Protein Alignment g and Ap1g2

DIOPT Version :10

• Sequence 1: NP_524785.2
• Gene: g / 44819
• FlyBaseID: FBgn0001087
• Length: 1034
• Species: Drosophila melanogaster
• Sequence 2: NP_031481.2
• Gene: Ap1g2 / 11766
• MGIID: 1328307
• Length: 791
• Species: Mus musculus
• Alignment Length: 845
• Identity: 195/845 - (23%)
• Similarity: 342/845 - (40%)
• Gaps: 196/845 - (23%)

  Fly    19 LTDLVRGIRNNKD--NEAKYISTCIEEIKQELRQDNISVKCNAVAKLTYIQMLGYDISWAGFNII 81
            |.||:..||..|.  .|.:.|.....:|:...|..:...:...:|||.|:.||||...:.....:
Mouse     8 LQDLIEEIRGAKTQAQEREVIQKECAQIRASFRDGDPLQRHRQLAKLLYVHMLGYPAHFGQMECL 72

  Fly    82 EVMSSSRFTCKRIGYLAASQCFHPDSELLMLTTNMIRKDLNSQNQYDAGVALSGLSCFISPDLSR 146
            ::::|.|||.||:|||.|........:..:|.||.|:.||:..||...|:||..||...|.::.|
Mouse    73 KLIASPRFTDKRVGYLGAMLLLDERHDSHLLITNSIKNDLSQGNQPVQGLALCTLSTMGSAEMCR 137

  Fly   147 DLANDIMTLMSSTKPYLRMKAVLMMYKVFLRYPEALRPAFPKLKEKLEDPDPGVQSAAVNVICEL 211
            |||.::..|:....||:|.||:|....:..:.||......|...:.|.:...|:|...|.:|.||
Mouse   138 DLAPEVEKLLLQPSPYVRKKAILTAVHMIRKDPELSGIFLPPCTKLLRERHHGIQLGTVTLITEL 202

  Fly   212 ARKNP------KNYLP-LAPIFFKLMTT--STNN--------WMLIKIIKLFGAL----TPLEPR 255
            ..:||      :..:| |..|...|:||  ||.:        ::.::|::|...|    ......
Mouse   203 CERNPAALRHFRKVVPQLVQILRTLVTTGYSTEHSISGVSDPFLQVQILRLLRILGRNHEESSET 267

  Fly   256 LGKKLIEPLTNLIHSTSA-MSLLYECINTVIAVLISISSGMPNHSAS--IQLCVQKLRILIEDSD 317
            :...|.:..||...|.:| .::|.|.:.|::|:          |||:  ..|.|..|...:.::|
Mouse   268 MNDLLAQVATNTDTSRNAGNAVLLETVLTIMAI----------HSAAGLRVLAVNILGRFLLNND 322

  Fly   318 QNLKYLGLLAMSKILKTHPKSVQAHKDLILACLDDKDESIRLRALDLLYGMVSKKNLMEIVKRLL 382
            :|::|:.|.::.:::::...:||.|:..::.||.:.|.|:..|||:|...:|:..|:..:::.|.
Mouse   323 KNIRYVALTSLLQLVQSDHSAVQRHRSTVVECLQETDASLSRRALELSLALVNSSNVRAMMQELQ 387

  Fly   383 GHMERAEGSAYRDELLYKVIEICAQSSYLYVTNF----EWYLTVLVELIQLEAGSRHGRLIAEQL 443
            ..:|........|         ||....|....|    .|::..::.:: ..||:.
Mouse   388 AFLESCPPDLRAD---------CASGILLAAERFAPSKRWHIDTILHVL-TTAGAH--------- 433

  Fly   444 LDVAIRVPVVRQFAVNEMTNL------LDTFTVS------AQSNSMYEVLYAAAWIVGEFA---- 492
                     ||..||..:|.|      |.|::|.      |:..|...::..|||.:||:.
Mouse   434 ---------VRDDAVANLTQLIGEAEELHTYSVRRLYSALAEDISQQPLVQVAAWCIGEYGDLLL 489

  Fly   493 -GELEDAE----KTLNIL-LRPRLLPGHI-----QGVYVQNVIKLFARLATTCLELQDLPGLVTL 546
             |..|:.|    :..::| |..::|..|:     :|..:..::||..||......::.:..:...
Mouse   490 EGNCEETEPFQVEEEDVLALLEKVLQSHMSLPATRGYAITALMKLSTRLRGDNNRIRQVVSIYGS 554

  Fly   547 CDHVLDKLQHFNGSSDIEVQERA---NSACMLIEMLRNQL-------------------STSTDA 589
            |             .|:|:|:||   |:.....:.:|..:                   ...|:|
Mouse   555 C-------------VDLELQQRAVEYNTLFQKYDHMRAAILEKMPLVERGDPHVKEGGKEKQTEA 606

  Fly   590 MAMDTTTEGGIPPLAIEIVQEMTLL--------------------FTGELI-----------PVA 623
            ..::.|......|.|.:::..:.||                    ..||.:           |.|
Mouse   607 QPLEVTAPAPTEPQATKLLDLLDLLGDTSEPLSSGHAQHLPPQTPSPGEALIHLLDLPCTPPPPA 671

  Fly   624 PKAQRKVPLPDGLDLDEWINAP--PPE----DAASSSSSEHDKDELFVSAT---------QAGTG 673
            |....:|...:||.||.....|  .|.    .|.:::||:.|.......|.         ||.:|
Mouse   672 PIPSVRVFEREGLQLDLSFMRPLETPALLLVTATTTNSSKEDVTHFVCQAAVPKSFQLQLQAPSG 736

  Fly   674 ----ADGGEKRRQSLELTPEQLERQRMARLIEQSNNPHYLK--STPTASGASNADQYDNIDDIPI 732
                |.||      |.:|       ::.|::..:..|..||  .|...||....:.:: :|::|:
Mouse   737 NTIPAQGG------LPIT-------QVFRILNPNQAPLRLKLRLTYNHSGQPVQEIFE-VDNLPV 787

  Fly   733  732
            Mouse   788  787

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
g	NP_524785.2	Adaptin_N	33..578	CDD:396262	147/602 (24%)
		AP3D1	687..840	CDD:461889	10/48 (21%)
Ap1g2	NP_031481.2	Adaptin_N	24..575	CDD:396262	147/601 (24%)
		Alpha_adaptinC2	678..786	CDD:197886	28/121 (23%)