Protein Alignment g and Ap4e1

DIOPT Version :9

• Sequence 1: NP_524785.2
• Gene: g / 44819
• FlyBaseID: FBgn0001087
• Length: 1034
• Species: Drosophila melanogaster
• Sequence 2: XP_006498611.1
• Gene: Ap4e1 / 108011
• MGIID: 1336993
• Length: 1131
• Species: Mus musculus
• Alignment Length: 1088
• Identity: 222/1088 - (20%)
• Similarity: 408/1088 - (37%)
• Gaps: 305/1088 - (28%)

  Fly    10 FFERMFDKNLTDLVRGIR--NNKDNEAKYISTCIEEIKQELRQDNISVKC--NAVAKLTYIQMLG 70
            ||.|     |..|:||:.  ::|..|.|.|...:..:|..:.....::|.  ..:.:|.|.:|||
Mouse    31 FFSR-----LGGLIRGVTALSSKHEEEKLIQQELSSLKATVSAPTTTLKTMKECMVRLIYCEMLG 90

  Fly    71 YDISWAGFNIIEVMSSSRFTCKRIGYLAASQCFHPDSELLMLTTNMIRK---------DLNSQNQ 126
            ||.|:...:.|::........||:||||.|...|...|||:|..|.:.|         ||.|.|.
Mouse    91 YDASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKTVFFACLWQDLQSTNL 155

  Fly   127 YDAGVALSGLSCFISPDLSRDLANDIMTL----MSSTKPYLRMKAVLMMYKVFLRYPEALRPAFP 187
            .:..:||:    .:|....|::...::.|    :..:|..:|.||||.:||.:|..|..::....
Mouse   156 VEVCMALT----VVSQIFPREMIPAVLPLIEDKLQHSKEIIRRKAVLALYKFYLIAPNQVQHIHT 216

  Fly   188 KLKEKLEDPDPGVQSAAVNVICELARKNPKNYLPLAPIFFKLMTTSTNN--------------WM 238
            |.::.|.|.|.||.:|::::...:.::|...|..|...|..::......              |:
Mouse   217 KFRKALCDRDVGVMAASLHIYLRMIKENASGYKDLTESFVTILKQVVGGKLPVEFSYHSVPAPWL 281

  Fly   239 LIKIIKLFGALTPLEPRLGKKLIEPL------TNLIHSTSAMSLLYECINTVIAVLISISSGMPN 297
            .|:::::.|.|...:.|..:.:.:.|      ..|.|:.: .::|:||::|:.:  |...|.:..
Mouse   282 QIQLLRILGLLGKDDERTSELMYDVLDESLRRAELNHNVT-YAILFECVHTIYS--IYPKSELLE 343

  Fly   298 HSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQAHKDLILACLDDKDESIRLRAL 362
            .:|.   |:.|   .:.....|||||||.|::.:::..|.....|:..|:.|||..|..|:...|
Mouse   344 KAAK---CIGK---FVLSPKINLKYLGLKALTYVIQQDPSLALQHQITIIECLDHPDPIIKRETL 402

  Fly   363 DLLYGMVSKKNLMEIVKRLLGHMERAEGSAYRDELLYKVIEICAQSSYLYVTNFEWYLTVLVELI 427
            :|||.:.:.:|::.||:::|.::.:::    .:.::..::...|:.:..|..:..|::..:..:.
Mouse   403 ELLYRITNAQNVVVIVQKMLEYLHQSK----EEHIIISLVGRIAELAEKYAPDNVWFIQTMNAVF 463

  Fly   428 QLEAGSRHG-------RLIAEQLLDVAIRVPVVRQFAVNEMTNLLDTFTVSAQSNSMY--EVLYA 483
            .:.....|.       ||:||. .|.......:|.:||.....|||      ..|:.|  ..|..
Mouse   464 SVGGDVMHPDILSNFLRLLAEG-FDDETEDQQLRLYAVQSYLTLLD------MENTFYPQRFLQV 521

  Fly   484 AAWIVGEFAGELEDAEKTLNILLR----------------------PRLLPGHIQGVYVQNVIKL 526
            .:|::||:: .|.|.|....::.|                      .:|.|.......|:.:|:.
Mouse   522 MSWVLGEYS-YLLDKESPEEVITRLYKLLMSDSISSETKAWLFAAVTKLTPQAHSSPLVEKLIQE 585

  Fly   527 FARLATTCLELQDLPGLVTLCDHVLDKLQHFNGSSDIEVQERANSACMLIEMLRNQLSTSTDAMA 591
            |.....|||.           .|..: |:|.:.::               |::::.|..:.:..
Mouse   586 FTVSLNTCLR-----------QHAFE-LKHLHENT---------------ELMKSLLQGAQNCE- 622

  Fly   592 MDTTTEGGIPPLAIEIVQEMTLLFTGELI---------PVAPKAQRKVPLPDGLDLDEWINAPPP 647
                          :||.:.:|.|....:         |..|..||:   .:.|..::.:|..|.
Mouse   623 --------------DIVADASLSFLDGFVAEGLSQGAAPYKPHHQRQ---EEQLSQEKVLNFEPY 670

  Fly   648 EDAASSS--SSEHDKDELFVSATQAGTGADGGEKRRQSLELTPEQLERQRMARLIEQSNNPHYLK 710
            ..:.|||  :.......:.:.:..:|..|:.|.|...||:
Mouse   671 GLSFSSSGFTGRQSPAGISLGSDISGNSAETGLKETSSLK------------------------- 710

  Fly   711 STPTASGASNADQYDNIDDIPITELPLDMEGVAALRVGITKRSDKYLQEQQAAQGSKDGKKKHKK 775
                                        |||:..|     ...:.||.::::..|.|
Mouse   711 ----------------------------MEGIKKL-----WGKEGYLPKKESGTGDK-------- 734

  Fly   776 GKKSKKAKNKVAYNSSSESEGEPKPLHIVNTTLDMPEGVSMSDSEDKDGKYDPND------PHRA 834
                .:|.:..|..::.|:..:      ..|..|..:| .:..:|:|:.:...:.      |...
Mouse   735 ----PEASHVPAEGATVENVDQ------ATTRKDQAQG-HIPSTEEKEKQLLASSLFVGLGPENT 788

  Fly   835 LDI--ELDITEFEAPAVRSASKKSAADKENLKTP-------------ADSAGGGNAAKKDRKKDK 884
            :|:  :.|:...:   .|..||...|..:  |||             :|.|||
Mouse   789 VDLLGKADVVSHK---FRRKSKLKVAQSD--KTPSAPTAPCSALSLGSDVAGG------------ 836

  Fly   885 DKDKERKVKREHRESKRE--RKE--AAVQSVIDLIDADTPTPSPSHISATSN--------NNNTS 937
            |:|....|.|...|...|  |.|  :...|...|.....|.||   :.|.:|        ::.||
Mouse   837 DEDGLSAVDRGDGELSSELFRSESLSGPPSAEKLESVSLPVPS---LFADNNMEVFNPPSSSATS 898

  Fly   938 TVLPDAPKHHKKKKNKEKTTDEAPDALATATGSSIIDVGGEEASEVAS 985
            ||             ||:|.:        ...|.::::...||..|:|
Mouse   899 TV-------------KEETPE--------CRHSGLVEICSNEAVSVSS 925

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
g	NP_524785.2	Adaptin_N	33..578	CDD:279882	135/610 (22%)
		HEAT repeat	152..173	CDD:293787	7/24 (29%)
		HEAT repeat	185..213	CDD:293787	7/27 (26%)
		Cnd1	<193..266	CDD:289487	16/92 (17%)
		HEAT repeat	221..263	CDD:293787	7/55 (13%)
		HEAT repeat	272..290	CDD:293787	4/17 (24%)
		HEAT repeat	302..331	CDD:293787	10/28 (36%)
		BLVR	687..840	CDD:283923	18/160 (11%)
Ap4e1	XP_006498611.1	Adaptin_N	51..601	CDD:366724	133/586 (23%)
		AP4E_app_platf	1027..1127	CDD:373308

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810