binding 5..80 22/74 (30%)