DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment g and ap1g2

DIOPT Version :9

Sequence 1:	NP_524785.2	Gene:	g / 44819	FlyBaseID:	FBgn0001087	Length:	1034	Species:	Drosophila melanogaster
Sequence 2:	NP_001276787.1	Gene:	ap1g2 / 100007877	ZFINID:	ZDB-GENE-030616-587	Length:	794	Species:	Danio rerio

Alignment Length:	699	Identity:	165/699 - (23%)
Similarity:	300/699 - (42%)	Gaps:	141/699 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LTDLVRGIRN--NKDNEAKYISTCIEEIKQELRQDNISVKCNAVAKLTYIQMLGYDISWAGFNII 81
            |.:::|.||:  .:..|...|.....||:.:.||.:...:.:::|||.|:.||||...:.....:
Zfish     7 LQEMIRVIRSARTQGEERGIIQKECAEIRAQFRQTDNGERSHSLAKLLYVHMLGYPAHFGQMECV 71

  Fly    82 EVMSSSRFTCKRIGYLAASQCFHPDSELLMLTTNMIRKDLNSQNQYDAGVALSGLSCFISPDLSR 146
            .:::|.|::.||||||.|........:..:|.||.|:.||:..:||...:||..|:|..|.::.|
Zfish    72 RLIASPRYSEKRIGYLGAMMLLDEKQDASLLITNSIKNDLSHSSQYVQSLALCTLACMGSSEMCR 136

  Fly   147 DLANDIMTLMSSTKPYLRMKAVLMMYKVFLRYPEALRPAFPKLKEKLEDPDPGVQSAAVNVICEL 211
            |||.:|..|:.::..|::.||.|....:..:.||......|..:..|.:.:.||...||.:|.||
Zfish   137 DLAPEIERLLRASTSYIKKKATLCAVHIIRKVPELAELFTPSARSLLSEKNHGVLHGAVVLITEL 201

  Fly   212 ARKNP------KNYLP-LAPIFFKLMTTS----------TNNWMLIKIIKLFGAL----TPLEPR 255
            ..:|.      :..:| |..|...|:|:|          ::.::.::|::|...|    ......
Zfish   202 CERNAETLDKFRKAVPELVTIMKGLVTSSYSPEHNVAGISDPFLQVRILRLLRILGHNNDSASDA 266

  Fly   256 LGKKLIEPLTNLIHS-TSAMSLLYECINTVIAVLISISSGMPNHSASIQLCVQKLRILIEDSDQN 319
            :...|.:..||...| |:..::|||.:.|::.  |:..||:.      .|.|..|...:.::|:|
Zfish   267 MNDLLAQVATNTDSSKTAGSAVLYETVLTIMD--INSESGLR------VLAVNILGRFLLNNDRN 323

  Fly   320 LKYLGLLAMSKILKTHPKSVQAHKDLILACLDDKDESIRLRALDLLYGMVSKKNLMEIVKRLLGH 384
            ::|:.:.::.||::|...:||.|:..|:.||.|:|.|::.|||:|...:||..|:..::|.||..
Zfish   324 IRYISMTSLQKIVQTDHNAVQRHRGTIVDCLKDQDTSVKRRALELSLALVSPVNIRSMMKELLIF 388

  Fly   385 MERAEGSAYRDELLYKVIEICAQSSYLYVTNFEWYLTVLVELIQLEAGSRHGRLIAEQLLDVAIR 449
            :     |:...||..:.......::..|..:..|::..::.::....|.
Zfish   389 L-----SSCPVELRSQTASGIFNAAERYSPSKRWHIDTILHVLTTAGGD---------------- 432

  Fly   450 VPVVRQFAVNEMTNLLDT------FTVS------AQSNSMYEVLYAAAWIVGEFA-----GELED 497
               ||...|..:..|:.|      :||.      .:..|...::..|.|.:||:.     ||.|:
Zfish   433 ---VRDETVPNLIQLITTASELHCYTVHKLYRALVKDISQQSLVQVACWCIGEYGDLLLKGECEE 494

  Fly   498 AE----------KTLNILLRPRLLPGHIQGVYVQNVIKLFARLAT-------------TCLELQ- 538
            .|          ..|..:|:..:.....:|..:...:||..|:..             :|::|:
Zfish   495 IEPVQVTEDDVLDALETVLQSHMSAPATRGFALTATMKLSTRITDNVDRIRSIVSIYGSCIDLEL 559

  Fly   539 -----DLPGLVTLCDH----VLDKLQ--------HFNGSSDIEVQ----------------ERAN 570
                 :...|....||    ||:::.        |.||.|..|::                |.||
Zfish   560 QQRAVEYNALFKKYDHMRAAVLERMPLMEKNSPGHTNGDSSGEIKEPEPAKTKPVEPILLSEPAN 624

  Fly   571 SACMLIEMLRN-----QLSTSTDAMAMDTTTE------GGIPPLAIEIV 608
            ..|.|:::|..     |.|::..:.|..|::.      ||:.|..:..|
Zfish   625 QVCDLLDLLGGTDTPVQPSSAPTSTATTTSSADLLDLLGGLEPTPVPAV 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
g	NP_524785.2	Adaptin_N	33..578	CDD:279882	152/640 (24%)
		HEAT repeat	152..173	CDD:293787	6/20 (30%)
		HEAT repeat	185..213	CDD:293787	9/27 (33%)
		Cnd1	<193..266	CDD:289487	19/93 (20%)
		HEAT repeat	221..263	CDD:293787	10/56 (18%)
		HEAT repeat	272..290	CDD:293787	4/17 (24%)
		HEAT repeat	302..331	CDD:293787	6/28 (21%)
		BLVR	687..840	CDD:283923
ap1g2	NP_001276787.1	Adaptin_N	23..574	CDD:279882	138/582 (24%)
ap1g2	NP_001276787.1	Alpha_adaptinC2	675..781	CDD:197886
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910