DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment for and NTE1

DIOPT Version :9

Sequence 1:	NP_477487.1	Gene:	for / 44817	FlyBaseID:	FBgn0000721	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_013652.1	Gene:	NTE1 / 854943	SGDID:	S000004524	Length:	1679	Species:	Saccharomyces cerevisiae

Alignment Length:	731	Identity:	139/731 - (19%)
Similarity:	247/731 - (33%)	Gaps:	237/731 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SSTTVDAPPRPADVDVATVPVATPAPPPQQPVSNLFYADYQKLQPAIIDRDWERDRDTDTDTRSE 90
            ||.:.|..|:|.:.:.::   ....||..:|...:.    |.|:.|        :.:.:|.:.|.
Yeast   498 SSGSADLEPKPKNSNASS---KLKKPPKAKPSDGII----QSLKIA--------NANANTSSNSL 547

  Fly    91 AKPPDIVEHIEPVEEQRQIHTQIQ-SPAEIQIQIP---------PTPPAPSIQIQIQQRYRRHSS 145
            :..|:...|  |......:.::.| :|.::...:|         |.|              .|
Yeast   548 SLKPEFTHH--PSSRHVVLGSRDQFNPGDLLSNVPLSRTMDILSPNP--------------IH-- 594

  Fly   146 AEDRNLNTRRNDSNITEALRKAASMQQEPNANYQFPTDLGLVSIVNNNNNTNTHPSGSNSGSNNN 210
                  |..||.||                         |:     |.:.:|.|...|.| |:||
Yeast   595 ------NNNRNKSN-------------------------GI-----NTSTSNQHKRSSRS-SSNN 622

  Fly   211 SNINNNLVGGIVTLPAAGGLIGLEHTASGLRLIPAPPTHSDVLTHTLIYGTPPSGAQQLNQDPRS 275
            :::::....            .|.......:|..:|.:..:...|..|:.:|.....:::..|..
Yeast   623 ASVHSKKFS------------SLSPELRNAQLSTSPLSLDNTSVHDHIHPSPVHLKGRVSPRPNL 675

  Fly   276 LLHQQELQLQQRYQQLQQLQAQTQGLYTSQGSPVLYHQPSPGSSQPVAIPGATCHSPTQLQPPNT 340
            |........|:..:......|..:.:.|..|.          :...:::..::..:.:.|..|.
Yeast   676 LPTTSFSAAQEETEDSALRMALVEAMLTYLGV----------NKSNMSVSSSSIANMSSLNSPQ- 729

  Fly   341 LNLQQQMQSLRISG--------CTPSGTGGSATPSPVGLVDPNFIVSNYVAASPQEERFIQIIQA 397
            ||   :|.|.|.|.        ||||...               :.|::  ||||.:..:..|..
Yeast   730 LN---EMYSRRPSNASFLMSPHCTPSDIS---------------VASSF--ASPQTQPTMLRILP 774

  Fly   398 KEL----------KIQEMQRALQFKDNEIAELKSHLDKFQSVFP----------FSRGSA---AG 439
            ||.          |.|:.::...:|:    ||..:|| |:.|..          |.:|:.   ..
Yeast   775 KEYTISNKRHNKSKSQDKKKPRAYKE----ELTPNLD-FEDVKKDFAQGIQLKFFKKGTTIVEQN 834

  Fly   440 CAGTG-----------GASGSGAGGSGGSGPGTATGATRKSGQNFQRQRAL-------GI----- 481
            ..|.|           ..:.|.:..|..|.|...:..:...|:|....:.|       ||
Yeast   835 ARGKGLFYIISGKVNVTTNSSSSVVSSMSKPEQVSAQSSHKGENPHHTQHLLYSVGSGGIVGYLS 899

  Fly   482 ---------SAEPQSE------SSLLLEHVSFPKYDKDERSRELIKAAILDNDFMKNLDLTQIRE 531
                     :...:|:      ||..||.: |.||       .||...|  :|.:..|..:::.:
Yeast   900 SLIGYKSFVNIVAKSDVYVGFLSSATLERL-FDKY-------FLIYLRI--SDSLTKLLSSRLLK 954

  Fly   532 IVDCMYPVKYPAKNLIIKEGDVGSIVYVMEDGRV----------------EVSREGKYLSTLSGA 580
            :...:..|...|...:..:||..:.:||:.:||:                ||..:...|..|:..
Yeast   955 LDHALEWVHLRASETLFSQGDSANGIYVVLNGRLRQLQQQSLSNSNTSSEEVETQNIILGELAQG 1019

  Fly   581 KVLGELAILYNCQRTATITAITECNLWAIERQCFQ-------TIMMRTG-LIRQAEYSDFLKSVP 637
            :..||:.:|....|.:||.|:.:..|..|.|..|:       :||:|.. |:.:....|  ::||
Yeast  1020 ESFGEVEVLTAMNRYSTIVAVRDSELARIPRTLFELLALEHPSIMIRVSRLVAKKIVGD--RTVP 1082

  Fly   638 IFKDLAEDTL-IKISD 652
            .   |..|.| ||.:|
Yeast  1083 A---LTGDPLSIKEND 1095

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374	15/66 (23%)
		Crp	518..>627	CDD:223736	29/132 (22%)
		CAP_ED	520..629	CDD:237999	28/132 (21%)
		Crp	632..>753	CDD:223736	8/22 (36%)
		CAP_ED	638..754	CDD:237999	6/16 (38%)
		S_TKc	778..1036	CDD:214567
		STKc_cGK	783..1043	CDD:270724
NTE1	NP_013652.1	cNMP_binding	821..933	CDD:394984	19/112 (17%)
		CAP_ED	957..1067	CDD:237999	25/109 (23%)
		Pat_Fungal_NTE1	1361..1629	CDD:132865
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900