DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment g and Ap2a1

DIOPT Version :9

Sequence 1:	NP_524785.2	Gene:	g / 44819	FlyBaseID:	FBgn0001087	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	NP_031484.1	Gene:	Ap2a1 / 11771	MGIID:	101921	Length:	977	Species:	Mus musculus

Alignment Length:	974	Identity:	217/974 - (22%)
Similarity:	385/974 - (39%)	Gaps:	243/974 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 KNLTDLVRGIRNNKDNEAKYISTCIEEIKQELRQ-----------DNISVKCNAVAKLTYIQMLG 70
            :.|...:..|||.|..||:     |:.|.:||..           |..|.| ..|.||.:|.:||
Mouse    11 RGLAVFISDIRNCKSKEAE-----IKRINKELANIRSKFKGDKALDGYSKK-KYVCKLLFIFLLG 69

  Fly    71 YDISWAGFNIIEVMSSSRFTCKRIGYLAASQCFHPDSELLMLTTNMIRKDLNSQNQYDAGVALSG 135
            :||.:.....:.::||:::|.|:||||..|...:.:|||:.|..|.|:.||.|:|.....:||..
Mouse    70 HDIDFGHMEAVNLLSSNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMCLALHC 134

  Fly   136 LSCFISPDLSRDLANDIMTLM--SSTKPYLRMKAVLMMYKVFLRYPEALRPA---FPKLKEKLED 195
            ::...|.::....|.||..::  ..:...::..|.|.:.:::...|: |.|.   ..::...|.|
Mouse   135 IANVGSREMGEAFAADIPRILVAGDSMDSVKQSAALCLLRLYKASPD-LVPMGEWTARVVHLLND 198

  Fly   196 PDPGVQSAAVNVICELARKNP---KNYLPLAPIFFKLMTTSTNN-------------WMLIKIIK 244
            ...||.:|||::|..|.:|||   |..:.||......:.:|.:.             |:.:|:::
Mouse   199 QHMGVVTAAVSLITCLCKKNPDDFKTCISLAVSRLSRIVSSASTDLQDYTYYFVPAPWLSVKLLR 263

  Fly   245 LFGALTPLEPRLGK-KLIEPLTNLI-------------HSTSAMSLLYECINTVIAVLISISSGM 295
            |.....|.|....| :|:|.|..::             ||.:..::|:|.|:.:|..     ...
Mouse   264 LLQCYPPPEDAAVKGRLVECLETVLNKAQEPPKSKKVQHSNAKNAILFETISLIIHY-----DSE 323

  Fly   296 PNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTH--PKSVQAHKDLILACL-DDKDESI 357
            ||  ..::.|.| |...::..:.||:||.|.:|..:..:.  .::|:.|.|.::..| .::|.|:
Mouse   324 PN--LLVRACNQ-LGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIDTVINALKTERDVSV 385

  Fly   358 RLRALDLLYGMVSKKNLMEIVKRLLGHMERAEGSAYRDELLYKVIEICAQSSYLYVTNFEWYLTV 422
            |.||.||||.|..:.|..:||..:|.::|.|: .|.|:|::.|| .|.|:.   |..::.||:..
Mouse   386 RQRAADLLYAMCDRSNAKQIVSEMLRYLETAD-YAIREEIVLKV-AILAEK---YAVDYSWYVDT 445

  Fly   423 LVELIQLEAGSRHGRLIAEQLLDVAIRVPVVRQFAVNEMTNLLDTFTVSAQSNSMYEVLYAAA-- 485
            ::.||::.     |..::|::....:::          :||..|....:|:  :::|.|.|.|
Mouse   446 ILNLIRIA-----GDYVSEEVWYRVLQI----------VTNRDDVQGYAAK--TVFEALQAPACH 493

  Fly   486 --------WIVGEF----AGE-----------LEDAEKTLNILLRPRLLPGHIQGV--------Y 519
                    :|:|||    ||:           |.......::..|..||..:|:.:        .
Mouse   494 ENMVKVGGYILGEFGNLIAGDPRSSPPVQFSLLHSKFHLCSVATRALLLSTYIKFINLFPETKAT 558

  Fly   520 VQNVIKLFARLATTCLELQ-----------------------DLPGLVTLCDHVLDKLQHFNG-- 559
            :|.|::..::|....:|||                       ::|........:|.||:...|
Mouse   559 IQGVLRAGSQLRNADVELQQRAVEYLTLSSVASTDVLATVLEEMPPFPERESSILAKLKRKKGPG 623

  Fly   560 -SSDIEVQERANSACML---IEMLRNQLST---STDAMAMDTTTEGGIPP------LAIEIVQEM 611
             :|.::...|..|:..:   :|...:.:||   |.|.:.:........||      |.:::..:.
Mouse   624 AASALDDSRRDTSSNDINGGVEPTPSTVSTPSPSADLLGLRAAPPPAAPPAPVGGNLLVDVFSDG 688

  Fly   612 TL-----------LFTGELIPVAPKAQRKV---PLPDGLDLDEWINAPPPEDAASSSSSEHDKDE 662
            ..           .|..||.|.||::...:   |.|......|.|..|.||           .||
Mouse   689 PTAQPSLGPTPEEAFLSELEPPAPESPMALLADPAPAADPGPEDIGPPIPE-----------ADE 742

  Fly   663 L---FVSATQAGTGADGGEKRRQSLELTPEQLERQRMARL---IEQSNNPHYLKSTPT------- 714
            |   ||...      .|.....|.|::..:...||.:.|:   .....:..:....||
Mouse   743 LLNKFVCKN------SGVLFENQLLQIGVKSEFRQNLGRMYLFYGNKTSVQFQNFLPTVVHPGDL 801

  Fly   715 --------------ASGASNADQYDNIDDI------PITELPLDMEGVA---ALRVGITKRSDKY 756
                          ..|.:...|..||:.:      |:..:.....|.|   .|::.:|  .:|:
Mouse   802 QTQLAVQTKRVAAQVDGGAQVQQVLNIECLRDFLTPPLLSVRFRYGGTAQSLTLKLPVT--INKF 864

  Fly   757 LQEQQAA----------------QGSKDGKKKHKKGKKSKKAKNKVAYNSSSESEGEPKPLHIV 804
            .|..:.|                :..|..|..|....:..||| .:.:.|:.....:|.|.:.|
Mouse   865 FQPTEMAAQDFFQRWKQLSLPLQEAQKIFKANHPMDAEVTKAK-LLGFGSALLDNVDPNPENFV 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
g	NP_524785.2	Adaptin_N	33..578	CDD:279882	156/655 (24%)
		HEAT repeat	152..173	CDD:293787	3/22 (14%)
		HEAT repeat	185..213	CDD:293787	9/30 (30%)
		Cnd1	<193..266	CDD:289487	25/89 (28%)
		HEAT repeat	221..263	CDD:293787	10/55 (18%)
		HEAT repeat	272..290	CDD:293787	4/17 (24%)
		HEAT repeat	302..331	CDD:293787	9/28 (32%)
		BLVR	687..840	CDD:283923	27/167 (16%)
Ap2a1	NP_031484.1	Adaptin_N	29..591	CDD:366724	146/598 (24%)
		HEAT repeat	332..355	CDD:293787	8/23 (35%)
		HEAT repeat	369..398	CDD:293787	13/28 (46%)
		HEAT repeat	408..434	CDD:293787	10/27 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	614..702		14/87 (16%)
		Alpha_adaptinC2	755..858	CDD:197886	15/102 (15%)
		Alpha_adaptin_C	864..972	CDD:367023	12/65 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810