DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment g and Ap1g1

DIOPT Version :9

Sequence 1:	NP_524785.2	Gene:	g / 44819	FlyBaseID:	FBgn0001087	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	NP_033807.2	Gene:	Ap1g1 / 11765	MGIID:	101919	Length:	825	Species:	Mus musculus

Alignment Length:	878	Identity:	203/878 - (23%)
Similarity:	346/878 - (39%)	Gaps:	187/878 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LTDLVRGIR--NNKDNEAKYISTCIEEIKQELRQDNISVKCNAVAKLTYIQMLGYDISWAGFNII 81
            |.:|:|.||  ..:..|.:.|......|:...|:::.:.:|..||||.|:.||||...:.....:
Mouse     7 LRELIRTIRTARTQAEEREMIQKECAAIRSSFREEDNTYRCRNVAKLLYMHMLGYPAHFGQLECL 71

  Fly    82 EVMSSSRFTCKRIGYLAASQCFHPDSELLMLTTNMIRKDLNSQNQYDAGVALSGLSCFISPDLSR 146
            ::::|.:||.||||||.|........::.:|.||.|:.|||...|:..|:||..|.|..|.::.|
Mouse    72 KLIASQKFTDKRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQGLALCTLGCMGSSEMCR 136

  Fly   147 DLANDIMTLMSSTKPYLRMKAVLMMYKVFLRYPEALRPAFPKLKEKLEDPDPGVQSAAVNVICEL 211
            |||.::..|:.::..|||.||.|....|..:.||.:....|..|..|.:.:.||...:|.::.|:
Mouse   137 DLAGEVEKLLKTSNSYLRKKAALCAVHVIRKVPELMEMFLPATKNLLNEKNHGVLHTSVVLLTEM 201

  Fly   212 A----------RKNPKNYLPLAPIFFKLMTTS----------TNNWMLIKIIKLFGALTPLEPRL 256
            .          |||.|....|..|...|:.:.          ::.::.::|::|...|...:...
Mouse   202 CERSPDMLAHFRKNEKLVPQLVRILKNLIMSGYSPEHDVSGISDPFLQVRILRLLRILGRNDDDS 266

  Fly   257 GKKLIEPLTNLIHSTSAM-----SLLYECINTVIAVLISISSGMPNHSASIQLCVQKLRILIEDS 316
            .:.:.:.|..:..:|...     ::|||.:.|::.  |...||:.      .|.:..|...:.::
Mouse   267 SEAMNDILAQVATNTETSKNVGNAILYETVLTIMD--IKSESGLR------VLAINILGRFLLNN 323

  Fly   317 DQNLKYLGLLAMSKILKTHPKSVQAHKDLILACLDDKDESIRLRALDLLYGMVSKKNLMEIVKRL 381
            |:|::|:.|.::.|.::|...:||.|:..|:.||.|.|.||:.||::|.:.:|:..|:..::|.|
Mouse   324 DKNIRYVALTSLLKTVQTDHNAVQRHRSTIVDCLKDLDVSIKRRAMELSFALVNGNNIRGMMKEL 388

  Fly   382 LGHMERAEGSAYRDELLYKVIEICAQSSYL----YVTNFEWYLTVLVELIQLEAGSRHGRLIAEQ 442
            |..::..|.....|         ||...:|    |..:..|::..::.:: ..|||
Mouse   389 LYFLDSCEPEFKAD---------CASGIFLAAEKYAPSKRWHIDTIMRVL-TTAGS--------- 434

  Fly   443 LLDVAIRVPVVRQFAVNEMTNLLDTFTVSAQSN---------------SMYEVLYAAAWIVGEF- 491
                     .||..||   .||:...|.|.:.:               |...::..|||.:||:
Mouse   435 ---------YVRDDAV---PNLIQLITNSVEMHAYTVQRLYKAILGDYSQQPLVQVAAWCIGEYG 487

  Fly   492 ----AGELEDAE-------KTLNIL---LRPRLLPGHIQGVYVQNVIKLFARLATTCLELQDLPG 542
                :|:.|:.|       :.|:||   |...:.....:|..:..::||..|...|...::.:..
Mouse   488 DLLVSGQCEEEEPIQVTEDEVLDILESVLISNMSTSVTRGYALTAIMKLSTRFTCTVNRIKKVVS 552

  Fly   543 LVTLCDHVLDKLQHFNGSSDIEVQERA---NSACMLIEMLRNQLSTSTDAMAMDTT--------T 596
            :             :..|.|:|:|:||   |:.....:.:|:.|......|...||        |
Mouse   553 I-------------YGSSIDVELQQRAVEYNALFKKYDHMRSALLERMPVMEKVTTNGPSEIVQT 604

  Fly   597 EGGIPPLAIEIVQE-------------MTLLFTGELIPVAPKAQRKVPLPDGLDLDEWIN----- 643
            .|...|..:|....             :.||...::.||.|.|....|...|.:|.:.:.
Mouse   605 NGETEPAPLETKPPPSGPQPTSQANDLLDLLGGNDITPVIPTAPTSKPASAGGELLDLLGDITLT 669

  Fly   644 -----APPPEDAASSSSSEH-----DKDELFVSATQAGTGADGGEKRRQSLELTPEQLERQRMAR 698
                 ||.|......|....     ....||..............|....:|.|
Mouse   670 GAPAAAPTPASVPQISQPPFLLDGLSSQPLFNDIAPGIPSITAYSKNGLKIEFT----------- 723

  Fly   699 LIEQSN-NPHYLKSTPTASGASNADQYDNIDD--IPIT-ELPL---DMEGVAALRVGITKRSDKY 756
             .|:|| ||.....|..||.::..|..|.:..  :|.| :|.|   ....|.|...|...:..|.
Mouse   724 -FERSNTNPSVTVITIQASNSTELDMTDFVFQAAVPKTFQLQLLSPSSSVVPAFNTGTITQVIKV 787

  Fly   757 LQEQQAAQGSKDGKKKHKKGKKSKKAKNKVAYN 789
            |..|                |:..:.:.|:.||
Mouse   788 LNPQ----------------KQQLRMRIKLTYN 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
g	NP_524785.2	Adaptin_N	33..578	CDD:279882	147/606 (24%)
		HEAT repeat	152..173	CDD:293787	7/20 (35%)
		HEAT repeat	185..213	CDD:293787	7/37 (19%)
		Cnd1	<193..266	CDD:289487	16/92 (17%)
		HEAT repeat	221..263	CDD:293787	6/51 (12%)
		HEAT repeat	272..290	CDD:293787	4/22 (18%)
		HEAT repeat	302..331	CDD:293787	6/28 (21%)
		BLVR	687..840	CDD:283923	25/110 (23%)
Ap1g1	NP_033807.2	Adaptin_N	23..577	CDD:396262	147/605 (24%)
		HEAT repeat	142..163	CDD:293787	7/20 (35%)
		HEAT repeat	175..203	CDD:293787	7/27 (26%)
		HEAT repeat	246..276	CDD:293787	4/29 (14%)
		HEAT repeat	287..319	CDD:293787	9/39 (23%)
		Herpes_BLLF1	<593..>705	CDD:282904	21/111 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	596..630		4/33 (12%)
		Alpha_adaptinC2	712..820	CDD:197886	27/121 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810