DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment for and PRKAR2A

DIOPT Version :9

Sequence 1:	NP_477487.1	Gene:	for / 44817	FlyBaseID:	FBgn0000721	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_001308911.1	Gene:	PRKAR2A / 5576	HGNCID:	9391	Length:	404	Species:	Homo sapiens

Alignment Length:	298	Identity:	90/298 - (30%)
Similarity:	150/298 - (50%)	Gaps:	22/298 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   477 RALGISAE---PQSESSLLLEHVSFPKYDKDERSRELIKAAILDNDFMKNLDLTQIREIVDCMYP 538
            |.:.:.||   |..|.......|..||.| ::|.|  ::.|..|....||||..|:.:::|.|:.
Human    96 RRVSVCAETYNPDEEEEDTDPRVIHPKTD-EQRCR--LQEACKDILLFKNLDQEQLSQVLDAMFE 157

  Fly   539 VKYPAKNLIIKEGDVGSIVYVMEDGRVEV----SREGKYLSTLSGAKVLGELAILYNCQRTATIT 599
            ....|...:|.:||.|...||:|.|..::    ..:.:.:.........||||::||..|.|||.
Human   158 RIVKADEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIV 222

  Fly   600 AITECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDY 664
            |.:|.:||.::|..|:.|:::....::..:..|::|||:.|.|.....:||.||:.|..|:.|:.
Human   223 ATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGER 287

  Fly   665 IVRQGARGDTFFIISKGKVRVTIKQQDT------QEEKFIRMLGKGDFFGEKALQGDDLRTANII 723
            |:.||.:.|:|:||..|:|.:.|:.:..      .:|..|....||.:|||.||..:..|.|:
Human   288 IITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAAS-- 350

  Fly   724 CESADGVSCLVIDRETFNQLISNLDEIKHR----YDDE 757
            ..:...|.|||:|.:.|.:|:....:|..|    |:::
Human   351 AYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQ 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374
		Crp	518..>627	CDD:223736	33/112 (29%)
		CAP_ED	520..629	CDD:237999	33/112 (29%)
		Crp	632..>753	CDD:223736	42/126 (33%)
		CAP_ED	638..754	CDD:237999	39/125 (31%)
		S_TKc	778..1036	CDD:214567
		STKc_cGK	783..1043	CDD:270724
PRKAR2A	NP_001308911.1	Dimerization and phosphorylation	2..138		13/44 (30%)
		DD_RIIalpha_PKA	4..44	CDD:213050
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	47..90
		Crp	135..>244	CDD:223736	34/108 (31%)
		CAP_ED	139..251	CDD:237999	33/111 (30%)
		Crp	255..>371	CDD:223736	40/117 (34%)
		CAP_ED	261..382	CDD:237999	39/122 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810